Korean Circulation Journal最新文献_第4页

Disparities in Heart Transplantation Allocation and Outcomes by Blood Type in Korea (2010-2022). 韩国心脏移植分配和结果的血型差异（2010-2022）。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-28 DOI: 10.4070/kcj.2024.0281

Kyung-Hee Kim, Byoung Geol Choi, Jin-Oh Choi, In-Cheol Kim, Jong-Chan Youn, Yang Hyun Cho, Hae-Young Lee, Sung-Ho Jung, Byung-Hee Oh

{"title":"Disparities in Heart Transplantation Allocation and Outcomes by Blood Type in Korea (2010-2022).","authors":"Kyung-Hee Kim, Byoung Geol Choi, Jin-Oh Choi, In-Cheol Kim, Jong-Chan Youn, Yang Hyun Cho, Hae-Young Lee, Sung-Ho Jung, Byung-Hee Oh","doi":"10.4070/kcj.2024.0281","DOIUrl":"https://doi.org/10.4070/kcj.2024.0281","url":null,"abstract":"Background and objectives: This study aimed to elucidate the influence of recipient blood type on heart transplant allocation dynamics in Korea, focusing on donor matching, wait times, and post-transplant survival from 2010 to 2022.Methods: In this retrospective cohort study, we examined 1,745 heart transplant recipients classified by blood types: A (n=631), B (n=488), AB (n=256), and O (n=370). Parameters studied encompassed donor and recipient ages, donor blood type compatibility, organ type, emergency status, waiting periods, and survival rates up to one year post-transplant.Results: This investigation revealed significant disparities in the outcomes for heart transplant waitlist patients, differentiated by blood type. O recipients encountered notably extended median wait times of 110 days (an average of 300±514 days), which is substantially longer compared to A (65 days), B (58 days), and AB (29 days). Furthermore, the mortality rate for O recipients while on the waitlist was markedly high at 78.1%, in contrast to 75.2% for A, 72.3% for B, and 48.5% for AB. O recipients who, despite constituting a significant proportion of the donor pool (34.1%), received transplants at disproportionately lower rates.Conclusions: Type O heart transplant recipients in Korea face significant challenges, including higher mortality rates during the waiting period and frequent necessity for left ventricular assist device interventions. Urgent policy reforms are needed to address these disparities and improve equitable organ allocation for blood type O patients.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Cutaneous Wounds and Infective Endocarditis: A Nationwide Self-Controlled Case Series Study in Taiwan. 皮肤伤口与感染性心内膜炎的关系：台湾一项全国性自我对照个案系列研究。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-25 DOI: 10.4070/kcj.2024.0306

Peter Pin-Sung Liu, Huai-Ren Chang, Huei-Kai Huang, Jin-Yi Hsu, Carol Chiung-Hui Peng, Kai-Ming Chang, Ching-Hui Loh, Jih-I Yeh

{"title":"The Association Between Cutaneous Wounds and Infective Endocarditis: A Nationwide Self-Controlled Case Series Study in Taiwan.","authors":"Peter Pin-Sung Liu, Huai-Ren Chang, Huei-Kai Huang, Jin-Yi Hsu, Carol Chiung-Hui Peng, Kai-Ming Chang, Ching-Hui Loh, Jih-I Yeh","doi":"10.4070/kcj.2024.0306","DOIUrl":"https://doi.org/10.4070/kcj.2024.0306","url":null,"abstract":"Background and objectives: We aim to investigate whether disruption of the skin defense in the form of cutaneous wounds may increase the incidence rate (IR) of infective endocarditis (IE) in the general population.Methods: We performed a retrospective population-based study using Taiwan's National Health Insurance Database from 2013 to 2022. Self-controlled case series (SCCS) was used to investigate the time-sequential association between cutaneous wounds and IE. Adult patients with both cutaneous wounds (exposure) and IE (outcome) in the database were included in the study. Conditional Poisson regression was used to calculate the adjusted IR ratios (aIRRs) of IE during the 4 weeks following wounds to that of the baseline period within the same individuals.Results: We enrolled 3,241 eligible patients for SCCS analysis. The risks of IE were elevated in the second week (aIRR, 2.16; 95% confidence interval [CI], 1.07-4.35; p value=0.032) after a treated traumatic wound. The risks of IE were elevated in the first (aIRR, 1.56; 95% CI, 1.17-2.09; p value=0.002) and second (aIRR, 1.58; 95% CI, 1.19-2.10; p value=0.002) after a treated non-traumatic wound.Conclusions: Both traumatic and non-traumatic cutaneous wounds are associated with an increased risk of IE within the first 2 weeks after treatments among the general population in Taiwan. Clinicians should be vigilant for symptoms or signs associated with IE in these patients to avoid delays in diagnosis and treatment.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryoballoon Ablation for Elderly Patients With Atrial Fibrillation: Results From the Korean Cryoballoon Registry. 老年房颤患者的冷冻球囊消融：来自韩国冷冻球囊登记的结果。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-21 DOI: 10.4070/kcj.2024.0308

Dong-Seon Kang, Pil-Sung Yang, Jun-Hyung Kim, Ki-Hun Kim, Ju Youn Kim, So-Ryoung Lee, Junbeom Park, Sung Ho Lee, Chang Hee Kwon, Myung-Jin Cha, Jaemin Shim, Il-Young Oh, Sang-Jin Han, Hong Euy Lim

{"title":"Cryoballoon Ablation for Elderly Patients With Atrial Fibrillation: Results From the Korean Cryoballoon Registry.","authors":"Dong-Seon Kang, Pil-Sung Yang, Jun-Hyung Kim, Ki-Hun Kim, Ju Youn Kim, So-Ryoung Lee, Junbeom Park, Sung Ho Lee, Chang Hee Kwon, Myung-Jin Cha, Jaemin Shim, Il-Young Oh, Sang-Jin Han, Hong Euy Lim","doi":"10.4070/kcj.2024.0308","DOIUrl":"https://doi.org/10.4070/kcj.2024.0308","url":null,"abstract":"Background and objectives: Cryoballoon ablation (CBA) is considered an effective rhythm control treatment for atrial fibrillation (AF) and is increasing exponentially. However, data regarding the efficacy and safety of CBA in elderly patients are limited.Methods: A total of 2,652 patients (55.2% with non-paroxysmal AF) from the Korean CBA registry database with follow-up of ≥12-months after de novo CBA were divided into 2 groups based on age (<75 and ≥75 years old). Procedure related complications and clinical outcomes were compared.Results: Compared to the control group (n=2,403), the elderly group (n=249) had female predominance (41.8% vs. 21.1%, p<0.001), a higher CHA₂DS₂-VASc scores (4.0 [3.0-5.0] vs. 2.0 [1.0-3.0]; p<0.001), and a higher prevalence of heart failure (33.3% vs. 21.9%; p<0.001) and chronic kidney disease (42.2% vs. 10.4%; p<0.001). A total of 120 procedure-related minor complications were reported, but no significant difference was observed between the 2 groups (6.4% vs. 4.3%; p=0.18). Recurrence of atrial tachyarrhythmias was observed in 67 patients (27.2%) in the elderly group and 788 patients (33.3%) in the control group. After adjusting for confounding variables, the freedom from atrial tachyarrhythmias during 24-month was similar between the 2 groups (67.0% vs. 62.7%; adjusted hazard ratio, 0.91; 95% confidence interval, 0.62-1.34; p=0.63).Conclusions: CBA showed a reasonable efficacy and safety profile in elderly population with AF, comparable to that in younger patients.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influenza Vaccination Trends and Associated Factors Among Middle-aged Working Adults With an Elevated Cardiovascular Risk in Korea. 韩国中年工作成年人心血管风险升高的流感疫苗接种趋势及相关因素

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-18 DOI: 10.4070/kcj.2024.0316

Min Sun Kim, Seonhye Gu, Sun-Hyung Kim, Ki Man Lee, Bumhee Yang, Hyun Lee

{"title":"Influenza Vaccination Trends and Associated Factors Among Middle-aged Working Adults With an Elevated Cardiovascular Risk in Korea.","authors":"Min Sun Kim, Seonhye Gu, Sun-Hyung Kim, Ki Man Lee, Bumhee Yang, Hyun Lee","doi":"10.4070/kcj.2024.0316","DOIUrl":"https://doi.org/10.4070/kcj.2024.0316","url":null,"abstract":"Background and objectives: The development of atherosclerotic cardiovascular disease (ASCVD) in middle-aged working groups can be a major contributor to disability-adjusted life years. However, information regarding the current trends in influenza vaccination within this demographic group remains scarce. Thus, we aimed to investigate the recent 11-year trends in influenza vaccination and related factors among these populations in Korea.Methods: Of 42,879 individuals aged 40-64 years enrolled in the Korea National Health and Nutrition Examination Survey between 2010 and 2021, 35,323 were included. We investigated the yearly trend of influenza vaccination rate according to ASCVD risk and factors associated with being unvaccinated in the elevated ASCVD risk group (ASCVD risk score: ≥7.5%).Results: Among the 35,323 participants, 20,392 (57.7%) were classified into the elevated ASCVD risk group. Over the 11 years, the vaccination rate was significantly higher in the elevated ASCVD risk group than in the low ASCVD risk group (33.8% vs. 25.3%, p<0.001). Factors associated with the unvaccinated status in the elevated ASCVD risk group included younger age (<50 years; adjusted odds ratio, 1.61; 95% confidence interval, 1.31-1.98), male sex (1.43; 1.16-1.76), current smoker status (1.41; 1.13-1.76), residence in an urban area (1.19; 1.01-1.41), and having higher education (1.3; 1.04-1.64).Conclusions: One in 3 middle-aged working adults with an elevated risk of ASCVD received the influenza vaccination. Although the influenza vaccination rate was higher in participants with an elevated ASCVD risk than in those with low ASCVD risk, the vaccination rate was relatively unsatisfactory.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-Based Therapy in Cardiovascular Diseases: A New Frontier in Cardiovascular Disease Treatment. 基于外泌体的心血管疾病治疗：心血管疾病治疗的新前沿。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-05 DOI: 10.4070/kcj.2025.0022

Cheong-Whan Chae, Gun Choi, Taehun Yoon, Yoo-Wook Kwon

{"title":"Exosome-Based Therapy in Cardiovascular Diseases: A New Frontier in Cardiovascular Disease Treatment.","authors":"Cheong-Whan Chae, Gun Choi, Taehun Yoon, Yoo-Wook Kwon","doi":"10.4070/kcj.2025.0022","DOIUrl":"https://doi.org/10.4070/kcj.2025.0022","url":null,"abstract":"Exosomes, small extracellular vesicles ranging from 30 to 150 nanometers in diameter, have emerged as pivotal mediators of intercellular communication. These vesicles, originally perceived as cellular debris, are now recognized for their intricate roles in transporting bioactive molecules, including proteins, lipids, and nucleic acids, between cells. Exosomes have received considerable attention due to their roles in diverse physiological and pathological processes, especially in relation to cardiovascular diseases (CVDs). CVDs are intricately linked, sharing common risk factors and pathological mechanisms, such as inflammation, oxidative stress, and endothelial dysfunction. Exosomes have been implicated in either directly or indirectly influencing these phenomena. They are secreted by virtually all cell types, including endothelial cells, cardiomyocytes, and stem cells, play critical roles in maintaining vascular homeostasis and responding to pathological stimuli. Their capacity to traverse biological barriers, maintain stability in circulation, and effectively encapsulate and deliver a variety of molecular cargos makes them promising candidates for both biomarkers and therapeutic agents. This review aims to explore the multifaceted roles of exosomes in CVDs. And we will discuss the mechanisms of exosome biogenesis and release, their molecular composition, and the ways in which they contribute to disease pathophysiology. Additionally, we will emphasize the potential of exosomes as diagnostic biomarkers and their therapeutic uses, highlighting their significance in the advancement of innovative treatment strategies. This review explores recent findings and advancements in exosome research, emphasizing their significance in CVD and paving the way for future studies and clinical applications.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathway of Leadless Pacemaker in Korea: From Now to Future. 韩国无铅起搏器之路：从现在到未来。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-04 DOI: 10.4070/kcj.2025.0032

Ki Hong Lee

引用次数: 0

Increasing Very Low-Dose Edoxaban Prescription: Effectiveness and Safety Data of Korean AF Patients. 增加极低剂量埃多沙班处方：韩国房颤患者的有效性和安全性数据。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-01 Epub Date: 2024-11-04 DOI: 10.4070/kcj.2024.0222

JungMin Choi, So-Young Yang, So-Ryoung Lee, Min Soo Cho, Kyung-Yeon Lee, Hyo-Jeong Ahn, Soonil Kwon, Myung-Jin Cha, Jun Kim, Gi-Byoung Nam, Kee-Joon Choi, Eue-Keun Choi, Seil Oh, Gregory Y H Lip

{"title":"Increasing Very Low-Dose Edoxaban Prescription: Effectiveness and Safety Data of Korean AF Patients.","authors":"JungMin Choi, So-Young Yang, So-Ryoung Lee, Min Soo Cho, Kyung-Yeon Lee, Hyo-Jeong Ahn, Soonil Kwon, Myung-Jin Cha, Jun Kim, Gi-Byoung Nam, Kee-Joon Choi, Eue-Keun Choi, Seil Oh, Gregory Y H Lip","doi":"10.4070/kcj.2024.0222","DOIUrl":"10.4070/kcj.2024.0222","url":null,"abstract":"Background and objectives: Evidence remains limited on the real-world prescription of very low-dose oral anticoagulation among frail patients with atrial fibrillation (AF). We described the practice patterns, effectiveness, and safety of very low-dose edoxaban (15 mg once daily).Methods: Patients with AF prescribed edoxaban 15 mg once daily in 2 tertiary hospitals between 2016 and September 2022 were included. Baseline clinical characteristics and clinical outcomes of interest were thromboembolic and bleeding events.Results: A total of 674 patients were included (mean age 78.3±9.1, 49.7% aged ≥80 years, 49.3% women, median follow-up 1.0±1.2 years). Mean CHA2DS2-VASc score was 3.9±1.6, and the modified HAS-BLED score was 2.0±1.1. Between 2016 and 2022, the number of very low-dose edoxaban prescriptions increased. The main reasons for the prescription of very low-dose were low body weight (55.5% below 60 kg), anaemia (62.8%), chronic kidney disease (40.2%), active cancer (15.3%), concomitant anti-platelet use (26.7%), and prior major bleeding (19.7%). During a median follow-up duration of 8 (interquartile range 3-16) months, overall thromboembolic and bleeding events occurred in 16 (2.3%) and 88 (13.1%) patients, respectively. Compared to the expected event rates on the established risk scoring systems, patients receiving very low-dose edoxaban demonstrated a 61% reduction in ischemic stroke, a 68% reduction of ischemic stroke/transient ischemic attack/systemic embolism, whereas a 49% increase in major bleeding.Conclusions: The prescription of very low-dose edoxaban was increased over time, attributable to various clinical factors. The use of very low-dose edoxaban reduced the expected risk of thromboembolic events.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"215-227"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Correction of Text in the Article "The Long-term Outcomes and Risk Factors of Complications After Fontan Surgery: From the Korean Fontan Registry (KFR)". 勘误：更正文章“Fontan手术后并发症的长期结果和危险因素：来自韩国Fontan登记处（KFR）”中的文本。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-01 DOI: 10.4070/kcj.2025.0999

Sang-Yun Lee, Soo-Jin Kim, Chang-Ha Lee, Chun Soo Park, Eun Seok Choi, Hoon Ko, Hyo Soon An, I Seok Kang, Ja Kyoung Yoon, Jae Suk Baek, Jae Young Lee, Jinyoung Song, Joowon Lee, June Huh, Kyung-Jin Ahn, Se Yong Jung, Seul Gi Cha, Yeo Hyang Kim, Youngseok Lee, Sanghoon Cho

引用次数: 0

Epigenetic Modulation in Heart Failure: HDAC Inhibitors as Emerging Therapeutic Allies. 心力衰竭的表观遗传调节：HDAC抑制剂作为新兴的治疗盟友。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-01 DOI: 10.4070/kcj.2024.0424

Jin-Oh Choi

引用次数: 0

Successful Customized Fenestrated Endovascular Aortic Aneurysm Repair in a Patient With Complex Abdominal Aortic Aneurysm. 成功定制开窗血管内修复复杂腹主动脉瘤患者。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-03-01 DOI: 10.4070/kcj.2024.0297

Markz Rmp Sinurat, Sungkwon Kang, Soohyung Park, Seung-Woon Rha

引用次数: 0