Korean Circulation Journal最新文献

{"title":"17-Year Coronary Angiographic Series of Sirolimus-Eluting Stent-Induced Giant Aneurysms: Stent-Assisted Coil Embolization.","authors":"Sang-Suk Choi, Jin Jung, Sung-Ho Her","doi":"10.4070/kcj.2026.0022","DOIUrl":"10.4070/kcj.2026.0022","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"844-847"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular Ultrasound-Guided Percutaneous Coronary Intervention for Severely Calcified Lesions Requiring Rotational Atherectomy.","authors":"Duck-Hyun Jang, Je Sang Kim, Sung-Ho Her, Kyusup Lee, Sang-Hoon Cho, Ik-Jun Choi, Jae-Hwan Lee, Jang-Hoon Lee, Sang-Rok Lee, Pil-Hyung Lee, Seung-Whan Lee, Ki-Dong Yoo, Kyeong Ho Yun, Young Jin Choi, Tae-Hoon Kim, Ho-Jun Jang, Ha Wook Park, Chi-Hoon Kim, Hyun-Jong Lee","doi":"10.4070/kcj.2025.0255","DOIUrl":"10.4070/kcj.2025.0255","url":null,"abstract":"<p><strong>Background and objectives: </strong>Intravascular ultrasound (IVUS) is an invaluable tool for accurate lesion assessment and optimal stent implantation during complex coronary interventions. This study evaluated the impact of IVUS guidance on the long-term clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) for severely calcified lesions requiring rotational atherectomy (RA).</p><p><strong>Methods: </strong>Between January 2010 and October 2019, 511 patients from nine tertiary centers in South Korea who underwent PCI with RA using second-generation drug-eluting stents were enrolled. The primary endpoint was a composite of cardiac death or myocardial infarction (MI).</p><p><strong>Results: </strong>IVUS was performed in 241 (47.2%) patients. Compared with the angiography-guided PCI (A-GP) group, the IVUS-guided PCI (I-GP) group had a higher prevalence of the left main disease (23.7% vs. 5.9%; p<0.001), larger stents (3.1 mm vs. 2.9 mm; p<0.001), longer stents (72 mm vs. 61 mm; p<0.001), and more frequent post-dilation (85.4% vs. 71.9%; p<0.001). Within a median follow-up of 20 (9-39) months, compared with the A-GP group, the I-GP group had a significantly lower risk of cardiac death or MI (7.0% vs. 11.2%; hazard ratio [HR], 0.481; 95% confidence interval [CI], 0.254-0.908; p=0.024). After adjusting for potential confounders with inverse probability of treatment weighting, the I-GP group still had a significantly lower risk of cardiac death or MI, and cardiac death (HR, 0.442; 95% CI, 0.226-0.865; p=0.017, and HR, 0.413; 95% CI, 0.181-0.944; p=0.036).</p><p><strong>Conclusions: </strong>IVUS guidance is likely to improve long-term clinical outcomes in patients undergoing PCI with RA for severely calcified lesions.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"776-790"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing Is Saving: Navigating the Rocky Path With Intravascular Ultrasound.","authors":"Oh-Hyun Lee","doi":"10.4070/kcj.2026.0135","DOIUrl":"10.4070/kcj.2026.0135","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"56 9","pages":"791-793"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epitranscriptomic Regulation of Cardiac Ischemia-Reperfusion Injury: Unveiling the METTL14/IGF2BP1/PDE4D Axis.","authors":"JaeHyuk Jang, Hun-Jun Park","doi":"10.4070/kcj.2026.0235","DOIUrl":"10.4070/kcj.2026.0235","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"56 9","pages":"841-843"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Persistent Challenge of Cardiogenic Shock Complicating Acute Myocardial Infarction: Insights From a Korean Nationwide Registry.","authors":"Minju Han, Jeehoon Kang","doi":"10.4070/kcj.2026.0093","DOIUrl":"10.4070/kcj.2026.0093","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"807-809"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-12Rβ2 is Expressed in the Synthetic SMC and Detected in the Blood of Patients With Acute Myocardial Infarction.","authors":"Dong Hoon Kang, Hee Su Lee, Jin-Ah Yang, In Sook Kang, Sodam Jung, Kihwan Kwon, Sang Won Kang","doi":"10.4070/kcj.2025.0330","DOIUrl":"10.4070/kcj.2025.0330","url":null,"abstract":"<p><strong>Background and objectives: </strong>De-differentiation and proliferation of smooth muscle cells (SMCs), triggered by pro-atherogenic factors or endothelial damage, contribute to progressive vascular remodeling. However, biomarkers reflecting the SMC phenotypic changes indicative of vulnerable plaques remain unavailable.</p><p><strong>Methods: </strong>We characterized mRNA and protein expression of interleukin-12 receptor beta 2 subunit (IL-12Rβ2) in human aortic SMCs and human carotid arteries with atherosclerotic lesions by quantitative real-time polymerase chain reaction, immunoblotting, flow cytometry, and immunohistochemistry. Functional roles of IL-12Rβ2 were evaluated by siRNA-mediated knockdown in synthetic SMCs and a rat carotid balloon injury model. A capture enzyme-linked immunosorbent assay (ELISA) was developed to measure circulating IL-12Rβ2 levels in plasma from patients with acute coronary syndromes.</p><p><strong>Results: </strong>The IL-12Rβ2 protein is about 2-fold higher in the thickened carotid arteries from patients with atherosclerosis than in normal arteries. The in vitro studies demonstrate that IL-12Rβ2 expression is induced in synthetic SMCs by interferon (IFN)-γ stimulation. The knockdown of IL-12Rβ2 significantly reduces proliferation, migration, and monocyte adhesion in synthetic SMCs and inhibits neointimal thickening in a rat carotid balloon injury model. IL-12Rβ2 is detected in SMC-derived extracellular vesicles (EVs) circulating in plasma from acute myocardial infarction (AMI) patients and is successfully quantified using a capture ELISA employing anti-PDGFRβ antibody as an SMC-specific marker.</p><p><strong>Conclusions: </strong>IL-12Rβ2, selectively induced in synthetic SMCs by IFN-γ, is released via EVs into blood in AMI patients, representing a novel biomarker to detect vulnerable atherosclerotic plaques through the newly-developed ELISA system.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"810-823"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiplatelet Therapy in Patients Receiving Percutaneous Coronary Intervention for Bifurcation Lesions.","authors":"Jeehoon Kang, Bon-Kwon Koo","doi":"10.4070/kcj.2025.0427","DOIUrl":"10.4070/kcj.2025.0427","url":null,"abstract":"<p><p>Antiplatelet therapy is crucial for patients after percutaneous coronary intervention (PCI), but there is limited high-quality evidence guiding the best strategy for those with bifurcation lesions. The antiplatelet strategy for bifurcation PCI requires balancing the patient's overall thrombotic and bleeding risks. Bifurcation lesions present a complex, high-thrombotic-risk milieu because the procedure often causes plaque disruption and forms an inevitable gap in the sealing of the stent, compounded by turbulent blood flow that promotes thrombosis. Factors like stent malapposition, underexpansion, and low/oscillatory shear stress also contribute to increased local thrombotic risk, making the optimal antiplatelet therapy for bifurcation PCI difficult to define. Previous observational registry data broadly suggested a prolonged duration of dual antiplatelet therapy (DAPT) may be safer than a shorter duration of DAPT in reducing major adverse clinical outcomes. However, the reliability of these findings is limited by the inherent flaws of registry data, including the retrospective study design, lack of clinical event adjudication, and lack of specific protocol of PCI or DAPT strategy. Moreover, specific lesions factors such as complex PCI and left main bifurcation lesions or patient factors such as the presence of high bleeding risk or clopidogrel resistance necessitate special consideration, which leads to a individualized DAPT strategy beyond registry generalizations. The future of care points toward precision medicine, necessitating dedicated, prospective randomized controlled trials with standardized procedures to establish clear, evidence-based recommendations.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"753-762"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PDE4D Mediates the Cardiac Ischemia Reperfusion Injury and Is m6A Modified by METTL14.","authors":"Beibei Li, Hui Liu","doi":"10.4070/kcj.2025.0415","DOIUrl":"10.4070/kcj.2025.0415","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cardiac ischemia-reperfusion (I/R) injury is a major contributor to morbidity following myocardial infarction. While PDE4D has been implicated in cerebral I/R injury, its role and regulatory mechanisms in the cardiac context remain unclear.</p><p><strong>Methods: </strong>PDE4D expression was analyzed using quantitative polymerase chain reaction and Western blot. Apoptosis was assessed by TUNEL staining, flow cytometry, and detection of caspase-3, Bax, and Bcl-2 levels. N6-methyladenosine (m6A) modification of PDE4D was examined via methylated RNA immunoprecipitation, luciferase reporter assays, and RNA stability measurements. The interaction between IGF2BP1 and PDE4D was confirmed by RNA immunoprecipitation.</p><p><strong>Results: </strong>PDE4D was significantly upregulated in I/R-injured myocardium and in H9c2 cardiomyocytes subjected to hypoxia/reoxygenation. Knockdown of PDE4D reduced infarct size, suppressed apoptosis, and improved cell viability. METTL14 mediated m6A methylation at 2 conserved sites within PDE4D mRNA, thereby enhancing its RNA stability. Silencing METTL14 decreased PDE4D expression and reduced its transcript stability. IGF2BP1 recognized m6A-modified PDE4D and promoted its RNA stability; ablation of IGF2BP1 abolished the effects of METTL14. Overexpression of PDE4D reversed the cardioprotective effects resulting from METTL14 silencing.</p><p><strong>Conclusions: </strong>METTL14 stabilizes PDE4D mRNA through m6A methylation, which is recognized by IGF2BP1, thereby exacerbating cardiac I/R injury.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"824-840"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Cardiogenic Shock Complicating Acute Myocardial Infarction in South Korea.","authors":"Pil Sang Song, Kye Taek Ahn, Mi Joo Kim, Seok-Woo Seong, Hyeon-Cheol Gwon, Seung-Ho Hur, Seung-Woon Rha, Chang-Hwan Yoon, Seung Hun Lee, Myung Ho Jeong, Jin-Ok Jeong","doi":"10.4070/kcj.2025.0308","DOIUrl":"10.4070/kcj.2025.0308","url":null,"abstract":"<p><strong>Background and objectives: </strong>We aimed to study temporal trends in cardiogenic shock (CS) complicating acute myocardial infarction (AMI) and assessed the predictors of shock development during hospitalization and of mortality.</p><p><strong>Methods: </strong>Data were obtained from 2 Korean AMI Registries (KAMIRs), the KAMIR-National Institutes of Health (early) and KAMIR-V (late). Patients with CS were those with CS before admission (ba-CS) and those who developed CS during admission as a complication of AMI (da-CS). Temporal trends were examined as early (2011-2015) and late (2016-2020) periods.</p><p><strong>Results: </strong>A total of 28,990 patients was included, of whom 3,179 (11.0%) had CS. The overall prevalence of CS decreased from 12.5% to 9.6% (p for trend <0.001). Among CS patients, 1,900 (59.8% of those with CS) had ba-CS and 1,279 developed da-CS. The prevalence of both ba- (7.1% to 6.1%, p<0.001) and da-CS (5.4% to 3.6%, p<0.001) decreased, while the use of percutaneous coronary intervention increased. Over the 10-year period, in-hospital mortality rates decreased in overall CS (from 27.3% to 22.9%; p=0.004) and ba-CS (from 25.1% to 17.0%; p<0.001), but not in da-CS (from 30.3% to 32.9%; p=0.335).</p><p><strong>Conclusions: </strong>The decline in mortality rates of overall and ba-CS but not that of da-CS emphasizes the need for enhanced prevention strategies, early identification of development of CS after admission, and alternative therapeutic strategies for patients at high risk of CS in the acute stage of AMI.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"794-806"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain-Volume Loop Dynamics: A Novel Perspective on Left Ventricular Dysfunction.","authors":"Hyue Mee Kim, Hyewon Lee, Yaeji Lim, Goo-Yeong Cho","doi":"10.4070/kcj.2025.0331","DOIUrl":"10.4070/kcj.2025.0331","url":null,"abstract":"<p><strong>Background and objectives: </strong>Strain-volume loop (SVL) dynamics demonstrate the relationship between myocardial strain and left ventricular (LV) volume throughout the cardiac cycle, offering insights into both systolic and diastolic function. This study aimed to identify SVL characteristics that differentiate heart failure (HF) patients from those without cardiac disease.</p><p><strong>Methods: </strong>This retrospective analysis included 352 individuals who underwent 3-dimensional (3D) echocardiography at tertiary care hospitals. Participants were classified into no cardiac disease, HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF) groups. Temporal 3D strain and LV volume data from each frame were used to construct SVLs. Key parameters-systolic, early and late diastolic slopes, area between curves, and peak strain-were analyzed.</p><p><strong>Results: </strong>Patients with HFpEF exhibited lower systolic slopes compared to those without cardiac disease, while patients with HFrEF had the lowest values (p<0.001). During early diastole, individuals without cardiac disease exhibited a sharp strain change relative to volume, whereas the HFpEF and HFrEF groups showed diminished changes. Differences in early and late diastolic slopes and the area between the systolic and diastolic curves progressively decreased from individuals without cardiac disease to those with HFpEF and HFrEF. Support vector machine analysis using SVL parameters showed strong discrimination, with 0.878 overall accuracy in classifying the 3 groups.</p><p><strong>Conclusions: </strong>SVL analysis comprehensively represents the strain-volume relationship, distinguishing HF patients from those without cardiac disease. It may serve as a non-invasive tool for evaluating cardiac function, providing insights into functional transitions across HF phenotypes.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"763-775"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}