Korean Circulation Journal最新文献

Diagnostic Performance of Angiography-Derived FFR According to the Analysis Factors. 基于分析因素的血管造影衍生FFR的诊断价值。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-03 DOI: 10.4070/kcj.2025.0077

You-Jeong Ki, Doyeon Hwang, Seokhun Yang, Sang-Hoon Na, Joon-Hyung Doh, Chang-Wook Nam, Doo-Youp Kim, Byung-Joo Choi, Chang-Bae Sohn, Hyun-Jong Lee, Hyun Kuk Kim, Yongcheol Kim, Eun-Seok Shin, Bon-Kwon Koo

{"title":"Diagnostic Performance of Angiography-Derived FFR According to the Analysis Factors.","authors":"You-Jeong Ki, Doyeon Hwang, Seokhun Yang, Sang-Hoon Na, Joon-Hyung Doh, Chang-Wook Nam, Doo-Youp Kim, Byung-Joo Choi, Chang-Bae Sohn, Hyun-Jong Lee, Hyun Kuk Kim, Yongcheol Kim, Eun-Seok Shin, Bon-Kwon Koo","doi":"10.4070/kcj.2025.0077","DOIUrl":"https://doi.org/10.4070/kcj.2025.0077","url":null,"abstract":"Background and objectives: Quantitative flow ratio (QFR) is a method for estimating fractional flow reserve (FFR) without the use of an invasive pressure wire or hyperemic agent. However, the reasons for variation in QFR accuracy across studies and the factors associated with its accuracy remain unclear. The aim of this study was to investigate the diagnostic performance of QFR under different clinical and analysis conditions.Methods: This multicenter trial prospectively enrolled patients undergoing coronary angiography with an indication for invasive FFR. The composite score for the QFR analysis factors was calculated based on the presence or absence of the angiographic factor, system factor, lesion factor, and subjective difficulty factor. The diagnostic performance of the QFR was assessed for each composite score using FFR ≤0.80 as the reference.Results: A total of 285 vessels from 239 patients were analyzed. The median FFR and QFR values were 0.83 (interquartile range [IQR], 0.78-0.88) and 0.83 (IQR, 0.76-0.89), respectively. Using FFR ≤0.80 as a reference, QFR showed an overall diagnostic accuracy of 81.4%. Higher composite scores were associated with lower diagnostic performance of QFR in predicting FFR ≤0.80 (p-for-trend=0.010). The diagnostic accuracy of QFR ranged from 94.1% in vessels with low composite scores to 73.7% in those with high composite scores.Conclusions: The diagnostic accuracy of QFR decreases with increasing lesion complexity, system factors, lower angiographic image quality, and analysis difficulty. These findings suggest that specific lesion, system, and imaging-related factors can significantly impact the reliability of QFR in clinical practice.Trial registration: ClinicalTrials.gov Identifier: NCT06305572.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Exercise Training in Patients With Fontan Circulation: A Systematic Review and Meta-Analysis. 运动训练对Fontan循环患者的影响：系统回顾和荟萃分析。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-04-30 DOI: 10.4070/kcj.2024.0381

Hee Joung Choi, Soo-Jin Kim, Duck Woo Lee, So Hyeon Gwon, Nak-Hoon Son, Min Jung Cho, Kyung Jin Oh, Jue Seong Lee, Jae Yoon Na, Jae Hee Seol

{"title":"Effects of Exercise Training in Patients With Fontan Circulation: A Systematic Review and Meta-Analysis.","authors":"Hee Joung Choi, Soo-Jin Kim, Duck Woo Lee, So Hyeon Gwon, Nak-Hoon Son, Min Jung Cho, Kyung Jin Oh, Jue Seong Lee, Jae Yoon Na, Jae Hee Seol","doi":"10.4070/kcj.2024.0381","DOIUrl":"10.4070/kcj.2024.0381","url":null,"abstract":"Background and objectives: As long-term survival after the Fontan operation has improved, exercise capacity has become a crucial determinant of prognosis. Various exercise rehabilitation programs involving different populations and protocols have been developed to improve these outcomes. This systematic review and meta-analysis compared the effects of exercise rehabilitation in patients with Fontan circulation according to age group and exercise method.Methods: We searched the PubMed, Embase, and Cochrane Library databases for articles on exercise rehabilitation programs for patients who had undergone the Fontan procedure up to November 2023. After selection and eligibility assessment, 20 studies (5 randomized controlled trials [RCTs], 2 randomized trials, and 13 cohort studies) were included in the meta-analysis of peak oxygen consumption (VO₂) and minute ventilation equivalents for carbon dioxide production (VE/VCO₂ slope).Results: Peak VO₂ was significantly better in groups with exercise training than in the control groups in 5 RCTs (standardized mean difference [SMD], 0.48; p=0.0017); it showed a notable increase in 20 studies before and after exercise training (SMD, 0.44; p=0.001). VE/VCO₂ showed no significant changes in the RCTs (SMD, 0.22; p=0.68) or before and after exercise training (SMD, -0.11; p=0.25). Subgroup analyses revealed significant improvements in peak VO₂ for aerobic exercise (SMD, 0.32; p=0.0136) and in groups that included children (SMD, 0.49; p=0.0013 in \"children and adults\" and SMD, 0.49; p=0.047 in \"children\" group).Conclusions: Exercise training is effective for improving exercise capacity in patients after the Fontan procedure, particularly when initiated at a young age and implemented as an aerobic exercise.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"813-825"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise Training in Patients With Fontan Circulation: Moving Towards Evidence-Based Rehabilitation. Fontan循环患者的运动训练：走向循证康复。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-05-23 DOI: 10.4070/kcj.2025.0141

Se Yong Jung

引用次数: 0

Pregnancy Outcomes in Women With Fontan Circulation: Single Tertiary Center Experience. Fontan循环妇女的妊娠结局：单一三级中心经验。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.4070/kcj.2024.0341

Jin Ah Kim, Gi Beom Kim, Sang-Yun Lee, Mi Kyoung Song, Eun-Jung Bae

{"title":"Pregnancy Outcomes in Women With Fontan Circulation: Single Tertiary Center Experience.","authors":"Jin Ah Kim, Gi Beom Kim, Sang-Yun Lee, Mi Kyoung Song, Eun-Jung Bae","doi":"10.4070/kcj.2024.0341","DOIUrl":"10.4070/kcj.2024.0341","url":null,"abstract":"Background and objectives: The Fontan operation is a significant advancement in the palliative treatment of patients with single ventricular physiology. However, pregnancy in women with Fontan circulation presents increased risks for both the mother and fetus, with limited data available on maternal and fetal outcomes. This study reports maternal and fetal outcomes of pregnancies in women with Fontan circulation from a single tertiary center.Methods: This retrospective study included all pregnant patients with Fontan physiology treated at Seoul National University Hospital from June 1986 to September 2023. The cases reviewed encompassed miscarriages, premature births, and full-term deliveries.Results: Eight patients underwent 15 pregnancies. The mean age at first pregnancy was 26.7 years. There were 7 live births (46.7%) and 8 miscarriages (53.3%), including 1 therapeutic miscarriage. The average age at first delivery was 28 years and the mean gestational age was 36±2.5 weeks. Out of 7 live births, 2 (28.6%) were premature births. For delivery, 6 (85.7%) underwent cesarean section. All pregnancies were monitored with echocardiography. Aspirin was administered as an antithrombotic medication in 5 patients (62.5%), and 2 patients (25%) was on warfarin prior to pregnancy. Two patients (28.6%) experienced postpartum cardiac complications (transient heart failure and thromboembolism, respectively), which were successfully managed.Conclusions: We observed a 46.7% success rate of live births among pregnant women with Fontan circulation. Although 2 pregnancies had cardiac complications, there was no severe morbidity and mortality. Thus, pregnancy and planned delivery are feasible in selected women with Fontan circulation under close monitoring.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"828-837"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy in Women With Fontan Circulation: Strategic Management for a High-Risk. Fontan循环妇女妊娠：高危策略管理。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI: 10.4070/kcj.2025.0176

Soo-Jin Kim

引用次数: 0

Sex-Specific Differences in Cardiogenic Shock: Does It Still Matter? 心源性休克的性别差异：仍然重要吗？

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-05-27 DOI: 10.4070/kcj.2025.0162

Nuri Lee, Hyukjin Park

引用次数: 0

Ticagrelor Monotherapy vs. Ticagrelor With Aspirin in Bleeding and Cardiovascular Events in Acute Coronary Syndrome Patients According to Renal Function: The Subanalysis From the TICO Trial. 替格瑞洛单药治疗与替格瑞洛联合阿司匹林治疗急性冠脉综合征患者的出血和心血管事件：来自TICO试验的亚分析

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-05-22 DOI: 10.4070/kcj.2024.0232

Ji Hyun Lee, Hyeonju Jeong, Eui-Seock Hwang, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Yun-Hyeong Cho, Yongsung Suh

{"title":"Ticagrelor Monotherapy vs. Ticagrelor With Aspirin in Bleeding and Cardiovascular Events in Acute Coronary Syndrome Patients According to Renal Function: The Subanalysis From the TICO Trial.","authors":"Ji Hyun Lee, Hyeonju Jeong, Eui-Seock Hwang, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Yun-Hyeong Cho, Yongsung Suh","doi":"10.4070/kcj.2024.0232","DOIUrl":"10.4070/kcj.2024.0232","url":null,"abstract":"Background and objectives: Ticagrelor monotherapy after short-term dual-antiplatelet therapy (DAPT) has not been established in chronic kidney disease (CKD) patients. This study evaluated the effects of ticagrelor monotherapy after 3-month of DAPT on renal function in acute coronary syndrome patients.Methods: From the TICO trial, the primary outcome was a composite of net adverse clinical events (NACEs), defined as a composite of major bleeding and major adverse cardiovascular and cerebrovascular events (MACCEs). The secondary outcomes were thrombolysis in myocardial infarction (TIMI) major or minor bleeding and MACCE.Results: Among patients without CKD (n=2,436), ticagrelor monotherapy after 3 months of DAPT had a lower rate of NACE (hazard ratio [HR], 0.41; 95% confidence interval [CI], 0.21-0.78; p=0.007) and TIMI bleeding (HR, 0.86; 95% CI, 0.19-0.81; p=0.011) than those of ticagrelor-based 12-month DAPT. Among CKD patients receiving ticagrelor monotherapy, lower risk of NACE (HR, 0.45; 95% CI, 0.20-1.02; p=0.055) and bleeding (HR, 0.20; 95% CI, 0.06-0.68; p=0.009) were observed. Otherwise, ticagrelor monotherapy was not significantly associated with an increased MACCE risk in those without CKD (HR, 0.62; 95% CI, 0.30-1.27; p=0.192) or with CKD (HR, 0.55; 95% CI, 0.21-1.48; p=0.237), versus 12-month DAPT.Conclusions: Regardless of renal function, ticagrelor monotherapy after 3 months of DAPT resulted in a reduced risk of not only NACE but also major or minor bleeding at 1 year compared with ticagrelor-based 12-month DAPT. Irrespective of renal function status, however, the MACCE risk was not significantly different between the two strategies.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"778-791"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-140-5p Ameliorates Atrial Fibrillation in Cardiomyocytes by Targeting the Water Channel Protein Aquaporin 4. miR-140-5p通过靶向水通道蛋白水通道蛋白4改善心肌细胞心房颤动

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-04-30 DOI: 10.4070/kcj.2025.0008

Bokyeong Park, Young Hoon Son, Sung Jin Park, Kyu-Sung Kim, Hyelim Park, Hyewon Park, Junbeom Park

{"title":"miR-140-5p Ameliorates Atrial Fibrillation in Cardiomyocytes by Targeting the Water Channel Protein Aquaporin 4.","authors":"Bokyeong Park, Young Hoon Son, Sung Jin Park, Kyu-Sung Kim, Hyelim Park, Hyewon Park, Junbeom Park","doi":"10.4070/kcj.2025.0008","DOIUrl":"10.4070/kcj.2025.0008","url":null,"abstract":"Background and objectives: MicroRNAs (miRNAs) are small, non-coding RNAs that control gene expression patterns by inducing the degradation of messenger RNAs (mRNAs). Furthermore, miRNAs are known to play an important role in the pathogenesis of atrial fibrillation (AF). AF is typically diagnosed using an electrocardiogram. However, this study investigated whether specific miRNAs could be involved in alleviating AF by regulating aquaporin 4 (AQP4).Methods: HL-1 cells were transfected with either miRNA negative control (NC) or miR-140-5p, followed by incubation with or without tachypacing (TP) condition. We investigated the protein expression of calcium-handling and inflammation-related proteins in control, control + miR-NC, control + miR-140-5p, TP, and TP + miR-140-5p groups by Western blotting. Also, the relative mRNA expression of AQP4 was determined through real-time polymerase chain reaction.Results: Compared to the control, miR-140-3p was increased in the TP-induced AF group. Additionally, AQP4 protein expression and mRNA level were increased in the AF group along with inflammation-related proteins toll-like receptor 4, nucleotide-binding domain-like receptor protein 3, ERK, AKT, and interleukin-1β. The increase in such proteins was mitigated through miR-140-5p treatment. In accordance with these results, calcium-handling protein markers CaMKII, phospholamban, and ryanodine receptor 2 gene were also increased in the AF group and alleviated with miR-140-5p treatment.Conclusions: miR-140-5p is engaged in suppressing the expression of AQP4 in TP-induced AF HL-1 cells. In doing so, miR-140-5p reduced the risk of AF by suppressing inflammation and phosphorylation of Ca-handling proteins.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"840-851"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-140-5p and Water Channel Aquaporin 4: Opening a New Channel for Treating Atrial Fibrillation. miR-140-5p与水通道水通道蛋白4：打开心房颤动治疗的新通道

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-05-27 DOI: 10.4070/kcj.2025.0156

Hyo-Jeong Ahn, Hyun-Jai Cho

引用次数: 0

Characterization of Proteome Features in Patients With Aortic Stenosis Using Data-Independent Acquisition-Based Proteomic Analysis. 基于数据独立获取的蛋白质组学分析对主动脉瓣狭窄患者蛋白质组特征的表征

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 DOI: 10.4070/kcj.2025.0137

Naaleum Song, Jiyoung Yu, Eunhye Ji, Jin Yoon, Kyoung-Hee Choi, Jeong Eun Yu, Bokyung Kim, Jihyeon Kim, Minjoong Kim, Sahmin Lee, Kyunggon Kim, Elena Aikawa

{"title":"Characterization of Proteome Features in Patients With Aortic Stenosis Using Data-Independent Acquisition-Based Proteomic Analysis.","authors":"Naaleum Song, Jiyoung Yu, Eunhye Ji, Jin Yoon, Kyoung-Hee Choi, Jeong Eun Yu, Bokyung Kim, Jihyeon Kim, Minjoong Kim, Sahmin Lee, Kyunggon Kim, Elena Aikawa","doi":"10.4070/kcj.2025.0137","DOIUrl":"https://doi.org/10.4070/kcj.2025.0137","url":null,"abstract":"Background and objectives: Aortic stenosis (AS) is a prevalent valvular heart disease that is increasing due to aging population and longer life expectancy. While most individuals have a tricuspid aortic valve (TAV), some are congenitally born with a bicuspid aortic valve (BAV). The mechanisms underlying AS pathogenesis remain unclear, limiting advancements in clinical treatment and biomedical research. This study aimed to identify differentially expressed protein (DEPs) in aortic valve interstitial cells (VICs) from AS patients with TAV and BAV using quantitative proteomic analysis.Methods: VICs were isolated from AS patients with TAV (n=10) and BAV (n=10), as well as from normal aortic valves of heart transplant patients (TAV, n=11). Spectral library generation was performed using a data-dependent acquisition approach, followed by data-independent acquisition analysis. Immunohistochemical staining validated key DEPs.Results: A total of 39 DEPs were identified, including 13 upregulated and 26 downregulated proteins. These were categorized into 4 groups: cellular structural protein (keratin family, SYNPO, PFDN1, COL5A1); kinase and transferase (OXSR1, DNMT1), mitochondrial-related proteins (SOD2, SQOR), and calcification-related proteins (SPARC, MXRA7, PTMA). Comparative analysis revealed 5 common DEPs in TAV- and BAV-AS, including SQOR, 20 TAV-AS-specific proteins (e.g., keratin family, oxidoreductase-related proteins), and 3 BAV-AS-specific proteins (e.g., SPARC, PTMA).Conclusions: This proteomic analysis identified potential molecular targets associated with AS pathogenesis, providing a foundation for further research on disease mechanism and therapeutic development.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0