Korean Circulation Journal最新文献

{"title":"Navigating the Gray Zone: Is Intensive Lipid-Lowering Always Necessary in Patients With Atherosclerotic Cardiovascular Disease?","authors":"Jaehoon Chung","doi":"10.4070/kcj.2024.0434","DOIUrl":"10.4070/kcj.2024.0434","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"437-439"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA uc003pxg.1 Interacts With miR-339-5p Promote Vascular Endothelial Cell Proliferation, Migration and Angiogenesis.","authors":"Ping Li, Feng Wang, Anna Yue, Yanling Xuan, Ying Huang, Jingyi Xu, Jiayi Weng, Yuan Li, Kangyun Sun","doi":"10.4070/kcj.2024.0153","DOIUrl":"10.4070/kcj.2024.0153","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to investigate the roles of lncRNA uc003pxg.1 and miR-339-5p in regulating the occurrence and development of coronary heart disease.</p><p><strong>Methods: </strong>First, the expression levels of uc003pxg.1 and miR-339-5p were verified in peripheral blood mononuclear cells of clinical samples. Then, the target gene was identified using high-throughput sequencing combined with bioinformatics. Human umbilical vein endothelial cells (HUVECs) were transfected with si-uc003pxg.1, miR-339-5p mimic and miR-339-5p inhibitor, and the expression of related genes was detected by reverse transcription-quantitative polymerase chain reaction and western blotting. EdU, CCK-8, Cell scratch and Transwell assays were used to analyze the effects of uc003pxg.1 and miR-339-5p on cell proliferation and migration.</p><p><strong>Results: </strong>The expression of uc003pxg.1 and miR-339-5p was negatively correlated in clinical samples and HUVECs. The si-uc003pxg.1 and miR-339-5p mimic decreased the proliferation and migration of HUVECs and decreased the expression of transforming growth factor (TGF)-β1 and α-smooth muscle actin (SMA). The protein expression levels of TGF-β1, α-SMA, CD31, collagen I, collagen III and endoglin were decreased, and angiogenesis was weakened. The miR-339-5p inhibitor had the opposite effect.</p><p><strong>Conclusions: </strong>Our study revealed that upregulation of uc003pxg.1 and downregulation of miR-339-5p in vitro promote cell proliferation, cell migration and angiogenesis and upregulate the expression of TGF-β1, α-SMA, CD31, collagen I, collagen III and endoglin, which may lead to the development of vascular atherosclerosis.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"440-455"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic Regulation of Endothelial-Mesenchymal Transition in Vascular Atherosclerosis Development.","authors":"JaeHyuk Jang, Hun-Jun Park","doi":"10.4070/kcj.2025.0006","DOIUrl":"10.4070/kcj.2025.0006","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 5","pages":"456-458"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Thick Biolimus A9-Eluting Stent and Thin Zotarolimus-Eluting Stent in Multi-Vessel Percutaneous Coronary Intervention.","authors":"Cheol Hyun Lee, Hee Jeong Lee, Tae-Wan Chung, Seonhwa Lee, Jongmin Hwang, In-Cheol Kim, Yun-Kyeong Cho, Hyuck-Jun Yoon, Seung-Ho Hur, Jin Young Kim, Yun Seok Kim, Woo Sung Jang, Jang Hoon Lee, Woong Kim, Jin Bae Lee, Young Joon Hong, Jung Ho Heo, Bong-Ryeol Lee, Joon-Hyung Doh, Eun-Seok Shin, Bon-Kwon Koo, Chang-Wook Nam","doi":"10.4070/kcj.2024.0101","DOIUrl":"10.4070/kcj.2024.0101","url":null,"abstract":"<p><strong>Background and objectives: </strong>There are limited randomized studies on patients undergoing multi-vessel percutaneous coronary intervention (PCI) comparing the outcomes between stent thickness and polymer types. To compare the clinical outcomes of thick biodegradable polymer-based biolimus A9-eluting stents (BESs) and thin durable polymer-based zotarolimus-eluting stents (ZESs) in patients undergoing multi-vessel PCI.</p><p><strong>Methods: </strong>A total of 936 patients who underwent multi-vessel coronary artery stenting were randomly assigned to the BES (n=472) or ZES (n=464) groups. The primary endpoint was 2-year major adverse cardiac events (MACEs), a composite of all-cause death, myocardial infarction (MI), and any revascularization at the 2-year follow-up.</p><p><strong>Results: </strong>Fifty-two (11.2%) of 472 patients in BES group and 50 (10.9%) of the 464 patients in ZES group met the 2-year primary endpoint of MACE (hazard ratio, 1.00; 90% confidence interval, 0.72, 1.38; p=0.994). All-cause death (BES vs. ZES: 2.8% vs. 2.7%, p=0.758), MI (2.1% vs. 2.6%, p=0.483), and repeat revascularization (6.7% vs. 6.9%, p=0.876) were not significantly different between the 2 groups. Although there was no significant outcome difference in any subgroup analysis, the technical failure rate leading to the use of other stents was higher in BES than in ZES (3.2% vs. 0.9%, p=0.023).</p><p><strong>Conclusions: </strong>In patients who underwent multi-vessel PCI, BES and ZES showed comparable 2-year clinical outcomes. However, BES was not established to demonstrate non-inferiority to ZES in terms of the incidence of the primary endpoint at the 2-year. The technical success rate of the index PCI with the assigned stent was higher for thinner ZES.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT01947439.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"396-407"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Strain as a Predictive Tool for Poor Exercise Capacity in Patients With Indeterminate Diastolic Function: The Utility and Challenges in Clinical Practice.","authors":"Hui-Jeong Hwang","doi":"10.4070/kcj.2025.0025","DOIUrl":"10.4070/kcj.2025.0025","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 5","pages":"394-395"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights and Challenges in Acute Myocarditis Management From a Korean Multicenter Registry.","authors":"Jin Joo Park","doi":"10.4070/kcj.2025.0033","DOIUrl":"10.4070/kcj.2025.0033","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 5","pages":"423-425"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thick or Thin, Durable or Biodegradable Polymers: Does Stent Design Still Matter?","authors":"Seung-Jun Lee","doi":"10.4070/kcj.2025.0038","DOIUrl":"10.4070/kcj.2025.0038","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 5","pages":"408-409"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Atrial Strain Predicts Poor Exercise Capacity in Patients With Indeterminate Diastolic Function.","authors":"Hyejung Choi, Houng-Beom Ahn, Jiesuck Park, Hong-Mi Choi, In-Chang Hwang, Yeonyee Yoon, Goo-Yeong Cho","doi":"10.4070/kcj.2024.0240","DOIUrl":"10.4070/kcj.2024.0240","url":null,"abstract":"<p><strong>Background and objectives: </strong>The 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines report that approximately 20% of diastolic dysfunction is indeterminate and has limited diagnostic accuracy. Left atrial strain may help accurately categorize diastolic dysfunction; however, its exact roles remain unclear. This study investigated the impact of left atrial reservoir strain (LARS) and its association with exercise capacity in patients with indeterminate diastolic function.</p><p><strong>Methods: </strong>Among 687 patients who underwent cardiopulmonary exercise tests and supine bicycle stress echocardiography for symptoms including dyspnea, chest pain, valvular heart disease, and other cardiovascular problems, 118 with indeterminate diastolic function were analyzed after excluding those with atrial fibrillation and significant valvular heart disease. Poor exercise tolerance was defined as peak oxygen consumption (pVO₂) <14 mL/kg/min.</p><p><strong>Results: </strong>Key diastolic dysfunction indices showed no statistical differences between patients with pVO₂ <14 mL/kg/min and ≥14 mL/kg/min. Only LARS was independently associated with pVO₂ (β=0.12 [0.09-0.15], p<0.001) in patients with indeterminate diastolic function. Receiver-operating characteristic curves highlighted LARS as a strong predictor of impaired pVO₂ among all echocardiographic variables (area under the curve: 0.871 [0.776-0.966]), with an optimal cut-off value of 21% after adjusting for clinical variables. Logistic analysis showed that patients with ≤21% LARS had significantly reduced exercise capacity (odds ratio, 12.77; 95% confidence interval, 3.83-48.65; p<0.001).</p><p><strong>Conclusions: </strong>LARS is significantly associated with pVO₂ in patients with indeterminate diastolic function. Impaired LARS is a robust predictor of exercise intolerance; measuring LARS enhances diastolic-function assessment accuracy, potentially improving individualized diastolic-dysfunction management and treatment.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"382-393"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Outcomes of Acute Myocarditis: An Analysis of Korean Multicenter Registry.","authors":"Junho Hyun, Dayoung Pack, Minjung Bak, Hyukjin Park, Hyung Yoon Kim, Seonhwa Lee, In-Cheol Kim, So Ree Kim, Mi-Na Kim, Kyung-Hee Kim, Sang Eun Lee, Jeong Hoon Yang","doi":"10.4070/kcj.2024.0229","DOIUrl":"10.4070/kcj.2024.0229","url":null,"abstract":"<p><strong>Background and objectives: </strong>Data are limited on the clinical manifestations and outcomes of acute myocarditis from a large-scale registry. We investigated acute myocarditis's clinical characteristics and prognosis from a large-scale, multi-center registry in the Republic of Korea.</p><p><strong>Methods: </strong>We collected data from seven hospitals between 2001 and 2021. Clinical variables and outcomes during the index hospitalization and follow-up periods were analyzed. We also evaluated inter-center and temporal differences in diagnostic and treatment patterns.</p><p><strong>Results: </strong>Eight hundred forty-one patients diagnosed with acute myocarditis were included. Common symptoms included chest pain (60.4%), followed by fever or myalgia (46.3%), and dyspnea (45.7%). Fulminant myocarditis occurred in 421 (50.1%), with 217 requiring extracorporeal membrane oxygenation (ECMO) support. Endomyocardial biopsy (EMB) was performed in 276 (32.8%) patients, and biopsy-proven diagnosis was made in 234 (27.8%). Based on the EMB results, lymphocytic myocarditis was the predominant form (69.6%), followed by eosinophilic (13.8%) and giant cell myocarditis (1.4%). Eighty-three in-hospital (9.9%) and 16 (1.9%) additional mortality during the follow-up occurred. An increase in the use of EMB, cardiac imaging, and immunosuppressive therapy was noted over time, but in-hospital mortality remained unchanged. Remarkable variations in diagnosis and treatment were observed across different centers.</p><p><strong>Conclusions: </strong>This study unveiled clinical features of acute myocarditis in the Republic of Korea, including a high incidence of fulminant myocarditis and complex cases requiring ECMO. Given the considerable inter-center variation in diagnostic and treatment patterns and prognosis, protocolized future trials are needed to clarify diagnosis and treatment in patients with acute myocarditis.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05933902.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"410-422"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Chronic Thromboembolic Pulmonary Hypertension: Expanding the Disease Concept and Treatment Options.","authors":"Sung-A Chang, Jeong Hoon Yang, Dong Seop Jung, Nick H Kim","doi":"10.4070/kcj.2024.0423","DOIUrl":"10.4070/kcj.2024.0423","url":null,"abstract":"<p><p>Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive form of pulmonary hypertension characterized by unresolved thromboembolic occlusion of pulmonary arteries, leading to increased pulmonary arterial pressure and right heart failure. This review examines recent advances in the pathophysiology, diagnosis, and management of CTEPH, focusing on expanding disease concepts and evolving therapeutic approaches. The incidence of CTEPH has been revised upward with improved diagnostic techniques revealing a higher prevalence than previously recognized. Advances in surgical and interventional therapies, particularly pulmonary endarterectomy and balloon pulmonary angioplasty, have significantly improved outcomes. Emerging medical therapies, including pulmonary vasodilators like riociguat, have offered new hope for inoperable cases. The understanding of CTEPH has broadened, leading to better diagnostic strategies and more comprehensive treatment options that significantly enhance patient outcomes. Multidisciplinary team approaches are crucial in managing the disease effectively.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"365-381"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}