Korean Circulation Journal最新文献_第2页

Characterization of Proteome Features in Patients With Aortic Stenosis Using Data-Independent Acquisition-Based Proteomic Analysis. 基于数据独立获取的蛋白质组学分析对主动脉瓣狭窄患者蛋白质组特征的表征

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 DOI: 10.4070/kcj.2025.0137

Naaleum Song, Jiyoung Yu, Eunhye Ji, Jin Yoon, Kyoung-Hee Choi, Jeong Eun Yu, Bokyung Kim, Jihyeon Kim, Minjoong Kim, Sahmin Lee, Kyunggon Kim, Elena Aikawa

{"title":"Characterization of Proteome Features in Patients With Aortic Stenosis Using Data-Independent Acquisition-Based Proteomic Analysis.","authors":"Naaleum Song, Jiyoung Yu, Eunhye Ji, Jin Yoon, Kyoung-Hee Choi, Jeong Eun Yu, Bokyung Kim, Jihyeon Kim, Minjoong Kim, Sahmin Lee, Kyunggon Kim, Elena Aikawa","doi":"10.4070/kcj.2025.0137","DOIUrl":"https://doi.org/10.4070/kcj.2025.0137","url":null,"abstract":"Background and objectives: Aortic stenosis (AS) is a prevalent valvular heart disease that is increasing due to aging population and longer life expectancy. While most individuals have a tricuspid aortic valve (TAV), some are congenitally born with a bicuspid aortic valve (BAV). The mechanisms underlying AS pathogenesis remain unclear, limiting advancements in clinical treatment and biomedical research. This study aimed to identify differentially expressed protein (DEPs) in aortic valve interstitial cells (VICs) from AS patients with TAV and BAV using quantitative proteomic analysis.Methods: VICs were isolated from AS patients with TAV (n=10) and BAV (n=10), as well as from normal aortic valves of heart transplant patients (TAV, n=11). Spectral library generation was performed using a data-dependent acquisition approach, followed by data-independent acquisition analysis. Immunohistochemical staining validated key DEPs.Results: A total of 39 DEPs were identified, including 13 upregulated and 26 downregulated proteins. These were categorized into 4 groups: cellular structural protein (keratin family, SYNPO, PFDN1, COL5A1); kinase and transferase (OXSR1, DNMT1), mitochondrial-related proteins (SOD2, SQOR), and calcification-related proteins (SPARC, MXRA7, PTMA). Comparative analysis revealed 5 common DEPs in TAV- and BAV-AS, including SQOR, 20 TAV-AS-specific proteins (e.g., keratin family, oxidoreductase-related proteins), and 3 BAV-AS-specific proteins (e.g., SPARC, PTMA).Conclusions: This proteomic analysis identified potential molecular targets associated with AS pathogenesis, providing a foundation for further research on disease mechanism and therapeutic development.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Specific Differences in Management and Outcomes of Cardiogenic Shock Patients With and Without Ischemic Cardiomyopathy. 伴有和不伴有缺血性心肌病的心源性休克患者的治疗和结局的性别差异。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.4070/kcj.2024.0440

Ik Hyun Park, Chang Hoon Kim, Woo Jin Jang, Ju-Hyeon Oh, Wang Soo Lee, Jeong Hoon Yang, Hyeon-Cheol Gwon

{"title":"Sex-Specific Differences in Management and Outcomes of Cardiogenic Shock Patients With and Without Ischemic Cardiomyopathy.","authors":"Ik Hyun Park, Chang Hoon Kim, Woo Jin Jang, Ju-Hyeon Oh, Wang Soo Lee, Jeong Hoon Yang, Hyeon-Cheol Gwon","doi":"10.4070/kcj.2024.0440","DOIUrl":"10.4070/kcj.2024.0440","url":null,"abstract":"Background and objectives: Comprehensive data on sex-based differences in the management and outcomes of patients with and without ischemic cardiomyopathy (ICMP) presenting with cardiogenic shock (CS) remain limited. This study aimed to investigate whether clinical management and outcomes differ by sex among CS patients, stratified by underlying etiology.Methods: We analyzed 1,247 CS patients from the RESCUE registry, a multicenter observational cohort, stratified by sex and CS etiology: ICMP (females: 276, males: 730) and non-ICMP (females: 111, males: 130). Primary outcomes included in-hospital and 12-month mortality. Multivariable Cox proportional hazards models and propensity-score matching were used to adjust for confounding factors.Results: Among ICMP patients, females were less likely to undergo coronary angiography (p=0.001), although rates of successful revascularization were similar between sexes (p=0.982). In-hospital 30-day mortality did not differ significantly between females and males in either the ICMP cohort (37.1% vs. 29.5%; adjusted hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.63-1.39; p=0.737) or the non-ICMP cohort (28.3% vs. 25.6%; adjusted HR, 1.23; 95% CI, 0.68-2.22; p=0.493). At 12 months, mortality risk remained comparable between sexes in both ICMP (46.4% vs. 37.1%; adjusted HR, 0.82; 95% CI, 0.57-1.17; p=0.274) and non-ICMP groups (40.1% vs. 41.3%; adjusted HR, 0.91; 95% CI, 0.56-1.45; p=0.685). These findings were consistent after propensity-score matching.Conclusions: There was no significant difference in management, 12-month or in-hospital mortality between females and males, irrespective of the etiology of CS.Trial registration: ClinicalTrials.gov Identifier: NCT02985008.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"795-809"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Antiplatelet Therapy in Chronic Kidney Disease: Insights From the TICO Trial in the Context of Contemporary Guidelines. 优化慢性肾脏疾病的抗血小板治疗：当代指南背景下TICO试验的见解

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 Epub Date: 2025-06-23 DOI: 10.4070/kcj.2025.0213

Seung-Yul Lee, Jae Youn Moon

引用次数: 0

Valve-in-Valve TAVR With Bioprosthetic Valve Fracture and Snaring Technique in Extreme Horizontal Aorta. 极端水平主动脉瓣膜断裂生物假体及诱捕技术的瓣中瓣TAVR。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-09-01 DOI: 10.4070/kcj.2025.0232

Seok Oh, Dae Young Hyun, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Kyo Seon Lee, Yochun Jung, Ju Han Kim

引用次数: 0

Effectiveness and Safety of COVID-19 Vaccination in Patients With Heart Failure: A Nationwide Retrospective Cohort Study. 心力衰竭患者COVID-19疫苗接种的有效性和安全性：一项全国回顾性队列研究

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-08-26 DOI: 10.4070/kcj.2024.0429

Kyeong-Hyeon Chun, Chan Joo Lee, Haeyong Park, Wooyong Jeong, Kwon-Duk Seo, Jiwon Seo, Jaewon Oh, Hyeongsoo Kim, Ji-Yong Jang, Hancheol Lee, Jong-Kwan Park, Seungjin Oh, Se-Jung Yoon, Seok-Min Kang

{"title":"Effectiveness and Safety of COVID-19 Vaccination in Patients With Heart Failure: A Nationwide Retrospective Cohort Study.","authors":"Kyeong-Hyeon Chun, Chan Joo Lee, Haeyong Park, Wooyong Jeong, Kwon-Duk Seo, Jiwon Seo, Jaewon Oh, Hyeongsoo Kim, Ji-Yong Jang, Hancheol Lee, Jong-Kwan Park, Seungjin Oh, Se-Jung Yoon, Seok-Min Kang","doi":"10.4070/kcj.2024.0429","DOIUrl":"https://doi.org/10.4070/kcj.2024.0429","url":null,"abstract":"Background and objectives: We aimed to evaluate the efficacy and safety of coronavirus disease 2019 (COVID-19) vaccination in patients with heart failure (HF) using national databases.Methods: We retrospectively analyzed the data from the Korean nationwide COVID-19 cohort, including patients with HF from February 2021 to June 2022. The study population was divided into the vaccinated (≥2 doses) and unvaccinated (≤1 dose) groups. Clinical outcomes assessed included hospitalization for HF, COVID-19-related events, and cardiovascular complications. Patients were matched by age, sex, and comorbidities, and were followed up for up to 15 months to assess vaccination-associated risks.Results: We included 651,127 patients with HF (mean age 69.5 years; 50.2% male), of whom 112,693 (17.3%) were unvaccinated, and 538,434 (82.7%) were vaccinated. After propensity score matching, 73,559 patients in each group were compared. Over a median follow-up of 6 months, vaccination was associated with a significantly reduced risk of COVID-19 (hazard ratio [HR], 0.27; 95% confidence interval [CI], 0.22-0.33) and critical COVID-19 infection (HR, 0.47; 95% CI, 0.31-0.71). The vaccinated group also had a significantly lower risk of hospitalization for HF (HR, 0.53; 95% CI, 0.52-0.55) and all-cause mortality (HR, 0.18; 95% CI, 0.17-0.18) compared with the unvaccinated group. Additionally, vaccination was associated with a significantly lower risk of stroke, myocardial infarction, myocarditis/pericarditis, and venous thromboembolism compared with the unvaccinated patients (all, p<0.0001).Conclusions: COVID-19 vaccination in patients with HF was associated with a reduced risk of hospitalization for HF, all-cause mortality, and other cardiovascular events.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De-escalating Medical Therapy in Heart Failure With Improved Left Ventricular Ejection Fraction. 改善左心室射血分数的心力衰竭降压药物治疗

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-08-25 DOI: 10.4070/kcj.2025.0319

Hyukjin Park, Jong-Chan Youn

引用次数: 0

Single versus Multiple Inflow Source for Coronary Artery Bypass Surgery in Ischemic Cardiomyopathy. 缺血性心肌病冠状动脉搭桥手术的单一与多个流源比较。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-08-21 DOI: 10.4070/kcj.2025.0103

Sung Jun Park, Kyung-Jong Yoo, Young-Nam Youn

{"title":"Single versus Multiple Inflow Source for Coronary Artery Bypass Surgery in Ischemic Cardiomyopathy.","authors":"Sung Jun Park, Kyung-Jong Yoo, Young-Nam Youn","doi":"10.4070/kcj.2025.0103","DOIUrl":"https://doi.org/10.4070/kcj.2025.0103","url":null,"abstract":"Background and objectives: The optimal grafting strategy for ischemic cardiomyopathy (ICMP) remains uncertain despite the growing heart failure population undergoing coronary artery bypass grafting (CABG). This study sought to explore the outcomes of CABG in ICMP patients according to the number of inflow sources.Methods: A total of 447 patients with an ejection fraction (EF) of ≤35% who underwent isolated CABG from 2009 to 2020 were analyzed. Patients were categorized into either a single inflow source group (single group, n=203), in which unilateral in situ internal thoracic artery (ITA) served as the sole inflow, or a multiple inflow source group (multiple group, n=244), utilizing additional inflow sources from the aorta or contralateral ITA. The primary outcome was all-cause mortality, analyzed after adjustment using the inverse-probability-of-treatment-weighting method.Results: There were no differences in the early outcomes between 2 groups. After adjustment, the single group exhibited significantly worse survival compared to the multiple group during a median follow-up of 5.3-years (adjusted hazard ratio, 1.88; 95% confidence interval, 1.26-2.80; p=0.001), particularly in the subgroup of patients without a recent myocardial infarction within 1 month (p=0.005) and those with an EF of ≥25% (p=0.007). At the last follow-up echocardiography (>6 months), the multiple group showed a significantly higher postoperative EF (p=0.009) and a smaller left ventricular end-systolic dimension (p=0.027) compared to the single group, which had not shown significant differences preoperatively.Conclusions: In ICMP patients, CABG using multiple inflow sources was associated with improved outcomes, particularly in those without recent or profound myocardial injury.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhythm Control as a Strategy to Mitigate Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation. 心律控制作为缓解心房功能性二尖瓣和三尖瓣反流的策略。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-08-14 DOI: 10.4070/kcj.2025.0310

Saerom Kim, Inki Moon

引用次数: 0

Management of Coronary Artery Disease in Patients With Severe Aortic Stenosis. 严重主动脉狭窄患者冠状动脉疾病的处理。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-08-14 DOI: 10.4070/kcj.2025.0268

Ju Hyeon Kim, Do-Yoon Kang, Jung-Min Ahn, Kyeong-Won Seo, Seung Han Lee, Seong-Bong Wee, Soo Yeon An, Hansu Park, Duk-Woo Park, Seung-Jung Park

{"title":"Management of Coronary Artery Disease in Patients With Severe Aortic Stenosis.","authors":"Ju Hyeon Kim, Do-Yoon Kang, Jung-Min Ahn, Kyeong-Won Seo, Seung Han Lee, Seong-Bong Wee, Soo Yeon An, Hansu Park, Duk-Woo Park, Seung-Jung Park","doi":"10.4070/kcj.2025.0268","DOIUrl":"https://doi.org/10.4070/kcj.2025.0268","url":null,"abstract":"The coexistence of severe aortic stenosis (AS) and coronary artery disease (CAD) presents complex diagnostic and therapeutic challenges, particularly as transcatheter aortic valve replacement (TAVR) expands to younger, lower-risk populations. CAD prevalence in AS patients ranges from 27.7% in low-risk cohorts to 74.9% in high-risk populations, synergistically worsening ventricular function and prognosis. Diagnostic evaluation remains challenging due to overlapping symptomatology and altered coronary physiology in severe AS. While invasive coronary angiography remains the gold standard, coronary computed tomography (CT) angiography with CT-derived fractional flow reserve (FFR) shows promise as a non-invasive alternative. Standard FFR thresholds may not be reliable in AS patients, with emerging evidence suggesting AS-specific cutoffs may be needed. Treatment strategies must balance the complexity of CAD with patient risk profiles. Current guidelines recommend bypass surgery with surgical aortic valve replacement for complex multivessel disease, while percutaneous coronary intervention (PCI) with TAVR is preferred for less complex lesions or high-risk patients. The optimal timing of PCI relative to TAVR remains debated, with recent data favoring a \"TAVR-first\" approach for non-critical lesions. As TAVR extends to younger patients, lifetime management considerations become paramount, including valve durability, future coronary access, and planning for potential re-interventions. Commissural alignment techniques during TAVR are crucial for preserving future coronary access. A multidisciplinary Heart Team approach with robust shared decision-making is essential for optimizing individualized care in this evolving field.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Hypertension Redefined: From Historical Thresholds to Prognostic Relevance. 重新定义肺动脉高压：从历史阈值到预后相关性。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-08-13 DOI: 10.4070/kcj.2025.0231

Sung-A Chang

引用次数: 0