Korean Circulation Journal最新文献

{"title":"Cardiovascular Involvement in Erdheim-Chester Disease: Importance of Multimodality Imaging.","authors":"Isabel Martins Moreira, Luís Sousa Azevedo, Catarina Ferreira, Patrícia Ferraz, Isabel Nóbrega Fernandes, Joana Trigo, Inês Silveira, Ilídio Moreira","doi":"10.4070/kcj.2026.0169","DOIUrl":"https://doi.org/10.4070/kcj.2026.0169","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Poor Adherence to Guideline-Directed Medical Treatment With Adverse Events Including Fatal Arrhythmia in Heart Failure With Reduced Ejection Fraction: A Nationwide Cohort Analysis.","authors":"Moojun Kim, Dong-Hyuk Cho, Jimi Choi, Jong-Chan Youn, Jung-Woo Son, Jooyeon Lee, Taeil Yang, Jaewon Oh, Chan Joo Lee, Byung-Su Yoo, Seok-Min Kang","doi":"10.4070/kcj.2026.0021","DOIUrl":"https://doi.org/10.4070/kcj.2026.0021","url":null,"abstract":"<p><strong>Background and objectives: </strong>Poor adherence to guideline-directed medical therapy (GDMT) in heart failure with reduced ejection fraction (HFrEF) correlates with increased risks of mortality and hospitalization. Whether it is associated with life-threatening ventricular arrhythmias (VA) remains unclear. We assessed GDMT adherence levels and clinical outcomes in patients with HFrEF.</p><p><strong>Methods: </strong>Using the National Health Insurance Service database, patients who underwent implantable cardioverter-defibrillator or cardiac resynchronization therapy with a defibrillator implantation between 2008 to 2020 for primary prevention were included. Those with sustained ventricular tachycardia, ventricular fibrillation/flutter, or aborted sudden cardiac death were excluded. Adherence to renin-angiotensin system blockers (RASB), beta blockers (BB), and mineralocorticoid receptor antagonists (MRA) was assessed using the weighted proportion of days covered method. The primary outcome was a composite of all-cause mortality and life-threatening VA.</p><p><strong>Results: </strong>Among 3,780 patients, prescription rates were 87.5% for RASB, 89.7% for BB, and 74.2% for MRA. Poor adherence was associated with an increased risk of the primary outcome (hazard ratio [HR], 1.54; 95% confidence interval [CI], 1.31-1.82) and all-cause mortality (HR, 1.83; 95% CI, 1.52-2.20) compared with optimal adherence. These associations were more pronounced in ischemic heart failure (HF). Although crude VA event rates were numerically higher with lower adherence, these associations were insignificant after covariate adjustment, regardless of HF etiology.</p><p><strong>Conclusions: </strong>Lower GDMT adherence was independently associated with increased mortality despite device therapy, particularly in ischemic HF. Although its relationship with arrhythmic outcomes was unclear, sustained adherence remains important and supports targeted interventions to enhance treatment continuity.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-Term Outcomes of Endovascular Aneurysm Repair With the INCRAFT Stent Graft System: Retrospective Combined Korean Multi-Center and Single-Center Registry Analysis.","authors":"In Tae Jin, Young-Guk Ko, Seung-Jun Lee, Chul-Min Ahn, Sang-Hyup Lee, Yong-Joon Lee, Sung-Jin Hong, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Ji Yong Jang, Cheol Woong Yu, Jae-Hwan Lee, Suk Won Song, Juhan Kim, In-Ho Chae, Woong-Chol Kang, Ung Kim","doi":"10.4070/kcj.2026.0103","DOIUrl":"https://doi.org/10.4070/kcj.2026.0103","url":null,"abstract":"<p><strong>Backgrounds and objectives: </strong>Endovascular aneurysm repair is widely used for the management of abdominal aortic aneurysm (AAA). Although short-term outcomes are favorable, concerns persist regarding long-term durability, particularly due to higher rates of secondary reintervention. This study aimed to evaluate the mid-term clinical outcomes of the ultra-low-profile INCRAFT stent-graft system.</p><p><strong>Methods: </strong>We analyzed 146 patients treated with the INCRAFT stent-graft system using a combined Korean multicenter prospective and single-center retrospective registry. Clinical follow-up was performed until the last clinical contact through electronic medical records, and imaging follow-up with computed tomography or ultrasonography was performed up to 3 years.</p><p><strong>Results: </strong>During a median follow-up of 44 months, there were no cases of aneurysm-related death or aneurysm rupture. At 3-year follow-up, sac shrinkage was observed in 41.5%, whereas sac enlargement was noted in 9.6%. Endoleaks were observed in 24.5% at 3 years. Type II endoleak was the most frequent endoleak type and cause of reintervention. Reinterventions were required in 17.1% (n=25), predominantly due to endoleaks (9.6%) and limb-related complications (6.8%).</p><p><strong>Conclusions: </strong>In Korean patients with AAA, the INCRAFT stent-graft system demonstrated favorable mid-term outcomes, with low rates of aneurysm-related mortality, acceptable reintervention rates, and stable aneurysm sac behavior.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subintimal Wiring in Chronic Total Occlusion: Imaging Insights and Proposed Mechanisms.","authors":"Chin-Yuan Chia, Ming-Yun Ho, Jih-Kai Yeh, Chao-Yung Wang, Ming-Jer Hsieh, Chun-Chi Chen, I-Chang Hsieh","doi":"10.4070/kcj.2026.0190","DOIUrl":"https://doi.org/10.4070/kcj.2026.0190","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal and 18-24-Month Growth and Neurodevelopmental Outcomes in Very Low Birth Weight Infants With Severe Congenital Heart Disease: A Korean Neonatal Network Study.","authors":"Jung Il Kwak, Soo Hyun Kim, Kyusang Yoo, Tae-Gyeong Kim, Juhee Park, Abraham Kwak, Joo Hyung Roh, Jeong Min Lee, Ha Na Lee, Jiyoon Jeong, Chae Young Kim, Euiseok Jung, Byong Sop Lee","doi":"10.4070/kcj.2026.0106","DOIUrl":"https://doi.org/10.4070/kcj.2026.0106","url":null,"abstract":"<p><strong>Background and objectives: </strong>Severe congenital heart disease (CHD) in very low birth weight (VLBW) infants poses substantial risks, yet contemporary national data remain limited. This study evaluated the prevalence, lesion spectrum, and neonatal and 18-24-month outcomes of VLBW infants with severe CHD in South Korea.</p><p><strong>Methods: </strong>We conducted a nationwide cohort study using the Korean Neonatal Network registry (2013-2021). Severe CHD was defined as a structural defect requiring surgical or catheter-based intervention within the first year of life and was categorized by physiological lesion type. Neonatal mortality, mortality before neonatal intensive care unit (NICU) discharge, major neonatal morbidities, and growth and neurodevelopmental outcomes at 18-24 months' corrected age were compared between infants with and without severe CHD.</p><p><strong>Results: </strong>Among 15,145 VLBW infants, 147 (1.0%) had severe CHD. Infants with severe CHD had higher neonatal mortality within 28 days (27.2% vs. 9.3%; adjusted odds ratio [OR], 3.37; 95% confidence interval [CI], 2.26-5.04) and mortality before NICU discharge (35.4% vs. 10.6%; adjusted OR, 5.95; 95% CI, 3.94-9.00) than those without severe CHD. Pulmonary hypertension, moderate-to-severe bronchopulmonary dysplasia, and necrotizing enterocolitis (stage ≥2) were more frequent in the severe CHD group. At 18-24 months, severe CHD was associated with higher rates of growth failure and neurodevelopmental impairment (34.1% vs. 20.0%; OR, 2.07, 95% CI, 1.32-3.24).</p><p><strong>Conclusions: </strong>Severe CHD occurred in ~1% of VLBW infants and was associated with markedly higher mortality, greater neonatal morbidity, and increased risks of impaired growth and neurodevelopment at 18-24 months' corrected age.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of GNX80 in Patients with Peripheral Arterial Disease and Intermittent Claudication.","authors":"Onyou Kim, Seung Hun Lee, Jang Yong Kim, Wonho Kim, Han Cheol Lee, Ji Woong Roh, Jin Hyeon Joh, Sang-Ho Park, Sanghoon Shin, Sung-Hun Park Md, Woohyeun Kim, Hyung Joon Ahn, Ho Kyun Lee, Sang Hoon Kim, Sung-Ho Her, Seung-Woon Rha, Cheol Woong Yu","doi":"10.4070/kcj.2026.0176","DOIUrl":"https://doi.org/10.4070/kcj.2026.0176","url":null,"abstract":"<p><strong>Background and objectives: </strong>Peripheral arterial disease (PAD) is associated with intermittent claudication (IC), leading to a lower quality of life. Although <i>Ginkgo biloba</i> extract (GbE) has been investigated for the treatment of IC, its clinical efficacy remains controversial. This study aimed to evaluate the efficacy and safety of high-dose, long-term GbE therapy in patients with PAD and IC.</p><p><strong>Methods: </strong>This randomized, double-blind, placebo-controlled, multicenter phase 4 trial enrolled patients with stable PAD and Fontaine stage IIb IC from 15 hospitals in South Korea. Participants were randomly assigned at a ratio of 1:1 to receive 80 mg of GbE (GNX80) twice daily or a placebo twice daily for 24 weeks. The primary endpoint was changes in the maximal walking distance (MWD) assessed using standardized treadmill testing after 24 weeks.</p><p><strong>Results: </strong>At 24 weeks, in the full analysis set (FAS), GNX80 treatment was associated with a numerically greater improvement in MWD than placebo that did not reach statistical significance (58.95±129.79 vs. 12.09±131.33 m; p=0.095); a significant difference was observed in the pre-specified per-protocol analysis (p=0.041). The overall incidence of adverse events was similar between the GbE and placebo groups, and no new safety signals or treatment-discontinuing adverse events were observed.</p><p><strong>Conclusions: </strong>For patients with stable PAD and IC, GNX80 was associated with a numerically greater improvement in MWD compared with placebo, although statistical significance was not achieved in the primary FAS analysis. Further randomized trials are warranted to determine whether GNX80 improves functional capacity in this patient population.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05400395.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension as a Metabolic Disease: New-Onset Diabetes in the Korean Hypertension Cohort.","authors":"Hyun-Jin Kim","doi":"10.4070/kcj.2026.0358","DOIUrl":"https://doi.org/10.4070/kcj.2026.0358","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide Trends in the Incidence and Fatality of Acute Myocardial Infarction and Stroke in Korea, 2011-2023.","authors":"Jaewon Khil, Sojung Shin, Seojeong Shin, Jaeyong Lee, Minsung Cho, Na Yeon Ahn, Sang Gyeong Lee, Yeongchang Jo, Seng Chan You, Yeonhee Yoo, Seung-Jun Lee, Jang-Whan Bae, Min Kim, Kyu Sun Yum, Jang-Hyun Baek, Hokyou Lee, Hyeon Chang Kim","doi":"10.4070/kcj.2026.0060","DOIUrl":"https://doi.org/10.4070/kcj.2026.0060","url":null,"abstract":"<p><strong>Background and objectives: </strong>In South Korea and other countries operating national health insurance, claims data are used to estimate the burden of acute myocardial infarction (AMI) and stroke. However, most previous studies relied on diagnostic claim codes and did not distinguish first-ever from recurrent events. To estimate nationwide trends in the incidence and fatality of AMI and stroke using validated claims-based algorithms that distinguish first-ever from recurrent events.</p><p><strong>Methods: </strong>We analyzed National Health Insurance Service (NHIS) claims data covering the entire Korean population from 2002 to 2023. The period from 2002-2010 served as a washout period, and annual incidence and case-fatality rates were estimated for 2011-2023. AMI (ICD-10: I21-I23) and stroke (ICD-10: I60-I61, I63-I64) events were identified from hospitalization episodes using diagnostic, procedure, imaging, and mortality codes. Crude and age-standardized rates were calculated.</p><p><strong>Results: </strong>Between 2011 and 2023, AMI events increased from 22,395 to 34,768, including 1,472 to 3,373 recurrent cases. Stroke events rose from 99,837 to 113,098, including 16,925 to 22,813 recurrent cases. Crude incidence increased for AMI (44.7 to 68.0 per 100,000 person-years) and stroke (199.2 to 221.1), whereas age-standardized incidence increased slightly for AMI (35.7 to 37.1) but declined markedly for stroke (158.3 to 113.2). AMI fatality rates remained stable, whereas stroke fatality rates declined initially but rose modestly in recent years.</p><p><strong>Conclusions: </strong>By linking NHIS claims with mortality statistics and applying validated algorithms, this study demonstrates that reliable national monitoring of AMI and stroke incidence and fatality is feasible without extensive hospital-based registries or active surveillance systems.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-Assisted Bifurcation Percutaneous Coronary Intervention With Initial Kissing Balloon, Provisional Main-Vessel Stenting, and Side-Branch Rewiring Through Stent Struts Using the AVIAR MX-03 System in a Porcine Model.","authors":"Jung-Min Ahn, Jeik Byun","doi":"10.4070/kcj.2026.0244","DOIUrl":"https://doi.org/10.4070/kcj.2026.0244","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Gatekeeper to Guide: Redefining the Role of Computed Tomography-Derived Fractional Flow Reserve in the Cardiac Catheterization Laboratory.","authors":"Si-Hyuck Kang, Tae-Jin Youn","doi":"10.4070/kcj.2026.0333","DOIUrl":"https://doi.org/10.4070/kcj.2026.0333","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}