Korean Circulation Journal最新文献

{"title":"Is Shank3 a 'Friend or Foe' of the Heart? Its Role in Cardiac Calcium Homeostasis.","authors":"Hyoung Kyu Kim, Jin Han","doi":"10.4070/kcj.2024.0377","DOIUrl":"https://doi.org/10.4070/kcj.2024.0377","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 2","pages":"118-120"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Korean Organ Transplant Registry (KOTRY): Third Official Adult Heart Transplant Report.","authors":"Hyo-In Choi, Sang Eun Lee, Junho Hyun, Darae Kim, Dong-Ju Choi, Eun-Seok Jeon, Hae-Young Lee, Hyun-Jai Cho, Hyungseop Kim, In-Cheol Kim, Jaewon Oh, Minjae Yoon, Jin Joo Park, Jin-Oh Choi, Min Ho Ju, Seok-Min Kang, Soo Yong Lee, Sung-Ho Jung, Jae-Joong Kim","doi":"10.4070/kcj.2024.0176","DOIUrl":"10.4070/kcj.2024.0176","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Korean Organ Transplant Registry (KOTRY) provided data for this third official report on adult heart transplantation (HT), including information from 709 recipients.</p><p><strong>Methods: </strong>Data from HTs performed at seven major centers in Korea between March 2014 and December 2020 were analyzed, focusing on immunosuppression, acute rejection, cardiac allograft vasculopathy (CAV), post-transplant survival, and mechanical circulatory support (MCS) usage.</p><p><strong>Results: </strong>The median ages of the recipients and donors were 56.0 and 43.0 years, respectively. Cardiomyopathy and ischemic heart disease were the most common preceding conditions for HT. A significant portion of patients underwent HT at waiting list status 1 and 0. In the multivariate analysis, a predicted heart mass mismatch was associated with a higher risk of 1-year mortality. Patients over 70 years old had a significantly increased risk of 6-year mortality. The risk of CAV was higher for male donors and donors older than 45 years. Acute rejection was more likely in patients with panel reactive antibody levels above 80%, while statin use was associated with a reduced risk. The employment of left ventricular assist device as a bridge to transplantation increased from 2.17% to 22.4%. Pre-transplant extra-corporeal membrane oxygenation was associated with worse post-transplant survival.</p><p><strong>Conclusions: </strong>In this third KOTRY report, we analyzed changes in the characteristics of adult HT recipients and donors and their impact on post-transplant outcomes. The most notable discovery was the increased use of MCS before HT and their impact on post-transplant outcomes.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"79-96"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shank3 Overexpression Leads to Cardiac Dysfunction in Mice by Disrupting Calcium Homeostasis in Cardiomyocytes.","authors":"Tae Hee Ko, Yoonhee Kim, Chunmei Jin, Byeongil Yu, Minju Lee, Phuong Kim Luong, Tran Nguyet Trinh, Yeji Yang, Hyojin Kang, Yinhua Zhang, Ruiying Ma, Kwangmin Yoo, Jungmin Choi, Jin Young Kim, Sun-Hee Woo, Kihoon Han, Jong-Il Choi","doi":"10.4070/kcj.2024.0179","DOIUrl":"10.4070/kcj.2024.0179","url":null,"abstract":"<p><strong>Background and objectives: </strong>SH3 and multiple ankyrin repeat domains 3 (Shank3) proteins play crucial roles as neuronal postsynaptic scaffolds. Alongside neuropsychiatric symptoms, individuals with <i>SHANK3</i> mutations often exhibit symptoms related to dysfunctions in other organs, including the heart. However, detailed insights into the cardiac functions of Shank3 remain limited. This study aimed to characterize the cardiac phenotypes of Shank3-overexpressing transgenic mice and explore the underlying mechanisms.</p><p><strong>Methods: </strong>Cardiac histological analysis, electrocardiogram and echocardiogram recordings were conducted on Shank3-overexpressing transgenic mice. Electrophysiological properties, including action potentials and L-type Ca²⁺ channel (LTCC) currents, were measured in isolated cardiomyocytes. Ca²⁺ homeostasis was assessed by analyzing cytosolic Ca²⁺ transients and sarcoplasmic reticulum Ca²⁺ contents. Depolarization-induced cell shortening was examined in cardiomyocytes. Immunoprecipitation followed by mass spectrometry-based identification was employed to identify proteins in the cardiac Shank3 interactome. Western blot and immunocytochemical analyses were conducted to identify changes in protein expression in Shank3-overexpressing transgenic cardiomyocytes.</p><p><strong>Results: </strong>The hearts of Shank3-overexpressing transgenic mice displayed reduced weight and increased fibrosis. In vivo, sudden cardiac death, arrhythmia, and contractility impairments were identified. Shank3-overexpressing transgenic cardiomyocytes showed prolonged action potential duration and increased LTCC current density. Cytosolic Ca²⁺ transients were increased with prolonged decay time, while sarcoplasmic reticulum Ca²⁺ contents remained normal. Cell shortening was augmented in Shank3-overexpressing transgenic cardiomyocytes. The cardiac Shank3 interactome comprised 78 proteins with various functions. Troponin I levels were down-regulated in Shank3-overexpressing transgenic cardiomyocytes.</p><p><strong>Conclusions: </strong>This study revealed cardiac dysfunction in Shank3-overexpressing transgenic mice, potentially attributed to changes in Ca²⁺ homeostasis and contraction, with a notable reduction in troponin I.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"100-117"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Jury Still Out for Judging the Right Decision for Intermediate Stenosis?","authors":"Bon-Kwon Koo","doi":"10.4070/kcj.2024.0413","DOIUrl":"https://doi.org/10.4070/kcj.2024.0413","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights on Mechanisms of Nicotine in Neointimal Hyperplasia.","authors":"Weon Kim","doi":"10.4070/kcj.2024.0326","DOIUrl":"10.4070/kcj.2024.0326","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"65-66"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pivot-Balloon: A First Step Toward a Novel Transcatheter Treatment for Severe Tricuspid Regurgitation.","authors":"Jaeoh Lee, Yong-Joon Lee","doi":"10.4070/kcj.2024.0304","DOIUrl":"10.4070/kcj.2024.0304","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"32-33"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Any ABCDE Stress Echocardiography Score Equivalent to Stress-Induced Ischaemia? Reply With a Modified 2-Stage Approach.","authors":"Nikolaos Miaris","doi":"10.4070/kcj.2024.0264","DOIUrl":"10.4070/kcj.2024.0264","url":null,"abstract":"<p><p>Stress echocardiography has evolved from the sole assessment of regional wall motion abnormalities (RWMAs) to the ABCDE protocol, as recommended by the recent clinical consensus statement from the European Association of Cardiovascular Imaging, reflecting the need for a more systematic patient assessment. Steps A, B, C, D, and E assess RWMAs, lung B-lines, left ventricular contractile reserve, coronary flow velocity reserve (CFVR) in mid-distal left anterior descending artery, and heart rate reserve, respectively. Impairment of CFVR is considered as the earliest abnormality in the ischaemic cascade. While mostly steps A and D have been studied for their relation to obstructive and non-obstructive coronary artery disease, the diagnostic accuracy of steps B, C, and E for chronic coronary syndromes (CCSs) remains unknown, particularly in the context of negative steps A and D. Additionally, while ABCDE steps have been studied for their prognostic significance, there is no evidence of patients management based on this protocol in order to change the estimated risk. These concepts could be depicted in a 2-stage approach. A negative stage 1 (no stress-induced RWMAs as assessed in step A and normal CFVR as assessed in step D) imply good prognosis and non-coronary causes of symptoms should be considered, whereas guidelines for CCSs should be followed in a positive stage 1. Stage 2 includes steps B, C, and E, for further risk stratification or symptoms assessment, but it lacks evidence-based risk-modifying management and is mainly useful when stage 1 is negative and a cardiac origin of symptoms is still suspected.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 1","pages":"1-4"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Pivot-Balloon for Severe Tricuspid Regurgitation: The First-in-Man Experiences.","authors":"Eun Kyoung Kim, Min-Ku Chon, Hyun-Sook Kim, Yong-Hyun Park, Sang-Hyun Lee, Ki Seok Choo, Hyung Gon Je, Dae-Hee Kim, Tae Oh Kim, Yoon Seok Koh, Jae-Hyeong Park, Jae-Hwan Lee, Young Jin Choi, Eun Seok Shin, Hyuck-Jun Yoon, Seung-Whan Lee, Joo-Yong Hahn","doi":"10.4070/kcj.2024.0147","DOIUrl":"10.4070/kcj.2024.0147","url":null,"abstract":"<p><strong>Background and objectives: </strong>Among various emerging catheter-based treatments for severe tricuspid regurgitation (TR), the spacer device can reduce the regurgitation orifice without manipulating the valve leaflet. However, its clinical application has been hampered by traumatic anchoring to the myocardium and the coaxial alignment of the balloon resulting in insufficient TR reduction. This study aimed to evaluate the early-stage safety, technical feasibility, and preliminary efficacy of the novel atraumatic vertical spacer in patients with isolated severe TR.</p><p><strong>Methods: </strong>All procedures were guided by fluoroscopy and transthoracic echocardiography. The maximum device placement time with an inflated balloon was 24 hours. Changes in the amount of TR, right ventricular function, and patient hemodynamics were measured during balloon deployment.</p><p><strong>Results: </strong>A total of 7 patients (median age 74), underwent successful device implantation without procedure-related complications. During balloon inflation (median 25 minutes), there were no symptoms or signs indicative of TR intolerance. TR was reduced by 1 grade or greater in all patients, with 2 patients exhibiting a reduction of 3 grades, from torrential TR to a moderate degree. Mild TR after balloon inflation was achieved in 3 patients with baseline severe TR. The TR reduction observed during initial balloon deployment was sustained during the subsequent balloon maintenance period.</p><p><strong>Conclusions: </strong>The Pivot-balloon procedure was safe, technically feasible, and effective in reducing TR in patients with severe TR. No periprocedural complications or adverse cardiovascular events were reported during device placement with TR reduction observed in all patients. However, longer-term follow-up is needed to confirm safety and treatment effect.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05648838.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"20-31"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Nicotine on Re-endothelialization, Inflammation, and Neoatherosclerosis After Drug-Eluting Stent Implantation in a Porcine Model.","authors":"Seok Oh, Ju Han Kim, Saleem Ahmad, Yu Jeong Jin, Mi Hyang Na, Munki Kim, Jeong Ha Kim, Dae Sung Park, Dae Young Hyun, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Seung-Won Lee, Youngkeun Ahn, Myung Ho Jeong","doi":"10.4070/kcj.2024.0171","DOIUrl":"10.4070/kcj.2024.0171","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cigarette smoking is a major risk factor for atherosclerosis. Nicotine, a crucial constituent of tobacco, contributes to atherosclerosis development and progression. However, evidence of the association between nicotine and neointima formation is limited. We aimed to evaluate whether nicotine enhances neointimal hyperplasia in the native epicardial coronary arteries of pigs after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).</p><p><strong>Methods: </strong>After coronary angiography (CAG) and quantitative coronary angiography (QCA), we implanted 20 DES into 20 pigs allocated to 2 groups: no-nicotine (n=10) and nicotine (n=10) groups. Post-PCI CAG and QCA were performed immediately. Follow-up CAG, QCA, optical coherence tomography (OCT), and histopathological analyses were performed 2 months post-PCI.</p><p><strong>Results: </strong>Despite intergroup similarities in the baseline QCA findings, OCT analysis showed that the nicotine group had a smaller mean stent and lumen areas, a larger mean neointimal area, greater percent area stenosis, and higher peri-strut fibrin and inflammation scores than the no-nicotine group. In immunofluorescence analysis, the nicotine group displayed higher expression of CD68 and α-smooth muscle actin but lower CD31 expression than the no-nicotine group.</p><p><strong>Conclusions: </strong>Nicotine inhibited re-endothelialization and promoted inflammation and NIH after PCI with DES in a porcine model.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"50-64"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Procedural Characteristics and Clinical Outcomes Among Patients Undergoing Bifurcation PCI.","authors":"Hyun Jin Ahn, Francesco Bruno, Jeehoon Kang, Doyeon Hwang, Han-Mo Yang, Jung-Kyu Han, Leonardo De Luca, Ovidio de Filippo, Alessio Mattesini, Kyung Woo Park, Alessandra Truffa, Wojciech Wanha, Young Bin Song, Sebastiano Gili, Woo Jung Chun, Gerard Helft, Seung-Ho Hur, Bernardo Cortese, Seung Hwan Han, Javier Escaned, Alaide Chieffo, Ki Hong Choi, Guglielmo Gallone, Joon-Hyung Doh, Gaetano De Ferrari, Soon-Jun Hong, Giorgio Quadri, Chang-Wook Nam, Hyeon-Cheol Gwon, Hyo-Soo Kim, Fabrizio D'Ascenzo, Bon-Kwon Koo","doi":"10.4070/kcj.2024.0172","DOIUrl":"10.4070/kcj.2024.0172","url":null,"abstract":"<p><strong>Background and objectives: </strong>The risk profiles, procedural characteristics, and clinical outcomes for women undergoing bifurcation percutaneous coronary intervention (PCI) are not well defined compared to those in men.</p><p><strong>Methods: </strong>COronary BIfurcation Stenting III (COBIS III) is a multicenter, real-world registry of 2,648 patients with bifurcation lesions treated with second-generation drug-eluting stents. We compared the angiographic and procedural characteristics and clinical outcomes based on sex. The primary outcome was 5-year target lesion failure (TLF), a composite of cardiac death, myocardial infarction, and target lesion revascularization.</p><p><strong>Results: </strong>Women (n=635, 24%) were older, had hypertension and diabetes more often, and had smaller main vessel and side branch reference diameters than men. The pre- and post-PCI angiographic percentage diameter stenoses of the main vessel and side branch were comparable between women and men. There were no differences in procedural characteristics between the sexes. Women and men had a similar risk of TLF (6.3% vs. 7.1%, p=0.63) as well as its individual components and sex was not an independent predictor of TLF. This finding was consistent in the left main and 2 stenting subgroups.</p><p><strong>Conclusions: </strong>In patients undergoing bifurcation PCI, sex was not an independent predictor of adverse outcome.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT03068494.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"5-16"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}