Korean Circulation Journal最新文献

{"title":"Is the Jury Still Out for Judging the Right Decision for Intermediate Stenosis?","authors":"Bon-Kwon Koo","doi":"10.4070/kcj.2024.0413","DOIUrl":"10.4070/kcj.2024.0413","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"196-198"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Invasive Hemodynamic Assessment of Heart Failure With Preserved Ejection Fraction.","authors":"Sabina Istratoaie, Charlotte L Frost, Erwan Donal","doi":"10.4070/kcj.2024.0370","DOIUrl":"10.4070/kcj.2024.0370","url":null,"abstract":"<p><p>Heart failure with preserved ejection fraction (HFpEF) is a major healthcare problem with increasing prevalence. There has been a shift in HFpEF management towards early diagnosis and phenotype-specific targeted treatment. However, diagnosing HFpEF remains challenging due to a lack of universal criteria and patient heterogeneity. This review aims to provide a comprehensive assessment of the diagnostic workup of HFpEF, highlighting the role of echocardiography in HFpEF phenotyping.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 3","pages":"165-184"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Thick Biolimus A9-Eluting Stent and Thin Zotarolimus-Eluting Stent in Multi-Vessel Percutaneous Coronary Intervention.","authors":"Cheol Hyun Lee, Hee Jeong Lee, Tae-Wan Chung, Seonhwa Lee, Jongmin Hwang, In-Cheol Kim, Yun-Kyeong Cho, Hyuck-Jun Yoon, Seung-Ho Hur, Jin Young Kim, Yun Seok Kim, Woo Sung Jang, Jang Hoon Lee, Woong Kim, Jin Bae Lee, Young Joon Hong, Jung Ho Heo, Bong-Ryeol Lee, Joon-Hyung Doh, Eun-Seok Shin, Bon-Kwon Koo, Chang-Wook Nam","doi":"10.4070/kcj.2024.0101","DOIUrl":"https://doi.org/10.4070/kcj.2024.0101","url":null,"abstract":"<p><strong>Background and objectives: </strong>There are limited randomized studies on patients undergoing multi-vessel percutaneous coronary intervention (PCI) comparing the outcomes between stent thickness and polymer types. To compare the clinical outcomes of thick biodegradable polymer-based biolimus A9-eluting stents (BESs) and thin durable polymer-based zotarolimus-eluting stents (ZESs) in patients undergoing multi-vessel PCI.</p><p><strong>Methods: </strong>A total of 936 patients who underwent multi-vessel coronary artery stenting were randomly assigned to the BES (n=472) or ZES (n=464) groups. The primary endpoint was 2-year major adverse cardiac events (MACEs), a composite of all-cause death, myocardial infarction (MI), and any revascularization at the 2-year follow-up.</p><p><strong>Results: </strong>Fifty-two (11.2%) of 472 patients in BES group and 50 (10.9%) of the 464 patients in ZES group met the 2-year primary endpoint of MACE (hazard ratio, 1.00; 90% confidence interval, 0.72, 1.38; p=0.994). All-cause death (BES vs. ZES: 2.8% vs. 2.7%, p=0.758), MI (2.1% vs. 2.6%, p=0.483), and repeat revascularization (6.7% vs. 6.9%, p=0.876) were not significantly different between the 2 groups. Although there was no significant outcome difference in any subgroup analysis, the technical failure rate leading to the use of other stents was higher in BES than in ZES (3.2% vs. 0.9%, p=0.023).</p><p><strong>Conclusions: </strong>In patients who underwent multi-vessel PCI, BES and ZES showed comparable 2-year clinical outcomes. However, BES was not established to demonstrate non-inferiority to ZES in terms of the incidence of the primary endpoint at the 2-year. The technical success rate of the index PCI with the assigned stent was higher for thinner ZES.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT01947439.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Performance of the Micra VR Leadless Pacemaker in a South Korean Cohort: A Comparison to Global Studies.","authors":"Myung-Jin Cha, Seung-Jung Park, Youngjin Cho, Min Soo Cho, Young Keun On, Ju Youn Kim, Tae-Hoon Kim, Hee Tae Yu, Yong-Seog Oh, So-Ryoung Lee, Jaemin Shim, Jong-Il Choi, Eue-Keun Choi, Jongmin Hwang, Kurt Stromberg, Jeffrey Murphy, Dedra H Fagan, Boyoung Joung","doi":"10.4070/kcj.2024.0317","DOIUrl":"https://doi.org/10.4070/kcj.2024.0317","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Micra leadless pacemaker demonstrated a favorable safety and efficacy profile in global trials, but its performance and safety in a South Korean-specific population are unknown.</p><p><strong>Methods: </strong>The prospective, single-arm Micra Acute Performance South Korean registry was designed to study the performance of the Micra VR leadless pacemaker in patients from South Korea. The primary objectives were to characterize the rate of acute (30 days) and longer-term (12 months) major complications. Electrical performance and quality of life at baseline and follow-up were also characterized.</p><p><strong>Results: </strong>A total of 100 enrolled patients underwent Micra VR implant at 8 centers in South Korea between July 2021 and February 2022 with 99% successfully implanted. Mean pacing capture threshold was 0.57±0.46 V at implant and remained stable through 12 months (0.65±0.44 V). Korean valuation of health status significantly increased from baseline (0.78±0.24) to 12 months (0.84±0.21) (p=0.016). Compared with global patients, South Korean patients were younger, had a lower body mass index, and fewer had a prior cardiovascular implantable electronic device (all p<0.01). During the follow-up period 1 major complication was reported (implant site hematoma) at 26 days post-implant. No pericardial effusion or tamponade events were observed. Through 12 months post-implant the major complication rate was 1.0% (95% confidence interval, 0.03%, 5.45%).</p><p><strong>Conclusions: </strong>In a South Korean cohort, the Micra VR leadless pacemaker was implanted with a high success rate and low major complication rate.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation.","authors":"Onyou Kim, David Hong, Ki Hong Choi, Joo Myung Lee, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Yang Hyun Cho, Hyeon-Cheol Gwon, Jeong Hoon Yang","doi":"10.4070/kcj.2024.0330","DOIUrl":"https://doi.org/10.4070/kcj.2024.0330","url":null,"abstract":"<p><strong>Background and objectives: </strong>Limited data are available on sex differences in clinical outcomes of patients with profound cardiogenic shock (CS) receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO). Therefore, our study sought to compare clinical pictures and outcomes between male and female patients treated with VA-ECMO.</p><p><strong>Methods: </strong>A total of 1,328 patients receiving VA-ECMO were selected from either the Samsung Medical Center or a multicenter CS registry named the SMART RESCUE study. The study population was divided into men (n=903) and women (n=425). The primary outcome was in-hospital mortality, and the secondary outcome was procedure-related complications, which included limb ischemia, extracorporeal membrane oxygenation (ECMO) site bleeding and infection, and wound dehiscence.</p><p><strong>Results: </strong>There was no significant difference in in-hospital mortality (men vs. women, 46.4% vs. 45.6%; adjusted odds ratio [OR], 0.78; 95% confidence interval [CI], 0.58-1.05; p=0.106) based on multivariable analysis. Women showed higher rates of procedure-related complication than men (18.7% vs. 25.9%; adjusted OR, 1.82; 95% CI, 1.29-2.57; p=0.001) mainly driven by higher incidence of limb ischemia (7.1% vs. 12.9%; adjusted OR, 2.32; 95% CI, 1.42-3.78; p=0.001) On multivariable logistic regression analysis, female sex was an independent predictor of procedure-related complications (adjusted OR, 1.68; 95% CI, 1.13-2.49; p=0.009).</p><p><strong>Conclusions: </strong>Although no significant difference in either in-hospital or mid-term mortality was found between men and women, female sex is an independent factor for ECMO-related complications.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT02985008.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Chronic Thromboembolic Pulmonary Hypertension: Expanding the Disease Concept and Treatment Options.","authors":"Sung-A Chang, Jeong Hoon Yang, Dong Seop Jung, Nick H Kim","doi":"10.4070/kcj.2024.0423","DOIUrl":"https://doi.org/10.4070/kcj.2024.0423","url":null,"abstract":"<p><p>Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive form of pulmonary hypertension characterized by unresolved thromboembolic occlusion of pulmonary arteries, leading to increased pulmonary arterial pressure and right heart failure. This review examines recent advances in the pathophysiology, diagnosis, and management of CTEPH, focusing on expanding disease concepts and evolving therapeutic approaches. The incidence of CTEPH has been revised upward with improved diagnostic techniques revealing a higher prevalence than previously recognized. Advances in surgical and interventional therapies, particularly pulmonary endarterectomy and balloon pulmonary angioplasty, have significantly improved outcomes. Emerging medical therapies, including pulmonary vasodilators like riociguat, have offered new hope for inoperable cases. The understanding of CTEPH has broadened, leading to better diagnostic strategies and more comprehensive treatment options that significantly enhance patient outcomes. Multidisciplinary team approaches are crucial in managing the disease effectively.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Implication of Left Ventricular Global Longitudinal Strain in Patients With Hypertrophic Cardiomyopathy and Coexisting Hypertension.","authors":"Soongu Kwak, Jihoon Kim, Chan-Soon Park, Hyun-Jung Lee, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Hyung-Kwan Kim, Sang-Chol Lee, Andrew Wang","doi":"10.4070/kcj.2024.0213","DOIUrl":"https://doi.org/10.4070/kcj.2024.0213","url":null,"abstract":"<p><strong>Background and objectives: </strong>The prognostic implication of coexisting hypertension in patients with hypertrophic cardiomyopathy (HCM) is poorly defined. This study aimed to evaluate the association between left ventricular global longitudinal strain (LV-GLS) and adverse cardiovascular (CV) events in patients with HCM and coexisting hypertension.</p><p><strong>Methods: </strong>We analyzed consecutive patients with HCM from 2 tertiary HCM referral centers. The primary outcome was CV events, defined as a composite of CV death, heart failure, and stroke. All LV-GLS measurements were conducted in a core laboratory.</p><p><strong>Results: </strong>Of 1,139 patients with HCM, 522 (45.8%) had hypertension. Patients with hypertension were older, had more CV comorbidities, and showed a lower LV-GLS (13.7% vs. 14.4%, <i>p</i>=0.001). During a median 6.6-year follow-up, 155 CV events occurred, with a significantly higher crude incidence in patients with hypertension than in those without (p=0.005). Lower LV-GLS was independently associated with a higher risk of CV events in patients with hypertension (per 1% decrease in LV-GLS, adjusted hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.01-1.13; p=0.013). When stratified by four groups based on hypertension and LV-GLS, CV events most frequently occurred in patients with both hypertension and a lower LV-GLS (<13.1%), with a significantly higher risk compared to those without hypertension and a higher LV-GLS (≥13.1%) (adjusted HR, 1.60; 95% CI, 1.01-2.54; p=0.044).</p><p><strong>Conclusions: </strong>Patients with HCM and coexisting hypertension were older, had more prevalent CV comorbidities, and exhibited a lower LV-GLS compared to those without hypertension. LV-GLS provides important prognostic information in patients with both HCM and hypertension.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotics in Interventional Cardiology: Where Are We? And How Can We Expand?","authors":"Jeehoon Kang","doi":"10.4070/kcj.2024.0399","DOIUrl":"https://doi.org/10.4070/kcj.2024.0399","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osfit™, a Novel Stent Designed for the Treatment of Coronary Ostial Lesions: Initial Clinical Experience and Intravascular Ultrasound Evaluation.","authors":"Kyoung-Woo Seo, Seung-Jea Tahk, Hyoung-Mo Yang, Hong-Seok Lim, Myeong-Ho Yoon, So-Yeon Choi","doi":"10.4070/kcj.2024.0256","DOIUrl":"https://doi.org/10.4070/kcj.2024.0256","url":null,"abstract":"<p><strong>Background and objectives: </strong>Stent implantation for coronary ostial lesions is challenging. This study evaluated the feasibility, safety, and immediate procedural results of the Osfit™, innovatively designed sirolimus drug-eluting stent delivery system for the treatment of coronary ostial lesions.</p><p><strong>Methods: </strong>The Osfit™ has a 5 mm long extended balloon proximal to the stent (bare balloon without mounted stent). When inflated at 1.5 atm, only bare balloon inflated and acts like a stopper. We evaluated the technical feasibility in 49 patients with a coronary ostial lesion (defined as stenosis within 3 mm from the origin of the vessel) who had received the Osfit™. Intravascular ultrasound (IVUS) analysis was done in 11 patients who consented to IVUS examination, and the depth from the proximal edge of the stent to the ostial plane (DSO) was measured.</p><p><strong>Results: </strong>In all 49 lesions, stents were successfully implanted in one single angiographic view without obvious stent protrusion or definite angiographic missing of the ostium. The proportions of aorto-ostial, and bifurcation lesions were 28.6% and 71.4%, respectively. The DSO was 0.2±0.69 mm, and the proximal stent edges were located within 1 mm of the ostial edge in all patients. No adverse events like death, myocardial infarction, target lesion revascularization, target vessel revascularization or stent thrombosis were reported during the in-hospital period or within 30 days.</p><p><strong>Conclusions: </strong>The implantation of the Osfit™ for coronary ostial lesions appears to be an accurate and safe procedure that may reduce multiple angiographic projections and advanced skills.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Atrial Strain Predicts Poor Exercise Capacity in Patients With Indeterminate Diastolic Function.","authors":"Hyejung Choi, Houng-Beom Ahn, Jiesuck Park, Hong-Mi Choi, In-Chang Hwang, Yeonyee Yoon, Goo-Yeong Cho","doi":"10.4070/kcj.2024.0240","DOIUrl":"https://doi.org/10.4070/kcj.2024.0240","url":null,"abstract":"<p><strong>Background and objectives: </strong>The 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines report that approximately 20% of diastolic dysfunction is indeterminate and has limited diagnostic accuracy. Left atrial strain may help accurately categorize diastolic dysfunction; however, its exact roles remain unclear. This study investigated the impact of left atrial reservoir strain (LARS) and its association with exercise capacity in patients with indeterminate diastolic function.</p><p><strong>Methods: </strong>Among 687 patients who underwent cardiopulmonary exercise tests and supine bicycle stress echocardiography for symptoms including dyspnea, chest pain, valvular heart disease, and other cardiovascular problems, 118 with indeterminate diastolic function were analyzed after excluding those with atrial fibrillation and significant valvular heart disease. Poor exercise tolerance was defined as peak oxygen consumption (pVO₂) <14 mL/kg/min.</p><p><strong>Results: </strong>Key diastolic dysfunction indices showed no statistical differences between patients with pVO₂ <14 mL/kg/min and ≥14 mL/kg/min. Only LARS was independently associated with pVO₂ (β=0.12 [0.09-0.15], p<0.001) in patients with indeterminate diastolic function. Receiver-operating characteristic curves highlighted LARS as a strong predictor of impaired pVO₂ among all echocardiographic variables (area under the curve: 0.871 [0.776-0.966]), with an optimal cut-off value of 21% after adjusting for clinical variables. Logistic analysis showed that patients with ≤21% LARS had significantly reduced exercise capacity (odds ratio, 12.77; 95% confidence interval, 3.83-48.65; p<0.001).</p><p><strong>Conclusions: </strong>LARS is significantly associated with pVO₂ in patients with indeterminate diastolic function. Impaired LARS is a robust predictor of exercise intolerance; measuring LARS enhances diastolic-function assessment accuracy, potentially improving individualized diastolic-dysfunction management and treatment.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}