Osfit™, a Novel Stent Designed for the Treatment of Coronary Ostial Lesions: Initial Clinical Experience and Intravascular Ultrasound Evaluation.

IF 3.1 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI:10.4070/kcj.2024.0256
Kyoung-Woo Seo, Seung-Jea Tahk, Hyoung-Mo Yang, Hong-Seok Lim, Myeong-Ho Yoon, So-Yeon Choi
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引用次数: 0

Abstract

Background and objectives: Stent implantation for coronary ostial lesions is challenging. This study evaluated the feasibility, safety, and immediate procedural results of the Osfit™, innovatively designed sirolimus drug-eluting stent delivery system for the treatment of coronary ostial lesions.

Methods: The Osfit™ has a 5 mm long extended balloon proximal to the stent (bare balloon without mounted stent). When inflated at 1.5 atm, only bare balloon inflated and acts like a stopper. We evaluated the technical feasibility in 49 patients with a coronary ostial lesion (defined as stenosis within 3 mm from the origin of the vessel) who had received the Osfit™. Intravascular ultrasound (IVUS) analysis was done in 11 patients who consented to IVUS examination, and the depth from the proximal edge of the stent to the ostial plane (DSO) was measured.

Results: In all 49 lesions, stents were successfully implanted in one single angiographic view without obvious stent protrusion or definite angiographic missing of the ostium. The proportions of aorto-ostial, and bifurcation lesions were 28.6% and 71.4%, respectively. The DSO was 0.2±0.69 mm, and the proximal stent edges were located within 1 mm of the ostial edge in all patients. No adverse events like death, myocardial infarction, target lesion revascularization, target vessel revascularization or stent thrombosis were reported during the in-hospital period or within 30 days.

Conclusions: The implantation of the Osfit™ for coronary ostial lesions appears to be an accurate and safe procedure that may reduce multiple angiographic projections and advanced skills.

用于治疗冠状动脉口病变的新型支架Osfit™:初步临床经验和血管内超声评估
背景和目的:冠状动脉口病变支架植入术具有挑战性。本研究评估了Osfit™(创新设计的西罗莫司药物洗脱支架输送系统)用于治疗冠状动脉口病变的可行性、安全性和即时操作结果。方法:Osfit™在支架近端有一个5mm长的延伸球囊(未安装支架的裸球囊)。当膨胀到1.5 atm时,只有裸露的气球膨胀,就像一个塞子。我们评估了49例接受Osfit™的冠状动脉口病变(定义为距离血管起源3mm以内的狭窄)患者的技术可行性。对11例同意接受血管内超声检查的患者进行血管内超声(IVUS)分析,并测量支架近端边缘到口平面(DSO)的深度。结果:49例病变均成功植入单片血管,无明显的支架突出或明显的血管造影缺失。主动脉口部病变占28.6%,分叉部病变占71.4%。DSO为0.2±0.69 mm,支架近端边缘均位于距口缘1 mm以内。住院期间及30天内未发生死亡、心肌梗死、靶病变血运重建、靶血管血运重建、支架内血栓形成等不良事件。结论:Osfit™植入治疗冠状动脉口病变是一种准确和安全的手术,可以减少多次血管造影投影和先进的技术。
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来源期刊
Korean Circulation Journal
Korean Circulation Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
4.90
自引率
17.20%
发文量
103
期刊介绍: Korean Circulation Journal is the official journal of the Korean Society of Cardiology, the Korean Pediatric Heart Society, the Korean Society of Interventional Cardiology, and the Korean Society of Heart Failure. Abbreviated title is ''Korean Circ J''. Korean Circulation Journal, established in 1971, is a professional, peer-reviewed journal covering all aspects of cardiovascular medicine, including original articles of basic research and clinical findings, review articles, editorials, images in cardiovascular medicine, and letters to the editor. Korean Circulation Journal is published monthly in English and publishes scientific and state-of-the-art clinical articles aimed at improving human health in general and contributing to the treatment and prevention of cardiovascular diseases in particular. The journal is published on the official website (https://e-kcj.org). It is indexed in PubMed, PubMed Central, Science Citation Index Expanded (SCIE, Web of Science), Scopus, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, KoreaMed, KoreaMed Synapse and KoMCI, and easily available to wide international researchers
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