Korean Circulation Journal最新文献_第5页

Exosome-Based Therapy in Cardiovascular Diseases: A New Frontier in Cardiovascular Disease Treatment. 基于外泌体的心血管疾病治疗：心血管疾病治疗的新前沿。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-03-05 DOI: 10.4070/kcj.2025.0022

Cheong-Whan Chae, Gun Choi, Taehun Yoon, Yoo-Wook Kwon

{"title":"Exosome-Based Therapy in Cardiovascular Diseases: A New Frontier in Cardiovascular Disease Treatment.","authors":"Cheong-Whan Chae, Gun Choi, Taehun Yoon, Yoo-Wook Kwon","doi":"10.4070/kcj.2025.0022","DOIUrl":"10.4070/kcj.2025.0022","url":null,"abstract":"Exosomes, small extracellular vesicles ranging from 30 to 150 nanometers in diameter, have emerged as pivotal mediators of intercellular communication. These vesicles, originally perceived as cellular debris, are now recognized for their intricate roles in transporting bioactive molecules, including proteins, lipids, and nucleic acids, between cells. Exosomes have received considerable attention due to their roles in diverse physiological and pathological processes, especially in relation to cardiovascular diseases (CVDs). CVDs are intricately linked, sharing common risk factors and pathological mechanisms, such as inflammation, oxidative stress, and endothelial dysfunction. Exosomes have been implicated in either directly or indirectly influencing these phenomena. They are secreted by virtually all cell types, including endothelial cells, cardiomyocytes, and stem cells, play critical roles in maintaining vascular homeostasis and responding to pathological stimuli. Their capacity to traverse biological barriers, maintain stability in circulation, and effectively encapsulate and deliver a variety of molecular cargos makes them promising candidates for both biomarkers and therapeutic agents. This review aims to explore the multifaceted roles of exosomes in CVDs. And we will discuss the mechanisms of exosome biogenesis and release, their molecular composition, and the ways in which they contribute to disease pathophysiology. Additionally, we will emphasize the potential of exosomes as diagnostic biomarkers and their therapeutic uses, highlighting their significance in the advancement of innovative treatment strategies. This review explores recent findings and advancements in exosome research, emphasizing their significance in CVD and paving the way for future studies and clinical applications.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"461-480"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultimately, the Problem Lies in the Arterial Diameter. 最终，问题出在动脉直径上。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI: 10.4070/kcj.2025.0030

Hyoung Woo Chang

引用次数: 0

Sex Differences in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation. 心源性休克患者接受静脉体外膜氧合的性别差异。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-10 DOI: 10.4070/kcj.2024.0330

Onyou Kim, David Hong, Ki Hong Choi, Joo Myung Lee, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Yang Hyun Cho, Hyeon-Cheol Gwon, Jeong Hoon Yang

{"title":"Sex Differences in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation.","authors":"Onyou Kim, David Hong, Ki Hong Choi, Joo Myung Lee, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Yang Hyun Cho, Hyeon-Cheol Gwon, Jeong Hoon Yang","doi":"10.4070/kcj.2024.0330","DOIUrl":"10.4070/kcj.2024.0330","url":null,"abstract":"Background and objectives: Limited data are available on sex differences in clinical outcomes of patients with profound cardiogenic shock (CS) receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO). Therefore, our study sought to compare clinical pictures and outcomes between male and female patients treated with VA-ECMO.Methods: A total of 1,328 patients receiving VA-ECMO were selected from either the Samsung Medical Center or a multicenter CS registry named the SMART RESCUE study. The study population was divided into men (n=903) and women (n=425). The primary outcome was in-hospital mortality, and the secondary outcome was procedure-related complications, which included limb ischemia, extracorporeal membrane oxygenation (ECMO) site bleeding and infection, and wound dehiscence.Results: There was no significant difference in in-hospital mortality (men vs. women, 46.4% vs. 45.6%; adjusted odds ratio [OR], 0.78; 95% confidence interval [CI], 0.58-1.05; p=0.106) based on multivariable analysis. Women showed higher rates of procedure-related complication than men (18.7% vs. 25.9%; adjusted OR, 1.82; 95% CI, 1.29-2.57; p=0.001) mainly driven by higher incidence of limb ischemia (7.1% vs. 12.9%; adjusted OR, 2.32; 95% CI, 1.42-3.78; p=0.001) On multivariable logistic regression analysis, female sex was an independent predictor of procedure-related complications (adjusted OR, 1.68; 95% CI, 1.13-2.49; p=0.009).Conclusions: Although no significant difference in either in-hospital or mid-term mortality was found between men and women, female sex is an independent factor for ECMO-related complications.Trial registration: ClinicalTrials.gov Identifier: NCT02985008.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"541-551"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disparities in Heart Transplantation Allocation and Outcomes by Blood Type in Korea (2010-2022). 韩国心脏移植分配和结果的血型差异（2010-2022）。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-03-28 DOI: 10.4070/kcj.2024.0281

Kyung-Hee Kim, Byoung Geol Choi, Jin-Oh Choi, In-Cheol Kim, Jong-Chan Youn, Yang Hyun Cho, Hae-Young Lee, Sung-Ho Jung, Byung-Hee Oh

{"title":"Disparities in Heart Transplantation Allocation and Outcomes by Blood Type in Korea (2010-2022).","authors":"Kyung-Hee Kim, Byoung Geol Choi, Jin-Oh Choi, In-Cheol Kim, Jong-Chan Youn, Yang Hyun Cho, Hae-Young Lee, Sung-Ho Jung, Byung-Hee Oh","doi":"10.4070/kcj.2024.0281","DOIUrl":"10.4070/kcj.2024.0281","url":null,"abstract":"Background and objectives: This study aimed to elucidate the influence of recipient blood type on heart transplant allocation dynamics in Korea, focusing on donor matching, wait times, and post-transplant survival from 2010 to 2022.Methods: In this retrospective cohort study, we examined 1,745 heart transplant recipients classified by blood types: A (n=631), B (n=488), AB (n=256), and O (n=370). Parameters studied encompassed donor and recipient ages, donor blood type compatibility, organ type, emergency status, waiting periods, and survival rates up to one year post-transplant.Results: This investigation revealed significant disparities in the outcomes for heart transplant waitlist patients, differentiated by blood type. O recipients encountered notably extended median wait times of 110 days (an average of 300±514 days), which is substantially longer compared to A (65 days), B (58 days), and AB (29 days). Furthermore, the mortality rate for O recipients while on the waitlist was markedly high at 78.1%, in contrast to 75.2% for A, 72.3% for B, and 48.5% for AB. O recipients who, despite constituting a significant proportion of the donor pool (34.1%), received transplants at disproportionately lower rates.Conclusions: Type O heart transplant recipients in Korea face significant challenges, including higher mortality rates during the waiting period and frequent necessity for left ventricular assist device interventions. Urgent policy reforms are needed to address these disparities and improve equitable organ allocation for blood type O patients.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"481-493"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Solutions for Coronary Ostial Lesions. 冠状动脉口病变的先进解决方案。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.4070/kcj.2025.0097

Seokhun Yang, Kyung Woo Park

引用次数: 0

Safety and Performance of the Micra VR Leadless Pacemaker in a South Korean Cohort: A Comparison to Global Studies. Micra VR无铅起搏器在韩国队列中的安全性和性能：与全球研究的比较

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-13 DOI: 10.4070/kcj.2024.0317

Myung-Jin Cha, Seung-Jung Park, Youngjin Cho, Min Soo Cho, Young Keun On, Ju Youn Kim, Tae-Hoon Kim, Hee Tae Yu, Yong-Seog Oh, So-Ryoung Lee, Jaemin Shim, Jong-Il Choi, Eue-Keun Choi, Jongmin Hwang, Kurt Stromberg, Jeffrey Murphy, Dedra H Fagan, Boyoung Joung

{"title":"Safety and Performance of the Micra VR Leadless Pacemaker in a South Korean Cohort: A Comparison to Global Studies.","authors":"Myung-Jin Cha, Seung-Jung Park, Youngjin Cho, Min Soo Cho, Young Keun On, Ju Youn Kim, Tae-Hoon Kim, Hee Tae Yu, Yong-Seog Oh, So-Ryoung Lee, Jaemin Shim, Jong-Il Choi, Eue-Keun Choi, Jongmin Hwang, Kurt Stromberg, Jeffrey Murphy, Dedra H Fagan, Boyoung Joung","doi":"10.4070/kcj.2024.0317","DOIUrl":"10.4070/kcj.2024.0317","url":null,"abstract":"Background and objectives: The Micra leadless pacemaker demonstrated a favorable safety and efficacy profile in global trials, but its performance and safety in a South Korean-specific population are unknown.Methods: The prospective, single-arm Micra Acute Performance South Korean registry was designed to study the performance of the Micra VR leadless pacemaker in patients from South Korea. The primary objectives were to characterize the rate of acute (30 days) and longer-term (12 months) major complications. Electrical performance and quality of life at baseline and follow-up were also characterized.Results: A total of 100 enrolled patients underwent Micra VR implant at 8 centers in South Korea between July 2021 and February 2022 with 99% successfully implanted. Mean pacing capture threshold was 0.57±0.46 V at implant and remained stable through 12 months (0.65±0.44 V). Korean valuation of health status significantly increased from baseline (0.78±0.24) to 12 months (0.84±0.21) (p=0.016). Compared with global patients, South Korean patients were younger, had a lower body mass index, and fewer had a prior cardiovascular implantable electronic device (all p<0.01). During the follow-up period 1 major complication was reported (implant site hematoma) at 26 days post-implant. No pericardial effusion or tamponade events were observed. Through 12 months post-implant the major complication rate was 1.0% (95% confidence interval, 0.03%, 5.45%).Conclusions: In a South Korean cohort, the Micra VR leadless pacemaker was implanted with a high success rate and low major complication rate.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"526-537"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathway of Leadless Pacemaker in Korea: From Now to Future. 韩国无铅起搏器之路：从现在到未来。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-03-04 DOI: 10.4070/kcj.2025.0032

Ki Hong Lee

引用次数: 0

Cryoballoon Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy: A Step Forward or a Frozen Compromise? 冷冻球囊消融治疗肥厚性心肌病心房颤动：向前迈进一步还是冷冻妥协？

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-03-31 DOI: 10.4070/kcj.2025.0066

Hee Tae Yu

引用次数: 0

CMR Parametric Mapping Helps Diagnose Diffuse Myocardial Leukemic Infiltration in the Relapse of Acute Lymphoblastic Leukemia. CMR参数定位有助于诊断急性淋巴细胞白血病复发时弥漫性心肌白血病浸润。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 DOI: 10.4070/kcj.2024.0334

Kyongmin Sarah Beck, Mi-Hyang Jung, Joo Hyun O, Jung Im Jung

引用次数: 0

Cryoballoon Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy: From the Korean Cryoballoon Ablation Registry. 肥厚性心肌病患者房颤的低温球囊消融：来自韩国低温球囊消融登记。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-21 DOI: 10.4070/kcj.2024.0310

Myoung Jung Kim, Pil-Sung Yang, Juwon Kim, Seung-Jung Park, Kyoung-Min Park, Young Keun On, So-Ryoung Lee, Myung-Jin Cha, Chang Hee Kwon, Sung Ho Lee, Junbeom Park, Jaemin Shim, Il-Young Oh, Ki-Hun Kim, Jun-Hyung Kim, Hong Euy Lim, Ju Youn Kim

{"title":"Cryoballoon Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy: From the Korean Cryoballoon Ablation Registry.","authors":"Myoung Jung Kim, Pil-Sung Yang, Juwon Kim, Seung-Jung Park, Kyoung-Min Park, Young Keun On, So-Ryoung Lee, Myung-Jin Cha, Chang Hee Kwon, Sung Ho Lee, Junbeom Park, Jaemin Shim, Il-Young Oh, Ki-Hun Kim, Jun-Hyung Kim, Hong Euy Lim, Ju Youn Kim","doi":"10.4070/kcj.2024.0310","DOIUrl":"10.4070/kcj.2024.0310","url":null,"abstract":"Background and objectives: Atrial fibrillation (AF) occurs in more than 20% of hypertrophic cardiomyopathy (HCM) patients, further increasing the risk of stroke. Although radiofrequency catheter ablation in AF patients with HCM has been performed, data on cryoballoon ablation (CBA) in HCM patients are limited. We evaluated the efficacy and safety of CBA in HCM patients with AF.Methods: The study included 2,649 patients with AF from the Korean CBA registry database with follow-up >12 months after de novo CBA. The primary efficacy outcome was recurrence of atrial tachyarrhythmias (ATs) ≥30s after a 3-month blanking period.Results: Totals of 1,176 paroxysmal AF (44.4%) and 1,473 persistent atrial fibrillation (PeAF, 55.6%) patients (mean age 61.7 years; 76.7% men) underwent de novo CBA. Compared to non-HCM patients (n=2,590), those with HCM (n=59) had larger left atrium and higher prevalence of heart failure, previous stroke or transient ischemic attack, and PeAF. Procedure-related complications were not statistically different between the 2 groups. During a mean follow-up period of 638±308 days, 875 (33.0%) patients experienced recurrence of ATs (845 [32.6%] non-HCM patients and 30 [50.8%] HCM patients) (p=0.01). The overall AT-free survival rate at 2 years was 45.9% in HCM group and 63.3% in non-HCM group, respectively (p=0.014), whereas there was no significant difference between the two groups in PeAF.Conclusions: CBA may be an effective rhythm control treatment for patients with AF and HCM, with an AT-free survival rate of approximately 50% at 2-year follow-up and low procedure-related complications.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"511-522"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0