Dong-Seon Kang, Pil-Sung Yang, Jun-Hyung Kim, Ki-Hun Kim, Ju Youn Kim, So-Ryoung Lee, Junbeom Park, Sung Ho Lee, Chang Hee Kwon, Myung-Jin Cha, Jaemin Shim, Il-Young Oh, Sang-Jin Han, Hong Euy Lim
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引用次数: 0
Abstract
Background and objectives: Cryoballoon ablation (CBA) is considered an effective rhythm control treatment for atrial fibrillation (AF) and is increasing exponentially. However, data regarding the efficacy and safety of CBA in elderly patients are limited.
Methods: A total of 2,652 patients (55.2% with non-paroxysmal AF) from the Korean CBA registry database with follow-up of ≥12-months after de novo CBA were divided into 2 groups based on age (<75 and ≥75 years old). Procedure related complications and clinical outcomes were compared.
Results: Compared to the control group (n=2,403), the elderly group (n=249) had female predominance (41.8% vs. 21.1%, p<0.001), a higher CHA₂DS₂-VASc scores (4.0 [3.0-5.0] vs. 2.0 [1.0-3.0]; p<0.001), and a higher prevalence of heart failure (33.3% vs. 21.9%; p<0.001) and chronic kidney disease (42.2% vs. 10.4%; p<0.001). A total of 120 procedure-related minor complications were reported, but no significant difference was observed between the 2 groups (6.4% vs. 4.3%; p=0.18). Recurrence of atrial tachyarrhythmias was observed in 67 patients (27.2%) in the elderly group and 788 patients (33.3%) in the control group. After adjusting for confounding variables, the freedom from atrial tachyarrhythmias during 24-month was similar between the 2 groups (67.0% vs. 62.7%; adjusted hazard ratio, 0.91; 95% confidence interval, 0.62-1.34; p=0.63).
Conclusions: CBA showed a reasonable efficacy and safety profile in elderly population with AF, comparable to that in younger patients.
背景和目的：冷冻球囊消融（CBA）被认为是房颤（AF）的一种有效的心律控制治疗方法，并呈指数增长。然而，关于CBA在老年患者中的有效性和安全性的数据有限。方法：从韩国CBA注册数据库中选取2,652例（55.2%为非阵发性房颤）患者，随访≥12个月，根据年龄分为2组(结果：与对照组（n=2,403）相比，老年组（n=249）以女性为主（41.8% vs. 21.1%）。结论：CBA在老年房颤患者中具有合理的疗效和安全性，与年轻患者相当。
期刊介绍：
Korean Circulation Journal is the official journal of the Korean Society of Cardiology, the Korean Pediatric Heart Society, the Korean Society of Interventional Cardiology, and the Korean Society of Heart Failure. Abbreviated title is ''Korean Circ J''.
Korean Circulation Journal, established in 1971, is a professional, peer-reviewed journal covering all aspects of cardiovascular medicine, including original articles of basic research and clinical findings, review articles, editorials, images in cardiovascular medicine, and letters to the editor. Korean Circulation Journal is published monthly in English and publishes scientific and state-of-the-art clinical articles aimed at improving human health in general and contributing to the treatment and prevention of cardiovascular diseases in particular.
The journal is published on the official website (https://e-kcj.org). It is indexed in PubMed, PubMed Central, Science Citation Index Expanded (SCIE, Web of Science), Scopus, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, KoreaMed, KoreaMed Synapse and KoMCI, and easily available to wide international researchers
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