Ulyanovsk Medico-biological Journal最新文献

{"title":"HOMOCYSTEINE LEVELS IN WOMEN WITH SYMPTOMATIC UTERINE FIBROIDS","authors":"Yuliya Dmitrievna Sidorova, Liana Yur'evna Davidyan, Azat Yur'evich Bogdasarov","doi":"10.34014/2227-1848-2022-3-61-72","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-61-72","url":null,"abstract":"Uterine fibroids are considered one of the most common benign tumors of the reproductive system. This disease ranks second (20–50 %) among the causes of hospitalization in gynecological hospitals. \u0000The aim of the study is to evaluate the effect of homocysteine levels on the state of uterine fibroids. \u0000Materials and Methods. The study involved 112 women: 60 with uterine fibroids and 52 without uterine fibroids. General clinical, biochemical, ultrasound, and statistical research methods were used. Mathematical data processing was carried out according to Lang T. and Altman D. (2014). Quantitative data analysis on the normality of distribution was carried out using the Shapiro-Wilk test. \u0000Results. The normal homocysteine (Hc) level was found in 80.7 (5.5) % of patients without uterine fibroids, which is statistically more significant than in the group of women with uterine myoma (38.3 (6.3) %, p<0.001). HC level was at the upper normal level in 33.3 (6.1) % of women in the main group and 15.3 (5.0) % of women in the comparison group. An excess of normal values was found in 25.0 (5.6) % of women in the main group and only in one in the comparison group (p<0.001). Due to additional therapy of uterine fibroids, the state of myomatous nodes stabilized in 61.6 (6.3) % of patients. There was no progression of uterine fibroids during a year. Before complex therapy, surgical indications were in 25.0 (5.6) % of patients with uterine fibroids. After a year of complex therapy, surgical indications remained only in 6.6 (3.3) % of women with uterine fibroids, which is statistically less significant than before the prescribed treatment (p=0.005). \u0000Conclusion. In women with uterine fibroids, there are multiple genital and somatic pathologies that contribute to the increase of Hc level and the development of uterine fibroids. \u0000The use of folic acid and B-group vitamins in addition to the clinical protocol for the treatment of uterine fibroids made it possible to stabilize the myomatous nodes and reduce surgical treatment by 4 times.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123213545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DISTURBANCE OF PRO-OXIDANT-ANTIOXIDANT BALANCE IN RATS WITH CEREBRAL ISCHEMIA","authors":"E. Bon', N. E. Maksimovich, I. Dremza, M. A. Nosovich, K. A. Khrapovitskaya","doi":"10.34014/2227-1848-2022-3-97-105","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-97-105","url":null,"abstract":"Excess of reactive oxygen can lead to membrane damage, accumulation of lipid, protein, and nucleic acid oxidation products, deficiency of reduced pyridine nucleotides and phospholipids of mitochondrial membranes, and then to electrolyte imbalance, mitochondrial swelling, uncoupling of oxidation and phosphorylation processes, and ischemic neuronal death. Thus, the study of oxidative stress and antioxidant system activity is relevant. \u0000The aim of the study is to examine the changes in the pro-oxidant-antioxidant balance in rats with ischemic brain damage of different degrees of severity (subtotal and total cerebral ischemia). \u0000Materials and Methods. The experiments were performed on 30 male outbred white rats weighing 260±20 g in compliance with the requirements of the Directive of the European Parliament and the Council of the European Union No. 2010/63/EU of September 22, 2010 on the protection of animals used for scientific purposes. \u0000Results. A more significant decrease in the content of total SH-groups of proteins and glutathione (by 58 (51; 64) % (p<0.05)), and GSH concentration (by 29 (19; 35) % (p<0.05)) was observed under 24-hour subtotal brain ischemia (SBI) compared with 1-hour SBI. Changes in the glutathione peroxidase activity were multidirectional: in 1-hour SBI, the activity increased by 12 (9; 18) % (p<0.05compared to the control level, and in 24-hour SBI, it decreased by 74 (67; 81) % (p<0.05). In 1-hour SBI, the content of total SH-groups of proteins and glutathione was higher by 60 (54; 65) % (p<0.05), and GSH concentration was higher by 42 (39; 56) % (p<0.05) compared with 1-hour total brain ischemia (TBI). The content of products that react with thiobarbituric acid increased by 59 (51; 63) % (p<0.05). In 24-hout SBI, the content of total SH-groups of proteins and glutathione was higher by 36 (29; 45) % (p<0.05), and GSH concentration was higher by 63 (59; 75) % (p<0.05) compared with 24-hour TBI. The content of products that react with thiobarbituric acid increased by 83 (78; 91) % (p<0.05). The glutathione peroxidase activity in TBI was equal to zero. \u0000Conclusions. Thus, the most pronounced disturbances in the pro-oxidant-antioxidant balance were observed in 24-hour TBI. Similar, but less pronounced disturbances were observed in 24-hour SBI.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130521546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHENOTYPIC CHARACTERISTICS OF ANDROGEN RECEPTOR-POSITIVE CANCER IN THE TRIPLE-NEGATIVE BREAST CANCER GROUP","authors":"I. Panchenko, Valery V. Rodionov, S. Panchenko, M. Sharafutdinov","doi":"10.34014/2227-1848-2022-3-49-60","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-49-60","url":null,"abstract":"The aim of the paper is to reveal the phenotypic characteristics of androgen-receptor-positive breast cancer in triple-negative breast cancer. \u0000Materials and Methods. The authors analyzed clinical and morphological tumour data in 253 patients with morphologically verified invasive triple-negative breast cancer (TNBC). The patients were treated at the Regional Clinical Oncologic Dispensary (Ulyanovsk) and the Breast Pathology Department of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov (Moscow) from 2014 to 2021. \u0000Results. Statistical analysis of 45 patients (18 % of the total sample) showed that androgen receptor (AR) expression in TNBC was observed in patients older than 61 years (p=0.054). It was associated with a more common stage of the disease (starting with IIB) (p=0.004), multifocal growth pattern (p=0.025), invasive lobular cancer (p=0.04), higher tumor differentiation (p<0.0001), low Ki67 level (p=0.000001), and more frequent involvement of regional lymph nodes (p=0.005). At the same time, there were no statistically significant correlations between the AR expression and menstrual function, breast lesion quadrant, and pathomorphological response after neoadjuvant polychemotherapy. \u0000Conclusion. AR expression in TNBC occurs in patients over 61 years of age, with a locally advanced disease stage, a multifocal tumor growth pattern, an invasive lobular cancer, and well-differentiated tumors with low proliferative activity.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117013656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREDICTORS OF COMPUTERIZED ELECTROACUPUNCTURE EFFICACY IN BRONCHIAL ASTHMA TREATMENT","authors":"T.S. Golubtsova, E. Yudina, S.A. Pribylova, I.R. Kerova, A. B. Peskov, Maksim Anatol'evich Volkov, M.P. Khokhlov, B. M. Kostishko","doi":"10.34014/2227-1848-2022-3-23-34","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-23-34","url":null,"abstract":"The aim of the study is to evaluate the significance of the initial clinical parameters of patients with bronchial asthma while predicting the efficacy of computerized electroacupuncture (CEAP). \u0000Materials and Methods. The two-stage study included 120 patients with bronchial asthma (BA). During the first stage, group OI underwent 3 CEAP monthly courses, while group P was treated with standard pharmacotherapy. Based on the results of the first study stage, patients were included in group OII, which consisted of a subgroup with expected good CEAP efficacy (group OII1) and a subgroup with expected insufficient CEAP efficacy (group OII2). Group OII underwent 3 monthly CEAP courses, which consisted of five daily events. \u0000Results. After three CEAP courses, group OI demonstrated a high proportion of patients with good and complete BA control. \u0000According to asthma controllability, patients were stratified into 4 subgroups: OI1 – patients of the main group 1 with improved disease control (n=20); OI2 – patients of the main group 1 with unchanged disease control (n=20); P1 – patients of the reference group with improved disease control (n=10); Р2 – patients of the reference group with unchanged disease control (n=30). The retrospective analysis showed no significant differences between respiratory function parameters in CT 1 and 2 in groups OI1 and OI2. The authors analyzed electrical resistance (ER) dynamics of all biologically active points (BAP) during the first CEAP course in group OI: the difference between the total indicators of the initial and final ER of all BAPs gradually increased. Thus, we considered it possible to apply ES indicators of BAPs to predict CEAP efficacy. There was a correlation between BA controllability and ES of BAT, as registered in the first two CEAP sessions in group OI. It was supposed to calculate the indicator of the expected treatment efficacy (IETE). IETE predicted negative treatment outcomes in 100 % of cases (sensitivity – 100 %, specificity – 100 %). Prediction of a positive effect was less accurate: sensitivity – 70 %, specificity – 80 %. The sensitivity of the prediction of dynamics absence was 80 %, specificity – 70 %. \u0000Conclusion. It is inappropriate to use the initial parameters of respiratory function as predictors of CEAP efficacy in BA treatment. IETE is an objective measurable indicator of BAPs and can be used to predict CEAP efficacy in BA treatment.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128829274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACUTE PHASE OF MYOCARDIAL INFARCTION: EFFECT OF If-CURRENT BLOCKADE ON ISOLATED RAT HEART","authors":"A. M. Kuptsova, R. K. Bugrov, N. Ziyatdinova, T. L. Zefirov","doi":"10.34014/2227-1848-2022-3-106-119","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-106-119","url":null,"abstract":"If-current density in cardiomyocytes changes not only with age, but also with pathophysiological hypertrophy. Thus, studies of pathological conditions in experimental animal models allow us to study If-current role in pathophysiological processes occurring in the heart after myocardial infarction (MI). \u0000The objective of the study is to examine the effect of If-currents blockade on the isolated heart of rats with modelled acute myocardial infarction (AMI) and sham-operated (SO) rats. \u0000Materials and Methods. MI was reproduced by the left coronary artery ligation. The study was conducted on a Langendorff-isolated heart (ADInstruments). During AMI, the authors studied chronotropy, inotropy and its temporal characteristics, and blood supply of the rat heart. \u0000Results. It was found that the initial values of contractile force and coronary flow were significantly lower in the group with an experimental AMI model. There were no differences in heart rate and temporal characteristics of contractile force. If-current blockade (ZD7288, 10-9 M, 10-5 M) reduced the contractile force and coronary flow of the isolated heart in both experimental groups, the changes were more pronounced in the SO group. If-current blockade (10-9 M) in the SO group led to tachycardia, and in the AMI group - to bradycardia. ZD7288 (10-5 M) reduced heart rate in both groups, but in the AMI group, bradycardia was more pronounced. It is possible that the obtained dynamics is associated with a change in the if-current density in the dyscrasic myocardium. Thus, it is obvious that If-currents are not only involved in the regulation of various MI heart functions, but their role changes at different stages of experimental myocardial infarction.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124831694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF BRAIN BIOELECTRICAL ACTIVITY AND CIRCULATORY SUPPLY IN ADOLESCENTS WITH ACUTE HYPOXIA","authors":"A. Ivanov, I. Borukaeva, Z. Abazova, A. Molov, T. B. Kipkeeva, A. G. Shokueva, Kazbek Yur'evich Shkhagumov","doi":"10.34014/2227-1848-2022-3-86-96","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-86-96","url":null,"abstract":"Brain bioelectrical activity and the degree of cerebral blood supply directly determine physiological brain activity. There is insufficient evidence on the regularity and continuity of these processes. \u0000The aim of the study is to conduct a comparative analysis of brain bioelectrical activity and circulatory supply in adolescents with acute hypoxia. \u0000Materials and Methods. The authors examined 100 adolescent males of two age groups: Group 1 consisted of boys aged 12–14 years old, Group 2 included those aged 15–17. \u0000Results. The authors revealed a positive correlation between blood supply, metabolism and brain function. In early pubertal adolescents, puberty-associated endocrine changes have a significant effect on EEG and REG indices in adolescents with hypoxia. An increase in the rheographic index is accompanied by an increase in the alpha- and a decrease in the delta-rhythm indices. In pubertal adolescents, an increase in the rheographic index causes a decrease in alpha rhythm and an increase in slow-wave delta oscillations in the frontal and occipital leads. Under short-term hypoxia, an increase in the brain filling with blood is observed. Under oxygen depletion (14%), despite the increase in pulmonary and blood minute volumes, tissue hypoxia develops in pubertal adolescents. It is especially evident in the early puberty, as there is even a decrease in oxygen consumption in adolescents aged 12–14. In adolescents with hypoxia cerebral blood flow increases.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127094911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ULTIMATE COMPOSITION OF NATURAL WORMWOOD IN VORONEZH REGION","authors":"N. A. D'yakova","doi":"10.34014/2227-1848-2022-3-156-165","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-156-165","url":null,"abstract":"Studies of the ultimate composition of wild-growing raw material are relevant due to the high efficacy and bioavailability of organometallic forms contained in plants. The available information on the abundance of elements in the medicinal plant raw material (Voronezh region) showed that studies were carried out mainly on several elements. It prevented from determining the complete chemical composition of plants and describing the accumulation of the entire mineral elements complex. \u0000The purpose of the paper is to study how macro and trace elements are accumulated in natural wormwood in Voronezh region. \u0000Materials and Methods. Raw material procurement was carried out during the blooming in the Voronezh State Nature Biosphere Reserve. The method of mass spectrometry was used to study the trace element composition of the samples, ELAN-DRC mass spectrometer. \u0000Results. The authors revealed that the trace element content was 4.4 %, 59 elements were determined. Macro elements made up 96.03 % of the total elemental composition of wormwood. Potassium (>25 mg/g) and calcium (>10 mg/g) were the main macro elements. Essential trace elements made up 3.49 % of the total wormwood complex. Among them, silicon (>1.2 mg/g) and iron (>0.1 mg/g) ranked the largest. The content of normalized heavy metals and arsenic in wormwood satisfied the regulatory requirements. Lead, mercury, cadmium and arsenic accounted for 0.0017 % of the total raw material mineral complex. The proportion of toxic and understudied elements in the total mineral wormwood complex was 0.48 %. The highest content was noted for aluminum (135.6 µg/g), rubidium (27.66 µg/g), strontium (24.95 µg/g), barium (11.98 µg/g), and titanium (9.52 µg/g). It was noted that wormwood also accumulated phosphorus, potassium, copper, zinc, cadmium, molybdenum, calcium, magnesium, nickel, arsenic, rubidium, tin and strontium from the soil.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129203568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGE-RELATED CHANGES IN RAT LIVER HYDRATION AND HISTOSTRUCTURE","authors":"Aleksandr Anatol'evich Vinogradov, E. S. Simakova","doi":"10.34014/2227-1848-2022-3-120-128","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-120-128","url":null,"abstract":"One of the aging hypotheses is based on the fact that the percentage of water in the human body decreases with age. To a greater extent, the loss of water affects the most energy-dependent organs, such as liver, which undergoes a number of structural compensatory-adaptive changes. The parameters of age-related changes are currently understudied. However, they should be taken into account when determining the actual organ transformations in experiments. \u0000The purpose of the study was to examine the change in the level of total water and liver histostructure in rats during a 75-day observation. \u0000Materials and Methods. The changes in the level of total water in the liver parenchyma were assessed in young outbred intact rats during 75-day observation. The authors examined liver histostructure on sections stained with hematoxylin-eosin and picrofuchsin (Van Gieson's stain). \u0000Results. A decrease in the level of total water in the rat liver parenchyma by 0.54±0.042 % was observed during a 75-day observation. At the same time, no visible changes were detected in the liver histostructure. \u0000Conclusion. During the trial a decrease in the level of total water in the liver of intact animals was observed. It did not affect the change in liver histostructure.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126472271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHRONIC KIDNEY DISEASE IN PATIENTS WITH CHRONIC LYMPHATIC LEUKEMIA AND THEIR SURVIVABILITY","authors":"M. V. Markovtseva, E. N. Zguralskaya","doi":"10.34014/2227-1848-2022-3-43-48","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-43-48","url":null,"abstract":"Chronic lymphocytic leukemia (CLL) is one of the most common lymphoproliferative diseases in the European population with an increase in the incidence in the elderly and senile age. However, it is among the elderly that a decrease in glomerular filtration rate (GFR) and concomitant chronic kidney disease (CKD) are associated with the severity in long-term prognosis. \u0000The aim of the study was to analyze CKD incidence and prognostic value in patients with CLL. \u0000Materials and Methods. CLL retrospective analysis was performed in 132 patients (60 men and 72 women). CKD was diagnosed according to the 2021-Guidelines of Russian Scientific Society of Nephrologists. Results. Among the examined patients, 64 (48.5 %) were diagnosed with CKD: stage C2 – in 23 patients. (17.4 %), stage C3a – in 41 patients. (31.1 %). CKD incidence in patients with CLL was higher than in the similar population without CLL. The authors revealed that there was no correlation between CLL stage and CKD severity. Survival analysis showed that only 43 patients (32.5 %) overcame the estimated Binet median survival. C3a in patients with CLL at the time of CKD diagnosis is strongly correlated with survival. \u0000Conclusion. CKD occurs in 48.5 % of patients with CLL. It has been established that C3a CKD worsens CLL patient survivability.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127957733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PULMONARY EMBOLISM: CHALLENGES IN CLINICAL DIAGNOSIS","authors":"Nadezhda Vasil'evna Makarova, Elena Isaakovna Busalaeva, I. Tuyzarova, M. A. Vize-Khripunova","doi":"10.34014/2227-1848-2022-3-35-42","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-3-35-42","url":null,"abstract":"Vein thrombosis of the lower extremities, especially deep, is an acute condition which develops under the influence of multiple factors. In this case, the immediate threat to the patient’s life is associated with the development of acute pulmonary embolism (PE). A wide range of symptoms accompanied by the underlying disease manifestations determines patient's grave condition, complicates timely diagnosis and treatment, contributes to a poor prognosis and high mortality. Thus, the risk ratio of PE development should be assessed in all patients, regardless of age. The article provides data on the epidemiology, risk factors, clinical features and diagnosis of thromboembolic complications in real clinical practice. \u0000The paper describes a clinical case of community-acquired pneumonia in a young man with asymptomatic deep vein thrombosis of the lower extremities and the development of multiple pulmonary embolism. A combination of diseases determined the severity of patient’s state, the challenges of intravital diagnosis of the concomitant pathology and a poor prognosis due to such a combination. The diagnosis was confirmed at autopsy by the detection of various clots in the lung vascular bed.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115126863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}