Ulyanovsk Medico-biological Journal最新文献

{"title":"CHARACTERISTICS OF COGNITIVE DYSFUNCTIONS IN PATIENTS WITH RIGHT-SIDE AND LEFT-SIDE ISCHEMIC STROKE","authors":"Zhanna Ivanovna Molchanova","doi":"10.34014/2227-1848-2023-4-48-54","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-48-54","url":null,"abstract":"The goal of the study is to assess the characteristics of cognitive dysfunctions in patients with right-side and left-side ischemic stroke (IS). Materials and Methods. We examined 55 patients (aged 38–65) with right-side and left-side ischemic stroke during the early rehabilitation period. The patients were treated at the regional vascular center, District Clinical Hospital, Khanty-Mansiysk in 2019–2022. Mini-Mental State Examination (MMSE) was used to check patients for cognitive impairments: Frontal assessment battery, Verbal fluency test, Clock-drawing test, Backward digit span test, Visual assessment battery, Auditory assessment battery, and Verbal assessment battery. Results. Cognitive impairments are common post-stroke complications, which can significantly complicate rehabilitation therapy. In the early rehabilitation period, 41.8 % of patients with a hemispheric stroke demonstrate predementia. In patients with right-side stroke, predementia was observed in 22.2 %, whereas 60.7 % of patients with left-side stroke exhibited impaired abilities (p<0.05). There was a significant decrease in short-term memory, time knowledge and orientation abilities in patients with left-side stroke. Assessment of visual, auditory and verbal memory also revealed poorer performance in patients with left-side stroke compared to those with right-side stroke – 20 (17–22) points versus 22 (22–24) points (p<0.05). Moderate frontal dysfunction was detected in all patients (100 %). Conclusion. All patients with hemispheric stroke should undergo early cognitive rehabilitation, even if there are no active complaints. Particular attention should be paid to patients with left-side brain damage.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"40 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREMENSTRUAL SYNDROME: BASIC APPROACHES TO TREATMENT","authors":"Marina Aleksandrovna Kiek","doi":"10.34014/2227-1848-2023-4-21-37","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-21-37","url":null,"abstract":"Premenstrual syndrome (PMS) is a common neuroendocrine pathology. PMS has a significant impact on the women’s lives. It negatively affects the psychophysiological state, social functioning, reduces ability to work and quality of life. Therefore, it has great medical and social significance. According to numerous studies, PMS prevalence ranges from 25 % to 80 %. PMS clinical picture is characterized by a variety of mental and somatic symptoms of varying severity, that leads to certain difficulties in choosing therapy. Currently, there are no clinical guidelines for the diagnosis and treatment of this pathology in Russia. The task of practitioners is to find the most effective, safe and pathogenetically justified treatment modes, based on an individual approach depending on the clinical manifestations of the disease. The review presents the results of various PMS treatment modalities, presented in eLibrary.ru, Pubmed, SpringerLink, APA PsycNET, ScienceDirect, and Google Scholar. Current experience shows that PMS therapy should be carried out comprehensively. In order to achieve and maintain good results, it is advisable to combine drug therapy with cognitive behavioral therapy, physical therapy and physiotherapy. PMS is an interdisciplinary problem, so it should be treated by various specialists. It is important to differentiate between PMS, somatic pathology and affective states. A large scope of treatment modalities does not exclude the patients who do not respond to therapy. It proves the need for further study of the disease pathogenesis and the development of preventive measures with respect to modern medical advances.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATROPHIC SCARS AS AN OBJECT OF INORGANIC GEL TREATMENT","authors":"Varvara Gennad'evna Nikonorova, V. Krishtop, I. Fateev, Anna Sergeevna Ovchinnikova","doi":"10.34014/2227-1848-2023-4-126-143","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-126-143","url":null,"abstract":"Atrophic scars are a complex problem, covering a huge number of patients with striae gravidarum, acne, atrophic surgical scars, and striae due to hypercortisolism and other metabolic disorders. Taking into account patients’ social status (pregnant women, adolescents, people with chronic hormonal disorders), our goal was to systematize the literature data on the least invasive treatment modality – atrophic scar therapy with inorganic gels – to identify new chemical classes with potential anti-scar activity. When summarizing research data over the past 10 years, it was found that the effect of anti-scar therapy depends on the atrophic scar color – hyper- or hypopigmented, its type – wedge-shaped, scaphoid, or rectangular, its origin – post-acne, cicatricial alopecia, infectious scars, stretch marks, or post-traumatic atrophic. The stage of pathogenesis also plays a significant role: aseptic inflammation, infiltration of hematogenous differential cells, mast cell degranulation, release of bioactive substances and changes in the VEGF, TGF-β1, EGF, FGF, PDGF growth factors, migration of activated macrophages, damage to elastic and collagen fibers, perivascular lymphocytic infiltration, impaired hemorheology, chronic inflammatory process, increased number of senescent fibroblasts, decreased synthetic activity of atrophic scar cells, decreased cellularity and vascularization of the atrophic scar area. In case of high bioinertness of inorganic gels, the anti-scar effect is achieved due to the exfoliating effect, epidermal-mesenchymal interactions, and the impact of the mesoporous gel structure on scar hydration. In addition to the well-known silicone gel, sol-gels based on aluminum dioxide have similar properties, which makes it possible to consider sol-gel as an alternative to silicone gel.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXTRAHEPATIC MANIFESTATIONS OF CHRONIC HEPATITIS C","authors":"Ya.E. Saranskaya, L. Kiseleva","doi":"10.34014/2227-1848-2023-4-120-125","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-120-125","url":null,"abstract":"Replication of hepatitis C virus is possible not only in the target organ - liver cells, but also in the vascular endothelium, mononuclear cells, B lymphocytes, macrophages, bone marrow, myocardium, skin and endocrine glands, which explains the disease clinical diversity and extrahepatic manifestations in HCV patients. Extrahepatic manifestations range from 50 % to 74 %. Kidneys are the most common target organs for extrahepatic manifestations of chronic hepatitis C. Renal irritation can lead to chronic HCV infection. Kidney disease can occur due to HCV influence on the renal epithelium and cryoglobulinemia development. The purpose of our paper is to increase the doctors’ alertness to HCV, its atypical course, and the onset of extrahepatic manifestations. Correct and timely diagnosis and etiotropic therapy will lead to an improvement in the patient’s clinical status. Treatment of chronic HCV infection is a multisystem problem that any physician can face. Etiotropic therapy for chronic hepatitis C leads not only to virus elimination, but also to the relief of extrahepatic manifestations. Combination therapy with direct antiviral drugs (glecaprevir + pibrentasvir) has proven its effectiveness in patients with extrahepatic manifestations. Sustainable virological response allows not only to stop degenerative changes in the liver, but also to reduce the clinical symptoms of extrahepatic manifestations of chronic HCV infection, reduce the disability rate in the working population, and improve the quality of life.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"89 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIFFERENCES IN THE CARDIOVASCULAR RISK FACTOR PROFILES IN PATIENTS WITH TRANSIENT GLOBAL AMNESIA AND TRANSIENT ISCHEMIC ATTACK","authors":"Aleksandr Yur'evich Ryabchenko","doi":"10.34014/2227-1848-2023-4-64-72","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-64-72","url":null,"abstract":"The purpose of the study is to examine the characteristics of cardiovascular risk factors in patients with transient global amnesia and transient ischemic attack. Materials and Methods. A study was conducted of patients with transient global amnesia and transient ischemic attack admitted to the primary vascular department, City Clinical Hospital named after N.I. Pirogov (January 2021 – March 2023). All patients were examined for main cardiovascular risk factors, such as age, male gender, coronary artery disease, atrial fibrillation, previous stroke, diabetes mellitus, smoking, arterial hypertension, dyslipidemia, increased hematocrit, left ventricular hypertrophy, valvular heart disease, and atherosclerosis of the brachiocephalic arteries. Statistical data processing was carried out with Data Analysis package, Microsolft Excel 2019. One-way ANOVA test was used to calculate statistical significance between the groups. For all data, statistical significance was p<0.05. Results. We examined 37 patients with transient global amnesia and 103 patients with transient ischemic attack. In patients with transient global amnesia, such cardiovascular risk factors as male gender, coronary artery disease, stroke, and atrial fibrillation were significantly less common, and the level of total cholesterol was significantly higher. There were no statistically significant differences in the incidence of other risk factors. Conclusion. Cardiovascular risk factor profiles differ in patients with transient global amnesia and those with transient ischemic attacks. The identified risk factors make it possible to focus on the developmental mechanisms of these pathologies and optimize primary and secondary prevention techniques.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"17 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STABILOMETRIC ANALYSIS OF MOTOR DISORDERS IN PATIENTS WITH ISCHEMIC STROKE IN THE CAROTID ARTERY IN THE EARLY REHABILITATION PERIOD","authors":"Tatiana N. Suvorova, Natalia P. Gribova","doi":"10.34014/2227-1848-2023-4-38-47","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-38-47","url":null,"abstract":"The purpose of the study is to analyze stabilometric parameters for motor disorders in patients with an ischemic stroke in the carotid artery in the early rehabilitation period and to monitor their dynamics under rehabilitation therapy with biofeedback (BFB) stabilization training. Materials and Methods. The study involved 24 patients aged 44–75. We chose the patients with mild and moderate motor impairments who were at the second stage of medical rehabilitation at Bryansk City Hospital No. 1. The patients suffered stroke 1–6 months ago. The stabilographic study was carried out on a BFB stabiloanalyzer “Stabilan-01-2” (RITM, Taganrog). The stabilometric training consisted of 7–10 sessions and included various computer games taking into account the type of paresis, the severity of coordination disorders and individual load tolerance. At the beginning of therapy, training lasted 5–10 minutes but gradually it increased up to 15–20 minutes. MS EXCEL and IBM Statistica 12.0 were used for statistical analysis of the obtained data. The Wilcoxon test was used to assess the dynamics. All obtained differences were significant (p≤0.05). Results. During the study, a change in stabilometric parameters was noted towards a decrease in the main parameters of the stabilographic test (“Frontal spread” (p=0.049), “Mean spread” (p=0.045)) and the Romberg test (“Mean spread” with eyes closed (p=0.046) and “Time rate of statokinesigram area” with eyes closed (p=0.043)), which indicated an improvement in the patients’ motor skills during rehabilitation therapy. Conclusions. The results of the analysis allow us to consider stabilization training with biofeedback an effective treatment modality in the early rehabilitation period for patients with ischemic stroke in the carotid artery.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"125 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MORPHOGENESIS OF SKIN REGENERATE AND LOCAL FACTORS OF ITS REGULATION","authors":"V. A. Shidin, Igor' Aleksandrovich Aptekar', Aleksandr Vladimirovich Akhmatov, D. S. Ledneva, Aleksandr Anatol'evich Markov, V. V. Matvienko, Sergey L'vovich Matusevich, A. R. Nurgalieva, Georgiy Sergeevich Solov'ev, Ol'ga Georgievna Solov'eva, Yu. S. Spirina, A. N. Steblyuk","doi":"10.34014/2227-1848-2023-4-153-168","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-153-168","url":null,"abstract":"Regeneration of the skin and its derivatives after injuries occurs in one of two ways: cutaneous (restitution) or dermal (substitution). However, there are three healing mechanisms: primary intention, secondary intention and healing by a scab. Regeneration activity correlates with environmental factors, stimulants, compliance with the chronovector of involvement in the cell regenerate of all differon derivatives, involved in histo- and organogenesis in the affected area. The aim of the study is to identify the importance of promoter cells, temperature and Eikovit gel at different stages of thermal burn wound healing, contact dermatitis and wound skin defects and to determine the stage of provisional regenerate transformation into the definitive state. Materials and Methods. The formation of reparative skin regenerate was studied on outbred male mice weighing 25±5 g (n=126). Different injuries to the skin of the back were modelled. All mice were divided into 4 groups: Full-thickness wound, Thermal burn, Contact dermatitis, and Control. Thermal damage was carried out with Tertsik RS232C device (Russia), module area – 1 cm2, exposure time – 3 minutes, and temperature – 80 °C. Contact dermatitis was modeled by rubbing a 0.5 % alcohol-acetone solution of 2,4-dinitrochlorobenzene (2,4-DNCB) into the skin. The skin wound was cut out using an oval stencil (3×4 mm). We used three temperature modes to influence the developing regenerate: +8 °C (cold), +42 °C (heat), and +33 °C (control). Sampling was conducted on days 3, 7, 10, 14, 20, 30 of the experiment, fixed in 10 % neutral formalin, and embedded in paraffin. Sections were stained with Mayer's hematoxylin and eosin. Immunohistochemistry detected CD1-alpha, CD3, and CD31. Proliferative activity was monitored by Ki-67-positive cells. Results. The convergence chronovector of immunocompetent cells during skin wound healing ensures the restitution of skin components and its derivatives. One of the signs of the correct chronovector direction is the formation of a provisional level substrate and its further transformation into a definitive state. Convergence desynchronosis can lead to dermal healing and substitution.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"24 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMORBIDITY OF PATIENTS WITH COVID-19 (PATHOLOGICAL STUDIES)","authors":"Valeriy Anatol'evich Serov, Diana Valer'evna Shiryaevskaya, V. V. Gnoevykh, V. A. Razin, Oleg Aleksandrovich Shiryaevskiy","doi":"10.34014/2227-1848-2023-4-88-98","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-88-98","url":null,"abstract":"Concomitant diseases increase the risk of hospitalization and poor prognosis in COVID-19 patients. However, in most studies devoted to prognostic value of comorbidity, only clinical manifestations were analyzed, which could lead to both under- and overdiagnosis of concomitant diseases and complications. The purpose of the study is to clarify the structure and prevalence of somatic diseases in patients who died in hospital from COVID-19, as well as the correlation of comorbidity with the development of vascular complications. Materials and Methods. A retrospective study examined the medical records of 322 patients (195 women and 127 men, mean age 71.5±12.2) with confirmed fatal COVID-19 and a post-mortem examination. Charlson comorbidity index was used to assess comorbidity. Results. A high incidence of cardiovascular pathology was revealed (96%). During hospitalization, 31 patients developed acute myocardial infarction, including 9 patients with reinfarction and 14 people with previous episodes of angina pectoris. In 10 patients without previous coronary heart disease, obliterating atherosclerosis of the coronary artery was detected. Twenty-three patients developed acute cerebrovascular accident; all of them suffered from arterial hypertension. Atrial fibrillation was observed in 9 patients. Pulmonary embolism was diagnosed in 139 patients, including 17 patients with phlebothrombosis in the lower extremities. Conclusion. Severe fatal COVID-19 is more often observed in elderly people with a high comorbidity level, and the complications depend on the comorbidity profile.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"95 S4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POST-COVID-19 LUNG PATHOGENESIS AND PATHOMORPHOLOGY","authors":"Sergey Sergeevich Yashin, Tat'yana Aleksandrovna Fedorina, Yuliya Vital'evna Serdobol'skaya, Elena Valerievna Sergeeva","doi":"10.34014/2227-1848-2023-4-6-20","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-6-20","url":null,"abstract":"The article describes the main pathogenetic and pathomorphological aspects of pulmonary fibrosis onset and development in patients with COVID-19 in anamnesis. The authors analyzed open access articles in Russian and English from eLibrary and Pubmed archives. The key aspect of the pulmonary fibrosis pathogenesis is fibroblast and myofibroblast activation. In response to the lung parenchyma damage, it leads to fibroblast and myofibroblast proliferation and differentiation and triggers a cascade of cytokine reactions. T-helper cells are responsible for the regulation of the inflammatory-reparative process in the lungs. T-helper cells directly or indirectly trigger the remodeling of the pulmonary parenchyma in favor of the fibrous component. Literature shows that the role of cytokines is assessed differently, and currently there is no consensus on their influence on pulmonary fibrosis formation. However, studies showing the possibility to prevent and treat fibrosis with anti-cytokine drugs place the development of a cytokine storm at the forefront. Growth factors, especially TGF, FGF, PDGF, are important not only in understanding pathogenesis, but also in finding new, promising therapeutic modalities. Due to external factors, many authors refrain from quantitative assessments of long-term consequences. Data on the persistence and regression of post-Covid pulmonary fibrosis are also contradictory. Despite much information on issues related to COVID-19 pathogenesis and pulmonary fibrosis development, many molecular mechanisms remain hidden from researchers. Thus, there are new prospects in diagnosis, prevention and treatment of the disease.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"22 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONTROVERSIAL ISSUES OF ANTIBIOTIC THERAPY DURATION IN PATIENTS AFTER INJURIES AND SURGERIES ON MUSCULOSKELETAL SYSTEM","authors":"I.M. Efremov, V. Midlenko","doi":"10.34014/2227-1848-2023-4-99-108","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-99-108","url":null,"abstract":"Improvements in surgical techniques and the introduction of minimally invasive osteosynthesis technologies have had a beneficial effect on the patient treatment after injuries and surgeries on the musculoskeletal system. However, the problem of treating infectious complications, especially in elderly patients with high comorbidity, has not lost its relevance. The purpose of the paper is to study the effectiveness of antibiotic therapy in elderly patients after injuries and surgeries on the musculoskeletal system in comorbidity. Materials and methods. An open prospective cohort study was conducted with a 12-month follow-up period. We examined 53 elderly and senile patients (24 men and 29 women, average age 69.1±7.3) who were hospitalized. The combined endpoint of treatment outcome was assessed. Comorbidity and duration of antibiotic therapy were determined in all patients. The GerontoNet ADR Risk Score was used to assess the risk of drug therapy complications. Results. The comorbidity index in elderly patients was 4 (3; 5) points. One third of patients (19 people; 35.9 %) had high comorbidity rates. The average number of antibacterial drugs was 2 (1; 2). Total course of administration was 8 (5; 21) days. Therapy duration less than 7 days was observed in 24 (45.3 %) patients. In 13 (24.5 %) patients, the result exceeded 5 points on the GerontoNet scale. During the observation period, a positive result was achieved in 45 (84.9 %) patients. There was no significant difference in achieving positive results based on the duration of antibiotic therapy (p>0.05). Conclusion. The use of long-term systemic antibiotic therapy in elderly patients after injuries and surgeries on the musculoskeletal system does not lead to better results compared to shorter treatment modalities, which help us avoid unwanted side effects and drug interactions, given the high comorbidity of this group of patients.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"47 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}