Ulyanovsk Medico-biological Journal最新文献

{"title":"STUDY OF PHYSICAL AND MECHANICAL PROPERTIES OF POLYMER-IMPREGNATED COMPOSITION IN CLINICAL PURULENT OSTEOLOGY","authors":"I. Efremov, V. Midlenko","doi":"10.34014/2227-1848-2022-1-56-64","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-56-64","url":null,"abstract":"Bone cement, or PMMA (polymethyl methacrylate) is often used in purulent surgery. Scientific literature contains very contradictory data on the physical and mechanical properties of polymer-impregnated compositions, in particular, on the temperature of the PMMA polymerization process and the ways to reduce it, such as introduction of antimicrobial drugs for prevention and treatment of infectious complications in patients after injuries and musculoskeletal surgery. \u0000The aim of the study is to conduct an in vitro experiment and to evaluate the temperature of the exothermic polymerization reaction of bone cement (PMMA) and possible ways to reduce it. \u0000Materials and Methods. The authors conducted 8 series of experiments in vitro. In each series, a disk (45–50 mm in diameter, 5–7 mm thick) was made by hand after mixing the components of the polymer composition. The temperature of the ongoing exothermic reaction was measured on the disk surface using a non-contact infrared thermometer ADA TemPro 300 in a continuous scanning mode. \u0000Results. The temperature of the exothermic polymerization reaction of PMMA Synicem 1-based bone cement was 92.8±1.6 °C (min 91.2 °C, max 94.9 °C), and Palacos®MV+G-based bone cement 92.7±1.2 °С (min 91.1 °C, max 93.8 °C). Reducing the monomer amount by 50 % (polymer / monomer ratio was equal to 4:1) and simultaneously introducing “Sextaphage” (10 ml) led to a sharp temperature decrease of the exothermic reaction by more than 30 °C. \u0000Conclusions. One of the ways to reduce the temperature of the exothermic reaction in vitro is to change the ratio of polymer powder and liquid monomer, reducing the amount of monomer introduced into the polymer composition.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131834762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYMPTOMS OF IMPAIRED CEREBRAL VENOUS HEMODYNAMICS \u0000IN ADOLESCENTS WITH CONNECTIVE TISSUE DYSPLASIA","authors":"A. Proshin, V. Mashin, L. Belova, D. Belov","doi":"10.34014/2227-1848-2022-1-6-17","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-6-17","url":null,"abstract":"The aim of the paper was to study clinical manifestations of cerebral venous insufficiency in adolescents with connective tissue dysplasia (CTD). \u0000Materials and Methods. The authors examined 156 adolescents. The main group consisted of 82 adoles-cents with CTD symptoms. The comparison group included 74 adolescents without CTD manifestations. Connective tissue dysplasia was assessed according to L.N. Abakumova scoring system (2006). Patient intake and examination revealed clinical signs of cerebral venous insufficiency. \u0000Results. The following complaints were peculiar for the patients of the main group: headache, which in-tensity increased when working in an inclined position, during or after a nocturnal sleep, with coughing and on straining, and decreased in the afternoon and after moderate physical activity; vertigo, which worsened in case of postural change, head rotation and bending; puffiness/pasty face and eyelids in the morning, “high pillow” symptom, “tight collar” symptom, sandy-gritty sensation in the morning; night-mares, frequent night awakenings because of the headaches; nasal stuffiness without ARD symptoms. The patients of the main group also demonstrated symptoms of cerebral venous insufficiency: facial puffi-ness, eyelid swelling; sclera injection; venous network on the anterior chest / neck; lip or nasolabial tri-angle cyanosis, hypoesthesia of the 1st or 2nd branch of the trigeminal nerve. \u0000Conclusion. Clinical symptoms of cerebral venous insufficiency are more prominent in adolescents with CTD than in the comparison group. This fact indicates the need for early detection of venous hemodynam-ic disorders, subsequent dynamic monitoring and preventive measures to avoid the early development of cerebrovascular diseases in adolescents.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125708917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INCREASING STRESS RESISTANCE BY TRANSCRANIAL ELECTRICAL STIMULATION IN PATIENTS AFTER PROSTATE CANCER SURGERY","authors":"A. Penzhoyan, G. Penzhoyan, S. Akhedzhak-Naguze, V. Abushkevich, A. Burlutskaya","doi":"10.34014/2227-1848-2022-1-75-86","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-75-86","url":null,"abstract":"Anxiety in men often increases during the rehabilitation period after prostate cancer surgery. Moreover, simultaneous development of erectile dysfunction is also observed. This contributes to psycho-emotional stress formation. \u0000The aim of the study is to evaluate the effect of transcranial electrical stimulation (tES) on stress vulnerability during the rehabilitation period after various types of prostate cancer surgery. \u0000Materials and Methods. The authors estimated anxiety level and erectile dysfunction in 124 men 6 months after prostate cancer surgery. The patients were divided into groups according to the surgery type: Group 1 (n=24) – high-intensity focused ultrasound (HIFU); Group 2 (n=50) – laparoscopic radical prostatectomy; Group 3 (n=50) – laparotomic radical prostatectomy. Serum concentration of adrenocorticotropic hormone (ACTH), cortisol, adrenaline, interleukins 1 and interleukins 2 (IL-1, IL-2) and stress vulnerability level according to N.V. Kirsheva and N.V. Ryabchikova test, Holmes and Rahe stress scale, S. Cohen and G. Williamson test, and “Prognosis” method was determined twice: before and after tES. \u0000Results. Erectile dysfunction was detected in 37 patients 6 months after radical prostatectomy (Group 2, n=17; Group 3, n=20). All the patients of Group 1 (HIFU) restored erection. A decrease in stress vulnerability was observed in all patients, regardless of the surgery type and the severity of functional disorders. After tES, a significant decrease in the levels of ACTH, cortisol, IL-1, IL-2 was estimated (p<0.05). According to all tests used, a significant increase in stress vulnerability was noted, regardless of the type of surgery (p<0.001). \u0000Conclusion. In terms of frequency of functional disorder development during the rehabilitation period, HIFU has advantages over radical prostatectomy, regardless of the surgical approach. Transcranial electrical stimulation 6 months after surgery significantly reduces the level of stress hormones and interleukins in patients’ blood serum; increases stress vulnerability regardless of the surgery type and functional disorders. Moreover, tES can be recommended for all patients after prostate cancer surgery.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"238 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129475079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PNEUMOCYSTIS CHRONIOSEPSIS AS AN OPTION OF PNEUMOCYSTIS INFECTION PROGRESSION: CASE REPORT","authors":"V. Gerasimov, E. Slesareva, Tat'yana Kuznetsova, Ya.S. Abuzova","doi":"10.34014/2227-1848-2022-1-117-124","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-117-124","url":null,"abstract":"Pneumocystis infection caused by Pneumocystis jiroveci tops the list of opportunistic infections, affecting mainly premature babies and people with various types of immunodeficiency disorders. Generalized forms of the disease in immunocompromised patients are extremely rare and do not have any pathognomonic symptoms, which often makes timely diagnosis and treatment difficult. \u0000The aim of the paper is to study clinical and morphological manifestations of generalized pneumocystosis and to clarify some aspects of its differential diagnosis as illustrated by an autopsy case. \u0000Materials and Methods. For histomorphological examination, autopsies of the liver, lung, pancreas, red bone marrow, brain, heart, and spleen were fixed in 10 % neutral formalin and embedded in paraffin. Sections of standard thickness were stained with hematoxylin-eosin; then histologic specimen were studied under a light microscope. The results of the histomorphological study were analyzed along with the medical history. \u0000Results. It has been shown that the following nonspecific clinical manifestations were specifically attributed to the generalized form of pneumocystosis: febrile fever, intoxication, non-productive cough, shortness of breath on little exertion, increased levels of hepatic transaminases, and leukocytosis. Histological manifestations included pneumocystis foci at different stages of development both in the parenchyma and in the interstitium of many internal organs, such as the liver, kidneys, spleen, brain, red bone marrow, lungs, and uterus. The preservation of the organ histoarchitectonics depended on the number of pneumocystis foci and the degree of organ damage. \u0000Conclusion. The generalized form of pneumocystis infection is very rare and it can be combined with other concomitant diseases. Moreover, it is characterized by a long asymptomatic period and complexity of laboratory diagnostics, so its mortality constantly increases. Generalized form of pneumocystis infection should be differentiated from acute respiratory diseases, cytomegalovirus infection, mycoplasmosis, chlamydia, toxoplasmosis, tuberculosis, sarcoidosis, neoplastic diseases, lymphogranulomatosis, and collagenoses, where the most precise methods are ELISA, indirect immunofluorescence test, immunofluorescence test, and PCR.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126432270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OPTIONS OF INTERFERON-FREE THERAPY FOR HCV INFECTION. A CASE STUDY. COMPARISON OF NON-INVASIVE METHODS FOR LIVER FIBROSIS ASSESSMENT","authors":"Ya.E. Saranskaya, L. Kiseleva, L. Il'mukhina","doi":"10.34014/2227-1848-2022-1-39-48","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-39-48","url":null,"abstract":"The incidence of hepatitis C virus infection in Russia is 2–3 %. In our country the socio-economic damage caused by the increase in the incidence of chronic hepatitis and its consequences, such as liver cirrhosis and hepatocarcinoma, is enormous. The goal of antiviral therapy for chronic hepatitis C is a sustained virological response, which is associated with a biochemical response and regression of hepatic tissue fibrosis, which leads to a decrease in the liver cirrhosis development. \u0000The purpose of the study is to determine the efficacy of interferon-free therapy; to compare the efficacy of non-invasive methods for liver fibrosis diagnostics in chronic hepatitis C. \u0000Materials and Methods. The study included 63 patients who underwent direct antiviral therapy (dasabuvir and ombitasvir + paritaprevir + ritonavir (3D-therapy)) in combination with ribavirin or without it, depending on the hepatitis C virus genotype and the stage of liver fibrosis. The stage of hepatic tissue fibrosis was assessed by non-invasive methods, namely, elastography and vibration-controlled transient elastometry using FibriScanCompact 530 (Echosens, France). Liver fibrosis biomarkers (AAR, APRI, Fib-4, Forns index) were calculated; MDA test was conducted. \u0000Results. 100 % efficacy of dasabuvir and ombitasvir + paritaprevir + ritonavir was confirmed for both 8- and 12-week therapy in comorbid patients with extrahepatic manifestations, patients who underwent interferon-based therapy, regardless of liver fibrosis stage and disease duration. \u0000The article provides a comparative description of non-invasive methods for assessing liver fibrosis in patients with chronic hepatitis C: elastography, elastometry and serum fibrosis indices (APRI, AAR, FIB-4, MDA, Forns index). Indirect fibrosis markers are useful, because they allow to determine the late stages of liver fibrosis (F3-F4 on the METAVIR scale) with a very high degree of confidence.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134039031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF LIPID PEROXIDATION ON COLLAGEN FIBRIL DEGRADATION IN EXPERIMENTAL PERIODONTITIS","authors":"A. Zakhvatov, D. Khaydar, T. Tarasova, A. Parshina, V. Timoshkin","doi":"10.34014/2227-1848-2022-1-125-134","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-125-134","url":null,"abstract":"Lipid peroxidation analysis and identification of the main damage predictors lead to introduction of new diagnostic and treatment technologies into medical practice. \u0000The aim of the study was to evaluate the activity of free radical damage processes and identify their association with collagen metabolism disorders in the disease dynamics in experimental periodontitis. \u0000Materials and Methods. An experimental study was carried out on 60 white non-linear rats. A rat model of periodontitis was reproduced according to K.D. Shkolnaya and V.G. Atrushkevich method (Patent RU No. 2625295, December 07, 2017). The overall activity of free radical oxidation and antioxidant potential was assessed according to biochemiluminescence parameters. Lipid peroxidation activity was assessed according to the parameters of primary and secondary peroxidation products. Collagen metabolism was assessed by P.N. Sharaev method. \u0000Results. The rat model of periodontitis demonstrated a high level of free radical oxidation parameters. At the same time decrease in the antioxidant potential was observed throughout the experiment. It proved a significant inhibition of the antioxidant system ability to neutralize bioradical oxidation reactions. The resulting free radicals caused the collagen destruction, which formed the frame of the periodontal connective tissue structures. It was confirmed by hydroxyproline increase due to its free and peptide-bound fractions throughout the experiment. Finally, an increase in protein-bound hydroxyproline was determined against the background of high levels of free hydroxyproline, which was explained by the formation of pathological granulations and fibrillar collagen with an inferior short-chain structure. \u0000Conclusion. Chronic periodontitis is characterized by disturbances in the bioradical balance followed by the oxidative stress development, which induces the dystrophy of periodontal collagen structures. The data obtained substantiate the use of collagen peroxidation and metabolism markers as diagnostic criteria to predict the course of periodontitis, and also prove the importance of antioxidants.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130046111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPLEX EFFECT OF LOW-INTENSITY LASER RADIATION AND POTASSIUM CHANNEL PEPTIDE INHIBITOR ON MELANOMA CELL SURVIVAL","authors":"E. Pogodina, E. Rastorgueva, E. Yurova, E. Beloborodov, D. Sugak, Y. Saenko","doi":"10.34014/2227-1848-2022-1-94-104","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-94-104","url":null,"abstract":"Melanoma is characterized by an aggressive development and a large number of metastases during diagnostics. Photodynamic therapy (PDT) is used to treat this type of cancer. However, the accumulation of photosensitizers is observed not only in malignant tumors, but also in high metabolic rate organs. Shortcomings of melanoma therapy can be eliminated using the complex effect of laser radiation and local administration of inhibitors of cellular processes. \u0000The goal. To study the complex effect of low-intensity laser radiation and potassium channel peptide inhibitor on melanoma cell survival. \u0000Materials and Methods. A875 melanoma cells were exposed to Kappa-theraphotoxin-Gr1b toxin and laser irradiation. The authors examined the level of apoptosis and necrosis in cells using fluorescence microscopy techniques. The xCELLigence system was used to assess the cytotoxic response of A875 melanoma cells. \u0000Results. The maximum number of apoptotic and necrotic cells was observed in the group of patients with A875 tumor cells exposed to a combination of Kappa-TRTX-Gr1b toxin and laser radiation (wavelength=1265 nm). This is due to the inhibition of potassium channels of intracellular cell membranes by Kappa-TRTX-Gr1b peptide, which are associated with the apoptosis. \u0000Conclusion. Selective potassium channel inhibition under pathological processes can be regarded as a significant supplement to the superficial malignant neoplasm complex therapy. The combination of toxin and irradiation will make it possible to potentiate their action and avoid the main PDT disadvantages. This approach unites the benefits of the local administration and precise exposure on the malignant tumor.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"170 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116670437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FACTORS AFFECTING THE LEVEL OF GLYCATED HEMOGLOBIN IN HOSPITALIZED TYPE 2 DIABETES MELLITUS PATIENTS","authors":"G. Milyukova, A. Peskov, Natal'ya Manina, M.P. Khokhlov, E. Yudina, T.S. Golubtsova, I.R. Kerova, S.A. Pribylova, Roksana Mamedova, Alisa Ismailova","doi":"10.34014/2227-1848-2022-1-18-28","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-18-28","url":null,"abstract":"Today type 2 diabetes mellitus is a socially significant disease with a high growth rate in the number of patients and the risk micro- and macrovascular complications. Modern diabetology considers the level of glycated hemoglobin to be the most important tool for diagnosing type 2 diabetes mellitus. The efficacy of therapy is assessed by the target values of this very indicator. \u0000The aim of the study was to analyze the correlation between the level of glycated hemoglobin in type 2 diabetes mellitus patients, hospitalized to a specialized endocrinology department, and a number of clinical and epidemiological characteristics that are mandatory for describing the patient’s status. \u0000Materials and Methods. The authors conducted a retrospective analysis of case histories of type 2 diabetes mellitus patients hospitalized to the endocrinology department of Ulyanovsk Regional Clinical Hospital in 2020. Continuous sampling method was used. Results on the correlation between the diagnosis and the glycated hemoglobin value were obtained. Statistica 13 (StatSoft) was used for data processing. The level of glycated hemoglobin was assessed once, when the patient was hospitalized, by high performance liquid chromatography on a Bio Rad analyzer. \u0000Results. When conducting multivariate regression analysis, negative correlations close to linear were found in the pairs “glycated hemoglobin - duration of type 2 diabetes mellitus anamnesis” and “glycated hemoglobin - number of concomitant diagnoses not associated with type 2 diabetes mellitus”. Such patterns may be explained by the fact that a longer duration of the disease and a wider range of comorbid pathologies increase patients’ adherence to treatment and physician’s recommendations. \u0000Conclusion. The work conducted allows us to clarify the mechanisms of influence on the patient's compliance in type 2 diabetes mellitus treatment.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"2009 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127330926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARACTERISTICS OF REDOX STATUS IN MALE AND FEMALE RATS WITH EXPERIMENTAL DIABETES MELLITUS, GUERIN'S CARCINOMA AND ASSOCIATED PATHOLOGY","authors":"I. Goroshinskaya, E. Frantsiyants, I. Kaplieva, L. Nemashkalova, L. Trepitaki, P. Kachesova, E. Surikova, V. Bandovkina, M. Morozova, I. Kotieva, A. Shaposhnikov","doi":"10.34014/2227-1848-2021-4-153-167","DOIUrl":"https://doi.org/10.34014/2227-1848-2021-4-153-167","url":null,"abstract":"Taking into account cancer and diabetes comorbidity, the role of free radicals in these conditions and the dependence of pathological processes on the gender of animals, the aim of the study was to examine lipid peroxidation (LPO) intensity and the activity of the key antioxidant enzyme superoxide dismutase (SOD) in the heart, kidneys, liver, and in tumors of male and female rats with diabetes mellitus (DM), Guerin's carcinoma (GC) or both diseases.\u0000Materials and Methods. The study included 80 white nonlinear male and female rats (180–220 g). The animals were divided into 4 groups, each group included 10 animals (either male or female). At the time of GC inoculation, the blood glucose level in animals with alloxan diabetes was 25.4±1.2 mmol/L. The authors used conventional spectrophotometric methods to examine the content of malondialdehyde (MDA), diene conjugates (DC), and SOD activity. Statistical analysis was performed using Statistical analysis software Statistica 10.0.\u0000Results. The most pronounced changes in the studied parameters were found in the heart of female rats with isolated GC and associated diabetes mellitus: more than a threefold increase in MDA, a significant increase in DC against the background of an increase in SOD activity (by 5.5–6.3 times in comparison to intact animals). The amount of MDA in GC tissue depended on the tumor size: the maximum increase in both parameters was observed in male rats with GC growth and associated DM.\u0000Conclusion. The changes in the content of LPO products and SOD activity in the heart, kidneys, and liver of rats with diabetes mellitus and tumor growth depend on the type of the examined tissue and the gender of the animals. Disorders of the redox status found in the heart tissue can make a significant contribution to cardiopathology, which is often observed in diabetes mellitus and malignant tumor growth.\u0000Key words: diabetes mellitus, Guerin's carcinoma, rats, combined pathology, heart, kidneys, liver, malondialdehyde, diene conjugates, superoxide dismutase.\u0000Учитывая коморбидность рака и диабета, роль свободнорадикальных процессов при этих состояниях и зависимость течения патологических процессов от пола животных, целью исследования явилось изучение интенсивности перекисного окисления липидов (ПОЛ) и активности ключевого антиоксидантного фермента супероксиддисмутазы (СОД) в сердце, почках, печени, а также в опухоли крыс разного пола при сахарном диабете (СД), карциноме Герена (КГ) и при их сочетании. \u0000Материалы и методы. В исследование были включены 80 белых нелинейных крыс обоего пола массой 180–220 г, разделенных на 4 группы по 10 животных каждого пола. На момент перевивки КГ уровень глюкозы в крови животных с аллоксановым СД составил 25,4±1,2 ммоль/л. Содержание малонового диальдегида (МДА), диеновых конъюгатов (ДК) и активность СОД исследованы общепринятыми спектрофотометрическими методами. Статистический анализ проведен с использованием программы Statistica 10.0. \u0000Результаты. Наиболее выраженн","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129644414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AUTONOMIC NERVOUS SYSTEM DYSFUNCTION IN BREAST CANCER PATIENTS","authors":"Y. Udalov, L. Belova, V. Mashin, L. A. Danilova, A. A. Kuvayskaya","doi":"10.34014/2227-1848-2021-4-73-88","DOIUrl":"https://doi.org/10.34014/2227-1848-2021-4-73-88","url":null,"abstract":"When studying oncology diseases, it is necessary not only to assess their nature, progress and outcome depending on the local disease process, but also to take into account overall health, since multiple organ damage has a prognostic value and determines the disease outcome. All mechanisms and structures that have an integrative and homeostatic effect on the overall health should be considered. One of these structures is the autonomic nervous system.\u0000Traditionally, the autonomic nervous system has been considered in terms of 3 components: sympathetic, parasympathetic and intestinal. However, in recent years, ideas about neuroendocrine and neuroimmune systems have come to the fore, justifying the expansion of the concept \"autonomy of the nervous system.\" In case of autonomous dysfunction, dysregulation of the involuntary body functions occurs, and autonomic neuropathy develops. There are cardiovascular, gastrointestinal, urogenital, and sudomotor forms of autonomic neuropathy, which are characterized by certain changes in various pathological states, especially in malignant processes. We pay attention to breast cancer, which ranks first in the structure of oncology diseases in the Russian Federation.\u0000Nowadays, there are only a few studies devoted to the changes in the autonomic nervous system in patients with breast cancer during anticancer drug therapy, taking into account the disease progress and clinical features, as well as methods for dysfunction remodeling.\u0000The article analyzes a number of scientific information sources that can help to study various forms of autonomic neuropathy in patients with breast cancer and allow assessing the use of medical rehabilitation for such patients.\u0000Key words: autonomic nervous system, autonomic neuropathy, breast cancer, antitumor drug therapy.\u0000При изучении онкологического заболевания необходимо не только оценивать его характер, течение и исход в зависимости от локального процесса, но и учитывать общее состояние организма, так как множественное поражение органов имеет прогностическое значение и определяет исход заболевания. Следует рассматривать все механизмы и структуры, которые оказывают интегративное и гомеостатическое действие на организм в целом. Одной из таких структур является вегетативная нервная система. \u0000Традиционно вегетативная нервная система рассматривалась в аспекте 3 составляющих: симпатической, парасимпатической и кишечной. Однако в последнее время на первый план вышли представления о нейроэндокринных и нейроиммунных системах, обосновывающие расширение значения понятия «автономность нервной системы». При поражении автономной нервной системы возникает дисрегуляция непроизвольных функций организма, развивается автономная нейропатия. Выделяют кардиоваскулярную, гастроинтестинальную, урогенитальную, судомоторную формы автономной нейропатии, которые характеризуются определенными изменениями при различных патологических состояниях организма, особенно при злокачественных процессах. Фокус нашего науч","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"24 1-2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120892531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}