M.P. Khokhlov, A. B. Peskov, N. N. Klimova, T.S. Golubtsova, S.A. Pribylova, I.R. Kerova, E. Yudina
{"title":"COMPUTER ELECTROACUPUNCTURE FOR IRRITABLE BOWEL SYNDROME: EFFICACY AND SEARCH FOR EFFICACY PREDICTORS","authors":"M.P. Khokhlov, A. B. Peskov, N. N. Klimova, T.S. Golubtsova, S.A. Pribylova, I.R. Kerova, E. Yudina","doi":"10.34014/2227-1848-2022-2-38-50","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-38-50","url":null,"abstract":"Non-pharmacological treatment modalities, in particular, a new technique in reflexology – computerized electroacupuncture (CEAP), allow us to increase the efficacy while treating patients with irritable bowel syndrome (IBS). Search for predictors of CEAP efficacy in IBS will optimize the choice of patients for treatment, improving the CEAP efficacy profile. \u0000The aim of the study is to evaluate CEAP efficacy in the complex therapy of various clinical IBS forms. \u0000Materials and Methods. The study involved 80 IBS patients. Patients of the main group underwent three courses of CEAP in addition to standard pharmacological therapy, patients of the reference group received only pharmacotherapy. At the beginning and at the end of each CEAP course, the severity of pain syndrome (visual analogue scale), stool frequency, stool consistency (Bristol stool scale), and subjective state indicators (Zung Self-Rating Depression Scale, Spielberger-Khanin test) were assessed. \u0000A retrospective analysis of the research results was carried out to search for predictors of CEAP efficacy. The impact of such parameters as patient’s gender, age, disease form and severity on treatment outcome was assessed. \u0000Results. After the first CEAP, the severity of abdominal pain in patients of the main group decreased from 6.1 mm to 3.9 mm and after the third CEAP to 3.7 mm. After three courses of CEAP, defecation frequency in IBS patients with diarrhea decreased from 4.7 to 1.9 per day, and in IBS patients with constipation increased from 0.26 to 0.77 per day. The proportion of patients with normal stool consistency increased significantly both among patients with constipation and among those with diarrhea to 47.1 and 55.6 %, respectively. \u0000Retrospective analysis showed the best treatment results in patients with mild and moderate IBS.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114909156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maksim Dmitrievich Ivanov, A. M. Parsadanyan, A. E. Kasparova
{"title":"SURGICAL TREATMENT OF OBESITY AS A RISK FACTOR FOR ATYPICAL HYPERPLASIA AND ENDOMETRIAL CANCER","authors":"Maksim Dmitrievich Ivanov, A. M. Parsadanyan, A. E. Kasparova","doi":"10.34014/2227-1848-2022-2-71-80","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-71-80","url":null,"abstract":"The aim of the study is to analyze the literature available, to examine bariatric surgery as a treatment for people with metabolic syndrome (a risk factor for atypical endometrial hyperplasia), and to evaluate bariatric surgery significance in reducing endometrial cancer incidence. \u0000Materials and Methods. The authors scanned the platforms Springer, Pubmed, IFSO, and Google Scholar using such key words as metabolic syndrome, simple and atypical endometrial hyperplasia, endometrial cancer and bariatric surgery, methods for the metabolic syndrome correction in patients with endometrial cancer, effects of bariatric surgery on endometrial cancer, treatment of metabolic syndrome in patients-at-risk for endometrial cancer. The authors examined the articles published in English and Russian no longer than 10 years ago. \u0000Results. Metabolic syndrome is a risk factor for endometrial cancer and comorbidity. It expands the bariatric surgery alternatives for patients with Class 1 and Class 2 obesity.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128999564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MACROMYCETES AS BIOINDICATORS OF RADIONUCLIDE CONTAMINATION IN FOREST ECOSYSTEMS","authors":"B. Churakov, U. Zyryanova","doi":"10.34014/2227-1848-2022-2-148-157","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-148-157","url":null,"abstract":"The aim of the paper is to determine the specific activity of radionuclides in macromycetes in Ulyanovsk region forest ecosystems exposed to radiation after the Chernobyl accident. \u0000Materials and Methods. The fruiting bodies of macromycetes (soil and wood-destroying fungi) gathered in the radioactive contaminated territories served as the material for the research. The authors determined the specific activity of Cs-137, K-40, Ra-226, Th-232 radionuclides. The study was conducted during the growing season in the Ulyanovsk region forests (Inza and Karsun districts). For comparison, fungi samples (control) were also gathered in the Novospassky region, where the excess background radiation was not observed. Trial sites with similar forest growth conditions were selected. The specific activity of radionuclides in the fungi fruiting bodies was determined according to Guidelines 2.6.1.1194–03. \u0000Results. In soil fungi, the highest average Cs-137 specific activity was found in the fruiting bodies of Leccinum scabrum, K-40 and Ra-226 specific activity – in the fruiting bodies of Suillus luteus, and Th-232 specific activity – in the fruiting bodies of Macrolepiota procera. \u0000In wood-destroying fungi, the highest average Cs-137, K-40 and Ra-226 specific activity was observed in the fruiting bodies of Fomitopsis pinicola, and the highest Th-232 specific radioactivity – in the fruiting bodies of Coriolus versicolor. The average specific activity of all radionuclides in the mushrooms from the radioactive contamination territories (Inza and Karsun districts) was mainly higher than in the control (Novospassky district). In the studied samples of soil and wood-destroying fungi, excess radioactive concentrations were not found. \u0000Conclusion. Forest mycobiota can be used as a bioindicator of radioactive environmental pollution.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125995673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ACCUMULATION OF MACRO- AND MICROELEMENTS IN LEAVES OF STINGING NETTLE (URTICA DIOICA L.)","authors":"N. A. D'yakova","doi":"10.34014/2227-1848-2022-2-139-147","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-139-147","url":null,"abstract":"Studies of the ultimate composition of wild-growing raw materials are relevant and significant due to the high efficiency and bioavailability of organometallic forms contained in plants. However, the available information on the content of elements in the medicinal plant raw materials in the Voronezh region concerns only a few elements. The lack of information does not allow us to determine the complete chemical composition of plants and to describe how the entire complex of mineral substances is accumulated in them. \u0000The aim of the study is to examine how macro- and trace elements are accumulated in the leaves of the stinging nettle in natural plant community of the Voronezh region. \u0000Materials and Methods. The harvesting of medicinal plant raw materials was carried out in the Voronezh State Nature Biosphere Reserve during the flowering period. The trace element sample composition was studied mass-spectroscopically (ELAN-DRC). \u0000Results. The proportion of trace elements in the leaves of stinging nettle was 7.68 %, in absolutely dry raw material equivalent. Only 59 elements were found in its leaves. Of these, 86.87 % were macroelements, the main ones being potassium (>26.5 mg/g) and calcium (>26 mg/g). Essential trace elements made up 12.68 % of the total plant mineral complex. Silicon (>9.2 mg/g) and iron (>0.3 mg/g) dominated among trace elements. The content of standardized heavy metals and arsenic corresponded to regulatory documentation. The proportion of toxic and under-investigated elements was 0.45 %. The highest content was observed for strontium (156.78 µg/g), aluminum (128.4 µg/g), barium (31.16 µg/g), rubidium (21.5 µg/g), titanium (3.26 µg /g), and tin (1.35 μg/g). Thus, the leaves of stinging nettle easily accumulated phosphorus, potassium, magnesium, calcium, molybdenum, copper, zinc, mercury, strontium, tin, nickel, chromium, manganese, cadmium, and rubidium from the soil.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131826857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Frantsiyants, V. Bandovkina, I. Kaplieva, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, M. Morozova, A. Salatova, A. Arakelova
{"title":"IMPACT OF DIABETES MELLITUS ASSOCIATED WITH GUERIN'S ARCINOMA GROWTH ON THYROID FUNCTION IN MALE AND FEMALE RATS","authors":"E. Frantsiyants, V. Bandovkina, I. Kaplieva, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, M. Morozova, A. Salatova, A. Arakelova","doi":"10.34014/2227-1848-2022-1-105-116","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-105-116","url":null,"abstract":"Thyroid dysfunction is associated with diabetes and cancer development. \u0000The aim of the study was to examine the level of thyroid hormones and TSH in blood serum and thyroid gland, thyrotropin releasing (T-releasing) level in the hypothalamus and TSH level in the pituitary gland in male and female rats with Guerin's carcinoma growth associated with diabetes mellitus (DM). \u0000Materials and Methods. White non-linear rats (180–220 g, males and females) were divided into 4 groups (n=9): intact animals; two control groups (inoculated Guerin's carcinoma growth, alloxan-induced DM); the main group (inoculated Guerin's carcinoma growth associated with DM). \u0000Results. Life expectance in male and female animals of the main group decreased by 1.6 times compared to the control animals with Guerin's carcinoma. The tumor volume in females of the main group was less, and in males it was more than in control. An active metastatic process was detected in females. DM caused a decrease in the level of regulatory peptides of hypothalamus and pituitary gland in animals of the main group compared with the control group with carcinoma: in females and males, T-releasing level decreased by 1.7 and 4.1 times, TSH decreased by 2.4 and 1.5 times, respectively. FT3 level was 62.9 times lower and FT4 level was 8.1 times lower in the thyroid gland of female rats of the main group, than those in the group with Guerin’s carcinoma, while in males FT3 level was 18 times higher and FT4 level was 1.5 times higher. In males, blood parameters demonstrated symptoms of hypothyroidism, and in females low3/low4 syndrome was registered. \u0000Conclusion. DM affects the thyroid axis in rats with comorbidity, affecting the hypothalamus, the pituitary gland, and the thyroid gland.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122237549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Demyashkin, Lyubov Bondurko, N. Fomina, L. Sevan'kaeva, Lyudmila Mikhina, Valentina Glushak, V. Shchekin
{"title":"EFFECT OF VASCULAR ENDOTHELIAL GROWTH FACTOR ON SPERMATOGENESIS AFTER 2 GY ELECTRON IRRADIATION","authors":"G. Demyashkin, Lyubov Bondurko, N. Fomina, L. Sevan'kaeva, Lyudmila Mikhina, Valentina Glushak, V. Shchekin","doi":"10.34014/2227-1848-2022-1-87-93","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-87-93","url":null,"abstract":"Platelet-rich plasma (PRP) influences tissue repair, stimulating the proliferation and differentiation of progenitor cells. \u0000The aim of the study was to evaluate the effect of vascular endothelial growth factor (VEGF) on spermatogenesis after 2 Gy electron irradiation. \u0000Materials and Methods. Light microscopy and immunohistochemical reactions with antibodies to VEGF were used to examine testes of 5 groups of experimental animals (Group 1 – control (n=10), Group 2 – 2IR (n=35), Group 3 – 2IR+LP-PRP+IGF-1 (n=30), Group 4 – 2IR+LP-PRP (n=30), Group 5 – LP-PRP (n=30)). \u0000Results. After irradiation, a decrease in the number of VEGF-positive cells was observed, which was restored under PRP administration. \u0000Conclusion. 2 Gy electron irradiation of the testes leads to a decrease in VEGF-positive cells. PRP administration, containing vascular endothelial growth factor, enhances reparative processes and restores spermatogenesis.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128828944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Mongalev, L. Rubtsova, N. Vakhnina, V. Shadrina, O. Chupakhin, E. Boyko
{"title":"EFFECT OF SUCCINATE-CONTAINING DRUGS ON CELLULAR COMPOSITION OF BLOOD IN RATS AT REST, DURING FREE SWIMMING AND WEIGHT-LOADED FORCED SWIMMING TEST","authors":"N. Mongalev, L. Rubtsova, N. Vakhnina, V. Shadrina, O. Chupakhin, E. Boyko","doi":"10.34014/2227-1848-2022-1-135-146","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-135-146","url":null,"abstract":"The aim of the study is to analyze the effect of succinate-containing drugs on the cellular composition of blood in rats at rest, during free swimming and weight-loaded forced swimming test. \u0000Materials and Methods The study was carried out on practically healthy sexually mature male Wistar rats (250–300 g). Animals received a succinate-containing drug (meso-2,3-dimercaptosuccinic acid) at rest, before free swimming and weight-loaded swimming (4 % of body weight), and after 12 hours before exercise. Then, the levels of hemoglobin, hematocrit, the number of erythrocytes, reticulocytes and leukocytes with the distribution of their subpopulation composition were detected in the blood of rats. The authors measured the diameter of 100 reticulocytes and erythrocytes stained according to Romanovsky-Giemsa technique and by brilliant cresyl blue. The significance of differences in the reactions of rats’ blood cells was determined by the Kruskal-Wallis test using the R package WRS2(version 3.4.2). \u0000Results. The use of a succinate-containing drug in animals increased the proliferative activity foremost of lymphoid tissue. At rest, the indicators of the cellular composition of blood in rats corresponded to those after free swimming without succinate-containing drug use, which is considered as a transition of the functional state of the body to a level corresponding to the physical activity. The effect of the succinate-containing drug was more pronounced in animals during weight-loaded forced swimming test: duration of swimming increased by 2.8 times. \u0000Conclusion. In rats, the efficacy of a succinate-containing drug is manifested under intense physical activity. The practical use of a succinate-containing drug is physiologically justified if animals are under functional stress.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121341825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Voloshin, Z. Rumyantseva, I. Glazkov, A. Sulima, N. Reznichenko, Viktoriya S. Moskvina
{"title":"PERINATAL OUTCOMES IN WOMEN WITH COVID-19","authors":"D. Voloshin, Z. Rumyantseva, I. Glazkov, A. Sulima, N. Reznichenko, Viktoriya S. Moskvina","doi":"10.34014/2227-1848-2022-1-49-55","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-49-55","url":null,"abstract":"COVID-19 pathogenesis has not been fully understood yet. However, the virus is known to enter the epithelial cells of the upper respiratory and gastrointestinal tracts, activating S-protein by angiotensin-converting enzyme 2. This process can significantly affect the pregnancy, childbirth and postpartum period. \u0000The aim of the study is to analyze the impact of COVID-19 on pregnancy course and outcomes. \u0000Materials and Methods. The authors retrospectively analyzed case histories and surgical protocols of 67 pregnant women with confirmed and suspected COVID-19, and neonatal records of 59 newborns who were in contact with COVID-19 patients. \u0000Results. Childbirth due to antenatal fetal death occurred in 13.4 % of cases, preterm births were observed in 15.5 %. Besides, 15.2 % of children were born prematurely by gestational age (the average rate for the Russian Federation is 8–11 %); invasive artificial lung ventilation was required in 3.4 % of newborns; primary neonatal resuscitation was performed in 18.6 % of cases. PCR examination of oropharyngeal swabs for SARS-CoV-2 detection did not confirm the presence of COVID-19 causative agents. Neonatal jaundice was diagnosed in 83.1 % of cases (the average rate for the Russian Federation is 60 %). Phototherapy (serum bilirubin >220 µmol/l, transcutaneous bilirubin index >200, Kramer scale score 3–4) was required in 77.5 % of such children (the average rate for Russia is 40–50 %). \u0000Conclusion. The conducted study indicates a significant impact of COVID-19 on pregnancy course and outcomes: the risks of preterm birth, antenatal fetus death, and the need for primary neonatal resuscitation also increase.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133283351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MORPHOLOGICAL ASSESSMENT OF KIDNEY CORTICAL SUBSTANCE DEVELOPMENT IN CHILDHOOD","authors":"Anton Sologub, E. Slesareva","doi":"10.34014/2227-1848-2022-1-65-74","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-65-74","url":null,"abstract":"One of the factors for arterial hypertension development is an increase in the activity of the renin-angiotensin-aldosterone system. It is supposed to be relevant to study the structure of subcortical and perimedullary nephrons in order to identify their morphofunctional characteristics in postnatal ontogenesis. \u0000The aim of the study was to investigate the age-related characteristics of the renal cortex structure in children of different age groups. \u0000Materials and Methods. The study was performed on the autopsy renal material obtained from children without any vascular and renoparenchymal diseases, who died at the age of 2 months – 10 years. Six age groups were identified: those who died at the age of 2–4 months, 6–9 months, 10–12 months, 3 years, 6 years, and 10 years. Paraffin microscope slides were prepared according to a standard method and stained with hematoxylin and eosin. The authors determined the number of subcortical and perimedullary renal corpuscles, cortical and perimedullary nephron area, glomeruli area of subcortical and perimedullary nephrons and their average capsule area using the Levenhuk morphometric program. \u0000Results. In postnatal ontogenesis, uneven maturation of the cortical renal substance is observed. Initially, the nephrons of the subcapsular zone develop faster, with predominant growth of convoluted tubules. Nephron number in the perimedullary zone is lower than in the subcortical one. Active tubule and stroma growth is observed since the age of 3. By the age of 10, the number of subcortical and perimedullary nephrons becomes the same and corresponds to the kidney structure in adults. In ontogenesis, the corpuscles and vascular glomeruli of the pericerebral nephrons are larger than those of the subcapsular ones. However, the urinary space is wider in the subcapsular nephrons, which indicates their earlier involvement in the urination process. A significant development of the vascular glomeruli of the perimedullary nephrons indicates their predominant involvement in the processes of blood pressure regulation through renin synthesis.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121408874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Kolchin, Yuliya Degtyareva, V. Ruzov, Baymurat Asanov, O. Prokhorov
{"title":"PLATELET AGGREGATION IN PATIENTS WITH PULMONARY TUBERCULOSIS AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROME","authors":"D. Kolchin, Yuliya Degtyareva, V. Ruzov, Baymurat Asanov, O. Prokhorov","doi":"10.34014/2227-1848-2022-1-29-38","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-1-29-38","url":null,"abstract":"Platelets play a special role in the systemic inflammatory response syndrome, as they acquire the ability to become activated and aggregate. Literature has no direct evidence of a link between platelet aggregation activity and the severity of the systemic inflammatory response syndrome in patients with pulmonary tuberculosis. \u0000The aim of the paper is to study platelet aggregation in patients with pulmonary tuberculosis with severe systemic inflammatory response syndrome. \u0000Materials and Methods. Spontaneous and induced by ADP (0.1, 1.0 and 5.0 ml) platelet aggregation was determined by Born turbodynamic method. The study enrolled 27 patients with severe and 33 patients with indolent systemic inflammatory response syndrome Spontaneous and induced by ADP (0.1 and 1.0 ml) platelet aggregation was evaluated in absorbance units (a.u.); platelet aggregation induced by 5.0 ml of ADP was measured in percentage terms. Statistica 10 was used to process the results. Discrepancy tests were used to determine the significance of differences of mean values; McNemar’s test and Fisher’s exact test were used to estimate event rate, p<0.05. \u0000Results. In Group 1 spontaneous and induced by ADP (0.1, 1.0 and 5 ml) platelet aggregation was 0.85–2.65 (1.210.1) a.u., 0.81–3.67 (3.030.38) a.u., 1.06–6.25 (6.50.51) a.u., 5–66 % (39.53.6); in Group 2 – 0.84–1.36 (1.10.04) a.u., 0.77–2.49 (2.10.26) a.u., 0.64–5.49 (2.200.08) a.u., 8–66 (35.74.14) %, respectively. Frequency of spontaneous and induced by ADP (0.1, 1.0 and 5 ml) platelet hypoaggregation in Groups 1 and 2 was 33.3 % and 27.3 %; 14.8 % and 24.2 %; 0 % and 39.4 %; 14.8 % and 24.2 %, respectively; frequency of hyperaggregation was 14.8 % and 0 %; 11.1 % and 9.1 %; 29.6 % and 0 %; 0 % and 0 %, respectively. \u0000Conclusion. Platelet aggregation activity in patients with pulmonary tuberculosis is determined by the severity of the systemic inflammatory response syndrome. A pronounced systemic inflammatory response syndrome is associated with increased spontaneous and induced by ADP (1.0 ml) platelet aggregation in 14.8 % and 29.6 % of cases, respectively.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121171180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}