Ulyanovsk Medico-biological Journal最新文献

{"title":"DIAGNOSIS AND TREATMENT OF PULMONARY PARAGONIMIASIS: A RARE CLINICAL CASE","authors":"Stanislav Ivanovich Stolyarov, A. Belyaev, Larisa Yur'evna Stolyarova, N. A. Mizurov, Nikita Alekseevich Kovaykin","doi":"10.34014/2227-1848-2022-2-15-21","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-15-21","url":null,"abstract":"Pulmonary paragonimiasis is a serious parasitic disease caused by the lung fluke larvae. In Russia, the partite is found in the south of the Far East. This article presents a rare clinical case of pulmonary paragonimiasis, which clinically and radiographically mimics the pulmonary tuberculoma. In 2012, the patient served in the Primorsky Krai (one of the natural paragonimiasis foci). In 2016, changes in the right lung were detected. In 2020, the patient underwent a lobectomy of the right lung. A thorough histopathological examination of the surgical material made it possible to reveal a disease, prescribe antiparasitic treatment and help the patient recover from the disease.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123614674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIOHEMODYNAMIC AND PROGNOSTIC SIGNIFICANCE OF RENAL ARTERY STENTING IN PATIENTS WITH CORONARY ARTERY DISEASE","authors":"El'za Kamilevna Kirishcheva, A. М. Shutov, E. V. Movchan, L. Matveeva","doi":"10.34014/2227-1848-2022-2-6-14","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-6-14","url":null,"abstract":"The aim of the study is to evaluate cardiohemodynamic and prognostic significance of endovascular revascularization of renal arteries (ERRA) in patients with coronary artery disease (CAD). \u0000Materials and Methods. The authors examined 106 patients (84 men, 22 women; mean age 53±15). All the patients underwent both coronary angiography and renal artery angiography to verify chronic CAD. The authors analyzed the incidence and severity of arterial hypertension, the results of coronary and renal artery angiography, the outcomes of endovascular management of renal artery stenosis (RAS),   and all-cause mortality rates. The follow-up period lasted for 10 years. \u0000Results. CAD was detected in 61 patients (58 %). Synchronous coronary and renal artery damage was detected in 12 patients (19.7 %), including hemodynamically significant renal artery stenosis (9 patients (14.8 %)). Eight patients underwent renal artery stenting. Arterial hypertension was observed in 58 of 61 patients (95.1 %) with verified CAD, including all the patients with synchronous coronary and renal artery damage. Seventeen patient (16 %) died during the monitoring period. During a 10-year period, 3 people (25 %) died from all causes in the group of RAS patients, while 14 people (14.8 %) died in the group of patients without RAS (χ=1.22; р=0.37). Twelve months after renal artery stenting, there was a decrease in systolic blood pressure load, a decrease in the number of unfavorable blood pressure profiles, and a decrease in end-diastolic dimension. \u0000Conclusions. In the medium term, ERRA is associated with a decrease in hypertensive load indices and systolic BP variability, an improvement of circadian blood pressure profiles, and a decrease in left ventricle end-diastolic and left atrium dimensions. Renal artery stenosis and ERRA did not significantly affect mortality over a 10-year follow-up.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134628869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIASTASIS RECTI ABDOMINIS: PROBLEMS OF DIAGNOSIS AND TREATMENT OF FALSE HERNIA","authors":"K. Sergatskiy, V. Nikol'skiy, Ekaterina Valer'evna Titova, Parastu Ravshanovna Pulotova, Artem Vladimirovich Korobov, Aleksandr Semenovich Ivachev","doi":"10.34014/2227-1848-2022-2-22-37","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-22-37","url":null,"abstract":"Diastasis recti abdominis (DRA) is a pathological state characterized by thinning and stretching of the aponeurotic plate of the white line. In the neglected cases, the entire muscular-aponeurotic skeleton of the anterior abdominal wall, up to the Spigelian line, sticks out and bulges. DRA is an urgent problem of modern surgery. Its management and treatment takes much time and effort. \u0000The literature review analyzes the main causes and risk factors of DRA, and describes its pathogenesis in detail. Particular attention is paid to diagnostic methods. A number of classifications are considered depending on diastasis etiology, localization and degree. It is shown that diastasis diagnosis is based on a thorough history, patient’s complaints, and clinical examinations. Ultrasonography, computed tomography, and magnetic resonance imaging should be performed when a concomitant umbilical or epigastric hernia or other reason for the patient’s symptoms cannot be ruled out. The authors describe practical methods for DRA surgical management. They evaluate the efficacy of various treatment modalities and the results of treating patients with DRA. It is noted that optimal surgical management for DRA correction has not been found yet. However, there is no treatment modality, which suggests an operation without general anesthesia. Any surgical intervention for DRA management implies the use of combined endotracheal anesthesia. Choosing a surgery for DRA management, the surgeon should take into account the patient’s opinion on the method of surgical assistance, minimize the period of hospital treatment if possible, use reliable techniques, ensure a patient’s quick recovery with a maximum cosmetic effect and minimum complications.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129365103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALCOHOL-INDUCED EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND STRUCTURAL CHANGES IN RAT CARDIOMYOCYTES","authors":"P. Belogubov, V. Ruzov, S. M. Slesarev, Rizida Rafaelevna Sharafutdinova","doi":"10.34014/2227-1848-2022-2-102-116","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-102-116","url":null,"abstract":"The aim of the study is to reveal the ethanol effects on the expression of hypoxia-associated factors (HIF-1α, VEGF-A) and structural changes in cardiomyocytes of healthy rats. \u0000Materials and methods. Ethanol-induced structural changes in cardiomyocytes were studied in 60 outbred mature rats. Control animals were intragastrically injected with sterile 0.9% saline, experimental animals – with 40 % ethanol. Ethanol exposure on myocardium lasted 4 and 8 days. Morphological study of the heart was carried out after decapitation preceded by ether anesthesia. PCR tests were used to determine mRNA expression of HIF-1α and VEGF-A genes from the left ventricle and serum concentration of vascular endothelial growth factor. Morphological studies of the left ventricle myocardium were carried out on histological sections using light microscopy. \u0000Results. A short ethanol exposure was accompanied by fatty and granular cytoplasm degeneration of cardiomyocytes with erythrocyte stasis in capillaries, arterioles and venules. VEGF-A serum concentration in control rats was lower if compared with ethanol-induced rats. Gender differences to ethanol response were revealed, in particular, a more pronounced HIF-1α and VEGF-A mRNA expression in females compared to males on the background of 4-day ethanol exposure, which correlated with VEGF-A level in blood serum. 8-day alcohol exposure was accompanied by an increase in VEGF-A mRNA expression in both female and male rats. \u0000Conclusion. Ethanol exposure causes activation of HIF-1α and VEGF-A transcription factors in cardiomyocytes of rats. It can be regarded as a mechanism of urgent adaptation without the development of pronounced structural maladaptive changes of the myocardium.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127406663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LAMOTRIGINE FOR THE TREATMENT OF EPILEPSY WITH CONCOMITANT COGNITIVE, EMOTIONAL-VOLITIONAL AND BEHAVIORAL DISORDERS IN GIRLS","authors":"Dar'ya Ivanovna Chizh, E.N. Obedkina, Tatyana Alexandrovna Pavlova","doi":"10.34014/2227-1848-2022-2-52-60","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-52-60","url":null,"abstract":"The aim of the study is to evaluate lamotrigine efficacy on concomitant cognitive, emotional-volitional and behavioral disorders in girls with epilepsy. \u0000Materials and Methods. The study enrolled 17 girls aged 4–11 (mean age 7.4) with epilepsy, cognitive and/or emotional-volitional and behavioral deficits. The authors examined initial cognitive, emotional-volitional and behavioral impairments. \u0000To objectify the impairments, the results are expressed as percentage. The coefficient was calculated by summarizing the percentages of a particular function for each girl and then dividing the sum by the total number of subjects. After psychological and pedagogical testing, all girls underwent titrated lamotrigine monotherapy. Three-hour video-EEG monitoring (wakefulness and sleep) was carried out after 3, 6, 12, 18 and 24 months, and control Psychological and pedagogical testing – after 6, 12, 18 and 24 months. \u0000Results. Before lamotrigine therapy 7 girls (41.5 %) demonstrated focal seizures, 10 girls (58.5 %) had focal seizures with secondary bilateral synchronization. After 3 months, the number of seizures decreased in 4 girls (25.5 %), and a year later – in 14 girls (82.3 %). The group-wide indicators of perception and psychomotor pathologies were 41 %, aptitude for learning and memory – 43 %, speech – 54 %, reasoning – 41 %, social intelligence – 73 %. The indicators of emotional-volitional disorders by the hyperexcitable type were 36 %, by the inhibited type – 82 %. The indicator of ADHD was 32 %, demonstrative behavior – 91 %, negativism – 73 %, aggression – 79 %. \u0000There was a decrease in the number of seizures and the severity of concomitant complications of epilepsy in patients with lamotrigine therapy. The overall level of negativism and aggression improved, ADHD symptoms decreased in most girls, emotional-volitional control improved significantly. Significant positive changes were noted in speech, reasoning, aptitude for learning and memory. Socialization skills also improved. \u0000Conclusion. Lamotrigine is an effective antiepileptic drug. It has an antiepileptic effect, and is able to correct cognitive, emotional-volitional and behavioral disorders in patients with epilepsy.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125234780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MITOCHONDRIA RESPIRATION IN RAT BRAIN NEURONS UNDER CEREBRAL ISCHEMIA OF VARYING SEVERITY","authors":"E. Bon', N. E. Maksimovich, I. Dremza, M. A. Nosovich, K. A. Khrapovitskaya","doi":"10.34014/2227-1848-2022-2-128-138","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-128-138","url":null,"abstract":"The knowledge of the mechanisms of energy deficiency development in ischemic lesions is necessary to specify the pathogenesis and assess the damage/compensation ratio. \u0000The aim of the paper is to study respiration indices of mitochondria of rat brain homogenates in total and subtotal cerebral ischemia. \u0000Materials and Methods. The experiments were carried out on 88 male outbred white rats weighing 260±20 grams in compliance with the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. \u0000Results. In 1-hour subtotal cerebral ischemia, V2 increased by 24 (18; 27) % (p<0.05), in the presence of malate/glutamate, if compared with the control, while the acceptor control coefficient and the phosphorylation coefficient decreased by 25 (17; 29) % (p<0.05). Other indices (V1, V3, V4, respiratory control coefficient) did not change (p>0.05). In the presence of malate/glutamate under 1-hour SCI, mitochondrial respiration rates V1, V2, V3, and V4 were higher than under 1-hour TCI 89 (82; 93), 58 (55; 63), 24 (21; 29) and 32 (27; 37) % respectively (p<0.05). Decrease in V1, V2, and V3 indices under 24-hour SCI is a consequence of the decrease in oxygen content for mitochondrial respiration. The inhibition of energy processes is more pronounced than under 1-hour SCI, which reflects the extremely low phosphorylation coefficient. Changes in V1, V2, and V3 indices under 1-hour SCI and 1-hour TCI are multidirectional. Their increase under SCI is associated with uncoupling between oxidation and phosphorylation, while their decrease under TCI is associated with a lack of substrates for mitochondrial respiration. \u0000Conclusion. The most pronounced decrease in respiration indices of the mitochondrial fraction of brain homogenates occurs under total cerebral ischemia due to the complete cessation of neuron blood supply.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122070379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ORGANIZATION OF BRAIN ACTIVITY IN MEN AND WOMEN DURING MENTAL PRONUNCIATION OF WORDS","authors":"E. Krivko, O. Bakhtin, V. N. Kiroy, Dmitriy Mikhaylovich Lazurenko, Dmitriy Grigor'evich Shaposhnikov","doi":"10.34014/2227-1848-2022-2-81-91","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-81-91","url":null,"abstract":"The purpose of the study is to examine gender differences associated with the mental pronunciation of words in EEG coherence patterns. \u0000Materials and Methods. The authors studied the impact of gender differences on the characteristics of EEG spatial synchronization patterns associated with the mental pronunciation of words denoting direction: up, down, left, right, forward, backward. The study enrolled 10 boys and 10 girls, aged 21±3. \u0000Results. The dominance of the left hemisphere was observed in young men, while the right hemisphere dominated in girls. Specific patterns of EEG coherence are formed in both left and right hemispheres. Discrimination of mentally pronounced words according to the EEG coherence values in young men is effectively implemented according to coherence patterns, which form separately in both left and right hemispheres, whereas in girls the coherence patterns of both hemispheres should be taken into account. Gender peculiarities in the structural and functional organization of the brain and the characteristics of its bioelectrical activity should not be underestimated, in particular, when developing a BCI based on EEG and inner speech. It is known that the internal (mental) pronunciation of words is reflected both in the cortical and superficially recorded bioelectrical activity of the brain. EEG recording of the activity has obvious advantages. However, so far little is known about manifestation of inner speech and its characteristics with respect to gender. \u0000Conclusion. The results obtained confirm gender differences in the EEG characteristics of the brain during the mental pronunciation of words denoting directions.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134040557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN THE ANTIOXIDANT STATUS OF THE ORAL FLUID IN STUDENTS DURING THE APPRENTICESHIP","authors":"O. V. Kiek, V. Pokrovskiy","doi":"10.34014/2227-1848-2022-2-92-101","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-92-101","url":null,"abstract":"The aim of the paper is to assess changes in the antioxidant status of the oral fluid in students training for “woodworking machine operator” during apprenticeship. \u0000Materials and Methods. Twenty-four male students of secondary vocational education, aged 18–19, took part in the trial. The total antioxidant activity, the enzyme activity of the antioxidant defense system – superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, the content of TBA-active products, namely, malondialdehyde, were determined in students’ oral fluid before and after a 3-month apprenticeship. \u0000Results. After apprenticeship, an increase in superoxide dismutase and catalase activity by 3.6 and 6.7 times relative to initial indicators was found in the oral fluid of students respectively. A decrease in the glutathione peroxidase activity by 5.3 times was also observed. The revealed changes were observed against the background of the overall balance of pro- and antioxidants in the oral fluid. \u0000Conclusion. The data obtained confirmed that any apprenticeship is accompanied by stress, in particular, oxidative stress. However, its main manifestations are balanced by an increase in the enzyme activity of the antiradical protection system. The revealed changes indicate the necessity to assess the nonspecific resistance system in students during apprenticeship and to improve the system if needed. The non-invasive nature of the study of the biological fluid determines the long-term benefits for using the method while monitoring the students’ metabolism during apprenticeship.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114369294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USE OF KNOTTIN AS A PSMA-TROPIC PEPTIDE CARRIER","authors":"E. Beloborodov, E. Yurova, E. Rastorgueva, E. Pogodina, D. Sugak, A. N. Fomin, Y. Saenko","doi":"10.34014/2227-1848-2022-2-117-127","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-117-127","url":null,"abstract":"Prostate cancer is the most common type of cancer in males. Approximately 1.3 million cases of prostate cancer and over 400,000 deaths from the disease are diagnosed annually. The number of deaths is expected to double by 2040. Common methods of prostate cancer treatment have many disadvantages; one of them is the relapse risk. The shortcomings of traditional therapy have led to peptide-receptor radionuclide therapy. \u0000The aim of the study is to examine binding efficiency of Lu177 labeled knottins containing PSMA-tropic peptide in different domains in vitro and their biodistribution in vivo. \u0000Materials and Methods. We used prostate cancer cell (LNCaP, PC3) and ovarian fibroblast cell (CHO-K1) cultures. The peptides were synthesized using a peptide synthesizer (ResPepSL, Intavis). \u0000We studied peptide stability, their toxicity, binding to cell cultures, and biodistribution on the example of breast adenocarcinoma-bearing BALB/c mice. Chromatographic methods and radiometric techniques \u0000were used. \u0000Results. The synthesized peptides with GTIQPYPFSWGY sequence inserted into U5-cytotoxin-Sth1a node are more stable in blood plasma and saline than 177Lu-PSMA-617a, but have a similar degree of binding. Biodistribution studies in BALB/c mice show a higher binding index of the synthesized peptide if compared to 177Lu-PSMA-617. \u0000Conclusion. Modified peptides with a PSMA-tropic peptide inserted into the structure of U5-Sth1a toxin demonstrate high stability both in saline and in blood plasma, as well as good binding to cell cultures and tumors.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116312196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL SIGNIFICANCE OF PROGRESSIVE TRAUMATIC INTRACRANIAL HEMATOMAS IN ACUTE PERIOD OF TRAUMATIC BRAIN INJURY","authors":"Aleksandr Il'ich Midlenko, Marat Il'darovich Shigapov, A. Salin, S. E. Ryabov, M. S. Sokolov","doi":"10.34014/2227-1848-2022-2-61-69","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-2-61-69","url":null,"abstract":"This work is devoted to one of the topical issues of neurosurgery, namely, craniocerebral injuries, in particular, intracranial hematomas. Timely diagnosis of traumatic intracranial hematomas and the choice of a correct treatment strategy are the main factors of patient’s recovery. \u0000The purpose of the study was to monitor intracranial hematomas and their changes using neuroimaging of brain structures, and to evaluate brain CT and MRI efficacy in a hospital setting. \u0000Materials and Methods. The authors analyzed 2255 medical records of patients treated in the neurosurgical departments of Ulyanovsk Regional Clinical Center for Specialized Types of Medical Care named after E.M. Chuchkalov and Central City Clinical Hospital, 61 reports of forensic autopsies and 373 surgical reports. Surgical procedures were performed in 2015. \u0000Results. Intracranial hematomas were diagnosed in 198 patients (8.7 %). According to the time factor, the hematomas were distributed as follows: 150 acute (75.8 %); 35 subacute (17.7 %); 8 chronic (4.0 %). In five cases (2.5 %), the authors identified hematomas that were not registered in the existing classification. Such hematomas have not been adequately investigated yet. Such hematomas were called “progressive”, due to their increase in case follow-up. \u0000Conclusion. The peculiarities of “progressive” intracranial hematoma development necessitates clinical suspicion. In this regard, the pathology requires a more detailed study in order to create a system of clinical and neuroimaging monitoring and develop management guidelines.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125058651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}