Ulyanovsk Medico-biological Journal最新文献

{"title":"LAPAROSCOPY FOR ACUTE PERITONITIS","authors":"E. K. Salakhov, A. Vlasov, Oleg Yur'evich Rubtsov, Anton Anatol'evich Zakharov, R.R. Kazakov, M.Yu. Dormidontov","doi":"10.34014/2227-1848-2023-4-109-119","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-109-119","url":null,"abstract":"Peritonitis is the most serious complication of urgent abdominal diseases, associated with high mortality rates (up to 13 %). The main component for complex peritonitis treatment is surgery. In some cases, it is carried out in several stages, that contributes to complete abdominal cavity sanitation. The choice of surgical treatment (laparotomy / laparoscopy) is made individually, taking into account a number of parameters: the objective patient status, the clinical course of the disease, the material and technical equipment of the medical institution and the professional surgical skills. It has been noted that laparoscopy for peritonitis, in contrast to laparotomy, is more sparing in terms of surgical access. Laparoscopy and laparotomy significantly reduce complications in the postoperative period, including wound complications and postoperative hernias. As a result, inpatient treatment decreases, and a better cosmetic effect is achieved. However, the advisability of laparoscopy for patients with complex clinical manifestations of acute peritonitis remains a highly controversial issue.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VARIATIONS IN THE CLINICAL COURSE OF CEREBRAL VENOUS THROMBOSIS","authors":"A. I. Sitnikova, L. A. Belova, V. V. Mashin, Yakutkhon Nabievna Madzhidova, Dmitriy Vyacheslavovich Belov","doi":"10.34014/2227-1848-2023-4-55-63","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-55-63","url":null,"abstract":"The goal of the paper is to study risk factors and variations in the clinical course of cerebral venous thrombosis (CVT). Materials and Methods. We examined 50 patients with CVT aged 25–77 (mean age 52.5±14): 15 men (30.0 %) aged 46–75 (mean age 54±12) and 35 women (75.0 %) aged 25–77 (mean age 53.5±14). A complete clinical and neurological examination was carried out, including an assessment of complaints, medical history, neurological examinations, which distinguish variations in the clinical course. The most obvious risk factors for each variation in clinical course have been identified. Results. We have identified the following variations in the CVT clinical course: acute manifestation in the form of generalized epileptic seizures and/or impaired consciousness – 17 (34.0 %) cases; isolated headache – 10 (20.0 %) cases; focal neurological symptoms – 6 (12.0 %) cases; gradual onset – 17 (34.0 %) cases. For acute manifestation in the form of epileptic seizures and/or impaired consciousness, the most typical risk factors were arterial hypertension – 9 (52.9 %) cases, obesity – 10 (58.8 %) cases, insufficient physical activity – 9 (52.9 %) cases. For isolated headache and gradual onset option, cerebrovascular insufficiency was a statistically significant risk factor (p<0.05). The most significant risk factors for patients with focal neurological symptoms were arterial hypertension and atherosclerosis (p<0.05). There were no statistically significant differences in the cerebral thrombosis localization based on the clinical course. Conclusion. Identification of risk factors and variations in the CVT clinical course in combination with neuroimaging methods helps to improve CVT diagnosis.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"69 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MORPHOLOGICAL PATTERN OF BONE TISSUE DURING IMPLANTATION OF DISPERSED BIOCOMPOSITE BASED ON WOLLASTONITE","authors":"I. Afonin, V. I. Apanasevich, Sergey Viktorovich Zinov'ev, E. Papynov, I. Evdokimov, O. Shichalin, V. Usov, E. P. Kostiv, N. Plekhova","doi":"10.34014/2227-1848-2023-4-144-152","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-144-152","url":null,"abstract":"The purpose of the study is to analyze the structure of the bone tissue surrounding a tooth under normal conditions, after tooth extraction and after placing wollastonite / hydroxyapatite scaffolds into the mandibular alveolus of a test animal (rabbit). Materials and Methods. Female New Zealand White rabbits (n=9), raised on a farm, were used as test animals. The animals were 12 months old, and weighed 1.7–3 kg. Surgeries were performed in a veterinary clinic in Vladivostok, under combined anesthesia. Mandibular lateral incisors were extracted in test animals. The surgery was followed by alveoli augmentation with wollastonite/hydroxyapatite scaffolds. After surgical procedures, the wounds were tightly sutured with nonabsorbable suture material (Vicryl, USA). Surgical wounds were debrided for 15 days (0.9 % NaCl solution). During first 24-hours after the operation, the animals were on a soft no chew diet. The rabbits were under dynamic observation throughout the experiment. Results. Alveoli augmentation of the extracted incisors with wollastonite / hydroxyapatite scaffolds had a positive effect on bone regeneration. It led to a significant restoration of the cortical plate thickness and preservation of the bone beams volume of the mandibular alveolar process. This is evidenced by the results of a morphological study of histologic specimen obtained from experimental subjects (mandibular alveolar process). No toxic effects on surrounding tissues were detected. Conclusion. The study allows us to confirm the bioactive qualities of the synthesized wollastonite/hydroxyapatite scaffolds and prove the lack of toxic side-effects on surrounding tissues.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"60 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARAMETERS OF FREE RADICAL OXIDATION IN THE BLOOD OF PATIENTS WITH NON-SMALL CELL LUNG CANCER AND COVID-19 IN ANAMNESIS","authors":"O. I. Kit, I. A. Goroshinskaya, E. Frantsiyants, D. Kharagezov, L. Nemashkalova, Y. Lazutin, A. Milakin, I. Leyman, O. Stateshnyy, O. V. Pandova","doi":"10.34014/2227-1848-2023-4-73-87","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-4-73-87","url":null,"abstract":"The role of redox processes imbalance in the onset of malignant transformation and neoplasia progression is well known. It has been suggested that COVID-19 is a metabolic disease. Reactive oxygen species (ROS) and glutathione-dependent antioxidant system contribute much to its development. Moreover, there is an opinion that it is necessary to precisely identify free radical oxidation products that contribute to a redox status imbalance in the blood of COVID-19 patients. The purpose of the study is to evaluate the intensity of lipid peroxidation and parameters of the antioxidant system in the blood cells of lung cancer patients with COVID-19 in anamnesis. Materials and methods. We studied lymphocytes and neutrophils in the blood of patients with non-small cell lung cancer (NSCLC) stages I-IIIA (T1-3NХM0). The main group included 30 patients with NSCLC (15 men and 15 women) who had suffered severe and moderate COVID-19. The control group consisted of 15 men and 15 women with NSCLC who had asymptomatic or mild SARS-CoV-2. Conventional spectrophotometric methods were used to study the levels of malondialdehyde (MDA), diene conjugates (DC) and reduced glutathione (RG), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GP). Statistical analysis of the data was performed using Statistica 10.0. Results: In lung cancer patients of both sexes who had suffered severe COVID-19, MDA levels in lymphocytes and neutrophils were almost two times as high as those in patients with mild COVID-19. A higher DC level in men with severe COVID-19 in anamnesis was observed only in lymphocytes, and in women – in neutrophils. Women in both groups were characterized by higher levels of MDA, DC, and lymphocyte SOD activity compared with men. Increased RG level was observed only in the control group. In men with severe COVID-19, there was a decrease in SOD activity both in lymphocytes and neutrophils, accompanied by an increased RG level. Conclusion. In lung cancer patients with COVID-19 in anamnesis, CRP activation is observed. Its severity correlates with the past COVID-19 severity.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIDLINE HERNIAS: AXIOMS AND CURRENT SURGICAL TRENDS","authors":"K. Sergatskiy, Artem Vladimirovich Korobov, V. Nikol'skiy, V. Romanova, Ekaterina Valer'evna Titova, Aleksandr Semenovich Ivachev","doi":"10.34014/2227-1848-2023-2-47-61","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-47-61","url":null,"abstract":"Midline hernia is a pathological condition that is characterized by a protrusion of some internal organs through the holes in the aponeurotic plate of the abdominal raphe. \u0000The presented analytical study provides information on the likely risk factors for hernia formation, the assessment of which remains relevant today. Besides, the authors examine diagnosis and classification of midline hernias and describe the advantages and disadvantages of the proposed surgical methods of hernia treatment. Despite a large number of proposed surgical methods for midline hernia correction and treatment, all of them have certain disadvantages, mainly associated with a high incidence of reherniation and postoperative complications. The choice between the proposed methods of hernia orifice closure and intraoperative midline strengthening to prevent reherniation is important for any surgeon. \u0000The information search for the literature review was performed on the platforms elibrary.ru and pubmed.ncbi.nlm.nih.gov.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115669332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF ENVIRONMENTAL AND PUBLIC HEALTH STATUS UNDER ANTHROPOGENIC DISTURBANCE","authors":"S. Ermolaeva, D. I. Khisamutdinov","doi":"10.34014/2227-1848-2023-2-145-154","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-145-154","url":null,"abstract":"Anthropogenic impact on the environment increases public health risks and requires improved approaches to evaluate complex bio-ecological interactions. The purpose of the study is to develop a methodology for a comprehensive evaluation of the environmental quality and its impact on public health, taking into account natural environment, ecosystem and biological effects from anthropogenic pollution. \u0000Materials and Methods. The authors developed a model for comprehensive evaluation of environment and its impact on public health, in terms of natural environment, ecosystem stability, and response to external influences. \u0000Results. The authors calculated the environmental pollution indices in 24 municipal districts of the Ulyanovsk region and distributed them in terms of anthropogenic impact. The authors also identified districts with low/high ecosystem stability, and indicated zones with severe environmental pathologies. \u0000Conclusion. The developed model makes it possible to identify territories with poor environmental quality and poor public health. Such territories need special programs to manage environmental and public health risks.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115679654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF HOMOCYSTEINE IN THE PATHOGENESIS OF GYNECOLOGICAL DISEASES","authors":"Yuliya Dmitrievna Sidorova, Liana Yur'evna Davidyan, Azat Yur'evich Bogdasarov","doi":"10.34014/2227-1848-2023-2-86-97","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-86-97","url":null,"abstract":"Despite the fact that homocysteine was first described in 1932, at present, the study of changes in the synthesis and content of this amino acid reveals new mechanisms for the disease development. It should be mentioned that studies confirming the correlation between elevated homocysteine levels and human pathologies (cardiovascular diseases, pregnancy complications, neuropsychiatric disorders) have appeared only recently. This indicates that hyperhomocysteinemia has not been resolved and deserves clinicians’ and researchers’ attention. \u0000Most publications present studies on hyperhomocysteinemia as part of the pathogenesis of cardiovascular diseases. However, more recently, elevated homocysteine level has been considered as a marker in preeclampsia and postoperative thromboembolism, including that after reproductive surgery. It was noted that in early pregnancy the activation of endothelial cells is changed in women with hyperhomocysteinemia and uterine fibroids. It increases thrombosis risks, and later, during the chorion formation, an endothelial defect can cause fetoplacental insufficiency, and in case of endotheliosis progression lead to preeclampsia and eclampsia. In recent years, some authors associate hyperhomocysteinemia with disorders of the female reproductive system and ovulatory abilities, possible pathogenesis of benign tumors, pregnancy pathologies and delivery issues. \u0000A detailed study of elevated homocysteine in women can help in solving a number of issues, such as the role of hyperhopmocysteinemia in the pathogenesis of gynecological diseases and development of reproductive disorders. \u0000There is much information on the role of homocysteine in the development of endothelial dysfunction and significant metabolic disorders. At the same time, there is not enough studies on the changes in folate metabolism, which cause hyperhomocysteinemia and directly affect the development of endocrine gynecological and obstetric pathologies. These problems require further analysis. The correlation between the hyperhomocysteinemia and development of gynecological pathologies is currently one of the promising scientific areas. Special attention is paid to the pathogenesis of uterine fibroids in terms of vascular theory. Despite ongoing research, there is only insufficient information on the role of excess homocysteine in the pathogenesis of uterine fibroids.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128879704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF DIFFERENT LIGHT INTENSITIES ON GROWTH AND DEVELOPMENT OF ARTEMIA (ARTEMIA SALINA) IN AN ARTIFICIAL ECOSYSTEM","authors":"T. Shlenkina, E. Romanova, V. Romanov, Eler Beknur ugli Fazilov, V. Lyubomirova, E. Sveshnikova","doi":"10.34014/2227-1848-2023-2-166-180","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-166-180","url":null,"abstract":"Artemia nauplii are the best initital food for most fish larvae. Feeder fish, Artemia nauplii, contain the ingredients necessary for the survival of aquatic organisms during critical periods of early postembryonic ontogenesis. Thus, it is important to improve the biotechnology of Artemia cultivation in artificial ecosystems. \u0000Materials and Methods. In the course of the study, various illumination modes were used, namely, 1.5; 2.5 and 4 klx to determine the most effective one. \u0000Results. Various illumination modes affect Artemia development in different ways. The most effective illumination mode at the stage of embryonic development and the initial stages of postembryonic ontogenesis was 4 klx.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124053143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AS AN INDICATION FOR COMPUTERIZED ELECTROACUPUNCTURE: RESULTS OF PROSPECTIVE CLINICAL STUDIES","authors":"M.P. Khokhlov, A. B. Peskov, E. Yudina, T.S. Golubtsova, S.A. Pribylova, I.R. Kerova, V. V. Gnoevykh","doi":"10.34014/2227-1848-2023-2-121-131","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-121-131","url":null,"abstract":"The purpose of the study is to evaluate the effect of the phase (exacerbation / remission) of chronic obstructive pulmonary disease (COPD) on the effectiveness of computerized electroacupuncture (CEAP). \u0000Materials and Methods. COPD patients took part in a two-stage study. During the first study phase, 80 COPD patients were randomized into two equal groups, regardless of the disease phase. Group I patients underwent a 5-day CEAP combined with standard pharmacotherapy, group II patients received isolated pharmacotherapy. The second study phase involved 33 patients with COPD exacerbation (Group O) and 32 patients with COPD remission (Group P). These patients underwent standard pharmacotherapy and a 5-day CEAP. The treatment effectiveness was evaluated according to the dynamics of respiratory function and the mMRC dyspnea scale. \u0000Results. At the first phase, the parameters of respiratory function and mMRC questionnaire did not have any significant changes in both comparison groups. However, in patients with COPD exacerbation, the rate of a positive clinical response was higher than in patients in remission (59 % and 17 %, respectively). During the second phase, in Group O, CEAP was accompanied by an increase in respiratory function and a decrease in dyspnea severity (mMRC questionnaire). In group P, the parameters did not change significantly. \u0000Conclusion. CEAP is more effective in COPD treatment if it is used during the exacerbation phase.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116258577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTIVENESS OF SYNTHETIC IMPLANTS FOR GENITAL PROLAPSE SURGERY","authors":"I. M. Ordiyants, I. A. Aleev, E.G. Ordiyants, D. R. Asatryan","doi":"10.34014/2227-1848-2023-2-98-106","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-98-106","url":null,"abstract":"The aim of the study is to evaluate the effectiveness of synthetic implants for genital prolapse surgery in women of different age groups. \u0000Materials and Methods. 139 patients underwent genital prolapse surgery, vaginal approach, with synthetic mesh and biologic grafts. For the anterior, posterior and complete reconstruction of the vaginal walls, two mesh implants were used: Pelvix (Lintex, Russia) and Prolift (Ethicon Women´s Health and Urology, Johnson and Johnson Company, USA). The size of mesh implant was adapted to each particular case. \u0000Results. The most common intraoperative complication was intraoperative blood loss. During pelvic floor reconstruction with mesh implants, it was 1.8 times and 1.5 times higher in reproductive age and perimenopause respectively, compared with grafts. In postmenopause, there was a tendency to greater blood loss in surgeries with biological grafts. In reproductive age, the frequency of early postoperative complications was the same for mesh and non-mesh repair. In perimenopause, complications were three times more often for mesh repair, and in postmenopause, complications were observed in every third examined patient, regardless of the repair used. Late postoperative complications (pelvic pain and dyspareunia) occurred more often for biological graft: in reproductive age – twice, in perimenopause – 1.5 times, and in postmenopause – 5 times as frequently as for mesh. \u0000Conclusion. Prolapse surgery with synthetic implants is effective, safe and justified in terms of pathogenesis.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125240001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}