Ulyanovsk Medico-biological Journal最新文献

{"title":"CYTOKINE BLOOD PROFILE IN PATIENTS WITH DIFFUSE LIVER DISEASE COMBINED WITH EPSTEIN-BARR VIRUS AND SECONDARY IMMUNODEFICIENCY","authors":"Marina Yur'evna Perfil'eva, Y. Sotskaya","doi":"10.34014/2227-1848-2023-2-76-85","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-76-85","url":null,"abstract":"The aim of the paper is to study cytokine blood profile (CBP) in patients with chronic diffuse liver disease (DLD) associated with the Epstein-Barr virus (EBV) and secondary immunodeficiency (SID), using a combination of drugs with hepatoprotective (arginine glutamate) and immunomodulatory effects (aminodihydrophthalazinedione sodium). \u0000Materials and Methods. The authors examined 66 patients, aged 19–45, with DLD, associated with EBV and SID. The main group consisted of 34 patients, whereas the experimental group enrolled 32 patients. When developing a therapy program for such patients the authors paid attention to a combination of drugs with hepatoprotective (arginine glutamate) and immunomodulatory effects (aminodihydrophthalazinedione sodium). Patients from the main group, in addition to conventional therapy, received combined therapy with the above-mentioned drugs. \u0000Results. All patients were under dynamic observation. Before treatment, patients of both groups had similar CBP imbalance, which was characterized by an increase in pro-inflammatory cytokines – TNF-α and IL-1β and a moderate increase in anti-inflammatory IL-4 and IL-10. After treatment, patients of the main group, who received aminodihydrophthalazinedione sodium and arginine glutamate, demonstrated normalization in CBP parameters, while the parameters of the patients from the comparison group exceeded the norm. \u0000Conclusion. Combined therapy in the complex treatment of patients with chronic DLD, combined with EBV and SID, contributes to the normalization of the studied CBP parameters (TNF-α, IL-1β, IL-4, IL-10).","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129545085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHYSIOLOGICAL RISK FACTORS CAUSED BY LOW PHYSICAL ACTIVITY","authors":"N. V. Sibiryakova","doi":"10.34014/2227-1848-2023-2-132-144","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-132-144","url":null,"abstract":"The biological need for movement is inherent in all living organisms, including a human being. It determines functionality and performance of the organism. However, a change in the lifestyle of modern people has led to a limitation of their physical activity. In this regard, the younger generation is of particular concern. The May 2017 WHO report, Global Accelerated Action for the Health of Adolescent (AA-HA!): Guidance to Support Country Implementation, noted that “more than 3000 adolescents die every day from largely preventable causes and that many key risk factors for future adult disease start or are consolidated in adolescence.” The low level of physical activity, observed throughout the world, is a risk factor for the development of many functional disorders and diseases. \u0000The physiological mechanisms of physical activity are being thoroughly studied. There are many publications devoted to the impact of physical activity on physiological processes. However, these studies are fragmented due to the constantly changing factors of human life (quarantine measures, distance learning, remote work). \u0000The paper presents a systematic review of publications devoted to the influence of physical activity on the physiological processes of the body. The authors used articles from databases Medline, Scopus, Pubmed, Cochrane, Embase, Web of Science, Google Scholar, eLIBRARY, and Cyberleninka for the review. Such terms as physical activity, low level of physical activity, sedentary lifestyle, hypokinesia, hypodynamia were used for the keyword search.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128453949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN IDEAS ON THE ROLE OF HEMODYNAMIC DISORDERS IN THE PATHOGENESIS OF ACUTE PANCREATITIS","authors":"O. Midlenko, V. Midlenko, Andrey Ivanovich Chavga, Stanislava Konstantinovna Lonskaya, Yakov Dmitrievich Popondopolo, Irina Olegovna Popondopolo","doi":"10.34014/2227-1848-2023-2-30-46","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-30-46","url":null,"abstract":"Acute pancreatitis remains one of the most common abdominal diseases, causing a large number of both local and systemic complications. Acute pancreatitis has a high death rate. The pathogenesis of acute pancreatitis is complex and needs careful examination. Many authors suppose, that hemodynamic disorders lead to the development of complications, often fatal. Thus, such disorders need be studied separately. \u0000The review is based on the analysis of articles included in such databases as elibrary.ru, cyberleninka.ru, and e-versions of specialized open access journals. All the articles outline modern views on the role of hemodynamic disorders in the pathogenesis of acute pancreatitis. \u0000The causes and mechanisms of development of hemodynamic disorders are considered in terms of central and regional hemodynamics, and microcirculation. The authors describe their mutual influence and role in the development of both local and systemic complications of acute pancreatitis. \u0000Contractility disorders can be observed in the pathogenesis of central hemodynamics. They can be caused by a highly active myocardial depressant factor. These disorders are supported and aggravated by other organs and systems with the development of multiple organ failure. \u0000Violations of regional hemodynamics are associated mainly with an increase in intra-abdominal pressure. A direct dependence of intestinal wall perfusion on intra-abdominal pressure is established. Intestinal barrier dysfunction contributes to the infection of necrosis foci. \u0000Microcirculation disorders are the most important element in the pathogenesis of acute pancreatitis, often defining its outcome. Microcirculation disorders include angiospasm, venous stasis, microthrombi formation, and interstitial edema. A decrease in local perfusion due to impaired gland microcirculation can cause tissue ischemia and pancreonecrosis.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132958360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF ONE-STAGE AND TWO-STAGE EXTENSIVE SURGICAL RESECTIONS IN LIVER ECHINOCOCCOSIS","authors":"A. O. Krasnov, V. V. Anishchenko, I. V. Pachgin, K. A. Krasnov, Vladislav Aleksandrovich Pel'ts, O. A. Krasnov, V. Pavlenko","doi":"10.34014/2227-1848-2023-2-62-75","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-62-75","url":null,"abstract":"Surgery is the main effective way to treat liver echinococcosis. The problem of choosing a surgical technique for treating liver echinococcosis under impaired liver functional reserve and development of post- hepatectomy liver failure remains relevant. \u0000The aim of the study is to analyze the effectiveness of extensive surgical resections while treating patients with liver echinococcosis. \u0000Materials and Methods. The article presents the results of surgical treatment of 85 patients with liver echinococcosis from 2006 to 2022. All patient underwent extensive liver resection: 61 patients (71.8 %) were operated on according to one-stage extensive surgical resection protocol; 24 patients (28.2 %) were operated on according to two-stage extensive surgical resection protocol. \u0000Results. The applied surgical step-by-step methods for prevention of post-resection liver failure were effective in 24 patients (100 %), Group 2. Three deaths (3.5 %) were recorded in the total mass of the trial patients. Progressive post-resection liver failure was the cause of deaths. After the introduction of a new examination protocol into clinical practice, the authors observed no deaths after extensive surgery resections because of the development of post-resection liver failure. Moreover, no relapses were observed after extensive surgery resections. \u0000Conclusion. Extensive surgical resections in patients with liver echinococcosis are effective and sufficiently safe when performed in specialized hepatological centers using an in-depth preoperative protocol. Two-stage surgical resections can be recommended in case of initial significant deficit in the volume of the future liver remnant and functional organ reserves.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130956644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTENSITY OF HEAVY METAL AND ARSENIC ACCUMULATION IN MEDICINAL PLANTS OF SYNANTHROPIC FLORA IN VORONEZH REGION","authors":"N. A. D'yakova","doi":"10.34014/2227-1848-2023-2-155-165","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-155-165","url":null,"abstract":"The aim of this study is to examine the peculiarities of the accumulation of the most dangerous heavy metals and arsenic in medicinal plant raw material of the synanthropic flora in the Voronezh region. \u0000Materials and Methods. The study was carried out by atomic absorption spectrometry. The author studied the accumulation of heavy metals (lead, mercury, cadmium, nickel, copper, zinc, cobalt, chromium) and arsenic in 10 types of medicinal plant raw materials harvested in 51 locations (Voronezh region), which differ in terms of anthropogenic impact. \u0000Results. The highest level of lead consentration was noted in Taraxacum officinale F.H. Wigg, and Arctium lappa L. roots, Рolygonum aviculare L. and Plantago major L. leaves. Mercury concentration in all studied samples was rather low. A bit higher mercury concentration was noted in Plantago major L and Urtica dioica L. leaves, and Artemisia absinthium L. High cadmium concentration was found in Taraxacum officinale F.H. Wigg and Arctium lappa L. roots, Plantago major L. leaves, Artemisia absinthium L. and Leonurus quinquelobatus Gilib. Arsenic accumulated intensively in Plantago major L. leaves, Arctium lappa L. roots, Artemisia absinthium L. and Achillea millefolium L. Nickel accumulated intensively in Plantago major L. and Urtica dioica L. leaves, Рolygonum aviculare L. and Leonurus quinquelobatus Gilib. Zinc accumulated mainly in the roots and herbs themselves. Having analyzed the accumulation coefficients of heavy metals and arsenic for all studied medicinal plant raw materials, we organized the heavy metals and arsenic in the decreasing order: zinc > copper > cadmium > cobalt > nickel > arsenic > chromium > lead > mercury.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127704104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOLECULAR AND CELLULAR MECHANISMS OF HYPOXIC RESPONSE","authors":"N. Bondarenko, Evgeniy Vladimirovich Khomutov, Tat'yana Leonidovna Ryapolova, M. Kishenya, Tat'yana Stepanovna Ignatenko, Vitaliy Arkad'evich Tolstoy, I. S. Evtushenko, S. V. Tumanova","doi":"10.34014/2227-1848-2023-2-6-29","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-6-29","url":null,"abstract":"Hypoxia is a typical pathological process characterized by oxygen tissue deficiency with the pathological and protective-compensatory reactions. The article briefly outlines the issues of hypoxia study and interval hypoxic training in clinical and rehabilitation practice while treating various diseases and pathological processes. The authors consider types of physiological and pathological responses to hypoxia, key aspects in the pathogenesis of normo- and hypobaric hypoxia under normal and reduced atmospheric pressure, and stages of hypoxia development. Physiological and biochemical responses to interval hypoxic training are associated with oxidative stress, which develops as a result of an imbalance between the pro- and antioxidant systems, and excessive production of reactive oxygen species. Interval hypoxic training is aimed at adequate activation of defense systems with the formation of stable adaptation to damaging factors. The authors prove the key role of HIF-1α biological effects in the mechanisms of cellular and tissue adaptation to oxygen deficiency. The authors also analyze the role of adenosine and adenosine receptors in acute and chronic inflammatory diseases associated with tissue hypoxia.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131188291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF TOXICITY OF BENZIMIDAZOLE DERIVATIVES AND THEIR EFFECT ON FUNCTIONAL PARAMETERS OF CERIODAPHNIA DUBIA RICHARD, 1894","authors":"Elena Mikhaylovna Fomicheva, L. I. Savina","doi":"10.34014/2227-1848-2023-2-181-194","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-181-194","url":null,"abstract":"Recently, due to active development of the pharmaceutical industry, an acute problem of environmental pollution with synthetic biologically active compounds has arisen. Benzimidazole cycle is one of the most frequently encountered pharmacophores in drugs. Substances containing even microquantities of benzimidazole have a toxic effect on living systems. Besides, being alien to nature, benzimidazoles are not included in metabolic processes and do not decompose for a long time. Evaluation of benzimidazole toxicity, its stability in the aquatic environment, benzimidazole impact on biological parameters will make it possible to predict possible changes in the populations of ceriodaphnia and other aquatic organisms. \u0000The purpose of the work is to evaluate the toxicity of benzimidazole derivatives and their effect on the survival and fertility of Ceriodaphnia dubia Richard, 1894. \u0000Materials and Methods. In acute and chronic experiments, the authors determoined parameters standard for toxicological studies: median lethal concentrations (LC50), life expectancy, total number of offspring, number of litters per female, and average hatching time. The stability of the toxicity of benzimidazole derivatives was established in terms of Ceriodaphnia dubia lethality during a 30-day exposure. \u0000Results. The authors evaluated the toxicity of benzimidazole and its seven derivatives for ceriodaphnia in terms of the 48-hour median lethal concentration, depending on their structure. The highest toxicity was noted for 5-bromo-2-(trifluoromethyl)-1H-benzimidazole (LC50 2.4 mg/l), the lowest one for 2-methyl-1H-benzimidazole (LC50 109.7 mg/l). It has been shown that long-term exposure (38 days) to potassium salt of pyrido[1,2-a]benzimidazole-7-carboxylic acid (LC50 69.18 mg/l) at a concentration of 20 mg/l in a chronic experiment does not lead to a statistically significant change in survival and fertility parameters of ceriodaphnia. Stability evaluation of toxicity of the potassium salt of pyrido[1,2-a]benzimidazole-7-carboxylic acid and residual toxicity of its degradation products revealed a relatively low stability of the compound toxicity. \u0000Conclusion. The toxicological evaluation of benzimidazole derivatives for hydrobionts showed the correlation between the degree of their toxicity and structural features.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"72 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116287034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND PSYCHOSOCIAL FACTORS DETERMINING THE QUALITY OF LIFE IN PATIENTS WITH ISCHEMIC STROKE","authors":"Ol'ga Aleksandrovna Morozova, Maksim Yur'evich Kiktev, I. G. Zolkornyaev","doi":"10.34014/2227-1848-2023-2-107-120","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-2-107-120","url":null,"abstract":"Acute cerebrovascular pathology, including common clinical forms such as ischemic stroke, remains the most important medical and socio-economic challenge, due to the severe consequences of the post-stroke period. Cognitive impairments are the most socially significant ones. \u0000The aim of the study is to assess the influence of psychosocial and clinical factors on the quality of life of patients with ischemic stroke. \u0000Materials and Methods. The authors examined 100 patients with ischemic stroke (54 men, 46 women). The age of patients ranged from 35–85; the average age of men was 59.6±11.0 years, the average age of women – 60.7±10.4 years. The authors interviewed the patients, conducted neurological examination, and neuropsychological testing using the HADS, MMSE scales, Personality Questionnaire of the Bekhterev Institute, SCL-90-R, and the SAGE test. Statistical processing was carried out using non-parametric (Mann–Whitney U test) and parametric (Student’s t-test) criteria. \u0000Results. The study establishes the main clinical and psychosocial factors of the acute period of ischemic stroke, which have the most significant impact on the patients’ quality of life. The most important are cognitive impairments associated with disorders of psycho-emotional background and autonomic regulation. They greatly reduce the adaptive abilities of a person. Despite neuropsychological and cognitive impairments, the motivation level for recovery remains high in all patients with ischemic stroke. \u0000Conclusions. While developing personalized rehabilitation programs, it is necessary to take into account personal characteristics of patients and to focus on the active restoration of their adaptive-compensatory capabilities.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128536108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NITRIC OXIDE IN BLOOD PLASMA OF WISTAR RATS RECEIVING VITAMIN D3","authors":"O. Parshukova, N. Potolitsyna, Zhanna Evgen'evna Ivankova, N. Alisultanova, N. Vakhnina, Lyubov' Borisovna Kalikova, Anastasiya Mikhaylovna Tret'yakova, A. Chernykh, V. Shadrina, E. Boyko","doi":"10.34014/2227-1848-2023-1-155-164","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-155-164","url":null,"abstract":"Recently, much data has been published on the correlation between vitamin D and endothelium. Which is known to regulate vascular homeostasis and hemodynamics. Nitric oxide is characterized by a strong vasodilating effect. It is also a powerful inhibitor of platelet aggregation and adhesion to the vascular wall. Vitamin D and its receptors can regulate the nitric oxide synthesis by changing the activity of endothelial NO synthase. \u0000The purpose of the study was to examine the effect of vitamin D3 (emulsion) consumption on the level of nitric oxide in the blood of Wistar rats. \u0000Materials and Methods. The study was carried out on mature male Wistar rats weighing 200–300 g (aged 2–3 months). The rats were randomly divided into two groups: 1) control (n=6), kept in vivarium during the whole experiment, 2) experimental (n=6), daily receiving vitamin D3 in emulsion for 30 days. The calculation of vitamin D3 dose was based on the recommended daily amount of vitamin D3 for an adult person (4000 IU). A biochemical blood test determined 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and the level of stable nitric oxide metabolites. Statistica software was used for statistical analysis. \u0000Results. The trial study showed that a 30-day intake of vitamin D3 in emulsion increased its concentration and the nitric oxide level in the blood of rats. It may indicate the intensification of the enzymatic nitric oxide synthesis and the improvement in endothelial function. \u0000Conclusion. Thus, vitamin D and nitric oxide are important functionally correlated compounds. Adequate vitamin D status can mitigate the development of cardiovascular disease.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"85 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132480078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS OF NORMOBARIC HYPOXIA STRESS IN HUMANS","authors":"E. Burykh, O. Parshukova","doi":"10.34014/2227-1848-2023-1-104-113","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-104-113","url":null,"abstract":"The aim of the study is to examine the dynamics of the sympathoadrenal and adrenocortical components of acute normobaric hypoxia stress and their correlation with some physiological and biochemical parameters characterizing the energy metabolism in humans. \u0000Materials and methods. Fourteen trial subjects were exposed to 40-minute hypoxia while breathing nitrogen-oxygen mixture containing 9 % of oxygen. At 5th, 10th, 20th, and 40th minutes of hypoxia, blood was taken from the cubital vein for further analysis. The authors determined a number of physiological parameters, such as pulse rate; blood pressure; oxygen consumption; rheographic index of cerebral blood flow. We also evaluated epinephrine, norepinephrine, cortisol, lactate and glucose blood levels at the time of sampling. The authors estimated the increase in parameters at control points compared to baseline, as well as the correlation of the increase in various indicators. \u0000Results. A significant increase in blood epinephrine (max. min 20), norepinephrine (max. min 10) and lactate (max. min 40) was found in trial subjects under hypoxia compared to baseline parameters. A significant increase in oxygen consumption and rheographic index of cerebral blood flow was established under hypoxia (max. min 40). The longer the trial subject was exposed to hypoxia, the more the degree of conjugation in the dynamics of sympathoadrenal response, cerebral blood flow, and energy metabolism (lactate, glucose) was. \u0000Conclusion. The obtained facts prove the heterochrony of sympathoadrenal and adrenocortical stress components in the dynamics of the human body response to acute normobaric hypoxia. With hypoxia development, the impact of the adrenergic component on mobilizing the energy of glycolytic processes increases.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130450724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}