Ulyanovsk Medico-biological Journal最新文献

{"title":"EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (DICLOFENAC, CELECOXIB, NIMESULIDE, DIACEREIN) ON RENAL TRANSPORT OF URIC ACID IN PATIENTS WITH OXALATE NEPHROPATHY AND CONCOMITANT GONARTHRITIS","authors":"Natal'ya Vladimirovna Voronina, Danir Danisovich Gel'mutdinov, O. Lemeshchenko","doi":"10.34014/2227-1848-2023-1-27-42","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-27-42","url":null,"abstract":"The aim of the study is to evaluate the excreted uric acid fraction in patients with oxalate nephropathy in the early stages of chronic kidney disease with gonarthritis under non-steroidal anti-inflammatory drug therapy. \u0000Materials and Methods. An open, comparative, randomized study included 192 women, aged 51.4±2.3, with oxalate nephropathy and primary gonarthritis. The glomerular filtration rate was >60 ml/min, BMI – 23.4±1.8. The first group of patients was taking Diclofenac Sodium (4500 mg/month), the second group – Celecoxib (6000 mg/month), the third group – Nimesulide (6000 mg/month), the fourth group – Diacerein (6000 mg/2 months). The control group for each drug consisted of patients with gonarthritis, but without nephropathy and hyperuricemia. The patients of the control groups were treated similarly. The excreted fraction of uric acid in the subjects was assessed on Day 15, Day 30, and Day 60 according to generally accepted methods. \u0000Results. A decrease in the excreted fraction of uric acid, hyperuricemia, and a decrease in the glomerular filtration rate were observed in patients taking Diclofenac. After one-month Diclofenac withdrawl, the parameters did not return to their original levels. Celecoxib and Nimesulide had margical effect on the changes of the excreted uric acid fraction and a decrease in glomerular filtration rate. A month after their withdrawl, the parameters returned to their original levels. Diacerein had no effect on the renal transport of uric acid. No significant changes were noted in the control.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123073530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REMODELING OF THE AERO-HEMATIC LUNG BARRIER COMPONENTS UNDER HIGH ALTITUDES","authors":"V. V. Matvienko, I. Abdumalikova, Y. Shidakov, A. V. Margaryan, O. V. Zakharchuk, O. F. Istomina, V. A. Shidin, T. Tulekeev","doi":"10.34014/2227-1848-2023-1-114-124","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-114-124","url":null,"abstract":"The aim of the study is to examine structural and ultrastructural aero-hematic barrier (AHB) changes in rats during adaptation to high-altitude hypoxia. \u0000Materials and Methods. The experiments were carried out on 60 sexually mature outbred laboratory male rats weighing 140–160 g at high altitude (3200 m above sea level). The authors followed Mayer's hematoxylin and eosin staining protocol, and used transmission and scanning electron microscopy on the 7th, 15th and 30th days of the animals' life in the mountains. Statistical data processing was carried out using Statistica 6.0 (USA) and StatTech v. 2.8.4 (Russia) and Student's t-test. Differences were considered statistically significant at p<0.05. \u0000Results. At early stages of high-altitude adaptation, dystrophic changes in the epithelial layer of lung capillaries, hypertrophy and hyperplasia of histiocytes, fibroblasts and lipofibroblasts were noted. The authors also revealed proliferation of type II alveolocytes, thickening of the interalveolar septa (IAS) and cytoplasmic processes of endotheliocytes, destruction of type II alveolocytes (apocrine method, with the release of surfactant into the alveoli lumen), multivesicular lamellar bodies in the cytoplasm of type II alveolocytes; interstitial edema with transudate in the alveoli lumen. In later periods, surfactant system activity decreases due to a reduced release of osmiophilic lamellated corpuscles (OLC) into the alveoli lumen. The main AHB components are next to control data, while the IAS thickness exceeds the norm. In the alveoli wall, the number of fibroblasts increases, causing an increase in the number of Kohn's pores and providing collateral breathing. \u0000Conclusion. The study of AHD components in experimental animals at different periods of high-altitude adaptation revealed dystrophic processes of AHD in IAS, compensated by type I alveolocytes and proliferation of type II alveolocytes, confirming the adaptive mechanisms of ultrastructural alteration of all epithelial and endothelial components of the pulmonary alveoli.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130459975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PATHOGENESIS OF AUTONOMIC AND PERIPHERAL NEUROPATHY IN PATIENTS WITH PSORIASIS","authors":"Mariya Vladimirovna Mashina, Aleksey Sergeevich Nesterov, L. A. Belova","doi":"10.34014/2227-1848-2023-1-63-73","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-63-73","url":null,"abstract":"There is enough data confirming the common mechanisms of damage to the nervous system and skin in psoriasis. Cardiac autonomic denervation is a mechanism of cardiovascular pathology in psoriasis. Thus, a simultaneous disturbance of sympathetic and parasympathetic impact on vascular tone and heart rhythm has been established. When performing an active orthotest in trial subjects, heart rate centralization and decreased autonomous circuit activity were found. In psoriasis, vegetative-vascular dystonia develops due to metabolic disorders that occur in diabetes mellitus. Inflammatory cytokines Th-1, adhesion molecules, and angiogenic factors are involved in pathological processes in obesity, diabetes, metabolic syndrome, and thrombotic complications. Microangiopathy, which develops in psoriasis, reduces the response of blood vessels to autonomic innervation. Such negative influences eventually lead to a persistent alteration of the autonomic nervous control. The authors resent the results of a few studies on the peripheral nervous system in patients with psoriasis. There is evidence of a symmetrical alteration of vibration, tactile, pain and temperature sensitivity in the distal regions of all four limbs. There are some histological studies of the sural nerve in patients with psoriasis, which indicate demyelination of nerve fibers. In this regard, the study of neuropathy pathogenesis in psoriasis is necessary to improve the disease course and the effectiveness of psoriasis therapy. \u0000Assessment of psoriatic lesion severity and timely detection of cardiac denervation will reduce the risk of fatal cardiovascular complications. Instrumental diagnostics of the peripheral nervous system will make it possible to differentiate damage to muscle and nerve fibers in psoriasis.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127628290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LIPOSOMAL TECHNOLOGIES FOR SILYBIN DELIVERY TO THE LIVER IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE","authors":"C. Pavlov, Taisiya Alekseevna Turankova, Dar'ya Leonidovna Varganova","doi":"10.34014/2227-1848-2023-1-50-62","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-50-62","url":null,"abstract":"The aim of the study is to evaluate the effectiveness and safety of liposomal technologies in the treatment of non-alcoholic fatty liver disease (NAFLD) using Silybin (Lipoliv) as an example. \u0000Materials and Methods. The authors conducted a randomized placebo-controlled study approved by the ethics committee. The study included 111 subjects with NAFLD, aged 18–65. Lipoliv therapy (experimental group) or placebo therapy (control group) lasted for 12 weeks, the trial subjects received 1 capsule per day. The authors evaluated success rates, such as steatohepatitis activity (AST, ALT), severity of liver steatosis (transient elastography with controlled attenuation parameter), quality of life(SF-36 questionnaire); and safety profile: adverse events. Statistical analysis was carried out using the StatTech v. 1.2.0. \u0000Results. The subjects of the experimental group demonstrated a significant decrease in ALT (p<0.001) and AST (p<0.001) levels as well as in steatosis (p<0.001) after treatment. There was a significant improvement in the parameters of physical and mental well-being in both groups (p<0.001). No adverse reactions or therapy interruption were noted. \u0000Conclusion. When treating patients with NAFLD, the effectiveness of Silybin, synthesized with liposomal technologies (Lipoliv), was confirmed by a significant decrease in steatohepatitis activity, improved quality of life, and a decrease in steatosis severity. The drug demonstrated a high safety profile.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132168465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTERVAL HYPOXIC HYPEROXIC TREATMENT IN THE REHABILITATION OF POST-COVID-19 PATIENTS","authors":"A. Ivanov, I. Borukaeva, Z. Abazova, I. Misirova, L. Bizhoeva, Diana Ramazanovna Ligidova","doi":"10.34014/2227-1848-2023-1-125-136","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-125-136","url":null,"abstract":"The aim of the study is to reveal the main pathogenetic mechanisms of the effectiveness of interval hypoxic hyperoxic treatment in the rehabilitation of post-COVID-19 patients. \u0000Materials and Methods. Hypo-Oxy, hypoxic therapy device produced by Oxyterra (Russia) was used to generate a hypoxic mixture with different oxygen content. Hypoxic periods followed the hyperoxic ones (30 % O2). To determine individual sensitivity to hypoxia, patients underwent a hypoxic test, the results of which were used to select the optimal oxygen content in the hypoxic mixture, the duration of hypoxic effects and the number of sessions. The authors determined the parameters of the functional respiratory system, oxygen regimen, lipid peroxidation, antioxidant system, exhaled air condensate and coagulation system. Statistical processing was carried out in accordance with the rules of mathematical statistics using Microsoft Excel and Statistica 6.0 for Windows. When conducting parametric analysis, paired and unpaired Student's t-tests were used. All numerical data were presented as the arithmetic mean and standard error of the mean (M±m). Differences were considered statistically significant at p<0.05. \u0000Results. Interval hypoxic hyperoxic treatment has proven to be an effective way to rehabilitate post-COVID-19 patients (medium severity). After hypoxic therapy, there was a decrease in respiratory, circulatory, hemic and tissue hypoxia, and an improvement in the parameters of the prooxidant and antioxidant systems. Hypoxic therapy had a normalizing effect on the hemostasis system: platelet count in the blood increased (p<0.05) (it was low before hypoxic therapy). Activated partial thromboplastin time, international normalized ratio, and antithrombin III content also increased. Prothrombin index, fibrinogen and D-dimer content in the blood serum showed a decreased risk of thrombosis. \u0000Conclusion. The conducted studies have proven the high efficiency of interval hypoxic hyperoxic treatment in the rehabilitation of post-COVID-19 patients.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"95 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116646248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOTHELIN-1 LEVEL IN BLOOD AND LUNG TISSUE IN POST-COVID-19 PATIENTS WITH NON-SMALL CELL LUNG CARCINOMA","authors":"O. Kit, E. Frantsiyants, D. Kharagezov, E. Surikova, I. Goroshinskaya, V. Bandovkina, N. Cheryarina, A. Shikhlyarova, Y. Pogorelova, T. Ayrapetova, Y. Lazutin, A. Milakin, I. Leyman, O. Stateshnyy","doi":"10.34014/2227-1848-2023-1-74-90","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-74-90","url":null,"abstract":"Long-term consequences of COVID-19 are associated with persistent endothelial dysfunction, so it is important to study both infectious and oncological processes. \u0000The aim of the study was to examine endothelin-1 (ET-1) level in the blood and lung tissues of post-COVID-19 patients (men and women) with non-small cell lung carcinoma (NSCLC). \u0000Materials and Methods. We examined 60 patients (59.1±3.9 years of age) with verified NSCLC, T1-3NxM0, hospitalized at the National Medical Research Center for Oncology in 2020–2021. All patients had a history of asymptomatic/mild COVID-19 (control group) or severe/moderate COVID-19 (main group). We also examined 15 healthy people (of the same age and sex) who did not suffer from COVID-19 at the time of blood sampling (donor group). The levels of endothelin-1 (ET-1-38, ET-1-21) were measured by ELISA in blood plasma of all trial subjects and in lung tissues these parameters were measured only in NSCLC patients before treatment. \u0000Results. In NSCLC patients of the main group, ET-1-21 level in plasma was on average twice as high as that in the control group and in donors. In the tumor and the perifocal zone, ET-1-21 level was higher than that in the resection line tissue: by 1.4–2.7 times in the control group, by 1.6–7.6 times in the main group in men and women. At the same time, women of the main group had a significantly more pronounced increase in ET-1-21 level in the perifocal zone and a decrease in the tumor tissue compared to that in the control group. ET-1-38 level in the control group was 3 and 2.1 times as low as in the tumor and perifocal zone, and in the main group it was 2.8 times as high in the perifocal zone in women as that in the resection line tissue. Gender differences in ET-1 level in both groups of patients were revealed. \u0000Conclusion. In NSCLC post-COVID-19 patients, changes in the endothelin-1 level were found, which could be caused not only by long-term endothelium dysfunction, but which also could modify NSCLC development.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128988453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATYPICAL HEMOLYTIC UREMIC SYNDROME: A CASE STUDY","authors":"L. A. Rogozina, I. L. Davydkin, O. V. Fatenkov, O. E. Danilova, R. K. Khayretdinov, G. R. Gimatdinova","doi":"10.34014/2227-1848-2023-1-6-13","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-6-13","url":null,"abstract":"Atypical hemolytic uremic syndrome (aHUS) is a systemic disease, a type of thrombotic microangiopathy (TMA). It is based on uncontrolled activation of the alternative complement pathway of a hereditary or acquired nature, leading to generalized thrombosis in the microvasculature. Chronic activation of the alternative complement pathway leads to the damage of endothelial cells, erythrocytes and platelets and, as a result, to thrombotic microangiopathy and systemic multiorgan damage. Currently, in roughly half of the cases, it is impossible to identify aHUS triggers. Fresh frozen plasma (FFP) is used as first-line drug to reverse the symptoms. It helps to eliminate the deficiency of self-proteins – complement factor H and complement factor I (CFH and CFI), membrane cofactor protein (MCP), and stable and labile proteins – factors of hemostasis, and to stop thrombosis in the microvasculature. FFP administration is a preparatory step before anticomplementary therapy. Disease prognosis is always serious and is associated with severe complications and high mortality. At least 6 % of patients develop multiple organ failure with generalized TMA, injury of the central nervous system, gastrointestinal tract, lungs, and kidneys. The paper describes a clinical case of a patient with aHUS.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126534150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF SODIUM CHANNELS IN THE DEVELOPMENT OF OXIDATIVE STRESS IN ISCHEMIA/REPERFUSION MODEL","authors":"E. Yurova, E. Pogodina, E. Rastorgueva, E. Beloborodov, D. Sugak, A. N. Fomin, Y. Saenko","doi":"10.34014/2227-1848-2023-1-145-154","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-145-154","url":null,"abstract":"Ischemic and reperfusion injury is a critical condition, as it is necessary to control cell death and maintain tissue function. Restoration of nutrient and oxygen flow causes secondary damage to ischemic cells and is called reperfusion injury. Reperfusion injury causes, on the one hand, fluctuations in ion concentration inside cells, in particular sodium ions, due to changes in the conductivity of voltage-dependent ion channels, and, on the other hand, activation of the antioxidant system as a response to oxidative stress, in which the key role is given to reactive oxygen species and nitric oxide. Thus, the effect of ion channel inhibitors on the progression of oxidative stress, apoptosis and necrosis during reperfusion is of particular interest. \u0000The aim of the study is to examine the impact of sodium channels on oxidative stress under ischemic and reperfusion injury and sodium channel blockers action. \u0000Materials and Methods. The authors studied the influence of the synthesized peptide toxin, an inhibitor of voltage-gated sodium channels, under modelled ischemia/reperfusion in CHO-K1 culture on the level of apoptosis, necrosis, and oxidative stress (concentration of reactive oxygen species, nitric oxide, and glutathione) using fluorescent dyes and fluorescence microplate reader. \u0000Results. Data obtained indicate a decreased level of apoptosis and necrosis, and a control level of nitric oxide under toxin at a nanomolar concentration. At the same time, the concentrations of reactive oxygen species and glutathione did not change. Thus, the inhibitor toxin acted as a protective agent by preventing a decrease in the nitric oxide concentration, which favorably affected the survival of the cell culture during reperfusion after ischemia.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127990372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RENAL CONTINUUM: CLASSIFICATION PROBLEMS","authors":"A. М. Shutov, E. V. Efremova, M. Menzorov","doi":"10.34014/2227-1848-2023-1-43-49","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-43-49","url":null,"abstract":"Disease classification is one of the most serious challenges in modern medicine. New data on disease etiology, pathogenesis, diagnosis, treatment and prognosis lead to the revision of existing principles for the classification of pathological conditions. This is also true about kidney disease. In renal continuum, the first three months from the disease onset are defined as acute kidney injury or acute kidney disease. Chronic kidney disease implies renal structural or functional damage which is observed for more than three months, or markers of kidney damage, regardless of etiology. Despite the apparent simplicity of the renal continuum, there are difficulties in diagnosing and determining the event sequence. Currently, there is no consensus on the place of acute kidney disease in the renal continuum. Therefore, despite high prevalence acute kidney disease is rarely diagnosed, included in the diagnosis or taken into account while assessing the patient prognosis. The authors propose a new classification of renal continuum, which allows us to clarify the criteria for acute kidney disease and acute kidney injury. The suggested classification can be easily used in routine clinical practice. The introduction of biomarkers into wide clinical practice and the clarification of the criteria for acute kidney injury do not affect the proposed classification, but only clarify the criteria for diagnosing acute kidney injury, acute kidney disease, and chronic kidney disease.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114728994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN THE CEREBRAL CORTEX NEURON ULTRASTRUCTURE IN RATS WITH PARTIAL CEREBRAL ISCHEMIA","authors":"E. Bon', N. E. Maksimovich, S. Zimatkin, O. Ostrovskaya, Vitaliy Yur'evich Smirnov, M. A. Nosovich, K. A. Khrapovitskaya","doi":"10.34014/2227-1848-2023-1-137-144","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-137-144","url":null,"abstract":"The ultrastructural characteristics of neuronal organelles are significant indicators of brain damage under ischemic exposure, which necessitates the study of changes in the ultrastructure of brain neurons. \u0000The aim of the study was to examine the disorders of brain neurons under its partial ischemia at the ultrastructural level using an experimental model. \u0000Materials and Methods. The experimental group included 12 male rats weighing 260±20 g, the control group consisted of 6 falsely operated male rats of the same weight. Partial cerebral ischemia (PCI) was modeled by right common carotid artery ligation. The material was taken 1 hour after the operation. \u0000Results. The study showed that the size and shape of the mitochondria of neurons of the parietal cortex and the hippocampus in PCI rats did not differ from those of the control group (p>0.05), except for a smaller number of cristae per unit area in the mitochondria of parietal cortex neurons (by 18 %, p<0.05). \u0000The size and shape of the Golgi complex and lysosomes did not differ in the groups either. However, there was an increase in the number of free ribosomes in the cytoplasm of neurons in the parietal cortex and hippocampus of PCI rats, by 58 % and 54 %, respectively (p<0.05). \u0000The ratio of fixed and free ribosomes in control rats decreased from 3.4 to 0.8 in the parietal cortex (p<0.05) and from 2.33 to 0.7 in the hippocampus (p<0.05). \u0000Conclusions. In general, the neuron ultrastructure in PCI rats was similar to that in the control group, which might be due to blood flow compensation in the circle of Willis. An increase in the number of free ribosomes is a sign of deranged protein biosynthesis in neurons. A decrease in the number of mitochondrial cristae in neurons in the parietal cortex indicates energy deficiency.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129447428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}