Ulyanovsk Medico-biological Journal最新文献

{"title":"EXCESS MORTALITY IN SAMARA REGION DURING COVID-19 PANDEMIC","authors":"R. Kuznetsova","doi":"10.34014/2227-1848-2023-1-91-103","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-91-103","url":null,"abstract":"COVID-19 pandemic has caused a significant damage to humanity worldwide. Over 500 million people have recovered from COVID-19 and over 6 million people have died from it. Restrictive measures taken by governments to prevent the spread of infection had negative economic impacts. Health care systems of most countries demonstrated significant shortcomings. Many countries have recorded excess deaths not only from COVID-19, but also from the negative consequences caused by the pandemic. \u0000The purpose of the study is to analyze and evaluate excess mortality in the Samara region during the COVID-19 pandemic. \u0000Materials and Methods. To analyze excess mortality, we used the COVID mortality multiplier (CMM). The calculation was carried out according to Rosstat data on the registered deaths from COVID-19 and daily published reports of the Operational Headquarters on the number of deaths from COVID-19. The multiplier was calculated for each month of the period under review, from April 2020 to December 2021. \u0000Results. The data obtained show that during the first two waves of the pandemic, excess mortality was due not only to those who died from COVID-19, but also due to negative consequences of the pandemic, which caused excess deaths. The multiplier showed very high figures. Since April 2021, the figures have been reducing to moderate, which suggests that the main reason for excess mortality was the novel coronavirus infection. The calculation method applied in the study can also be used while analyzing excess mortality in any other epidemiological emergencies.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130297424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANEMIA AND STRUCTURAL AND FUNCTIONAL HEART CONDITIONS IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPY","authors":"E. N. Ievlev, I. Kazakova, I. Rudenko, Lyudmila Leont'evna Shamova","doi":"10.34014/2227-1848-2023-1-14-26","DOIUrl":"https://doi.org/10.34014/2227-1848-2023-1-14-26","url":null,"abstract":"Anemia is one of the modifiable risk factors for the development of left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). However, there are not enough studies on the effect of iron metabolism on left ventricular geometry. \u0000Materials and Methods. The authors examined 147 patients (69 males and 78 females) with CKD undergoing long-term hemodialysis. The mean age was 55.6±13.4 years. Median dialysis treatment was \u00003 [2; 5] years. Kt/V index was 1.52±0.2. Based on the echocardiogram data, we calculated left ventricular mass (LVM), left ventricular mass index (LVMI), relative wall thickness index (RWTI), intima, and medium fiber fractional shortening. Ferritin, transferrin, and transferrin saturation were also determined. \u0000Results. Changes in LV geometry were detected in 124 (84.4 %) patients. Higher LVMI, and RWTI parameters were observed in the group of patients with hemoglobin <100 g/l. Patients with ferritin levels >800 ng/l demonstrated higher end-systolic dimension and lower left ventricular ejection fraction compared to patients with ferritin levels <500 ng/mL. \u0000Conclusion. Structural and functional indicators of the heart in patients undergoing long-term hemodialysis correlate not only with hemoglobin level, but also with indicators of iron metabolism (ferritin, transferrin, and transferrin saturation). In patients with a high ferritin level, left ventricle functional parameters are lower.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129972369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEPHROPROTECTIVE THERAPY IN ACUTE PERITONITIS","authors":"Vladimir Evgen'evich Ryazantsev, A. Vlasov, N. Stepanov, T. I. Vlasova, I. Mashnin, Z. Duvayarov","doi":"10.34014/2227-1848-2022-4-58-65","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-58-65","url":null,"abstract":"Increasing the effectiveness of peritonitis treatment remains an urgent issue for abdominal urgent surgery. So far, several effective surgical technologies have been developed. However, conservative therapy in the early postoperative period is an object for development, including the target organ protection influence. \u0000The aim of the study is to determine the nephroprotective efficacy of complex treatment with remaxol in acute peritonitis. \u0000Materials and Methods. The authors examined 46 patients with acute peritonitis. The patients were divided into two groups: Groups 1 (comparison, n=26) received standardized treatment, Group 2 (main, n=20) was treated with remaxol. Research methods, in addition to routine ones, included the assessment of kidney functional state, endotoxicosis, and oxidative stress. \u0000Results. It is revealed that in acute peritonitis, the authors recorded substantial deviations in the functional state of the kidneys, such as endogenous intoxication, and oxidative stress. Maximum imbalance is diagnosed on the 1st day of the early postoperative period. The use of remaxol in the complex therapy of patients with acute peritonitis significantly improves the functional state of the kidneys, thus, optimizing the course of the early postoperative period and reducing the severity of endogenous intoxication. The positive effect of the drug is caused by its ability to manage the oxidative stress, a universal pathogenetic trigger for system and organ damage, including kidneys. \u0000Conclusions. Remaxol has a nephroprotective effect and improves the course of the early postoperative period.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133141708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LIPID METABOLISM IN YOUNG MILITARY MEN","authors":"E. Belozerov, Nelli Alekseevna Shchukina, Aleksandr Leonidovich Smetanin, A. Andriyanov, O. G. Korosteleva, E. S. Martynova","doi":"10.34014/2227-1848-2022-4-120-127","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-120-127","url":null,"abstract":"The purpose of the paper is to assess the influence of the nutritional factor on lipid metabolism in young military men. \u0000Materials and methods. The objects of the study were young conscripted men aged 19.3±1.2, who feed on combined arms ration (n=71). Lipid metabolism indicators (cholesterol, triglycerides, high-density lipoprotein, low density lipoprotein, very low density lipoproteins and atherogenic index) were assessed in military men. For this purpose, chromatography-mass spectrometry (Beckman Coulter AU480 automatic biochemical analyzer) was used. The study was conducted in the consultative and diagnostic polyclinic of the medical and diagnostic center, Military Medical Academy. The assessment of the studied indicators was made 60 days apart in the autumn-winter period. Nonparametric methods were used for statistical processing of experimental data. Risk analysis of the potential influence of the nutritional factor on lipid metabolism was carried out. \u0000Results. Differences in the lipoprotein content in the servicemen blood serum at the beginning and end of trial were random. Levels of cholesterol levels and low density lipoproteins, as well as atherogenic index decreased significantly. \u0000Conclusion. During the study, no statistically significant negative changes in lipid metabolism were found. \u0000Risk assessment of potential violation of the nutritional status in young military men indicates a favorable effect of nutrition on their lipid metabolism.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130602227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYTOKINE-MEDIATED REACTIONS IN THE PATHOGENESIS OF EXPERIMENTAL PERIODONTITIS","authors":"A. Zakhvatov, D. Khaydar, I. Zakharkin, T. Kurmysheva, S.A. Tambovtsev, A.S. Kurmyshev, Alina Yur'evna Parshina, I. E. Zhuravleva","doi":"10.34014/2227-1848-2022-4-139-148","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-139-148","url":null,"abstract":"Determining cytokinemia role in the destructive processes of the periodontal complex gives new opportunities to the development and subsequent implementation of practical methods for chronic periodontitis diagnosis, justifies including pathogenetic drugs that inhibit the secretion of pro-inflammatory mediators in treatment regimens. \u0000The aim of the study is to evaluate the dynamics of cytokine profile indicators and identify their correlation with the local status of periodontal tissues in animals with experimental periodontitis. \u0000Materials and methods. The study enrolled 65 white outbred rats weighing 180±20 g. The authors reproduced the model of experimental periodontitis according to K.D. Shkolnaya, V.G. Atrushkevich method (patent RU No. 2625295, December 07, 2017). The cytokine profile was assessed by pro-inflammatory and anti-inflammatory cytokine levels, determined by enzyme-linked immunosorbent assay, Bender MedSystems reagent kit. Local status of periodontal tissues was assessed according to the degrees of gingival hemorrhage, dental mobility and depth of periodontal pockets with a button-shaped and modified periodontal probes. \u0000Results. During the experimental periodontitis modeling, a high level of cytokinemia was determined. It destructively effects the periodontal connective tissue matrix, which was confirmed by an increase in the depth of periodontal pockets, gingival hemorrhage and dental mobility. A strong correlation between a high level of cytokinemia and local destructive changes in periodontal tissues was determined. This fact emphasized the conjugation of these pathophysiological mechanisms. \u0000Conclusion. Defined disorders of physiological balance in the cytokine balance necessitate the use of pathogenic drugs, as they have an inhibitory effect on the synthesis of pro-inflammatory cytokines and prevent further destruction of the periodontal complex. Changes in the cytokine profile indicate inflammation process, and a decrease in the level of cytokinemia indicate the resolution of infection and can be considered a criterion for the effective treatment.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122023672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE OF ARTERIAL HYPERTENSION CANDIDATE GENES IN THE NEWLY ARRIVED POPULATION OF THE NORTH-EAST RUSSIA","authors":"I. Bezmenova","doi":"10.34014/2227-1848-2022-4-109-119","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-109-119","url":null,"abstract":"Arterial hypertension (AH) is one of the most serious problems of modern health care. In the northern regions it has become a catastrophe, being the most common cause of early disability and mortality among the employable newly-arrived population. At high latitudes, AH is characterized by a more severe course; it is accompanied by early damage to target organs; and it is more often in young people. AH occurs as a result of a combined interaction of polymorphism in genes, which are involved in blood pressure regulation. It is also provoked by the environmental factors. \u0000The aim of the study is to assess the prevalence of polymorphisms in four AH candidate genes (AGT (rs4762), AGTR1 (rs5186), ADD1 (rs4961), NOS3 (rs2070744)) in the newly arrived population of the North-East Russia. \u0000Materials and methods. The cross-sectional study involved practically healthy unrelated men, mostly Europeans, living or born on the territory of the Magadan region (n=101). The average age of the subjects was 46.12±1.5 (20–77 years old). PCR was used to perform molecular genetic testing of genes directly involved in the work of the main blood pressure regulation systems: AGT, AGTR1, ADD1, NOS3. The author calculated phenotypic and gene frequencies, observed and expected heterozygosity levels, Wright's fixation index (D) and population genetic distance (according to Nei). Clustering methods and multidimensional scaling were used to visualize the genetic relationship of different populations. \u0000Results. In the newly arrived population of the North-East Russia, genotype distribution corresponds to the Hardy – Weinberg equilibrium (p>0.05). Allelic diversity for the studied loci varies from Ho=0.25 (AGT locus) to Ho=0.44 (eNOS locus). \u0000Conclusion. The result of the study is the revealed characteristics of AH candidate gene frequency in the newly arrived population of the North-East Russia. It is found that allelic variants that increase the risk of AH developing are minor. Their frequency varies from 13.37 % (AGT*T allele, AGT locus) to 35.64 % (eNOS*C allele, eNOS locus).","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133496067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LUNG DAMAGE AS A COMPLICATION OF SYSTEMIC JUVENILE ARTHRITIS","authors":"Ol'ga Aleksandrovna Sizova, N. V. Efremova, Z. Rumyantseva","doi":"10.34014/2227-1848-2022-4-38-48","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-38-48","url":null,"abstract":"According to modern science, systemic juvenile arthritis (sJA) is an autoinflammatory disease characterized by severe systemic manifestations and life-threatening complications. This article discusses the developmental predictors, clinical and radiological manifestations and pathogenetic features of the disease. Particular attention is paid to genetically engineered biological therapy. \u0000Numerous pulmonary complications are now known in sJA children, including interstitial lung disease (ILD), pulmonary alveolar proteinosis (PAP), pulmonary hypertension (PH), and lipoid pneumonia. Fatality rate in sJA patients increases against the macrophage activation syndrome (MAS) development and pulmonary hypertension, which occurs with proliferation of endothelial cells, muscle tissue and fibroblasts in the lungs vessels. A more severe disease progression is typical for children with genetic defects. SAM and PAP relapses are observed more often in such patients. Instrumental diagnostic methods helped to identify, 5 subtypes determining the lung tissue damage in sJA. Computer tomography (CT) revealed the main signs of lung damage in sJA patients: ground-glass opacity, crazy-paving sign, thickening of the bronchial wall, interlobar septum, pleura, peripheral consolidation, and lymphadenopathy. Due to the high level of sJA activity, children were prescribed genetically engineered biological drugs (GEBP). Timely therapeutic correction is necessary to exclude life-threatening adverse reactions. Under dynamic observation, it is possible to diagnose lung damage in children at the early stage and to control the pathology. \u0000The purpose of this review is to systematize the existing data on developmental predictors, pathogenetic features of the disease, sJA clinical and radiological manifestations, and genetically engineered biological therapy as a method of sJA treatment.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122597361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TISSUE HEALING IN OVERWEIGHT PATIENTS DURING ALLOHERNIOPLASTY WITH VARIOUS PLASTIC MATERIALS","authors":"Rustam Khasanovich Azimov, Viktor Aleksandrovich Gorskiy, A. Vlasov, K. A. Shemyatovskiy, P. Glushkov, Shokhrukh Nodirbekovich Madrakhimov","doi":"10.34014/2227-1848-2022-4-66-73","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-66-73","url":null,"abstract":"Excess body weight aggravates disease progression and negatively affects wound healing. \u0000The aim of the study is to the examine the features of tissue healing along the suture line of a postoperative wound in overweight patients with hernia repair with polypropylene material and titanium silk. \u0000Materials and Methods. Clinical laboratory examination was carried out in 44 overweight patients. Polypropylene mesh (n=23) or titanium silk endoprosthesis (n=21) were used for hernioplasty of inguinal or umbilical hernias. In the early postoperative period, the healing process was assessed in dynamics using cytological and instrumental methods. \u0000Results. It was established that after allohernioplasty in the early postoperative period, inflammation and microcirculation disturbances were recorded in the area of the wound tissues. In patients with polypropylene mesh, inflammation and microcirculation disturbances were more severe. Thus, the reparative processes in such patients were longer. Titanium silk endoprosthesis proved to be more effective. Its use in overweight patients did not disrupt reparative processes. However, in the early postoperative period, seroma was observed in the wound area in 5 patients with a polypropylene mesh (21.7 %) (χ2=4.176; р=0.041). In the long-term period, hernia recurrence was diagnosed in 4 patients (17.4 %) (χ2=3.394; p=0.066). \u0000Conclusion. Titanium silk in hernioplasty in overweight patients contributes to a better incomplete reparative tissue regeneration compared to polypropylene material. It also reduced wound complications both in the early and late postoperative periods.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123689008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREGNANCY COMPLICATIONS AND MODE OF DELIVERY IN COVID-19 WOMEN PERFORMING DELIVERY IN THE DISTRICT CLINICAL HOSPITAL IN KHANTY-MANSIYSK","authors":"A. E. Kasparova, E. I. Kutefa, E. N. Vasil'kovskaya, L. Chegus, Ekaterina Evgen'evna Chernaya, Irina Evgen'evna Reutova, Dmitriy Vyacheslavovich Reutov","doi":"10.34014/2227-1848-2022-4-74-92","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-74-92","url":null,"abstract":"The aim of the study is to assess the frequency of pregnancy complications and the mode of delivery in COVID-19 women performing delivery in the district clinical hospital in the city of Khanty-Mansiysk. \u0000Materials and Methods. The authors retrospectively analyzed 148 medical histories of COVID-19 women, who delivered in Khanty-Mansiysk perinatal center. All patient medical records were divided into 4 subgroups depending on the delivery term, and 3 subgroups depending on the disease severity. Statistical analysis was carried out using analytics software packages Statistica 10 (USA) and StatTech v. 2.8.4 (Stattech, Russia, 2020). Given group heterogeneity, non-parametric statistical methods were used to calculate quantitative and qualitative parameters. Fisher Z transformation and the Mann-Whitney test were used to compare the parameters. Differences were considered statistically significant at p≤0.05, CI 95 %. \u0000Results. In all subgroups the most common pregnancy complication in COVID-19 patients was anemia. It was observed in 50.8 % to 74.3 % of cases. The maximum incidence of moderate preeclampsia was 2.7 %, that is below the average population value. Most placental abnormalities were detected in subgroups of women who gave birth during 3rd and 4th waves of COVID-19 (37.1 % and 33.8 % respectively). In the same subgroups, fetal growth retardation (28.6 % and 32.3 %), statistically significant increase in the proportion of preterm births (34.3 % and 38.5 %) and transfers to the neonatal intensive care unit (28.6 % and 26.2 %) were often observed.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129809274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTIVENESS OF LIQUID-BASED CYTOLOGY AS CERVICAL CANCER SCREENING","authors":"V. N. Zhurman, Tat'yana Yur'evna Maslennikova, E. Eliseeva, L. S. Matyushkina","doi":"10.34014/2227-1848-2022-4-6-18","DOIUrl":"https://doi.org/10.34014/2227-1848-2022-4-6-18","url":null,"abstract":"The incidence of cervical cancer is gradually shifting to an earlier age range, creating many problems, such as a decrease in life expectancy, working and fertile periods, and an increase of social and economic burden on the healthcare system and the state as a whole. Screening with liquid-based cytology can help to diagnose dysplasia and the initial cancer manifestation in situ. \u0000The purpose of this article is to analyze the possible advantages of liquid-based cytology for mass screening.","PeriodicalId":177722,"journal":{"name":"Ulyanovsk Medico-biological Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117241795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}