NEPHROPROTECTIVE THERAPY IN ACUTE PERITONITIS

Increasing the effectiveness of peritonitis treatment remains an urgent issue for abdominal urgent surgery. So far, several effective surgical technologies have been developed. However, conservative therapy in the early postoperative period is an object for development, including the target organ protection influence. The aim of the study is to determine the nephroprotective efficacy of complex treatment with remaxol in acute peritonitis. Materials and Methods. The authors examined 46 patients with acute peritonitis. The patients were divided into two groups: Groups 1 (comparison, n=26) received standardized treatment, Group 2 (main, n=20) was treated with remaxol. Research methods, in addition to routine ones, included the assessment of kidney functional state, endotoxicosis, and oxidative stress. Results. It is revealed that in acute peritonitis, the authors recorded substantial deviations in the functional state of the kidneys, such as endogenous intoxication, and oxidative stress. Maximum imbalance is diagnosed on the 1st day of the early postoperative period. The use of remaxol in the complex therapy of patients with acute peritonitis significantly improves the functional state of the kidneys, thus, optimizing the course of the early postoperative period and reducing the severity of endogenous intoxication. The positive effect of the drug is caused by its ability to manage the oxidative stress, a universal pathogenetic trigger for system and organ damage, including kidneys. Conclusions. Remaxol has a nephroprotective effect and improves the course of the early postoperative period.