AGE-RELATED CHANGES IN RAT LIVER HYDRATION AND HISTOSTRUCTURE

Aleksandr Anatol'evich Vinogradov, E. S. Simakova
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Abstract

One of the aging hypotheses is based on the fact that the percentage of water in the human body decreases with age. To a greater extent, the loss of water affects the most energy-dependent organs, such as liver, which undergoes a number of structural compensatory-adaptive changes. The parameters of age-related changes are currently understudied. However, they should be taken into account when determining the actual organ transformations in experiments. The purpose of the study was to examine the change in the level of total water and liver histostructure in rats during a 75-day observation. Materials and Methods. The changes in the level of total water in the liver parenchyma were assessed in young outbred intact rats during 75-day observation. The authors examined liver histostructure on sections stained with hematoxylin-eosin and picrofuchsin (Van Gieson's stain). Results. A decrease in the level of total water in the rat liver parenchyma by 0.54±0.042 % was observed during a 75-day observation. At the same time, no visible changes were detected in the liver histostructure. Conclusion. During the trial a decrease in the level of total water in the liver of intact animals was observed. It did not affect the change in liver histostructure.
大鼠肝脏水化和组织结构的年龄相关性变化
其中一个衰老假说是基于人体中水分的百分比随着年龄的增长而减少这一事实。在更大程度上,水分的流失影响到最依赖能量的器官,如肝脏,它经历了许多结构上的代偿适应性变化。年龄相关变化的参数目前还没有得到充分的研究。然而,在实验中确定实际器官转化时,应考虑到这些因素。本研究的目的是观察大鼠在75天的观察中总水水平和肝脏组织结构的变化。材料与方法。在75天的观察中,我们观察了幼龄远交系完整大鼠肝实质总含水量的变化。作者在苏木精-伊红和微红染色(Van Gieson染色)的切片上检查肝脏组织结构。结果。在75天的观察中,大鼠肝实质总含水量下降了0.54±0.042%。同时,肝脏组织结构未见明显变化。结论。在试验期间,观察到完整动物肝脏中总水水平下降。不影响肝组织结构的改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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