PREDICTORS OF COMPUTERIZED ELECTROACUPUNCTURE EFFICACY IN BRONCHIAL ASTHMA TREATMENT

T.S. Golubtsova, E. Yudina, S.A. Pribylova, I.R. Kerova, A. B. Peskov, Maksim Anatol'evich Volkov, M.P. Khokhlov, B. M. Kostishko
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Abstract

The aim of the study is to evaluate the significance of the initial clinical parameters of patients with bronchial asthma while predicting the efficacy of computerized electroacupuncture (CEAP). Materials and Methods. The two-stage study included 120 patients with bronchial asthma (BA). During the first stage, group OI underwent 3 CEAP monthly courses, while group P was treated with standard pharmacotherapy. Based on the results of the first study stage, patients were included in group OII, which consisted of a subgroup with expected good CEAP efficacy (group OII1) and a subgroup with expected insufficient CEAP efficacy (group OII2). Group OII underwent 3 monthly CEAP courses, which consisted of five daily events. Results. After three CEAP courses, group OI demonstrated a high proportion of patients with good and complete BA control. According to asthma controllability, patients were stratified into 4 subgroups: OI1 – patients of the main group 1 with improved disease control (n=20); OI2 – patients of the main group 1 with unchanged disease control (n=20); P1 – patients of the reference group with improved disease control (n=10); Р2 – patients of the reference group with unchanged disease control (n=30). The retrospective analysis showed no significant differences between respiratory function parameters in CT 1 and 2 in groups OI1 and OI2. The authors analyzed electrical resistance (ER) dynamics of all biologically active points (BAP) during the first CEAP course in group OI: the difference between the total indicators of the initial and final ER of all BAPs gradually increased. Thus, we considered it possible to apply ES indicators of BAPs to predict CEAP efficacy. There was a correlation between BA controllability and ES of BAT, as registered in the first two CEAP sessions in group OI. It was supposed to calculate the indicator of the expected treatment efficacy (IETE). IETE predicted negative treatment outcomes in 100 % of cases (sensitivity – 100 %, specificity – 100 %). Prediction of a positive effect was less accurate: sensitivity – 70 %, specificity – 80 %. The sensitivity of the prediction of dynamics absence was 80 %, specificity – 70 %. Conclusion. It is inappropriate to use the initial parameters of respiratory function as predictors of CEAP efficacy in BA treatment. IETE is an objective measurable indicator of BAPs and can be used to predict CEAP efficacy in BA treatment.
电针治疗支气管哮喘疗效的预测因素
本研究的目的是评估支气管哮喘患者初始临床参数在预测计算机电针(CEAP)疗效中的意义。材料与方法。这项两阶段的研究纳入了120例支气管哮喘(BA)患者。在第一阶段,OI组接受3个CEAP每月疗程,而P组接受标准药物治疗。根据第一阶段的研究结果,将患者纳入OII组,其中包括预期CEAP疗效良好的亚组(OII1组)和预期CEAP疗效不足的亚组(OII2组)。OII组接受3个月的CEAP课程,包括5个日常活动。结果。经过三个CEAP疗程后,OI组显示有较高比例的患者具有良好和完全的BA控制。根据哮喘可控性将患者分为4个亚组:OI1 -疾病控制改善的主要1组患者(n=20);OI2 -主要1组患者,疾病控制不变(n=20);P1 -疾病控制改善的参照组患者(n=10);Р2 -疾病控制不变的参照组患者(n=30)。回顾性分析显示OI1组和OI2组CT 1、2呼吸功能参数无显著差异。作者分析了OI组患者首个CEAP疗程中各生物活性点(BAP)的电阻(ER)动态:各BAP的初始和最终ER总指标之间的差异逐渐增大。因此,我们认为应用bap的ES指标预测CEAP疗效是可能的。在OI组的前两次CEAP会话中,BA可控性与BAT的ES之间存在相关性。计算预期治疗效果指标(IETE)。IETE预测100%病例的治疗结果为阴性(敏感性为100%,特异性为100%)。对积极作用的预测不太准确:敏感性为70%,特异性为80%。预测动力缺失的敏感性为80%,特异性为- 70%。结论。用呼吸功能的初始参数作为CEAP治疗BA疗效的预测指标是不合适的。IETE是BAPs的客观可测量指标,可用于预测CEAP治疗BA的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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