JURNAL BIOMEDIK (JBM)最新文献

{"title":"Gambaran Kasus Kematian pada Korban Terpapar Alkohol yang Diautopsi di Bagian Ilmu Kedokteran Forensik dan Medikolegal RSUP Prof. Dr. R. D. Kandou Periode 2014 - 2017","authors":"Angela A. Pangemanan, James F. Siwu, Nola T. S. Mallo","doi":"10.35790/JBM.10.3.2018.21987","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21987","url":null,"abstract":"Abstract: Alcohol is an addictive substance that could cause adverse effects to human body. Moreover, it is also related to a variety of criminal acts. North Celebes is one of the provinces with the highest alcohol consumption in Indonesia. This study was aimed to describe the death cases exposed to alcohol that were autopsied at Prof. Dr. R. D Kandou Hospital Manado during 2014-2017. This was a descriptive retrospective study using data of visum et repertum. The results showed that there were 17 death cases exposed to alcohol. The majority were in 2016 as many as 6 cases (35.3%). The most common age group was 26-35 years as many as 7 cases (41.2%). All cases were males (100%). The most cause of death in these cases were due to violence using sharp objects as many as 15 cases (88.2%). Conclusion: Most death cases exposed to alcohol were males aged 26-35 years, and the cause of death was violence using sharp object.Keywords: alcohol, death casesAbstrak: Alkohol adalah zat adiktif yang dapat berdampak buruk bagi tubuh manusia serta terkait juga dengan berbagai tindakan kriminalitas. Sulawesi Utara merupakan salah satu provinsi dengan konsumen alkohol terbanyak di Indonesia. Penelitian ini bertujuan untuk mengetahui gambaran kasus kematian pada korban terpapar alkohol yang diautopsi di RSUP Prof. Dr. R. D Kandou periode 2014-2017. Jenis penelitian ialah deskriptif retrospektif menggunakan data hasil visum et repertum. Jenis penelitian ialah deskriptif retrospektif. Hasil penelitian mendapatkan 17 kasus kematian korban terpapar alkohol. Kasus terbanyak pada tahun 2016 yaitu 6 kasus (35,3%). Kelompok usia terbanyak 26-35 tahun yaitu 7 kasus (41,2%) dan jenis kelamin laki-laki (100%). Penyebab kematian terpapar alkohol terbanyak karena kekerasan benda tajam yaitu 15 kasus (88,2%). Simpulan: Sebagian besar kasus kematian akibat terpapar alkohol berada dalam kelompok usia 26-35 tahun, semua berjenis kelamin laki-laki, dengan jenis penyebab kematian akibat kekerasan benda tajam.Kata kunci: alkohol, kasus kematian","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"178 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77302396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on Food Allergy, Increasingly Prevalent Challenge","authors":"T. Tanus, Sunny Wangko","doi":"10.35790/jbm.10.3.2018.21980","DOIUrl":"https://doi.org/10.35790/jbm.10.3.2018.21980","url":null,"abstract":"Abstrak: Prevalensi alergi makanan makin meningkat di seluruh dunia dan mengenai semua usia. Keparahan dan kompleksitas penyakit juga meningkat terlebih pada populasi anak. Terdapat beberapa jenis reaksi alergi yang dibahas: immunoglobulin E (IgE) mediated allergies and anaphylaxis, food triggered atopic dermatitis, eosinophilic esophagitis, dan non IgE mediated gastrointestinal food allergic disorders seperti food protein induced enterocolitis syndrome (FPIEs). Tes alergi, baik melalui kulit maupun IgE yang telah dikerjakan sekian lama masih dibebani dengan hasil positif palsu dan negatif palsu yang bermakna dengan manfaat terbatas pada beberapa alergi makanan. Selain menghindari, tidak terdapat terapi yang ampuh untuk alergi makanan. Berbagai imunoterapi telah dipelajari melalui jalur, subkutan, epikutan, oral dan sublingual yang hanya menghasilkan desensitisasi sementara dan dibebani dengan berbagai isu mengenai keamanannya. Agen biologik yang menghambat sitokin/interleukin (IL) dan molekul pada reaksi alergi makanan tampaknya merupakan pilihan yang menjanjikan. Anti IgE telah dipergunakan pada asma dan urtikaria kronis. Anti IL-4 dan IL-13 yang menghambat produksi IgE diindikasikan untuk dermatitis atopik. Anti eosinofil anti IL-5 berhasil menurunkan eksaserbasi asma. Berbagai agen biologik telah dipelajari untuk berbagai kondisi alergik dan imunologik, tetapi efektivitas dan kepraktisan terapi yang mahal ini untuk alergi makanan masih menjadi tanda tanya.Kata kunci: alergi makanan, reaksi alergi, terapi alergi makananAbstract: Food allergies have been increasing in prevalence for years affecting all ages. Disease severity and complexity have also increased, especially in the pediatric population. There are several types of reactions including: immunoglobulin-E (IgE) mediated allergies and anaphylaxis, food-triggered atopic dermatitis, eosinophilic esophagitis, and non IgE mediated gastrointestinal food allergic disorders such as FPIEs. Though allergy testing has been around for years, both skin and IgE testing are burdened by significant false positives and negatives, and are only useful in some food allergies. Avoidance is the sole therapy for food allergy. A variety of immunotherapies have been studied; subcutaneous, epicutaneous, oral, and sublingual. At best they only produce a temporary state of desensitization and have many safety issues. Examples of biologicals which block critical cytokines/interleukins (IL) in allergic conditions are Anti IgE, anti IL-4 and IL-13, and Anti eosinophils, Anti IL-5. Other biologicals are being studied for allergic conditions, but whether these expensive future treatments will be proven effective and practical in food allergy is unknown.Keywords: food allergy, allergic reaction, food allergy therapy","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81607977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan antara Kebiasaan Merokok dan Hipertrofi Ventrikel Kiri pada Laki-laki Dewasa Muda dengan Obesitas Sentral","authors":"Ribka Wowor","doi":"10.35790/JBM.10.3.2018.21983","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21983","url":null,"abstract":"Abstract: Left ventricular hypertrophy (LVH) is an independent risk factor for mortality. This state should be prevented by controlling the underlying factor, such as smoking. This study was aimed to determine the association between smoking and left ventricular hypertrophy in young adult men with central obesity. This was a case control study, conducted at Cardiology Department of Prof. Dr. R. D. Kandou Hospital in Manado from January to March 2015. Subjects were young adult male students (18-30 years old) at Prof. Dr. R. D. Kandou Hospital with central obesity divided into two groups: case group and control group. The case group consisted of 31 subjects with LVH meanwhile the control group consisted of 21 subjects without LVH. The statistical analysis showed that smoking was a risk factor for LVH in young adult men with central obesity, but not statistically significant (OR=3.846; 95% CI: 0.494-14.901; P=0.432). Conclusion: Smoking is a risk factor of left ventricular hypertrophy in young adult men (<30 years old) with central obesity, but not statistically significant.Keywords: smoking, left ventricular hypertrophy, young adult men, central obesityAbstrak: Hipertrofi ventrikel kiri (HVK) merupakan salah satu prediktor kematian independen. Pembesaran jantung kiri sebenarnya merupakan keadaan yang dapat dicegah dengan pengendalian faktor risiko, salah satunya ialah merokok. Penelitian ini bertujuan untuk mengetahui hubungan antara kebiasaan merokok dan hipertrofi ventrikel kiri pada laki-laki dewasa muda dengan obesitas sentral. Jenis penelitian ialah penelitian kuantitatif metode analitik dengan menggunakan rancangan case-control. Penelitian dilaksanakan di Bagian Kardiologi RSUP Prof. Dr. R. D. Kandou Manado selama 3 (tiga) bulan, yaitu dari bulan Januari 2015 s/d Maret 2015. Subyek penelitian ialah laki-laki dewasa muda (usia 18-30 tahun) dengan obesitas sentral dan sementara menjalani KKM di RSUP Prof. Dr. R. D. Kandou Manado. Subyek yang mengalami HVK sebagai kelompok kasus dan yang tidak mengalami HVK sebagai kelompok kontrol. Hasil penelitian mendapatkan bahwa kebiasaan merokok merupakan faktor risiko terjadinya HVK pada laki-laki dewasa muda dengan obesitas sentral walaupun secara statistik tidak bermakna (OR=3,846; 95% CI: 0,494-14,901; P=0,432). Simpulan: Kebiasaan merokok merupakan faktor risiko terjadinya pembesaran jantung kiri pada laki-laki dewasa muda (<30 tahun), walaupun secara statistik tidak bermakna.Kata kunci: merokok, hipertrofi ventrikel kiri, dewasa muda, obesitas sentral","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"9 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78634382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Kasus Luka Tembak di Kota Manado","authors":"Margareta Pabur, Djemi Tomuka, Johannis F. Mallo","doi":"10.35790/jbm.10.3.2018.21986","DOIUrl":"https://doi.org/10.35790/jbm.10.3.2018.21986","url":null,"abstract":"Abstract: Death and severe injury caused by firearm become an important concern worldwide. The increasing crime actions result in the increased use of firearms. In Manado, data of cases of vulnus sclopetorum (injuries or wound caused by the use of firearm) have not been well organized. This study was aimed to obtain the profile of vulnus sclopetorum in Manado. This was a descriptive retrospective study using data of vulnus sclopetorum stated in visum et repertum in Forensic Medicine and Medicolegal Department of Prof. Dr. R. D. Kandou Hospital, Bhayangkara Hospital, and Manado Police Department from January 2013 to December 2017. The results showed that there were 11 cases of vulnus sclopetorum. All cases were males, mostly in productive age, and the type of wound was infiltrated vulnus sclopetorum.Keywords: vulnus sclopetorum, firearmAbstrak: Kematian dan atau luka berat yang diakibatkan oleh penggunaan senjata api telah menjadi salah satu masalah global. Tingkat kejahatan yang semakin meningkat menyebabkan penggunaan senjata api sebagai alat untuk melukai seseorang makin bertambah. Di Kota Manado sendiri, data mengenai kasus luka tembak (vulnus sclopetorum) belum terorganisir dengan baik. Penelitian ini bertujuan untuk mendapatkan gambaran luka tembak di Kota Manado. Jenis penelitian ialah deskriptif retrospektif. Dari hasil pengumpulan data kasus luka tembak di Kota Manado selama periode Januari 2013-Desember 2017 melalui penelusuran Visum et Repertum pada kasus luka tembak di Bagian Ilmu Kedokteran Forensik Medikolegal RSUP Prof. Dr. R. D. Kandou Manado, RS Bhayangkara Manado, dan Kepolisian Resor Kota Manado tercatat 11 kasus luka tembak yang terjadi di Kota Manado. Secara keseluruhan kasus luka tembak terjadi pada laki-laki, didominasi oleh usia produktif, dengan gambaran luka tembak masuk.Kata kunci: luka tembak, senjata api","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"26 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91422246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mekanisme Kompleks Sepsis dan Syok Septik","authors":"Diana S. Purwanto, Dalima A.W. Astrawinata","doi":"10.35790/JBM.10.3.2018.21979","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21979","url":null,"abstract":"Abstract: Sepsis and septic shock are still important medical problems. As sepsis progresses to septic shock, the risk of death increases significantly. Sepsis is a complex mechanism which can include infectious pathogen with its virulence factors, host response, inflammatory response, impaired coagulation system, and organ dysfunction. The complexity of the pathogenesis and pathophysiology of sepsis involves almost all types of cells, tissues, and organ systems.Keywords: sepsis, septic shockAbstrak: Sepsis dan syok septik masih merupakan masalah medis yang penting. Seiring penjalanan sepsis menjadi syok septik, risiko kematian meningkat secara signifikan. Sepsis ialah mekanisme kompleks yang dapat meliputi patogen penyebab infeksi dengan faktor virulensinya, respon pejamu, respon inflamasi, sistem koagulasi yang terganggu, dan disfungsi organ. Kompleksnya patogenesis dan patofisiologi sepsis melibatkan hampir semua jenis sel, jaringan, dan sistem organ.Kata kunci: sepsis, syok septik","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81392128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Krim Ekstrak Buah Merah (Pandanus conoideus ) 10% Sama Efektifnya dengan Krim Hidrokuinon 4% dalam Mencegah Peningkatan Jumlah Melanin Kulit Marmut (Cavia porcellus) yang Dipapar Sinar Ultraviolet B","authors":"Corazon H. Dumaria, A. Wiraguna, Wimpie Pangkahila","doi":"10.35790/jbm.10.2.2018.20085","DOIUrl":"https://doi.org/10.35790/jbm.10.2.2018.20085","url":null,"abstract":"Abstract: This study was aimed to prove that administration of 10% redfruit extract cream could prevent the increase of skin melanin in guinea pig exposed to UVB and to compare this effect with 4% hydroquinone cream. This was a true experimental study using post test only control group design. Subjects were devided into three groups; each of 10 guinea pigs. Group 1, the control group, was exposed to UVB and applied with basic cream. Group 2 was exposed to UVB and applied with 4% hydroquinone cream. Group 3 was exposed to UVB and applied with 10% redfruit extract cream. The total dose of UVB was 390 mJ/cm2 given for 2 weeks. The amount of melanin was calculated using the percentage of the pixel area of melanin and was compared with the pixel areas of all epidermal tissues. The results showed that the highest percentage of melanin area was in group 1 (19.78%±3.79%). The percentage of melanin area in group 3 was 1.25%±0.76% meanwhile in group 2 was 0.85%±0.37%. There were signi-ficant differences in melanin percentage between the control group and group 2 as well as group 3 (P <0.05). There was no significant difference in melanin percentage between group 2 and group 3 (P >0.05). Conclusion: The 10% redfruit extract cream could prevent the increase of skin melanin in guinea pig exposed to UVB as effectively as the 4% hydroquinone cream.Keywords: redfruit extract cream, melanin, UVBAbstrak: Penelitian ini bertujuan untuk membuktikan efek pemberian krim ekstrak buah merah 10% dalam mencegah peningkatan jumlah melanin kulit marmut yang dipapar sinar UVB dan perbandingannya dengan krim hidrokuinon 4%. Jenis penelitian ialah eksperimental murni dengan post test only control group design. Sampel terdiri dari tiga kelompok dengan jumlah sampel 10 ekor marmut jantan tiap kelompok. Kelompok 1 yaitu kelompok kontrol, diberi paparan sinar UVB dan diolesi krim dasar. Kelompok 2 diberi paparan sinar UVB dan diolesi krim hidrokuinon 4%. Kelompok 3 diberi paparan sinar UVB dan diolesi krim ekstrak buah merah 10%. Dosis total UVB yaitu 390 mJ/cm2 diberikan selama 2 minggu. Jumlah melanin dihitung dengan persentase pixel luas area melanin dibandingkan dengan pixel seluruh jaringan epidermis. Hasil penelitian menunjukkan jumlah melanin tertinggi pada kelompok 1 (19,78± 3,79%) dan terendah pada kelompok 2 (0,85±0,37%), sedangkan jumlah melanin pada kelompok 3 di antara keduanya (1,25±0,76%). Terdapat perbedaan bermakna antara kelompok 1 dengan kelompok 2 dan 3 (P <0,05). Tidak terdapat perbedaan bermakna antara kelompok 2 dan 3 dalam mencegah peningkatan jumlah melanin (P >0,05 ). Simpulan: Krim ekstrak buah merah 10% dapat mencegah peningkatan jumlah melanin kulit marmut yang dipapar sinar UVB sama efektif dengan krim hidrokuinon 4%.Kata kunci: krim ekstrak buah merah, melanin, UVB","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83052940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoftalmitis yang dinduksi penggunaan lensa kontak – Laporan kasus","authors":"A. J. Nursalim, Herny Poluan","doi":"10.35790/jbm.10.2.2018.20094","DOIUrl":"https://doi.org/10.35790/jbm.10.2.2018.20094","url":null,"abstract":"Abstract: Nowadays, the popularity of contact lens increases progressively, not only in refractive anomaly correction but also in fashion purposes. Albeit, among contact lens wearers, there is a tendency of the occurence of eye infection, especially the cornea. We reported a 13-year-old female that came to the Eye Departement of Prof. Dr. R. D. Kandou Hospital Manado with the main complaint of blurred left eye since a week ago. Physical examination resulted in normal right eye and its visual acuity was within normal limit (6/6). Examination of the left eye resulted in visual acuity of 1/300, palpebral blepharospasm, conjunctival and ciliar injections, anterior stromal defect of 3x5 mm in the cornea, and hypopion <1mm in the anterior chamber. The ultrasound examination showed spreading aggregations and turbidity of the vitreous body. This patient was diagnosed as emmetropia of the right eye and contact-lens-induced endophthalmitis of the left eye. The therapy consisted of tobramycin, artificial tears, polyvinylpyrrolidone, vitamin C, mefenamic acid, and chlorpheniramine maleate tablet. Although there was improvement of visual acuity and clinical signs during 8-day hospitalization, the prognosis was good for ad vitam but poor for functionam and sanationam. This case indicates that education to the contact lens wearers is still needed even in this modern era.Keywords: contact lens, endophthalmitisAbstrak: Dewasa ini, lensa kontak mengalami peningkatan popularitas yang pesat, bukan saja dalam hal kelainan refraksi tetapi juga untuk keperluan mode. Pemakaian lensa kontak berisiko terjadinya infeksi pada mata, terutama kornea. Kami melaporkan seorang perempuan berusia 13 tahun, datang ke Poliklinik Ilmu Kesehatan Mata, RSUP Prof. Dr. R. D. Kandou Manado dengan keluhan pandangan mata kiri kabur sejak satu minggu lalu. Pada pemeriksaan fisik ditemukan mata kanan (OD) dalam batas normal dengan visus 6/6. Pada mata kiri (OS) didapatkan visus 1/300, blefarospasme palpebra, injeksi konjungtiva dan silier, pada kornea terdapat defek 1/3 anterior stroma dengan ukuran 3x5 mm, dan pada kamera okuli anterior terdapat hipopion setinggi <1 mm. Hasil pemeriksaan USG dari OS menunjukkan gambaran agregat yang menyebar dan kekeruhan vitreus. Pasien didiagnosis dengan emetropia okuli dekstra dan endoftalmitis okuli sinistra yang diinduksi penggunaan lensa kontak. Terapi yang diberikan ialah antibiotika tobramisin, artificial tears, polyvinylpyrrolidone, vitamin C, asam mefenamat, dan klorfeniramin maleat tablet. Pasien mengalami perbaikan visus dan gejala klinis selama delapan hari rawat inap. Prognosis pasien tergolong baik untuk prognosis ad vitam tetapi tergolong buruk untuk functionam dan sanationam. Kasus ini mengindikasikan bahwa edukasi terhadap pengguna lensa kontak tetap diperlukan dalam era modern ini.Kata kunci: lensa kontak, endoftalmitis","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79516243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Kadar Interleukin-10 Serum dan Kadar Leukosit Darah Perifer pada Pasien Cedera Otak Berat Akibat Trauma","authors":"Edi Suyanto, E. Prasetyo, M. C. Oley","doi":"10.35790/JBM.10.2.2018.20090","DOIUrl":"https://doi.org/10.35790/JBM.10.2.2018.20090","url":null,"abstract":"Abstract: This study was aimed to prove that in severe traumatic brain injury (TBI) there was an elevation in serum IL-10 level as well as in peripheral blood leukocyte level, and a correlation between both of them. This was an analytical correlational study. All patients had IL-10 level above normal value (18 pg/ml). There were three patients with normal blood leukocyte level. The correlation between IL-10 and blood leukocyte level was tested by using simple linear regression analysis and Pearson correlation coefficient analysis which obtained r = 0.045 with a P of 0.426 (>0.05). These results indicated a positive relationship between IL-10 and leukocytes levels, but not statistically significant. Conclusion: Interleukin-10 was consistantly elevated following severe traumatic brain injury and was a better TBI biomarker than the peripheral leukocyte level.Keywords: IL-10, leukocytes, TBIAbstrak: Penelitian ini bertujuan untuk membuktikan bahwa pada cedera otak akibat trauma (COT) berat terdapat peningkatan kadar serum IL-10 dan kadar leukosit darah perifer serta korelasi antara keduanya. Jenis penelitian ini ialah analitik korelasional. Hasil penelitian mendapatkan 20 pasien dengan COT berat berusia 16-65 tahun. Semua pasien memperlihatkan kadar Il-10 di atas nilai normal (18 pg/ml). Terdapat 3 pasien dengan kadar leukosit dalam batas normal Hubungan antara IL-10 dan leukosit diuji dengan analisis regresi linier sederhana dan analisis koefisien korelasi Pearson dan mendapatkan r = 0,045 dengan P = 0,426. Hasil ini menunjukkan hubungan positif antara IL-10 dan leukosit, tetapi tidak bermakna secara statistik (P = 0,426 >0,05). Simpulan: IL-10 secara konsisten meningkat setelah COT dan sebagai biomarker COT yang lebih baik daripada leukosit perifer.Kata kunci: IL-10, leukosit, COT","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76483850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gangguan Kelenjar Keringat Apokrin: Bromhidrosis dan Kromhidrosis","authors":"S. Setiawan, P. L. Suling","doi":"10.35790/jbm.10.2.2018.20084","DOIUrl":"https://doi.org/10.35790/jbm.10.2.2018.20084","url":null,"abstract":"Abstract: Apocrine gland is one of the sweat glands in humans. This gland is considered as a gland that causes odor. Primary abnormalities in the apocrine glands are bromhidrosis and chromhidrosis. Bromhidrosis is a state of abnormal or offensive body odor due to the secretion of apocrine sweat glands lies in the armpit, scalp, soles of the feet, fingers, and genital. Chromhidrois is a fairly rare condition, characterized by the secretion of colored sweat from the pigmented apocrine glands that usually present in the armpits and face. In general, management of bromhidrosis and chromhidrosis including non-medicamentous, medica-mentous, and surgery shows satisfying result.Keywords: apocrine bromhidrosis and apocrine chromhidrosisAbstrak: Kelenjar apokrin merupakan salah satu kelenjar keringat pada manusia, dan kelenjar ini dianggap sebagai kelenjar yang menyebabkan bau badan. Kelainan primer pada kelenjar apokrin yaitu apokrin bromhidrosis dan apokrin kromhidrosis. Bromhidrosis adalah keadaan bau badan seseorang yang berlebihan dari normal akibat sekresi kelenjar keringat apokrin yang terletak di ketiak, kulit kepala, telapak kaki, sela-sela jari, dan genital. Kromhidrohis merupakan keadaan yang cukup jarang ditemukan, ditandai dengan sekresi keringat dari kelenjar apokrin yang berwarna, biasanya terdapat pada ketiak dan wajah. Secara umum penatalaksanaan bromhidrosis dan apokrin kromhidrosis meliputi nonmedikamentosa, medikamentosa, dan pembedahan memperlihatkan hasil yang memuaskan.Kata kunci: apokrin bromhidrosis, apokrin kromhidrosis","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79786058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Korelasi antara Gambaran Spektral Doppler Arteri Tibialis Posterior dan Arteri Dorsalis Pedis dengan Skor PEDIS pada Penderita Ulkus Kaki Diabetik","authors":"Leise Limpeleh, Richard M. Sumangkut, Djoni E. Tjandra","doi":"10.35790/JBM.10.2.2018.20087","DOIUrl":"https://doi.org/10.35790/JBM.10.2.2018.20087","url":null,"abstract":"Abstract: Diabetic foot ulcer is still a major health problem worldwide due to its increasing prevalence. This study was aimed to prove the correlation between PEDIS score and vascular Doppler examination performed on dorsalis pedis and posterior tibial arteries of patients with diabetic foot ulcers. This was an observational study with a cross sectional design. The results showed that during the period of August 2017 until January 2018, there were 62 patients with diabetic foot ulcers at the wards of Surgery Department and Internal Medicine Department of Prof. Dr. R. D. Kandou Hospital Manado. Most patients were in the age group of 60-69 years, had leukocytosis (74.1%), poor blood sugar control (70.9%), and hypoalbuminemia (98.3%). Moreover, smoking history in 20.9% of patients; hypertension in 35.4% of patients; and dyslipidemia in 20.9% of patients. The Doppler examination resulted in biphasic waveform in posterior tibial artery (40.3%) as well as in dorsalis pedis artery (41.9%). Perfusion score showed 50% of subjects had PAD. Most subjects (90.3%) had ulcers of >3 cm2 and were infected superficially in the subcutaneous area (56.4%). Most subjects (58%) suffered from severe infection with high leucocyte counts, however, only 29% of subjects had lost of sensoric ability. The correlation Spearman test obtained r = -0.486 and P = 0.000 in the posterior tibial artery; and r = -0.281 and P = 0.0027 in the dorsalis pedis artery. Conclusion: There was a significant correlation between vascular Doppler result and PEDIS score. The higher the PEDIS score, the worse the vascular Doppler result.Keywords: diabetic foot ulcer, PEDIS score, vascular DopplerAbstrak: Ulkus kaki diabetik masih merupakan masalah kesehatan utama sedunia dengan prevalensi yang terus meningkat. Penelitian ini bertujuan untuk membuktikan apakah terdapat hubungan antara skor PEDIS dan pemeriksaan spektral Doppler vaskuler pada arteri poplitea, dorsalis pedis, dan tibialis posterior pada pasien dengan ulkus kaki diabetik. Jenis penelitian ialah observasional dengan desain potong lintang. Hasil penelitian mendapatkan 62 pasien dengan ulkus kaki diabetik di bangsal Bagian Bedah dan Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado selama periode Agustus 2017 sampai Januari 2018. Ukus diabetik tersering ditemukan pada kelompok usia 60-69 tahun dengan rerata usia 58,5 tahun. Sebagian besar pasien mengalami leukositosis (74,1%), kontrol gula darah buruk (70,9%), dan hipoalbuminemia (98,3%). Riwayat merokok didapatkan sebesar 20,9%; hipertensi 35,4%; dan dislipidemia 20,9%. Hasil pemeriksaan Doppler bifasik pada arteri tibialis posterior (40,3%) dan arteri dorsalis pedis (41,9%). Skor perfusi menunjukkan 50% subyek mengalami penyakit arteri perifer (PAD). Sebagian besar (90,3%) subjek memiliki ulkus >3 cm2 luas area. Infeksi sebagian besar superfisial di subkutan (56,4%), selebihnya menderita infeksi hingga fasia, otot, dan tendon. Sebagian besar subyek penelitian menderita infeksi berat (","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79299790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}