JURNAL BIOMEDIK (JBM)最新文献

{"title":"Gambaran Mikrokopik Serebelum pada Hewan Coba Postmortem","authors":"Belinda V. Nangoy, Sonny J. R. Kalangi, T. Pasiak","doi":"10.35790/JBM.11.1.2019.23205","DOIUrl":"https://doi.org/10.35790/JBM.11.1.2019.23205","url":null,"abstract":"Abstract: After death, there will be cellular changes that cause definite signs of death. These changes could be used to determine the time of death. This study was aimed to determine the microscopic changes of the cerebellum during 1 hour to 24 hours postmortem. This was a descriptive study. Four domestic pigs of more than 90 kg were used as animal models. After being killed, we made slices in the pig heads to expose and observe cerebellar microscopic changes in several time intervals, as follows: 90 minutes, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 10 hours, 11 hours, 12 hours, 13 hours, 14 hours, 15 hours, 16 hours, 17 hours, 18 hours, 19 hours, 20 hours, 21 hours, 22 hours, 23 hours, and 24 hours postmortem. The results showed that the cerebellum became progressively pale and softened at 8 hours postmortem. Congestion in all tissues occured at 2 hours postmortem, however 69.2% of the Purkinje cells still had normal nuclei. At 7 hours postmortem, Purkinje cells began to enlarge associated with karyorrhexis, and at 21 hours postmortem most of the cells shrank. Albeit, at 24 hours postmortem the cerebellar layers could still be identified and some Purkinje cells with normal morphology could be found. Conclusion: Microscopic changes could be identified at 2 hours postmortem in the form of congestion of the cerebellar layers. Purkinje cells underwent karyorrhexis at 7 hours postmortem and shrank at 21 hours postmortem.Keywords: Purkinje cells, cerebellar layers, postmortemAbstrak: Setelah kematian, terjadi perubahan pada sel-sel yang menimbulkan tanda-tanda pasti kematian. Perubahan-perubahan yang terjadi dapat membantu menentukan saat kematian dalam suatu kasus hukum. Penelitian ini bertujuan untuk mengetahui perubahan mikroskopik serebelum selama interval waktu 1 jam hingga 24 jam postmortem. Jenis penelitian ialah deskriptif. pada hewan coba babi dengan rerata berat lebih dari 90 kg. Setelah hewan coba dimatikan, dibuat irisan di bagian kepala untuk menampakkan serebelum dan mengamati perubahan mikroskopiknya pada rentang waktu 90 menit, 2 jam, 3 jam, 4 jam, 5 jam, 6 jam, 7 jam, 8 jam, 9 jam, 10 jam, 11 jam, 12 jam, 13 jam, 14 jam, 15 jam, 16 jam, 17 jam, 18 jam, 19 jam, 20 jam, 21 jam, 22 jam, 23 jam, dan 24 jam postmortem. Hasil penelitian mendapatkan serebelum tampak pucat dan melunak secara progresif pada 8 jam postmortem. Kongesti di semua jaringan mulai terjadi pada 2 jam postmortem dan ditemukan 69,2% sel Purkinje berinti yang masih normal. Sel Purkinje mulai membesar dan inti mengalami karioreksis pada 7 jam postmortem tetapi pada 21 jam postmortem sel-sel tersebut tampak menyusut. Meskipun demikian hingga 24 jam postmortem struktur lapisan serebelum masih dapat diidentifikasi dan sel Purkinje dengan morfologi normal masih ditemukan. Simpulan: Perubahan mikroskopik serebelum sudah dapat diidentifikasi pada 2 jam postmortem yaitu berupa kongesti lapisan serebelum. Sel Purkinje mengalami karioreksis pada 7 j","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"80 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90936865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Kadar Interleukin 6 Serum dan Klasifikasi CT Marshal pada Penderita Cedera Otak Berat Akibat Trauma","authors":"Mervin Manginte, E. Prasetyo, M. C. Oley","doi":"10.35790/JBM.11.1.2019.23210","DOIUrl":"https://doi.org/10.35790/JBM.11.1.2019.23210","url":null,"abstract":"Abstract: Increase of interleukin 6 (IL-6) level occurs in the brain after traumatic brain injury (TBI), however, studies about IL-6 as a prodictor based on CT-scan is still limited. This study was aimed to evaluate the relationship between serum IL-6 level and CT Marshall classification in patients with severe TBI. This was an observational study with a cross sectional design. There were 20 patients with severe TBI admitted at the Emergency Surgery Installation of Prof. Dr. R. D. Kandou Hospital Manado in this study. CT-scan was performed on them to determine the CT Marshall classification and to categorize the hemorrhage location (extra-axial, intra-axial, both), hemisphere (midline/diffuse, dextral, sinistral), and area (frontal, parietal, temporal, occipital, multiple). Venous blood sample used for IL-6 examination was drawn less than 24 hours after trauma. The results showed that mean IL-6 level was 22.0060 pg/mL (SD 4.64494 pg/mL). Patients were distributed relatively uniform in 4 detected categories (diffuse injury II, III, V, and VI) of CT Marshall classification. Final regression model consisted of IL-6, age, and temporal injury as predictors. The Spearman coefficient correlation showed rs = -0.005 (P=0.491). Conclusion: There was no significant relationship between serum Il-6 level and CT Marshall classification, albeit, both of them increased consistantly following the severity of TBI and could be potential predictors to determine the prognosis of severe TBI patients.Keywords: IL-6, CT Marshall, severe TBIAbstrak: Pada cedera otak berat akibat trauma (COBT) terjadi peningkatan ekspresi IL-6 di otak namun penelitian mengenai kemampuannya untuk memrediksi hasil berdasarkan klasifikasi CT scan masih terbatas. Penelitian ini bertujuan untuk mengevaluasi hubungan antara kadar IL-6 serum dan klasifikasi CT Marshall pada pasien dengan COBT. Jenis penelitian ialah observasional dengan desain potong lintang. Hasil penelitian mendapatkan 20 pasien yang dirawat dengan COBT di IRDB RSUP Prof. Dr. R. D. Kandou Manado. CT-scan segera digunakan untuk menentukan klasifikasi CT Marshall dan untuk mengategorikan lokasi (ekstra-aksial, intra-aksial, keduanya), belahan (garis tengah/difus, dekstra, sisnitra), dan area otak yang terlibat dalam cedera. Sampel darah vena untuk IL-6 diambil kurang dari 24 jam setelah trauma. Hasil penelitian mendapatkan rerata kadar IL-6 22,0060 pg/mL (SD 4,64494 pg/mL). Pasien didistribusikan relatif seragam dalam empat kategori yang terdeteksi (difus cedera II, III, V, dan VI) dari klasifikasi CT Marshall. Model regresi akhir terdiri dari IL-6, usia, dan cedera pada area temporal sebagai prediktor. Korelasi antara kadar IL-6 serum dan klasifikasi CT Marshall dianalisis dengan koefisien korelasi Spearman dan mendapatkan rs = -0,005 (P=0,491). Simpulan: Walaupun secara statistik tidak terdapat hubungan bermakna antara kadar Il-6 serum dan CT Marshall namun keduanya secara konsisten meningkat mengikuti COBT dan dapat menjadi p","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90593868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kelengkapan Rekam Medik Kasus Kekerasan Fisik akibat Tindak Pidana di RSUP Prof. Dr. R. D. Kandou Periode September 2017- Agustus 2018","authors":"Cherryl A. Lumentut, Erwin G. Kristanto, James F. Siwu","doi":"10.35790/JBM.11.1.2019.23208","DOIUrl":"https://doi.org/10.35790/JBM.11.1.2019.23208","url":null,"abstract":"Abstract: Complete medical record is clearly important to health service of a hospital. In cases of violence, medical records play a significant role in law enforcement. Prof. Dr. R. D. Kandou Hospital is categorized as type A service hospital that has been fully accredited in 2015. Therefore, its medical personnels should be responsible for the completeness of each patient’s medical record, especially of violence cases. This study was aimed to determine the completeness of physical violence cases’ medical records due to criminal acts at Prof. Dr. R. D. Kandou Hospital in the period of September 2017-August 2018. This was a descriptive retrospective study. The results obtained as many as 40 cases of physical violence due to criminal acts. The medical record completeness of physical violence cases due to criminal acts were as follows: in Emergency Care 40%, inpatients 12%, surgery 58.82%, anesthesia/ sedation 45.45%, blood transfusion 66.67%, and informed consent 96.87%. Conclusion: In physical violence cases due to criminal acts, the medical record completeness with informed consent had higher percentage than the other medical record documents.Keywords: completeness of medical record, physical violence casesAbstrak: Kelengkapan rekam medik merupakan hal penting dalam pelayanan kesehatan dari suatu rumah sakit. Dalam kasus kekerasan, rekam medik berperan dalam penegakan hukum. RSUP Prof. Dr. R. D. Kandou sebagai rumah sakit pelayanan tipe A yang telah terakreditasi paripurna pada tahun 2015, sudah seharusnya kelengkapan rekam medis bagi setiap pasien menjadi tanggung jawab tenaga medis terutama rekam medik kasus kekerasan yang ada di RSUP. Prof. Dr. R. D. Kandou. Penelitian ini bertujuan untuk mengetahui kelengkapan rekam medik kasus kekerasan fisik akibat tindakan pidana di RSUP Prof. Dr. R. D. Kandou periode September 2017 - Agustus 2018. Jenis penelitian ialah deskriptif retrospektif. Hasil penelitian mendapatkan sebanyak 40 kasus kekerasan fisik akibat tindak pidana. Secara keseluruhan kelengkapan rekam medik pada kasus kekerasan fisik akibat tindak pidana di Instalasi Rawat Darurat sebesar 40%, rawat inap 12%, tindakan operatif 58,82%, tindakan anestesi/sedasi 45,45%, transfusi darah 66,67%, dan informed consent 96,87%. Simpulan: Pada kasus kekerasan fisik akibat tindakan pidana, kelengkapan rekam medik dengan informed consent memiliki persentase yang lebih tinggi daripada berkas rekam medik lainnya.Kata kunci: kelengkapan rekam medik, kasus kekerasan fisik","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74094086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbandingan Massa Tulang Sebelum dan Sesudah Melakukan Senam Zumba pada Wanita Dewasa","authors":"Madeleine N. W. Senduk, H. Polii, D. V. Doda","doi":"10.35790/JBM.11.1.2019.23206","DOIUrl":"https://doi.org/10.35790/JBM.11.1.2019.23206","url":null,"abstract":"Abstract: Osteopenia commonly occurs in people over 50 years, however, several studies also showed that osteopenia affected young adults. Osteopenia can develop into osteoporosis. International Osteoporosis Foundation estimated that women in Indonesia had risk of developing osteoporosis four times greater than men. Osteopenia and osteoporosis can be prevented by physical exercise such as aerobic exercises inter alia Zumba exercise. This study was aimed to determine whether there was a difference in bone mass before and after 4-week Zumba exercise. This was an experimental study with one group pretest and posttest design conducted on 16 subjects of adult females in a fitness center in Manado, North Sulawesi. Zumba exercise was performed in 4 weeks. Bone mass before and after Zumba exercise was measured by using Bioelectrical Impedance Analysis (BIA). Data were analyzed with paired sample t-test. The results showed that the average of bone mass before Zumba exercise was 2.281 kg and the average of bone mass after Zumba exercise was 2.306 kg with a P value of 0.104. Conclusion: There was no significant difference in bone mass before and after 4-week Zumba exercise.Keywords: bone mass, Zumba exerciseAbstrak: Osteopenia umumnya terjadi pada orang berusia di atas 50 tahun, namun beberapa penelitian menunjukkan bahwa osteopenia telah menyerang usia muda. Osteopenia dapat berlanjut menjadi osteoporosis. Menurut International Osteoporosis Foundation, risiko osteoporosis pada wanita di Indonesia 4 kali lebih tinggi dibandingkan pria. Osteopenia dan osteoporosis dapat dicegah dengan melakukan aktivitas fisik seperti olahraga aerobik, antara lain senam Zumba. Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan massa tulang sebelum dan sesudah melakukan senam Zumba. Jenis penelitian ialah eksperimental lapangan dengan rancangan one group pretest dan posttest yang dilakukan pada 16 wanita dewasa pada salah satu pusat kebugaran di Manado, Sulawesi Utara. Senam Zumba dilaksanakan selama 4 minggu. Massa tulang sebelum dan sesudah senam Zumba diukur menggunakan Bioelectrical Impedance Analysis (BIA). Uji statistik dilakukan menggunakan uji t berpasangan. Hasil penelitian menunjukkan rerata massa tulang sebelum senam Zumba 2,281 kg dan rerata massa tulang sesudah senam Zumba selama 4 minggu 2,306 kg dengan nilai P=0,104. Simpulan: Tidak terdapat perbedaan bermakna antara massa tulang sebelum dan sesudah melakukan senam Zumba selama 4 minggu.Kata kunci: massa tulang, senam Zumba","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85771678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peningkatan Kadar Interleukin 10 Setelah Cedera Otak Berat akibat Trauma Berhubungan dengan Skor FOUR Rendah","authors":"David Loing, E. Prasetyo, M. Oley","doi":"10.35790/JBM.11.1.2019.23211","DOIUrl":"https://doi.org/10.35790/JBM.11.1.2019.23211","url":null,"abstract":"Abstract: Serum level of interleukin 10 (IL-10) and the FOUR score have both been suggested as predictors for the outcomes after severe traumatic brain injury (TBI). Studies are limited, however, on how they are related to each other. This study was aimed to assess the relationship between serum level of IL-10 and the FOUR score in patients with severe TBI. This was an observational study with a cross sectional design. The study was conducted on 25 severe TBI patients with FOUR score of 0-14 consecutively admitted at the the Emergency Surgery Installation of Prof. Dr. R. D. Kandou Hospital. Classification of the hemorrhage location (extra-axial, intra-axial, both), hemisphere (midline/diffuse, dextral, sinistral), and area (frontal, parietal, temporal, occipital, multiple) was established by using CT scans. Venous blood sample for IL 10 was performed less than 24 hours after trauma. Binary logistic regression was used to model the relationship of interest, with covariates selected through stepwise forward selection. The results obtained 25 patients dominated by males (84%), with median age 31. Mean IL-10 was 107.3 pg/ml (SD 16.2 pg/ml). Median FOUR score was 10, with fairly equal proportion in the category of high (FOUR score 0-7; 48%) and moderate (FOUR score 8-14; 52%) mortality risks. Final regression model included age and injury on temporal area (yes, no) as covariates for IL-10. Adjusting for these variables, the average patients had about 1.12 (95% CI 1.01, 1.25) times higher odds for worse FOUR scores (0-7, high mortality risk) in each pg/ml addition of serum IL-10. Conclusion: The finding indicates that increased IL-10 level is a potential alternative to the lower FOUR score for predicting worse outcome in patients with severe TBI.Keywords: IL-10; FOUR score; TBIAbstrak: Interleukin 10 (IL-10) serum dan skor FOUR disarankan sebagai prediktor luaran setelah cedera otak akibat trauma (COT) berat namun penelitian mengenai hubungan keduanya masih terbatas. Penelitian ini bertujuan untuk menilai hubungan antara kadar IL-10 serum dan skor FOUR pada pasien dengan COT berat. Jenis penelitian ialah observasional dengan desain potong lintang. Penelitian dilaksanakan pada 25 pasien dengan COT berat dan skor FOUR 0-14 secara berurut masuk ke UGD Prof. Dr. R. D. Kandou. Klasifikasi lokasi perdarahan (ekstra-aksial, intra-aksial, keduanya), hemisfer (garis tengah/difus, dekstra, sinistra), dan area (frontal, parietal, temporal, oksipital, multipel) ditetapkan dengan CT scan. Sampel darah vena untuk pemeriksaan IL-10 diambil kurang dari 24 jam setelah trauma. Regresi logistik biner digunakan pada model untuk hubungan ketertarikan dan kovariat stepwise forward. Hasil penelitian mendapatkan 25 pasien didominasi oleh laki-laki (84%), median usia 31 tahun. Rerata IL-10 107,3 pg/ml (SD 16,2 pg/ml). Median skor FOUR 10 dengan proporsi berimbang pada kategori tinggi (skor FOUR 0-7; 48%) dan sedang (skor FOUR 8-14; 52%) risiko mortalitas. Model regresi akhir t","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84449838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Klinis Glomerulonefritis Akut pada Anak di RSUP Prof. Dr. R. D. Kandou Manado","authors":"Valentine Umboh, Adrian Umboh","doi":"10.35790/JBM.10.3.2018.21985","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21985","url":null,"abstract":"Abstract: Acute glomerulonephritis (AGN) is characterized by classical clinical triad of sudden onset of edema, hematuria, and hypertension. The clinical picture is unmistakable but laboratory evidences lend additional diagnostic support. This study was aimed to evaluate the clinical profile and complication of children with AGN at Prof. DR. R.D.Kandou Manado Hospital. This was a retrospective study of patients from December 2009 to December 2014. This study was perfomed on 45 patients diagnosed as AGN, aged 1-15 years, admitted at the Pediatric Ward of Prof. Dr. R. D. Kandou Manado Hospital. Data of the clinical and laboratory presentation of these patients were obtained from the medical records. The results showed that the majority of patients (88.8%) were between 5-12 years; only 5 patients below 5 years of age. AGN was twice as common in males as it was in females. It was ushered as acute onset of edema (64.4%), hypertension (46.6%), tea-colored urine (33.3%), and fever (28.8%). The ASTO titre was elevated above 250 Todd units in 68.8% of cases. Of 45 patients, only 18 patients were checked for C3 level and the result showed that all of the 18 patients had C3 <50 mg/dL. The main complications were hypertensive encephalopathy (8.9%) and crisis hyper-tension (4.4%). Conclusion: Clinical profiles of AGN in children in this study are not significantly different from those of other developing countries. Therefore, it will help us a lot in confirming the diagnosis of patients with AGN.Keywords: acute glomerulonephritis, clinical profile, ASTO, complicationAbstrak: Glomerulonefritis akut (GNA) mempunyai karakteristik berupa trias gejala klasik yaitu edema yang terjadi secara tiba-tiba, hematuria, dan hipertensi. Meskipun gambaran klinisnya cukup jelas, tetapi hasil pemeriksaan laboratorium dapat memberikan tambahan untuk mendukung diagnosis. Penelitian ini bertujuan untuk mengevaluasi gambaran klinis dan komplikasi dari GNA yang terjadi pada anak di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah retrospektif pada pasien-pasien dari periode Desember 2009-Desember 2014. Sebanyak 45 pasien yang didiagnosis GNA dengan rentang usia mulai dari 1-15 tahun yang dirawat di bangsal anak rumah sakit Prof. Dr. R. D. Kandou dimasukkan ke dalam penelitian ini. Data mengenai gambaran klinis dan hasil pemeriksaan laboratorium pasien diperoleh dari rekam medik. Hasil peneltiian mendapatkan bahwa sebagian besar pasien (88,8%) berusia 5-12 tahun, hanya 5 pasien dengan usia kurang dari 5 tahun. Anak laki–laki dua kali lebih sering terkena daripada anak perempuan. Penyakit ini ditandai dengan edema yang terjadi secara tiba-tiba (64,4%), hipertensi (46,6%), urin berwarna seperti teh (33,3%), dan demam (28,8%). Peningkatan titer ASTO di atas 250 Todd unit dijumpai pada 68,8% kasus. Dari 45 pasien, hanya 18 pasien yang diperiksakan nilai C3 dan hasilnya memperlihatkan bahwa 18 pasien tersebut memiliki hasil C3 <50 mg/dL. Komplikasi yang sering terjadi ialah hip","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77013789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sindroma Marfan – Laporan Kasus","authors":"Rillya D. P. Manoppo","doi":"10.35790/JBM.10.3.2018.21988","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21988","url":null,"abstract":"Abstract: Marfan's syndrome is a FBN1 gene mutation that encodes a connective tissue protein, fibrillin-1. Patients usually present with multiple defects including mayor ocular system abnormalities such as ectopic lens and minor criteria such as flat normal cornea, various axial lengths, ciliary hypoplasia, and myopia. We reported a case of a 6-year-old boy with vision complaint since one year ago. Ophthalmological examination revealed 6/60 right eye vision and 1/60 left eye vision. The pressure of the right eyeball was 15 mmHg and of the left eyeball was 13 mmHg. Eye vision could not be corrected with lenses. There were normal eyeball movements to all directions. Examination of the anterior segment showed no injection, clear cornea, and clear anterior chamber. There were superonasal subluxation of the right eye lens with zonular pull and superotemporal subluxation of the left eye lens with zonular pull. Examination of the posterior segment showed positive non-uniform fundus reflex, however, examination of the vitreous body, retina, and macula was difficult to evaluate. The patient was treated with lens extraction and was advised to come to the eye clinic every month for further evaluation of the eye ball pressure and ophthalmological examination as well as the possibility of further intervention treatment such as anterior lens implant in the anterior chamber.Keywords: Marfan syndrome, ectopic lensAbstrak: Sindrom Marfan adalah mutasi gen FBN1 yang mengkode protein jaringan ikat yang disebut fibrilin-1. Pasien biasanya datang dengan cacat multipel termasuk kelainan pada sistem okular yang meliputi kriteria mayor berupa ektopia lentis dan kriteria minor berupa kornea normal datar, peningkatan panjang aksial, hipoplasia silia, dan miopia. Kami melaporkan kasus seorang anak laki-laki berusia 6 tahun dengan keluhan penglihatan kedua mata kabur sejak 1 tahun lalu. Pada pemeriksaan oftalmologik didapatkan visus mata kanan 6/60, visus mata kiri 1/60, tekanan bola mata kanan 15 mmHg, dan tekanan bolamata kiri 13 mmHg. Visus kedua mata tidak dapat dikoreksi dengan menggunakan lensa. Gerakan bola mata baik ke segala arah. Pemeriksaan segmen anterior menunjukkan tidak terdapat injeksi, kornea jernih, dan bilik mata depan jernih. Lensa mata kanan mengalami subluksasi ke arah superior nasal dengan tarikan zonula Zinii sedangkan lensa mata kiri mengalami subluksasi ke arah superior temporal dengan tarikan zonula Zinii. Pemeriksaan segmen posterior kedua mata didapatkan refleks fundus positif non-uniform, sedangkan pemeriksaan untuk badan vitreus, retina dan makula sulit dievaluasi. Tindakan yang dilakukan berupa ekstraksi lentis. Pasien diminta untuk kontrol berkala di poliklinik mata setiap bulan untuk menilai tekanan bola mata dan status oftalmologiknya serta kemungkinan intervensi lanjutan seperti pemasangan lensa anterior pada bilik mata depan.Kata kunci: sindrom Marfan, ektopia lentis","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72647260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Tingkat Risiko Musculoskeletal Disorders (MSDs) Mengguna-kan Rapid Entire Body Assessment (REBA) dengan Keluhan MSDs pada Residen Ilmu Bedah","authors":"Ade P. Tubagus, D. V. Doda, H. Wungouw","doi":"10.35790/JBM.10.3.2018.21982","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21982","url":null,"abstract":"Abstract: According to WHO, musculoskeletal disorders are categorized as the second rank of work-related disease. Various factors such as work, individual, and social factors can cause MSDs. These disorders play an important role in morbidity of workers such as healthcare workers. This study was aimed to analyze the correlation between the risk level of MSDs evaluated by using REBA and MSDs complaints among surgery residents. This was an analytical observational study with a cross-sectional design. The instruments used in this study were the Rapid Entire Body Assessment (REBA) worksheet and the Nordic Body Map (NBM) questionnaire. Data were analyzed with the Spearman correlation test. There were 42 surgery residents of Faculty of Medicine, Sam Ratulangi University, Manado participated in this study. The majority of them were males (81%) and young adults (88%). The prevalence of MSDs complaints were as follows: 60% of respondents had mild complaints, 33% had moderate complaints, and 7% had severe complaints. The bivariate analysis showed that the risk level of MSDs evaluated by REBA had a strong positive correlation with MSDs complaints (P=0.000; r=0.603). Conclusion: There was a significant correlation between risk level of MSDs evaluated by using REBA and the MSDs complaints. Based on the results, ergonomics interventions are recommended to surgery residents in order to prevent the occurence of MSDs.Keywords: musculoskeletal disorders (MSDs), REBA, surgery residentsAbstrak: Musculoskeletal disorders (MSDs) menurut WHO berada di urutan kedua terbanyak penyakit akibat kerja. Berbagai faktor seperti pekerjaan serta faktor individu dan sosial dapat menyebabkan terjadinya MSDs. Gangguan ini berperan dalam morbiditas di banyak bidang pekerjaan salah satunya di bidang kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan tingkat risiko MSDs menggunakan REBA dengan keluhan MSDs pada residen ilmu bedah. Jenis penelitan ialah analitik observasional dengan desain potong lintang. Alat ukur yang digunakan ialah lembar kerja Rapid Entire Body Assessment (REBA) dan kuesioner Nordic Body Map (NBM). Analisis data menggunakan uji korelasi Spearman. Hasil penelitian mendapatkan sebanyak 42 residen ilmu bedah Fakultas Kedokteran Universitas Sam Ratulangi Manado menjadi responden penelitian. Mayoritas responden berjenis kelamin laki-laki (81%) dan berada dalam kategori dewasa muda (88%). Prevalensi keluhan MSDs ialah 60% keluhan MSDs ringan, 33% keluhan sedang, dan 7% keluhan berat. Hasil uji korelasi Spearman mendapatkan tingkat risiko MSDs menggunakan REBA memiliki hubungan positif kuat dengan keluhan MSDs (P=0,000, r=0,603). Simpulan: Terdapat hubungan bermakna antara tingkat risiko MSDs menggunakan REBA dengan keluhan MSDs. Berdasarkan hasil penelitian maka direkomendasikan intervensi ergonomi pada residen bedah untuk mencegah terjadinya keluhan MSDs.Kata kunci: musculoskeletal disorders (MSDs), REBA, residen bedah","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88947788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Tingkat Kecemasan dalam Menghadapi UKMPPD OSCE dengan Nilai UKMPPD Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi","authors":"Gilbert Limen, J. Runtuwene, Christillia Wagiu","doi":"10.35790/JBM.10.3.2018.21981","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21981","url":null,"abstract":"Abstract: Exam is a potential stressor to cause anxiety among students. As an exit exam, the medical competency examination consists of two parts: multiple choice question computer-based test and an objective structured clinical examination (OSCE). The anxiety level during the latter part where the cognitive, psychomotor and professional behaviour aspects of examinees are tested, is considered the highest. Passing grade of the exam as one criterion used for important decisions can also be another source of anxiety. Anxiety may impact performance during exam and consequently the passing grade. This study was aimed to evaluate the correlation between the anxiety level right before medical competency examination OSCE and the August 2018 OSCE final results. This was an analytical study with a cross sectional design. Respondents were all students partaking in OSCE at Sam Ratulangi University Medical School. The Hamilton Anxiety Rating Scale was used to measure the anxiety level. The OSCE results were retrieved from the Academic Department. Data were analyzed with the Spearman correlation test that obtained a P value of 0.289. Overall, 81.20% of respondents experienced anxiety, however, the majority (43.50%) were considered as mild anxiety. Moreover, the median score of August 2018 OSCE was 80.00. Conclusion: There is no correlation between anxiety level right before OSCE and August 2018 final results.Keywords: anxiety level, medical competency examination, OSCE scoreAbstrak: Ujian dapat menjadi sebuah stresor yang menimbulkan kecemasan. Uji Kompetensi Mahasiswa Program Profesi Dokter (UKMPPD) sebagai exit exam terdiri atas dua jenis ujian yakni pilihan ganda berbasis komputer dan Objective Structured Clinical Examination (OSCE). Tingkat kecemasan yang dihasilkan oleh OSCE paling tinggi karena OSCE menguji aspek kognitif, psikomotor dan professional behavior. Nilai batas lulus ujian UKMPPD juga dapat menjadi sumber kecemasan karena digunakan untuk menentukan keputusan yang penting. Kecemasan dalam menghadapi ujian dapat menjadi salah satu penyebab yang memengaruhi performa dan berdampak pada kelulusan. Penelitian ini bertujuan untuk mengetahui hubungan tingkat kecemasan mahasiswa dalam menghadapi UKMPPD OSCE dengan nilai UKMPPD OSCE periode Agustus 2018. Jenis penelitian ialah analitik dengan desain potong lintang. Responden ialah seluruh mahasiswa yang mengikuti UKMPPD OSCE di Fakultas Kedokteran Universitas Sam Ratulangi (Unsrat) dengan menggunakan instrumen penelitian Hamilton Anxiety Rating Scale untuk mengukur tingkat kecemasan dan nilai OSCE dari Bagian Akademik Fakultas Kedokteran Unsrat. Analisis statistik menggunakan uji kore-lasi Spearman. Hasil analisis hubungan antara kecemasan dalam menghadapi UKMPPD OSCE dengan nilai UKMPPD OSCE periode Agustus 2018 mendapatkan nilai P=0,289. Responden yang mengalami kecemasan sebanyak 81,20% dan umumnya memiliki tingkat kecemasan yang ringan (43,50%). Median nilai UKMPPD OSCE periode Agustus 2018 yang di","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73538315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbandingan Efektifitas Antibiotik Ceftriaxone dan Ciprofloxacine pada Penderita Infeksi Saluran Kemih di RSUP Prof. Dr. R. D. Kandou Manado","authors":"Sasangka H. Wardhana, A. Monoarfa, R. Monoarfa","doi":"10.35790/JBM.10.3.2018.21984","DOIUrl":"https://doi.org/10.35790/JBM.10.3.2018.21984","url":null,"abstract":"Abstract: Urinary tract infection (UTI) is the most common infection affecting about 40% of women in their lives. Most infections are mild, albeit, they might cause sepsis. This study was aimed to compare the effectiveness of ceftriaxone to ciprofloxacin in patients with UTIs at Prof. Dr. R. D. Kandou Hospital Manado. This was an observational study with a cross sectional design implemented from September 2017 until January 2018. Subjects were divided into two groups, Gram positive and Gram negative bacterial infections. Data were analyzed by using the chi-Square test. The results showed that in the Gram negative group, the significance value did not support the difference between efficacy of ciprofloxacin and of ceftriaxone (r = 0.366; P >0.05). However, in the Gram positive group, there was a significant difference (r = 0.003; P <0.05) between the efficacy of the two kinds of antibiotics. Conclusion: Ciprofloxacin was more effective compared to ceftriaxone for the treatment of Gram positive urinary tract infectionKeywords: urinary tract infection (UTI), ceftriaxone, ciprofloxacineAbstrak: Infeksi saluran kencing (ISK) merupakan infeksi tersering yang mengenai sekitar 40% dari populasi perempuan dalam hidupnya. Walaupun umumnya infeksi berlangsung ringan, ISK dapat juga menyebabkan sepsis. Penelitian ini bertujuan untuk membandingkan efektivitas ceftriaxone dan ciprofloxacin pada pasien dengan ISK di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah observasional dengan desain potong lintang. Penelitian ini dilaksanakan sejak September 2017 sampai Januari 2018. Subyek penelitian dibagi dalam dua kelompok, ISK oleh bakteri Gram positif dan oleh Gram negatif. Data dianalisis menggunakan chi-square test. Hasil penelitian memperlihatkan bahwa pada kelompok Gram negatif, tidak terdapat perbedaan bermakna antara efektivitas ciprofloxacin dan ceftriaxone (r=0,366; P>0,05) namun pada kelompok Gram positif, terdapat perbedaan bermakna antara efektivitas kedua jenis antibiotik (r=0,003; P<0,05). Simpulan: Ciprofloxacin lebih efektif dibandingkan ceftriaxone pada pengobatan ISK yang disebabkan oleh bakteri Gram positif.Kata kunci: infeksi saluran kencing (ISK), ceftriaxone, ciprofloxacine","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75677208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}