JURNAL BIOMEDIK (JBM)最新文献

{"title":"Korelasi antara Letak Ujung Kateter Lumen Ganda Femoralis Jangka Pendek Non-tunneling dengan Laju Aliran darah pada Saat Hemodialisis di RSUP Prof Dr. R. D. Kandou","authors":"Fery Purba, Richard M. Sumangkut, Djoni E. Tjandra","doi":"10.35790/JBM.10.2.2018.20088","DOIUrl":"https://doi.org/10.35790/JBM.10.2.2018.20088","url":null,"abstract":"Abstract: Patients with end-stage renal failure are unable to survive without dialysis or renal transplantation. To achieve effective dialysis using a double lumen catheter, placement of the catheter tip plays an important role because it may affect blood flow/Quick of Blood (QB). The selection of femoral vein access is more favorable in critical patients. This study was aimed to obtain the correlation between the tip position of the non-tunneling short-term femoral double lumen catheter (DLC) and QB at the time of hemodialysis. This was an analytical correlative and prospective study with a cross-sectional design in patients with end-stage renal failure undergoing hemodialysis using a non-tunneling short-term femoral DLC. This study was conducted at the Hemodialysis Installation of Prof. Dr. R. D. Kandou Hospital Manado. Data were analyzed by using the Pearson's r test. The results showed that there were 31 patients enrolled in this study. The Pearson’s r test obtained an r of 0.147 (statistically weak) and Sig (2-tailed) of 0.430 which showed no correlation but the scatter plot showed a tendency of a weak positive relationship. Conclusion: There was no significant correlation between Qb and the tip position of DLC, albeit, there was a tendency of a weak positive relationship. Increasing the number of samples will more accurately predict the presence or absence of the correlation between Qb and the tip position of the DLC.Keywords: DLC, QB, hemodialysisAbstrak: Pasien dengan penyakit ginjal stadium akhir tidak dapat mempertahankan hidup tanpa dukungan terapi pengganti ginjal yaitu dialisis atau transplantasi ginjal. Untuk mencapai dialisis yang efektif dengan menggunakan kateter lumen ganda, penempatan kateter berperan penting karena dapat memengaruhi aliran darah/Quick of Blood (QB). Pemilihan akses vena femoralis lebih menguntungkan pada pasien kritis. Penelitian ini bertujuan untuk mengetahui korelasi letak ujung kateter lumen ganda femoralis jangka pendek (DLC) dengan QB pada saat hemodialisis. Jenis penelitian ialah analitik korelatif dan prospektif dengan desain potong lintang. Subyek penelitian ialah pasien dengan gagal ginjal tahap akhir yang menjalani hemodialisis menggunakan kateter lumen ganda femoralis jangka pendek non-tunneling. Penelitian dilakukan di Instalasi Hemodialisis RSUP Prof. Dr. R. D. Kandou, Manado. Data dianalisis menggunakan koefisien korelasi Pearson. Hasil penelitian mendapatkan 31 pasien sebagai subyek. Hasil analisis koefisien Pearson terhadap korelasi antara letak ujung DLC dan QB memperlihatkan hubungan statistik lemah (r = 0,147) dengan Sig (2-tailed) 0,430 yang menunjukkan tidak terdapat hubungan bermakna tetapi pada scatter plot terlihat adanya kecenderungan hubungan positif lemah. Simpulan: Tidak terdapat korelasi bermakna antara Qb dan letak ujung DLC tetapi terdapat kecenderungan hubungan positif lemah. Menambah jumlah sampel akan lebih akurat untuk memrediksi ada tidaknya hubungan antara Qb dan letak ujun","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"104 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72629754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penyakit Adamantiades-Behcet Koinfeksi dengan Herpes Genital","authors":"Charly M. M. Korompis, Triomega F. X. Sengkey, Shienty Gaspersz, J. Niode","doi":"10.35790/jbm.10.2.2018.20092","DOIUrl":"https://doi.org/10.35790/jbm.10.2.2018.20092","url":null,"abstract":"Abstract: Adamantiades-Behcet (AB) disease is a rare multi-systemic inflammatory disorder with unknown cause. It is characterized by recurrent mucocutaneous ulcer in the mouth and genitalia, and mostly affects the age group of 20 to 30 ys. Genital lesion of AB must be differentiated from others caused by sexually transmitted disease, such as genital herpes. Co-infection of AB with genital herpes is very rare. We reported a male 72-year old, came with painful ulcers in the mouth and genital area since a week before visit. Symptoms were recurrent since three years ago. History of arthritis, recurrent headache, eye and skin lesions were denied. Patient was sexually promiscuous. Physical examination revealed multiple ulcers on the labium oris sized 0.5cm-1cm, irregular border, base covered by fibrin tissue, associated with erosion and crust. Multiple ulcers were also found on penile glans, sized 0.1x1x0.2 cm, irregular border, with pus and necrotic tissue. The ulcers were punched out. Pathergy test and anti HSV-1 IgM were negative meanwhile anti HSV-1 IgG, anti HSV-2 IgM as well as anti HSV-2 IgG were positive. Acyclovir 200mg 5x/day for five days, triamcinolone acetonide lotion bid for the mouth ulcer, NaCl 0,9% dressing applied tid for 30 minutes, and fucidic acid cream bid were given and the symptoms improved after 10 days. The prognosis was bonam for ad vitam and dubia for ad functionam and ad sanationam. Conclusion: The diagnosis of AB was based on the International Criteria for Behcet Disease, with a total score of 4 for the recurrent ulcer in mouth and genital area. The positive result of anti HSV-1 IgG, anti HSV-2 IgM and anti HSV-2 IgG supported the coinfection with genital herpes. This coinfection of AB and genital herpes was the first reported in Manado. Immunosenescence was a possible risk factor of the recurrent genital herpes. Symptomatic and antiviral treatment improved the symptoms with possible recurrent genital herpes.Keywords: Adamantiades-Behcet, genital herpes, coinfectionAbstrak: Penyakit Adamantiades-Behçet (AB) merupakan kelainan inflamasi multisistemik yang tidak diketahui penyebabnya dengan manifestasi mukokutan tersering berupa ulkus berulang pada mulut dan genital. Penyakit ini terutama terjadi pada usia 20-30an. Lesi genital pada AB perlu dibedakan dengan ulkus genital akibat infeksi menular seksual termasuk herpes genitalis. Koinfeksi AB dan herpes genitalis jarang terjadi. Kami melaporkan kasus seorang laki-laki, usia 72 tahun, dengan keluhan luka di bibir dan kelamin yang nyeri sejak 1 minggu lalu, bersifat hilang-timbul selama 3 tahun terakhir. Riwayat nyeri sendi, sakit kepala berulang, serta kelainan kulit disangkal. Terdapat riwayat promiskuitas yang tinggi. Pada pemeriksaan fisik di regio labialis oris ditemukan ulkus multipel, diameter ±0,5-1 cm, tepi tidak teratur, dasar tertutup jaringan fibrin, dengan erosi dan krusta. Di regio glans penis ditemukan ulkus multipel, ukuran bervariasi ± 1x2x0,2cm, tepi tidak ter","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81853817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermal Filler","authors":"F. O. Mawu","doi":"10.35790/jbm.10.2.2018.20083","DOIUrl":"https://doi.org/10.35790/jbm.10.2.2018.20083","url":null,"abstract":"Abstract: Dermal filler is a non-surgical procedure to improve facial volume or the anatomy of other parts of the body. It is also a rejuvenate therapy to achieve a younger appearance. Besides that, the need of lipodystrophy therapy is increasing. There are several types of fillers with their superiorities and inferiorities; therefore, it is pretty difficult to determine and choose the ideal filler. Dermal fillers vary in duration of therapeutic effect, filler technique, filler origin, and their physical properties. To date, there is no perfect filler so far. An ideal filler must be non-allergenic, non-carcinogenic, non-teratogenic, as well as has achievable cost and long acting effect. In case that dermal filler is therapeutical indicated, good preparation of doctor and patient is essentially needed. Consultation and information have to cover the therapy indication, filler technique, filler limitation, side effects, outcome, cost, and informed consent. As the other cosmetic procedures, to achieve optimal satis-faction, the doctor must be able to provide effective communication to the patient before and after the dermal filler therapy.Keywords: dermal fillerAbstrak: Dermal filler adalah prosedur non-bedah untuk penambahan volume wajah atau anatomi tubuh lainnya. Prosedur ini juga merupakan salah satu terapi rejuvenasi yang bertujuan untuk tampilan lebih muda. Selain itu, kebutuhan untuk terapi lipodistrofi juga makin meningkat. Terdapat berbagai jenis filler dengan keunggulan dan kekurangaood prepnnya masing-masing, sehingga agak sulit menentukan atau memilih produk filler yang ideal. Dermal filler bervariasi dalam hal lamanya efek terapi yang diperoleh, cara pemberian, asal filler, dan sifat fisiknya. Sampai saat ini tidak ada produk filler yang sempurna. Untuk menjadi ideal, produk filler harus nonalergenik, nonkarsinogenik, nonteratogenik, harga terjangkau dan berefek terapi yang panjang. Saat dermal filler menjadi pilihan terapi atau tindakan, persiapan yang tepat baik dokter maupun pasien merupakan hal yang esensial. Konsultasi dan informasi harus meliputi ketepatan indikasi pemberian filler, tehnik pemberian, keterbatasan filler, efek samping, kemungkinan hasil akhir, biaya, dan informed consent. Sebagaimana prosedur kosmetik lainnya, untuk kepuasan bersama, dokter harus mampu dan bersedia memberikan komunikasi efektif kepada pasien sebelum dan sesudah terapi dermal filler.Kata kunci: dermal filler","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76626888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis Gutata - Laporan Kasus","authors":"Julieta D. P. Dotulong, Charly M. M. Korompis, Herry E. J. Pandaleke","doi":"10.35790/JBM.10.2.2018.20093","DOIUrl":"https://doi.org/10.35790/JBM.10.2.2018.20093","url":null,"abstract":"Abstract: Guttate psoriasis (GP) is a variant of psoriasis with typical drop-shaped lesions sized 0.5-1 cm in diameter, localized especially in the upper part of the body and proximal extremities. It usually occurs in young adult. We reported a female,11 years old, with red, itchy, and scaly patches distributed nearly all over the body. There was a history of sore throat. Dermatologic status showed multiple erythematous plaques which were miliar to numular, discrete, and were covered with layered silvery white scales. The Auspitz sign, wax spot phenomenon, and ASTO were positive. The histopathologic examination showed para-keratosis and Munro microabcesses. The patient treated with topical steroid for 4 weeks made improvement. Conclusion: In this case, diagnosis of guttate psoriasis was based on anamnesis, examination, and supporting examinations. Streptococcal infection was suspected as the trigger factor due to the positive ASTO examination. Topical steroid as the first line therapy for mild to moderate psoriasis made great improvement.Keywords: guttate psoriasis, streptococcal infectionAbstrak: Psoriasis gutata (PG) merupakan varian dari psoriasis. Gambaran khasnya seperti tetesan air dengan diameter 0,5-1 cm, di badan bagian atas dan ekstremitas proksimal. Sering terjadi pada dewasa muda. Kami melaporkan kasus seorang perempuan berusia 11 tahun dengan bercak merah meninggi, bersisik, disertai gatal pada hampir seluruh tubuh. Riwayat nyeri menelan positif. Riwayat pengobatan sebelumnya disangkal. Status dermatologis ditemukan plak eritem, multipel, miliar-numular, diskret, ditutupi skuama berlapis warna putih keperakan. Pemeriksaan tanda Auspitz, fenomena bercak lilin, dan ASTO positif. Pada pemeriksaan histopatologik didapatkan adanya parakeratosis dan mikroabses Munro. Terapi steroid topikal potensi tinggi selama 4 minggu menunjukkan perbaikan. Simpulan: Pada kasus ini diagnosis psoriasis gutata ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang yang khas. Infeksi streptokokus diduga sebagai faktor pencetus berdasarkan hasil pemeriksaan ASTO. Terapi steroid topikal merupakan lini pertama untuk psoriasis ringan sampai sedang memperlihatkan perbaikan yang nyata.Kata kunci: psoriasis gutata, infeksi streptokokus","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74472846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Nilai Carcinoembryonic Antigen dengan Derajat Diferensiasi pada Karsinoma Kolorektal di RSUP Prof. Dr. R. D. Kandou Manado","authors":"John Wesley, Toar Mambu, Heber B. Sapan, Winfried M. Sumanti","doi":"10.35790/JBM.10.2.2018.20086","DOIUrl":"https://doi.org/10.35790/JBM.10.2.2018.20086","url":null,"abstract":"Abstract: Colorectal cancer is a serious health problem in Indonesia as well as in North Sulawesi. Serum carcinoembryonic antigen (CEA) is a progmostic factor in patients with this disease. This study was aimed to obtain the correlation between the histopathological differentiation stage and serum CEA level in colorectal cancer patients at Prof. Dr. R. D. Kandou Hospital Manado. This was an analytical correlation study. Subjects were colorectal cancer patients who had preoperative serum CEA level and histopathological differentiation stage results. Data were analyzed with Anova test (variant analysis) and Spearman Rho test. The results showed that there were 58 colorectal cancer patients enrolled in this study. The patients’ data were obtained from the Digestive Surgery clinic and nursery room of Prof. Dr. R. D. Kandou Hospital Manado. Of the 58 patients, 37 (63.79%) had moderate differentiated colorectal cancer. Related to serum CEA level, 23 patients (39.65%) had moderate differentiated colorectal cancer with serum CEA level 20-100 ng/ml. The Spearman Rho test showed that there was a positive correlation between serum CEA level and histopathoplogical differentiation stage of cancer (r = 0.877 and P = 0.001). Conclusion: There was a significant correlation between serum CEA level and histopathological differentiation stage of colorectal cancer. The better the differentiation stage, the higher the serum CEA level.Keywords: carcinoembryonic antigen, colorectal cancer, differentiation stageAbstrak: Karsinoma kolorektal (KKR) telah menjadi masalah kesehatan yang serius di Indonesia dan Sulawesi Utara pada khususnya. Kadar carcinoembryonic antigen (CEA) merupakan salah satu faktor prognostik pada penderita KKR. Penelitian ini bertujuan untuk mengetahui hubungan antara derajat diferensiasi histopatologik dengan kadar CEA dalam serum pada pasien KKR di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini ialah analitik korelatif. Subyek penelitian ialah 58 pasien KKR yang mempunyai hasil pemeriksaan kadar CEA serum preoperasi dan pemeriksaan derajat diferensiasi histopatologik. Analisis statistik menggunakan uji Anova (analisis variansi) dan korelasi Spearman Rho. Data pasien diambil dari pasien yang datang dan kontrol di Poliklinik Bedah Digestif serta dari ruang perawatan Bedah Digestif RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan derajat diferensiasi tumor kolorektal terbanyak ialah diferensiasi sedang/moderate differentiated yaitu 37 pasien (63,79%). Bila dihubungkan dengan nilai CEA serum, yang terbanyak ditemukan ialah jenis diferensiasi sedang pada pasien dengan kadar CEA serum 20-100 ng/ml sebanyak 23 orang (39,65%). Uji Spearman Rho memperlihatkan bahwa kadar CEA berkorelasi positif dengan derajat diferensiasi KKR (r = 0,877 dan P = 0,0001). Simpulan: Terdapat korelasi bermakna antara kadar CEA serum dan derajat diferensiasi kanker kolorektal. Derajat diferensiasi KKR yang baik memiliki kadar CEA yang tinggi.Kata kun","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88473621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karakteristik dan Motivasi Augmentasi Penis dengan Komplikasinya di RSUP Prof. Dr. R. D. Kandou dan RS Jejaring","authors":"Adrian Purba, Ari Astram, R. Monoarfa","doi":"10.35790/jbm.10.2.2018.20091","DOIUrl":"https://doi.org/10.35790/jbm.10.2.2018.20091","url":null,"abstract":"Abstract: Penile augmentation is an individual effort to enlarge one’s penile size for his sexual satisfaction and his mate without functional alteration. This study was aimed to obtain the profile of motivation, sexual satisfaction, mental distortion, and complications in patients with penile augmentation. This was a descriptive categorical study with a retrospective approach. This study was conducted at Prof. Dr. R. D. Kandou Hospital and its link hospitals for 10 months involving 23 patients; most of them (34.78%) were 26-35 years old. Most patients (61%) had internal motivation based on NSSS scale >30. Based on ulcer free period, 3 patients had free period of ulcer I; no patient had free period of ulcer II. Based on pain scale, 14 patients (60.87%) had pain scale of <5 and 9 patients (39.13%) had pain scale of >5. Most complications were in the form of ulcers located in preputium (56.52%). The relationships between motivation and NSSS scale before and after penile augmentation were analyzed using Fisher exact test which obtained P = 0.000 for relationship between motivation and NSSS scale (sexual satisfaction) before and after penile augmentation and P = 0.360 between post augmentation (with its complications) and sexual satisfaction. Conclusion: Patients with penile augmentation were internally and externally motivated without any mental distortion. There was a significant relationship between internal motivation and penile augmentation as well as between motivation and sexual satisfaction. Albeit, there was no significant relationship bewteen complications of penile augmentation and sexual satisfaction. Most patients suffered complications.Keywords: penile augmentation, NSSSAbstrak: Augmentasi penis merupakan usaha individu untuk membesarkan ukuran penis demi memenuhi hasrat seksual dan pasangannya tanpa perubahan fungsi. Penelitian ini bertujuan untuk mendapatkan gambaran motivasi, kepuasan seksual, adanya gangguan jiwa, dan komplikasi pada pasien yang melakukan augmentasi penis. Jenis penelitian ialah deskriptif kategorik dengan pendekatan retrospektif. Penelitian ini dilakukan di RSUP Prof. Dr. R. D. Kandou dan RS jejaring selama 10 bulan yang melibatkan 23 pasien. Rentang usia pasien 16-59 tahun, terbanyak pada usia 26-35 tahun (34,78%). Sebagian besar pasien (61%) dengan motivasi secara internal berdasarkan skala NSSS>30. Berdasarkan periode bebas ulkus didapatkan 3 pasien dengan periode bebas ulkus I; tidak didapatkan pasien dengan periode bebas ulkus II. Berdasarkan skala nyeri didapatkan 14 pasien (60,87%) dengan skala nyeri <5 dan 9 pasien (39,13%) dengan skala nyeri >5. Lokasi komplikasi terbanyak berupa ulkus di preputium (56,52%). Analisis menggunakan Fisher exact terhadap hubungan motivasi dan skala NSSS sebelum dan sesudah augmentasi penis memper-lihatkan hubungan antara motivasi dan kepuasan seksual dengan nilai P = 0,000 (<0,05) serta hubungan antara pasca augmentasi (beserta komplikasi) dan kepuasaan seksual dengan nilai P ","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"143 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86634157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Perlakuan Hipotermia Ringan pada Kasus Cedera Otak akibat Trauma Risiko Tinggi Berdasarkan Glasgow Coma Scale dan Kadar Protein TNF-α","authors":"Josep Hendratno, E. Prasetyo, M. C. Oley","doi":"10.35790/JBM.10.2.2018.20089","DOIUrl":"https://doi.org/10.35790/JBM.10.2.2018.20089","url":null,"abstract":"Abstract: Mild hypothermia treatment could be a useful method for improving the outcome of neurological treatment in patients with severe traumatic brain injury (TBI). There are several mechanisms underlying this effect inter alia reduction of metabolic rate, attenuation of excitatory amino acid and free radical synthesis, suppression of inflammatory responses, and prevention of blood-brain barrier disruption and brain edema. This study was aimed to obtain the effect of mild hypothermia treatment on Glasgow Coma Scale (GCS) dan TNF-α level among patients with severe TBI. This was an experimental analytical study. Subjects were adults aged 16-45 years, divided randomly into two groups (mild hypothermia and control groups) which were observed within 24 and 72 hours. TNF-α serum level was estimated by using TNF-α in vitro simple step ELISA. The assessments of outcomes were determined by using Glasgow Coma Scale (GCS) during the mild hypothermia therapy. The results showed that there were 20 TBI patients enrolled in this study, divided randomly into two groups. The treatment group, treated with mild therapeutic hypothermia, showed a decrease in TNF-α serum level and improved clinical value of GCS score (P <0.05). Conclusion: Mild hypothermia could significantly improve the GCS score and decrease TNF-α serum level among patients with severe TBI.Keywords: mild hypothermia treatment, TNF-α, GCS score,TBIAbstrak: Terapi hipotermia ringan (HPTr) dapat memperbaiki hasil pengobatan neurologik pada pasien dengan cedera otak traumatik (COT) risiko tinggi. Beberapa mekanisme yang mendasari efek tersebut ialah antara lain pengurangan tingkat metabolisme, atenuasi asam amino rangsang maupun sintesis radikal bebas, penekanan respons inflamasi, dan pencegahan gangguan sawar darah otak serta edema otak. Penelitian ini bertujuan untuk mengetahui pengaruh perlakuan HPTr pada kasus COT risiko tinggi berdasarkan skor Glasgow Coma Scale (GCS) dan kadar TNF-α. Jenis penelitian ialah analisis eksperimental. Subjek ialah orang dewasa berusia 16-45 tahun, diacak menjadi dua kelompok yaitu kelompok perlakuan HPTr dan kelompok kontrol. Pengamatan subjek dilakukan pada 24 jam dan 72 jam. Kadar serum TNF-α diperoleh dengan menggunakan metode TNF-α in vitro simple step ELISA. Penilaian klinis dilakukan dengan mengunakan skor GCS pada 24 dan 72 jam perlakuan HPTr. Hasil penelitian mendapatkan 20 penderita COT, dibagi menjadi dua kelompok secara acak. Kelompok perlakuan HPTr menunjukkan kecenderungan penurunan kadar TNF-α serum dan perbaikan nilai klinis dinilai dengan skor GCS (P <0,05). Simpulan: Pada penderita dengan cedera otak traumatik risiko tinggi, terapi hipotermia ringan dapat meningkatkan nilai klinis skor GCS dan menurunkan kadar TNF-α serum secara bermakna.Kata kunci: hipotermia ringan, TNF-α, skor GCS, COT","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87480743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}