该研究表明，坎杜·马纳多教授在RSUP中的心肌梗塞癌中表现出低分化程度的癌样

JURNAL BIOMEDIK (JBM) Pub Date : 2018-07-11 DOI:10.35790/JBM.10.2.2018.20086

John Wesley, Toar Mambu, Heber B. Sapan, Winfried M. Sumanti

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引用次数: 1

摘要

摘要:结直肠癌在印度尼西亚和北苏拉威西岛是一个严重的健康问题。血清癌胚抗原(CEA)是本病患者的一个预后因素。本研究旨在了解万鸦老康杜医院大肠癌患者组织病理分化阶段与血清CEA水平的相关性。这是一项分析相关性研究。研究对象为术前血清CEA水平及组织病理分化分期结果的结直肠癌患者。数据分析采用方差分析(Anova)和Spearman Rho检验。结果显示，本研究共纳入58例结直肠癌患者。患者资料来自万鸦老医院Dr. Dr. Kandou教授的消化外科诊所和育室。58例患者中，37例(63.79%)为中度分化型结直肠癌。与血清CEA水平相关，23例(39.65%)为中度分化型结直肠癌，血清CEA水平为20 ~ 100 ng/ml。Spearman Rho检验显示血清CEA水平与肿瘤组织病理分化分期呈正相关(r = 0.877, P = 0.001)。结论:血清CEA水平与结直肠癌组织病理分化分期有显著相关性。分化阶段越好，血清CEA水平越高。摘要:Karsinoma kolorektal (KKR)， telah, menjadi, masalah, kesehatan, yang, serius, Indonesia, Sulawesi, Utara, pada khususnya。卡达尔癌胚抗原(CEA)是影响预后的重要因素。Penelitian ini bertujuan untuk mengetahui hubungan antara derajat差异，组织病理学，dengan kadar CEA dalam血清，pada pasen KKR di RSUP教授Dr. Dr. Kandou Manado。Jenis penelitian的翻译结果:Subyek penelitian ialah, 58例患者kkkyang mempunyya, 2例患者术前CEA血清与术前病变组织病理学差异。方差分析(Anova) dan korelasi Spearman Rho数据分析，数据分析，数据分析，数据分析，数据分析，数据分析，数据分析，数据分析，数据分析，数据分析，数据分析，数据分析Hasil penelitian meperlihatkan derajat diffensii tumor kolorektal terbanyak /中度分化yait37例(63,79%)。Bila dihubungkan dengan nilai CEA血清，yang terbanyak ditemukan ialjenis差异，sedang pada dengan kadar CEA血清20-100 ng/ml sebanyak 23 orang(39,65%)。Uji Spearman Rho memperlihatkan bahwa kadar CEA berkorelasi阳性denengan derajat差异(r = 0.877, P = 0.0001)。猕猴桃:Terdapat korelasbermakna antara kadar CEA血清与不同类型的dna。德拉吉特差异——KKR杨柏基记忆卡达尔CEA杨廷基。Kata kunci:癌胚抗原，karsinoma kolorektal, derajat差异

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Hubungan Nilai Carcinoembryonic Antigen dengan Derajat Diferensiasi pada Karsinoma Kolorektal di RSUP Prof. Dr. R. D. Kandou Manado

Abstract: Colorectal cancer is a serious health problem in Indonesia as well as in North Sulawesi. Serum carcinoembryonic antigen (CEA) is a progmostic factor in patients with this disease. This study was aimed to obtain the correlation between the histopathological differentiation stage and serum CEA level in colorectal cancer patients at Prof. Dr. R. D. Kandou Hospital Manado. This was an analytical correlation study. Subjects were colorectal cancer patients who had preoperative serum CEA level and histopathological differentiation stage results. Data were analyzed with Anova test (variant analysis) and Spearman Rho test. The results showed that there were 58 colorectal cancer patients enrolled in this study. The patients’ data were obtained from the Digestive Surgery clinic and nursery room of Prof. Dr. R. D. Kandou Hospital Manado. Of the 58 patients, 37 (63.79%) had moderate differentiated colorectal cancer. Related to serum CEA level, 23 patients (39.65%) had moderate differentiated colorectal cancer with serum CEA level 20-100 ng/ml. The Spearman Rho test showed that there was a positive correlation between serum CEA level and histopathoplogical differentiation stage of cancer (r = 0.877 and P = 0.001). Conclusion: There was a significant correlation between serum CEA level and histopathological differentiation stage of colorectal cancer. The better the differentiation stage, the higher the serum CEA level.Keywords: carcinoembryonic antigen, colorectal cancer, differentiation stageAbstrak: Karsinoma kolorektal (KKR) telah menjadi masalah kesehatan yang serius di Indonesia dan Sulawesi Utara pada khususnya. Kadar carcinoembryonic antigen (CEA) merupakan salah satu faktor prognostik pada penderita KKR. Penelitian ini bertujuan untuk mengetahui hubungan antara derajat diferensiasi histopatologik dengan kadar CEA dalam serum pada pasien KKR di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini ialah analitik korelatif. Subyek penelitian ialah 58 pasien KKR yang mempunyai hasil pemeriksaan kadar CEA serum preoperasi dan pemeriksaan derajat diferensiasi histopatologik. Analisis statistik menggunakan uji Anova (analisis variansi) dan korelasi Spearman Rho. Data pasien diambil dari pasien yang datang dan kontrol di Poliklinik Bedah Digestif serta dari ruang perawatan Bedah Digestif RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan derajat diferensiasi tumor kolorektal terbanyak ialah diferensiasi sedang/moderate differentiated yaitu 37 pasien (63,79%). Bila dihubungkan dengan nilai CEA serum, yang terbanyak ditemukan ialah jenis diferensiasi sedang pada pasien dengan kadar CEA serum 20-100 ng/ml sebanyak 23 orang (39,65%). Uji Spearman Rho memperlihatkan bahwa kadar CEA berkorelasi positif dengan derajat diferensiasi KKR (r = 0,877 dan P = 0,0001). Simpulan: Terdapat korelasi bermakna antara kadar CEA serum dan derajat diferensiasi kanker kolorektal. Derajat diferensiasi KKR yang baik memiliki kadar CEA yang tinggi.Kata kunci: carcinoembryonic antigen, karsinoma kolorektal, derajat differensiasi

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JURNAL BIOMEDIK (JBM)

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