JURNAL BIOMEDIK (JBM)最新文献

{"title":"Peran Vitamin dalam Penanganan Penyakit Parkinson","authors":"Aurelia R. Onibala, Christi D. Mambo, A. S. R. Masengi","doi":"10.35790/jbm.13.3.2021.31956","DOIUrl":"https://doi.org/10.35790/jbm.13.3.2021.31956","url":null,"abstract":"Abstrak: Penyakit Parkinson atau Parkinson’s disease (PD) merupakan penyakit neurodegeneratif yang bersifat kronis, progresif, dan tidak dapat disembuhkan sehingga penyakit ini memiliki dampak sosial yang besar. Pengobatan yang digunakan saat ini tidak dapat menghentikan perjalanan PD dan memiliki efek samping yang merugikan. Oleh sebab itu diperlukan terapi tambahan dengan risiko efek samping yang lebih rendah seperti vitamin. Penelitian ini bertujuan untuk mengetahui vitamin apa saja yang berperan dan bagaimana mekanisme peran vitamin tersebut dalam membantu penanganan PD. Penelitian ini dilakukan dengan menggunakan metode Literature Review. Berdasarkan artikel yang dianalisis, vitamin memiliki peran dalam penanganan PD. Vitamin A (9-cis-retinoic acid) bermanfaat melalui mekanisme neuroproteksi pada neuron dopaminergik. Vitamin B3 (niasin) berpotensi dalam mengurangi peradangan saraf. Vitamin B12 dalam penelitian in vitro berperan melalui  mekanisme inhibisi terhadap agregasi α-synuclein, menghambat aktivitas kinase leucine-rich repeat kinase 2 (LRRK2), dan mencegah neurotoksisitas. Vitamin C (asam askorbat) efektif untuk menurunkan stres oksidatif. Vitamin E memiliki efek antiinflamasi dan antioksidan serta dapat meningkatkan kapasitas antioksidan total, dan meningkatkan GSH. Penggunaan vitamin A (9-cis-retinoic acid), vitamin B3, vitamin B12, vitamin C (dalam dosis dan jangka waktu tertentu), dan vitamin E bermanfaat untuk agen terapeutik PD. Vitamin B12, berdasarkan literature review perlu penelitian lebih lanjut namun tampaknya dapat menjadi terapi pendukung PD.Kata kunci: Vitamin, Penyakit Parkinson, Stres Oksidatif, Peradangan Saraf  Abstract: Parkinson's disease (PD) is a chronic, progressive, and incurable neurodegenerative disease that has a major social impact. The medications currently used cannot stop the course of PD and have adverse side effects. Therefore additional therapy with a lower risk of side effects such as vitamins is needed. This study aims to determine which vitamins play a role and how the mechanism of the role of these vitamins in helping treat PD. This research was conducted using the Literature Review method. Based on the articles analyzed, vitamins have a role in the management of PD. Vitamin A (9-cis-retinoic acid) is beneficial through neuroprotection in dopaminergic neurons. Vitamin B3 (niacin) has the potential to reduce nerve inflammation. Vitamin B12 in in vitro studies plays a role through inhibitory mechanisms of α-synuclein aggregation, inhibits the activity of leucine-rich repeat kinase 2 (LRRK2), and prevents neurotoxicity. Vitamin C (ascorbic acid) is effective for reducing oxidative stress. Vitamin E has anti-inflammatory and antioxidant effects and can increase the total antioxidant capacity and increase GSH. The use of vitamin A (9-cis-retinoic acid), vitamin B3, vitamin B12, vitamin C (in certain doses and for a certain time), and vitamin E are beneficial for the therapeutic agent of PD. For vitami","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"1998 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89914705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Latihan Sit-up Terhadap Persentase Lemak Tubuh","authors":"Reynaldy A. S. Walukow, Jimmy F. Rumampuk, F. Lintong","doi":"10.35790/jbm.13.3.2021.31727","DOIUrl":"https://doi.org/10.35790/jbm.13.3.2021.31727","url":null,"abstract":"Abstract: The human body consists of fat mass and fat-free mass. Most people assume that the higher the body mass index value, the higher the fat level is in a person's body. Sit-ups are movements that rely on the hips and buttocks with the knees raised and performed repeatedly. This study aims to determine whether sit-up exercise has effects on body fat percentage. This research was conducted in the form of a literature review, which is explaining and discussing the topic by taking the material from various literatures such as books, journals, papers and so on. The results of the research of Todingan et al and Meriawati  et al on the fat percentage with the sit-up method, a significant decrease in the body fat percentage was found. Whereas in a research conducted by Tendean et al on exercise with Zumba, there was a decrease in the fat percentage from 39.300% to 39.031%. Similar to what Santika did to subjects with jogging and walking exercises, there was a decrease in the fat percentage by 3.8% in jogging exercise and 0.6% in walking exercise. In conclusion, doing sit-ups besides building muscles in the abdomen, doing sit-ups can also reduce the diameter of fat in the abdomen.Key Words: sit-up training, body fat percentage.  Abstrak: Tubuh manusia terdiri dari massa lemak dan massa bebas lemak. Sebagian besar orang berasumsi semakin tinggi nilai indeks massa tubuh semakin banyak kadar lemak di dalam tubuh seseorang. Sit-up adalah gerakan yang bertumpu pada pinggul dan bokong dengan lutut yang diangkat ke arah atas dan dilakukan secara berulang-ulang. Penelitian ini bertujuan untuk mengetahui apakah memiliki pengaruh latihan sit-up terhadap persentase lemak tubuh. Penelitian ini dilakukan dalam bentuk tinjauan pustaka yaitu memaparkan dan membahasnya dengan mengambil bahan dari berbagai kepustakaan seperti buku, jurnal, makalah dan sebagainya. Dari hasil penelitian todingan dkk dan meriawati dkk terhadap presentase lemak dengan metode sit-up, didapatkan penurunan presentase lemak tubuh yang cukup signifikan. Sedangkan pada penelitian yang dilakukan tendean dkk pada latihan dengan zumba, terdapat penurunan presentase lemak dari 39,300% ke 39,031%. Sama hal dengan yang dilakukan santika pada subjek dengan latihan jogging dan berjalan, terdapat penurunan persentase lemak sebanyak 3,8% pada latihan jogging dan 0,6% pada latihan berjalan Sebagai simpulan, melakukan latihan sit-up selain membentuk otot pada bagian perut, melakukan sit-up juga dapat mengurangi diameter lemak pada bagian perut.Kata Kunci: latihan sit-up, persentase lemak tubuh","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85795947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Gangguan Pendengaran Pada Penyelam","authors":"Angelina C. Walangitan, O. Palandeng, J. Runtuwene","doi":"10.35790/jbm.13.2.2021.31868","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.31868","url":null,"abstract":"Abstract: Hearing loss is the inability to hear sounds in one or both ears. Being a diver carries a high risk of harm, which can lead to hearing loss. This study  aimed to determine the description of hearing loss in divers. The research method used is literature review (literature study) with data search using three databases, namely Pubmed, Google Scholar and Clinical Key. The results of the study literature review conducted on eleven literature indicated that divers were very susceptible to hearing loss. In conclusion, hearing loss can occur in divers. In addition, the hearing loss most often experienced by a divers is mild deafness and ear barotrauma.Keywords: hearing loss, divers  Abstrak: Gangguan Pendengaran merupakan ketidakmampuan mendengarkan suara pada salah satu atau kedua telinga. Menjadi seorang penyelam memiliki tingkat risiko bahaya yang tinggi, sehingga dapat menyebabkan gangguan pendengaran. Tujuan penelitian ini untuk mengetahui gambaran gangguan pendengaran pada penyelam. Metode penelitian yang digunakan adalah literature review (studi pustaka) dengan pencarian data menggunakan tiga database yaitu Pubmed, Google Scholar dan Clinical Key. Hasil penelitian literature review yang dilakukan pada sebelas literatur menunjukkan bahwa penyelam sangat rentan terhadap terjadinya gangguan gangguan pendengaran. Sebagai simpulan, gangguan pendengaran dapat terjadi pada penyelam. Selain itu juga gangguan pendengaran yang paling sering dialami seorang penyelam yaitu tuli ringan dan barotrauma telinga.Kata Kunci: gangguan pendengaran, penyelam","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84192397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbandingan Efektivitas Penggunaan Donepezil dan Memantine Terhadap Perbaikan Fungsi Kognitif pada Penyakit Alzheimer","authors":"Khairun N. H. Alamri, J. Posangi, Edward Nangoy","doi":"10.35790/jbm.13.2.2021.31950","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.31950","url":null,"abstract":"Abstract: Pharmacological therapy for Alzheimer’s disease are cholinesterase inhibitors (donepezil) and N-methyl-D-aspartate (memantine) receptor antagonists. The use of donepezil and memantine in elderly patients must be considered because they can affect the pharmacokinetic process of drugs and the effect of drugs on the body.The aim of the study was knowing the difference in the effectiveness of using Donepezil and Memantine on the improvement of cognitive function in Alzheimer's patients. This study was in the form of a literature review with data searches using three databases, namely Pubmed, ClinicalKey, Science Direct.  Keywords used are Donepezil AND Cognitive .AND Alzheimer, Memantine AND Cognitive AND Alzheimer. After being selected, 12 literature was obtained based on inclusion and exclusion criteria. In this study, Donepezil and memantine are beneficial in improving cognitive function in moderate to severe Alzheimer's disease but side effects tend to be more frequent with the use of donepezil than memantine. donepezil and memantine can be combined for the treatment of Alzheimer's disease but must pay attention to the effectiveness in clinical evaluation of patients and the cost effectiveness of the combination. Conclusion: Memantine and donepezil are effective and safe to use as therapy for moderate to severe Alzheimer’s disease. Donepezil and memantine combination therapy is more effective than donepezil or memantine monotherapy.Keywords: Donepezil, Memantine, Cognitive, Alzheimer  Abstrak: Terapi farmakologi untuk penyakit alzheimer adalah inhibitor kolinesterase (donepezil) dan antagonis reseptor N-metil-D-aspartat (memantine). Penggunaan donepezil dan memantine pada pasien lanjut usia harus diperhatikan karena dapat mempengaruhi proses farmakokinetik obat dan efek obat terhadap tubuh. Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas penggunaan Donepezil dan Memantine terhadap peningkatan fungsi kognitif pada pasien Alzheimer. Penelitian ini berbentuk Literature Review dengan pencarian data menggunakan tiga database yaitu Pubmed, ClinicalKey, Science Direct. Kata kunci yang digunakan adalah Donepezil AND Cognitive AND Alzheimer, Memantine AND Cognitive AND Alzheimer. Setelah dipilih, diperoleh 12 literatur berdasarkan kriteria inklusi dan eksklusi. Dalam penelitian ini, Donepezil dan memantine bermanfaat dalam meningkatkan fungsi kognitif pada penyakit Alzheimer sedang hingga berat tetapi efek sampingnya cenderung lebih sering dengan penggunaan donepezil daripada memantine. donepezil dan memantine dapat digabungkan untuk pengobatan penyakit Alzheimer tetapi harus memperhatikan keefektifan dalam evaluasi klinis pasien dan efektivitas biaya dari kombinasi tersebut. Kesimpulan: Memantine dan donepezil efektif dan aman digunakan sebagai terapi penyakit Alzheimer sedang hingga berat. Terapi kombinasi donepezil dan memantine lebih efektif dibandingkan dengan monoterapi donepezil atau memantine.Kata Kunci : Donepezil, Meman","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88273876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Tingkat Kecemasan pada Mahasiswa di Masa Pandemi COVID-19","authors":"Clinton J. S. Walean, Cicilia Pali, J. Sinolungan","doi":"10.35790/jbm.13.2.2021.31765","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.31765","url":null,"abstract":"Abstract: : COVID-19 has spread worldwide and become a global pandemic. This situation may pose psychological stress, including anxiety. In this situation, students are vulnerable to anxiety. Anxiety levels experienced by students differ from one to another. This study aimed to discover students' anxiety level illustration in countering the COVID-19 pandemic in various countries from each literature. This study was a literature review that searched data using three databases, i.e., Pubmed, ClinicalKey, and ScienceDirect. Keywords used were Anxiety AND College Students OR University Students AND COVID-19. The study found that of the total 25,984 students from all literature, 53% of students had no anxiety, 28.9% of students had mild anxiety, 10.7% of students had moderate anxiety, 6.6% of students had severe anxiety, and 0.8% students had very severe anxiety. The literature review results demonstrate that students could have anxiety during the COVID-19 pandemic era. Mild anxiety was the most prominent type that occurred in students, while severe anxiety was rare. Female students were more susceptible to anxiety during the COVID-19 pandemic era than male students. First-year and second-year students and also young adults students experiences anxiety more often. The predictors of anxiety are things related to the academic fields.Keywords: Anxiety, Students, COVID-19 Pandemic  Abstrak: COVID-19 telah menyebar ke seluruh penjuru dunia dan telah menjadi global pandemic. Situasi ini dapat menyebabkan tekanan psikologis termasuk kecemasan. Pada situasi ini mahasiswa rentan mengalami kecemasan. Tingkatan kecemasan yang dialami oleh mahasiswa berbeda – beda setiap orang. Penelitian ini bertujuan untuk mengetahui gambaran tingkat kecemasan mahasiswa dalam menghadapi pandemi COVID-19 di berbagai negara dari setiap literatur. Penelitian ini merupakan penelitian berbentuk literature review dengan pencarian data menggunakan tiga database yakni Pubmed, ClinicalKey dan ScienceDirect. Kata kunci yang digunakan yaitu Anxiety AND College Students OR University Students AND Covid-19. Penelitian ini mendapatkan hasil bahwa dari 25.984 jumlah keseluruhan mahasiswa yang dijumlahkan dari setiap literatur, terdapat 53% mahasiswa tidak cemas, 28.9% mahasiswa cemas ringan, 10.7% mahasiswa cemas sedang, 6.6% mahasiswa cemas berat, 0.8% mahasiswa cemas sangat berat. Hasil penelitian literature review menunjukkan mahasiswa dapat mengalami kecemasan di masa pandemi COVID-19, kecemasan ringan adalah tingkat kecemasan yang paling sering dialami oleh mahasiswa sedangkan kecemasan berat sangat jarang dialami oleh mahasiswa. Mahasiswa perempuan lebih sering mengalami kecemasan di masa pandemi COVID-19 dibandingkan mahasiswa laki – laki. Mahasiswa tahun pertama dan tahun kedua juga mahasiswa di usia dewasa muda lebih sering mengalami kecemasan. Faktor-faktor penyebab kecemasan paling sering yaitu cemas terkait hal-hal bidang akademik mahasiswa.Kata Kunci: Kecemasan, Mahasiswa, COVID-","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76003466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Volume Sinus Etmoid dengan Tingkat Keparahan Rhinosinusitis Kronik berdasarkan Skor Lund-Mackay pada Suku Toraja-Mandar dan Bugis-Makassar (menggunakan computed tomography scan sinus paranasal)","authors":"Syahruna Syarifuddin, Bachtiar Murtala, Nurlaily Idris","doi":"10.35790/jbm.13.2.2021.32536","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.32536","url":null,"abstract":"Abstract: The volume of the paranasal sinuses varies between individuals and is one of the factors that influence the risk of chronic rhinosinusitis. The severity of chronic rhinosinusitis can be determined based on the Lund-Mackay score on a CT scan. The purpose of this study was to determine the relationship between ethmoid sinus volume and the severity of chronic rhinosinusitis based on the Lund-Mackay score in the Toraja-Mandar and Bugis-Makassar tribes that were subjected to a CT scan of the paranasal sinuses. A total of 103 people aged> 15 years were measured for the ethmoid sinus volume and a Lund-Mackay score was calculated for each side.The subjects consisted of 65 people from Bugis-Makassar ethnicity (63.1%) and Toraja-Mandar ethnicity for 38 people (36.9%). The mean volume of the right ethmoid sinus in the Bugis-Makassar tribe group is 5.44 cm3, in the Toraja-Mandar tribe it is 6.30 cm3 with p-value 0.007, while on the left side is 5.46 cm3 in the Bugis-Makassar tribe and 6.11 cm3 in the Toraja-Mandar tribe with p-value 0.03. There was a significant relationship between ethmoid sinus volume with Lund-Mackay score on each side with a p-value of 0.001 on the right side and a p-value of 0.002 on the left side. conclusion, there is a difference in the mean volume of ethmoid sinuses between the two ethnic groups, where a larger mean volume was found in the Toraja-Mandar ethnic group. The smaller the volume of the ethmoid sinus, the higher the severity of chronic rhinosinusitis.Keywords: ethmoid sinus volume, rhinosinusitis, Toraja tribe  Abstrak.Volume sinus paranasal berbeda antar individu dan merupakan salah satu faktor yang  mempengaruhi resiko terjadinya rinosinusitis kronik. Derajat keparahan rinosinusitis kronik dapat ditentukan berdasarkan skor Lund-Mackay pada pemeriksaan CT scan.Tujuan penelitian ini adalah untuk mengetahui hubungan volume sinus etmoid dengan derajat keparahan rhinosinusitis kronik berdasarkan skor Lund-Mackay pada sukuToraja-Mandar dan Bugis-Makassar yang dilakukan pemeriksaan CT-scan sinus paranasalis. Sebanyak 103 orang yang berusia> 15 tahun dilakukan pengukuran volume sinus etmoid dan dihitung skor Lund-Mackay pada setiap sisi.Subyek terdiri dari suku Bugis-Makassar 65 orang (63,1%) dan suku Toraja-Mandar 38 orang (36,9. Rerata volume sinus etmoid kanan pada kelompok suku Bugis-Makassar adalah 5,44 cm3, pada sukuToraja-Mandar adalah 6,30 cm3 p-value 0,007, sedangkan pada sisi kiri 5,46 cm3 pada suku Bugis-Makassar dan 6,11 cm3 pada suku Toraja-Mandar p-value 0,03. Terdapat hubungan yang bermakna antara volume sinus etmoid dengan skor Lund-Mackay pada setiap sisi  p-value 0,001 pada sisi kanan dan p-value 0,002 pada sisi kiri. Sebagai simpulan, terdapat perbedaan rerata volume sinus etmoid antar kedua kelompok suku, dimana rerata volume lebih besar ditemukan pada kelompok suku Toraja-Mandar. Semakin kecil volume sinus etmoid maka semakin tinggi derajat keparahan rinosinusitis kronik.Kata kunci: volume sinus etm","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"345 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76749110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anosmia pada Coronavirus Disease 2019 (Covid-19)","authors":"Megawati Kiay, Olivia. C. P. Pelealu, Steward K. Mengko","doi":"10.35790/jbm.13.2.2021.31827","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.31827","url":null,"abstract":"Abstrack: COVID-19 is a disease caused by Coronaviruses (CoVs). WHO has declared the prevalence of COVID-19 as a Public Health Emergency of International Concern (PHEIC). The World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) have listed symptoms of anosmia or loss of smell as one of the symptoms of COVID-19 that worth watching out for. This study aims to determine whether there is a relationship between anosmia and the 2019 coronavirus disease (COVID-19). Using the Literature review method, which is carried out by identifying, evaluating and interpreting all the results of certain studies which are the focus of the research. Anosmia is one of the earliest signs of COVID-19 infection with an average onset of 7 days. Symptoms can appear just before, with or immediately after the onset of the usual symptoms, with an average recovery of 14 days. Most patients do not experience nasal congestion or rhinorrhea. There is a relationship between anosmia and coronavirus disease 2019 (COVID-19). Anosmia was found as an early sign of Coronavirus Disease (Covid-19) infection with the average duration of anosmia is 7 days and the results appear to be favorable in less than 28 days. The mechanism of the olfactory disturbance by COVID-19 is not explained. One hypothesis is that SARS-CoV-2 will cause a change of smell through direct access and damage to the CNS through its penetration by the cribriform plate. Another hypothesis is direct viral damage to olfactory cells and taste receptors.Key words: Anosmia, loss of smell, olfactory disorder, coronavirus disease 2019, COVID-19, SARS-Cov2.  Abstrak: COVID-19 adalah penyakit yang di sebabkan Coronaviruses (CoVs). WHO telah menyatakan prevalensi COVID-19 sebagai Public Health Emergency of International Concern (PHEIC).World Health Organization (WHO) dan Centers for Disease Control and Prevention(CDC) telah mencantumkan gejala anosmia atau kehilangan kemampuan penciuman sebagai salah satu gejala COVID-19 yang patut diwaspadai. Penelitian ini bertujuan untuk mengetahui apakah ada hubungan anosmia dengan coronavirus disease 2019 (COVID-19). Menggunakan metode Literature review yang di lakukan dengan cara identifikasi, evaluasi dan interpretasi terhadap semua hasil penelitian tertentu yang menjadi fokus penelitian. Anosmia adalah salah satu tanda awal infeksi COVID-19 dengan rata-rata onset 7 hari. Gejala dapat muncul tepat sebelum, bersamaan atau segera setelah timbulnya gejala yang biasa, dengan rata-rata pemulihan 14 hari. Kebanyakan pasien tidak mengalami hidung tersumbat atau rinorea. Ada hubungan antara anosmia dengan coronavirus disease 2019 (COVID-19). Dimana Anosmia di temukan sebagai tanda awal infeksi Coronavirus Disease (Covid-19) dengan durasi rata-rata anosmia adalah 7 hari dan hasilnya tampak menguntungkan dalam waktu kurang dari 28 hari. Mekanisme gangguan penciuman oleh COVID-19 tidak dijelaskan. Salah satu hipotesis adalah bahwa SARS-CoV-2 akan menyebabkan perubaha","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"33 247 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83978359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dampak Psikologis Tenaga Kesehatan Selama Pandemi COVID-19","authors":"Brian Pinggian, H. Opod, Lydia E. V. David","doi":"10.35790/jbm.13.2.2021.31806","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.31806","url":null,"abstract":"Abstract: The Corona Virus Disease 2019 (COVID-19) outbreak that emerged in December 2019 in Wuhan, quickly spread outside of China, so the World Health Organization (WHO) declared an Emergency at the Public Health Emergency of International Concern (PHEIC), causing Psychological Stress on Health workers who handle COVID-19 patients, the purpose of this study is to determine the Psychological Disorders of Health Workers during the COVID-19 pandemic. This study is a literature review by comparing articles, journals or secondary data from previously published literature contained in the medical journal database Science Direct, PubMed and ClinicalKey. Result of the ten articles reviewed, there were 11,611 respondents consisting of 3,070 men, 8,534 women, 4 respondents who did not fill in gender and 1 Genderqueer respondent obtained data on increased psychological pressure from health workers during the COVID-19 pandemic. In conclusion, it found the prevalence of psychological impacts such as stress, anxiety and depression from mild to severe among health workers during the COVID-19 pandemic. These findings will help improve our understanding of the impact or impact of the COVID-19 pandemic on the Psychology of Health Workers.Keywords: Psychological Impacts, Health Workers, the COVID-19 Pandemic  Abstrak: Wabah Corona Virus Disease 2019 (COVID-19) yang muncul pada Desember 2019 di Wuhan, dengan cepat menyebar ke luar Tiongkok, sehingga World Health Organization (WHO) mengumumkan Darurat pada Public Health Emergency of International Concern (PHEIC), menyebabkan Tekanan Psikologis pada tenaga Kesehatan yang menangani Pasien COVID-19, tujuan dari penelitian ini untuk mengetahui Gangguan Psikologis pada Tenaga Kesehatan selama Masa pandemi COVID-19. Metode penelitian berupa literature review dengan membandingkan artikel jurnal atau data sekunder dari literatur-literatur yang dipublikasi sebelumnya  yang terdapat dalam database jurnal kedokteran Science direct, PubMed dan ClinicalKey. Hasilnya sebanyak sepuluh artikel yang direview terdapat 11.611 responden yang terdiri dari 3.070  laki-laki, 8.534 perempuan, 4 responden tidak mengisi gender dan 1 responden Genderqueer didapatkan data peningkatan tekanan Psikologis dari para tenaga Kesehatan selama masa pandemi COVID-19. Sebagai simpulan,  ditemukan prevalensi dampak psikologis seperti stres, kecemasan dan depresi dari ringan hingga Berat pada Tenaga Kesehatan selama masa pandemi COVID-19. Temuan ini akan membantu meningkatkan pemahaman kita tentang pengaruh atau dampak pandemi COVID-19 pada Psikologis Tenaga Kesehatan.Kata Kunci: Dampak Psikologis,Tenaga Kesehatan, Pandemi COVID-19","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82360097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aktivitas Fisik dan Status Gizi Mahasiswa Saat Pandemi COVID-19","authors":"Enrico D. Supit, N. Mayulu, Alexander S. L. Bolang, Shirley E. S. Kawengian","doi":"10.35790/jbm.13.2.2021.31763","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.31763","url":null,"abstract":"Abstract: The imposition of social restrictions during the Covid-19 pandemic resulted in limitations in carrying out physical activities. Physical activity is a determining factor for a person's nutritional status by affecting body mass index (BMI). The purpose of this study was to determine the relationship between the metabolic equivalent (MET) and the body mass index (BMI) of Class 2017 Students for the Medical Education Study Program of the Faculty of Medicine Unsrat during the Covid-19 Pandemic and the relationship between physical activity and nutritional status based on Class 2017 Student Education Study Program Doctor of the Faculty of Medicine Unsrat during the Covid-19 Pandemic. The study used an analytical method with a cross-sectional approach to students of class 2017 of the medical education program at the Faculty of Medicine Unsrat during the Covid-19 pandemic with a total sample of 105 people. Data analysis and hypothesis testing were carried out using SPSS. Result. The significance value between metabolic equivalent (MET) and body mass index (BMI) was (p) 0.035 and the significance value between physical activity and nutritional status was (p) 0.069. In conclusion, Statistically, it was found that there was a significant relationship between metabolic equivalent (MET) and body mass index (BMI) (p) 0.035 <0.05 and there was no significant relationship between physical activity and nutritional status (p) 0.069> 0.05.Keywords: physical activity, nutritional status.  Abstrak: Pemberlakuan pembatasan sosial selama pandemi Covid-19 menyebabkan keterbatasan dalam melakukan aktivitas-aktivitas fisik. Aktivitas fisik merupakan suatu faktor penentu status gizi seseorang dengan mempengaruhi indeks massa tubuh (IMT). Tujuan penelitian ini adalah, Mengetahui hubungan antara metabolic equivalent (MET) dengan indeks massa tubuh (IMT) Mahasiswa Angkatan 2017 Program Studi Pendidikan Dokter Fakultas Kedokteran Unsrat saat Pandemi Covid-19 dan hubungan antara aktivitas fisik dan status gizi berdasarkan Mahasiswa Angkatan 2017 Program Studi Pendidikan Dokter Fakultas Kedokteran Unsrat saat Pandemi Covid-19. Penelitian menggunakan metode analitik dengan pendekatan cross-sectional pada mahasiswa angkatan 2017 program studi pendidikan dokter Fakultas Kedokteran Unsrat saat pandemi Covid-19 dengan total sampel 105 orang. Analisis data dan uji hipotesis dilakukan dengan menggunakan SPSS. Hasil. Didapatkan nilai signifikansi antara metabolic equivalent (MET) dan indeks massa tubuh (IMT) sebesar (p) 0.035 dan diapatkan nilai signifikansi antara aktivitas fisik dan status gizi sebsesar (p) 0.069. Sebagai simpulan, secara satatistik didapatkan ada hubungan signifikan antara metabolic equivalent (MET) dan indeks massa tubuh (IMT) (p) 0.035 < 0.05 dan tidak ditemukan hubungan signifikan antara aktivitas fisik dan status gizi (p) 0.069 > 0.05.Kata Kunci: aktvitas fisik, status gizi.","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88361194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efektivitas Anti Jamur Sistemik Terhadap Dermatofitosis","authors":"Mathilda W. Warouw, Tara S. Kairupan, P. L. Suling","doi":"10.35790/jbm.13.2.2021.31833","DOIUrl":"https://doi.org/10.35790/jbm.13.2.2021.31833","url":null,"abstract":"Abstract: Dermatophytosis or tinea is the most frequent fungal infection in the world caused by the dermatophyte fungi group. These dermatophytes infect the stratum corneum of the skin, hair shaft, and nails. Systemic antifungals are one of the treatment options for dermatophytosis, especially in cases of widespread infection or failure of topical therapy. This study aims to determine the effectiveness of various systemic antifungals (griseofulvin, terbinafine, and azole derivatives) against dermatophytosis. This study was in the form of a literature review by searching and collecting data using the PubMed and ClinicalKey databases, with the keywords antifungal sistemik, dermatofitosis, tinea (bahasa Indonesia), and systemic antifungal, dermatophytosis, tinea (English). Based on the results of the literature search, 10 articles were found that match the inclusion and exclusion criteria. From the article review, it is known that the effectiveness of systemic antifungal therapy against dermatophytosis varies according to the classification and duration of therapy. In conclusion, systemic antifungals in the treatment of dermatophytosis have been shown to be effective.Keywords: systemic antifungal, dermatophytosis, tinea  Abstrak: Dermatofitosis atau kata lainnya tinea merupakan infeksi jamur paling sering di dunia yang disebabkan oleh golongan jamur dermatofita. Dermatofita  ini menginfeksi stratum korneum kulit, batang rambut, dan kuku. Antijamur sistemik merupakan salah satu pilihan terapi dermatofitosis terutama pada kasus infeksi luas atau kegagalan terapi topikal. Penelitian ini bertujuan untuk mengetahui efektivitas dari berbagai antijamur sistemik (griseofulvin, terbinafin, dan turunan azole) terhadap dermatofitosis. Penelitian ini berbentuk literature review dengan pencarian dan pengumpulan data menggunakan database PubMed dan ClinicalKey, dengan kata kunci antijamur sistemik, dermatofitosis, tinea (Bahasa Indonesia), serta systemic antifungal, dermatophytosis, tinea (Bahasa Inggris). Berdasarkan hasil pencarian literatur didapatkan 10 artikel yang sesuai dengan kriteria inklusi dan eksklusi. Dari tinjauan artikel diketahui efektivitas dari pemberian terapi antijamur sistemik terhadap dermatofitosis bervariasi sesuai klasifikasi dan durasi terapi. Sebagai simpulan, antijamur sistemik pada terapi dermatofitosis terbukti efektif.Kata kunci: antijamur sistemik, dermatofitosis, tinea.","PeriodicalId":17726,"journal":{"name":"JURNAL BIOMEDIK (JBM)","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86880986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}