Journal Pharmasci (Journal of Pharmacy and Science)最新文献_第4页

The effect of Material used in the Lime Infused water Packaging on Vitamin C Level 石灰水包装材料对维生素C含量的影响

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-08-01 DOI: 10.53342/pharmasci.v7i2.293

Vika Ayu Devianti, D. Arifiyana

引用次数: 0

Pattern of Drug Use in Influenza Self-Medication Efforts in Communities in Bettet Village, Pamekasan Regency 帕梅卡桑县Bettet村社区流感自我药疗工作中的药物使用模式

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-07-31 DOI: 10.53342/pharmasci.v7i2.282

Achmad Fairuz Zabadi, Septiana Kurniasari

引用次数: 0

Development and Challenges of Using Serratiopeptidase Enzymes as Anti-Inflammatory in the Present Era: Literature Review 当今时代使用塞拉肽酶作为抗炎药的发展和挑战:文献综述

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-07-31 DOI: 10.53342/pharmasci.v7i2.283

F. A. Muslikh, Sukardiman

引用次数: 0

Effectiveness of Azithromycin As Therapy Covid-19 阿奇霉素治疗新冠肺炎疗效观察

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-02-16 DOI: 10.53342/pharmasci.v7i1.276

Nur Hidayah, Denova Haryavany

{"title":"Effectiveness of Azithromycin As Therapy Covid-19","authors":"Nur Hidayah, Denova Haryavany","doi":"10.53342/pharmasci.v7i1.276","DOIUrl":"https://doi.org/10.53342/pharmasci.v7i1.276","url":null,"abstract":"Corona virus infection 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2. Covid-19 has been declared a pandemic by the WHO, where the scale of the spread of the disease occurs globally. Azithromycin alone and its combination with hydroxychloroquine has been proposed as a treatment that can improve the prognosis of COVID-19. The purpose of this review is to determine the use of doses and how long azithromycin is active in COVID-19 patients. This research method uses a literature review of articles through internet searches by accessing the database from the google scholar site, pubmed. The object of this research is a scientific article published in the period 2017-2021 and relates to the effectiveness of azithromycin as a therapy to treat Covid-19 infection in humans. The results of the literature study show that Azithromycin has the potential as a therapy in COVID-19 patients, either alone or in combination. The average duration of azithromycin administration was 5 days, of which 500 mg was the loading dose followed by 250 mg for the next 4 days. The effectiveness of Azithromycin either alone or in combination with hydroxychloroquine (HCQ) showed effectiveness in reducing viral load where the decline began on day 6 and complete recovery of the patient was achieved on day 10 to day 12. The conclusion of this study is that Azithromycin has the potential as a therapy in COVID-19 patients, either alone or in combination.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91495271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Nano Extract Formulation on Antioxidant Activity of 70% Ethanolic Extract of Purple Sweet Potato’s Leaves (Ipomoea batatas L.) Antin-3 Variety 纳米提取物配方对紫薯叶70%乙醇提取物抗氧化活性的影响Antin-3品种

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-02-06 DOI: 10.53342/pharmasci.v7i1.270

G. G. Kusumo, D. Dipahayu

引用次数: 0

The Potential of Aloe Vera as Formalin Reductor in Formalyzed Javanese Chicken Meat 芦荟作为甲醛还原剂在爪哇鸡肉中的应用前景

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-02-02 DOI: 10.53342/pharmasci.v7i1.228

Cicik Herlina Yulianti, Surahmaida

{"title":"The Potential of Aloe Vera as Formalin Reductor in Formalyzed Javanese Chicken Meat","authors":"Cicik Herlina Yulianti, Surahmaida","doi":"10.53342/pharmasci.v7i1.228","DOIUrl":"https://doi.org/10.53342/pharmasci.v7i1.228","url":null,"abstract":"One of the hazardous materials that are often found during food control surveys is formalin. Formalin is used by irresponsible traders as a food preservative because it is cheap and easy to use. Therefore, efforts are needed to reduce the formalin content in food, one of which is by using natural ingredients such as aloe vera. Based on research, aloe vera contains saponins that can be used to reduce the formaldehyde content in food. This study aims to find out the concentration of aloe vera solution that can provide the largest reduction in formalin levels in samples of formalized chicken meat. The methods used in this study have three stages. The first stage is to soak the chicken meat in a 0.1% formalin solution for 1 hour then filtered to get samples of formalized chicken meat. The second stage is to soak samples of formalized chicken meat in a solution of aloe vera reduction with concentrations of 0, 30, 60, and 90% for 1 hour then filtered to get the filtrate. The third stage is to analyze the immersion filtrate using the UV-Vis Spectrophotometer to find out what the remaining formalin levels are in the chicken meat. The result of this study was that the higher the concentration of aloe vera solution, the greater the decrease in formalin content in the sample. The largest decrease in formalin content was obtained from soaking aloe vera solution with a concentration of 90%, which can reduce formalin by 29,87%.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"232 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76975532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Reduction of MHCII Expression on M1 Polarity Activated HMC3 Microglia Cells By n-Hexane And Ethyl Acetate Fraction of Semanggi (Marsilea crenata Presl.) Leaves 正己烷和乙酸乙酯提取物对M1极性激活的HMC3小胶质细胞MHCII表达降低的影响叶子

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-02-01 DOI: 10.53342/pharmasci.v7i1.271

Burhan Ma’arif, Faisal Akhmal Muslikh, Abdul Malik Guhir, H. Fitri, Luqman Alfani Najib, Novyananda Salmasfattah, H. Laswati, M. Agil

{"title":"Effects of Reduction of MHCII Expression on M1 Polarity Activated HMC3 Microglia Cells By n-Hexane And Ethyl Acetate Fraction of Semanggi (Marsilea crenata Presl.) Leaves","authors":"Burhan Ma’arif, Faisal Akhmal Muslikh, Abdul Malik Guhir, H. Fitri, Luqman Alfani Najib, Novyananda Salmasfattah, H. Laswati, M. Agil","doi":"10.53342/pharmasci.v7i1.271","DOIUrl":"https://doi.org/10.53342/pharmasci.v7i1.271","url":null,"abstract":"Neuroinflammatory is a pathological condition in which neuronal cells experience progressive loss of function, one of which is due to estrogen deficiency. Phytoestrogens are compound that has structure and function similar to 17β-estradiol, the most potent natural form of estrogen. Semanggi (Marsilea crenata Presl.) is known to contain phytoestrogens which can replace the function of 17β-estradiol in maintaining organ homeostasis, so that is potential to be developed as an anti-neuroinflammatory drug. This study was aimed to prove the anti-neuroinflammatory effect of the n-hexane and ethyl acetate fraction of Semanggi leaves on HMC3 microglia cells, by measuring the expression of major histocompatibility complex II (MHC II). Both fractions with a concentration of 62.5; 125; and 250 μg/ml were administered to HMC3 microglia cells which had been induced by interferon gamma (IFN-γ) for 24 hours. Measurement of MHC II expression were using immunocytochemistry (ICC) methods and confocal laser scanning microscopy (CLSM) instruments. The results showed that n-hexane fraction could reduce MHC II expression at concentrations of 250 μg/ml with p<0.05, and showed a non-monotonic dose response (NMDR) pattern, while ethyl acetate fraction could reduce MHC II expression at all concentrations with p<0.05. Based on the results of the correlation test, the best anti-neuroinflammatory activity on HMC3 microglia cells is showed by the ethyl acetate fraction of Semanggi leaves.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85561054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual Mapping of Secondary Metabolite Activities Containing in Caesalpinia sappan L. Heartwood through In Silico Study 利用计算机研究对杉木心材次生代谢物活性进行虚拟映射

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-01-31 DOI: 10.53342/pharmasci.v7i1.274

Dewi Ratih Tirto Sari, Gabriella Chandrakirana Krisnamurti, Y. Bare

{"title":"Virtual Mapping of Secondary Metabolite Activities Containing in Caesalpinia sappan L. Heartwood through In Silico Study","authors":"Dewi Ratih Tirto Sari, Gabriella Chandrakirana Krisnamurti, Y. Bare","doi":"10.53342/pharmasci.v7i1.274","DOIUrl":"https://doi.org/10.53342/pharmasci.v7i1.274","url":null,"abstract":"Caesalpinia sappan L heartwood is a leguminoceae plant that grow in Indonesia landscape, uses as traditional herbal medicine and natural textile dye. Caesalpinia sappan heartwood also contains homoisoflavonoids as natural pigment and bioactive compound, promotes several human health benefits. This study provide biological function prediction and mapping through in silico approach. The compounds from Caesalpinia sappan were listed and downloaded from Knapsack webserver. PubChem NCBI was used to retrieve the canonical smiles of Caesalpinia sappan compounds. Biological activity of Caesalpinia were predicted by Online PASS Two Way drug website and performed in heatmap. Structure activity relationship (SAR) of quercetin-3,7-Di-O-Methyl Ether 3'-O-Methylbrazilin, 2'-Methoxyisoliquiritigenin, Isoliquiritigenin 2'-Methy Ether and Quercetin-3′,4′-Di-O-Methyl Ether revealed antioxidant, nitric oxide scavenger, antimycobacterial, antibacterial, antiinflammation, and act as lipoxygenase inhibitor agent. Furthermore, Quercetin-3′,4′-Di-O-Methyl Ether (17) proved higher antivirus activity than other compounds. 2'-Methoxyisoliquiritigenin (20) and Isoliquiritigenin 2'-Methy Ether (27) performed higher neuroprotective effect than others. Molecular docking and dynamis are required for further investigation.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77269309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation of Instan Powder from the Combination of Single-bulb Black Garlic (Allium sativum L.) and Rosella Flower (Hibiscus sabdariffa L.) with Foam Mat Drying Method 泡沫垫干燥法制备单球茎黑蒜(Allium sativum L.)和玫瑰花(Hibiscus sabdariffa L.)的即食粉

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-01-27 DOI: 10.53342/pharmasci.v7i1.273

Alfian Hendra Krisnawan, Asti Gusni Dharmawati, Husin Rayesh Mallaleng

{"title":"Formulation of Instan Powder from the Combination of Single-bulb Black Garlic (Allium sativum L.) and Rosella Flower (Hibiscus sabdariffa L.) with Foam Mat Drying Method","authors":"Alfian Hendra Krisnawan, Asti Gusni Dharmawati, Husin Rayesh Mallaleng","doi":"10.53342/pharmasci.v7i1.273","DOIUrl":"https://doi.org/10.53342/pharmasci.v7i1.273","url":null,"abstract":"Single-bulb garlic (Allium sativum L.) is a plant with various properties, such as anticancer, antibacterial, antihypertensive, and antioxidant. The processed product of garlic is black garlic which is made by fermenting garlic by heating at a temperature of 60-90°C within a few days. Formulated products in instant powder drinks can increase public consumption interest. This study aimed to formulate an instant powder functional beverage from single-bulb black garlic combined with rosella flower (Hibiscus sabdariffa L.) using the foam mat drying method. Egg white is used as a foaming agent and methylcellulose as a foam stabilizer. The formula consisted of single-bulb black garlic powder, rosella flower powder, powder combination of single-bulb black garlic, and rosella flower (30:70) and (50:50). The color, smell, taste, and water content of the four formulas have met the quality standard of SNI 01-4320-1996. DPPH free radical scavenging test with parameter IC50 showed that the combination powder of single-bulb black garlic and rosella flower (30:70) had higher antioxidant activity than the other combination (50:50). The consumer acceptance test on the combined instant powder formula showed that consumers preferred the combination powder of single-bulb black garlic and rosella flower (30:70).","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82925454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Sensitivity Test of Generic Ceftriaxone Injection Against Salmonella typhi 通用头孢曲松注射液对伤寒沙门氏菌的敏感性试验

Journal Pharmasci (Journal of Pharmacy and Science) Pub Date : 2022-01-27 DOI: 10.53342/pharmasci.v7i1.235

E. Susanti, Leony Liza Andriani, Musyrina Rahmah

{"title":"Antibacterial Sensitivity Test of Generic Ceftriaxone Injection Against Salmonella typhi","authors":"E. Susanti, Leony Liza Andriani, Musyrina Rahmah","doi":"10.53342/pharmasci.v7i1.235","DOIUrl":"https://doi.org/10.53342/pharmasci.v7i1.235","url":null,"abstract":"Research on antibacterial sensitivity test of several generic ceftriaxone injection preparations against Salmonella typhi have been conducted. The purpose of this study was to determine the antibacterial sensitivity of several generic ceftriaxone injection preparations against Salmonella typhi using the Agar diffusion method, with 3 samples taken from 3 different manufacturers in hospital S Pekanbaru. The result of inhibition zone diameter obtained by product P is 27,76 mm, product Q is 28,83 mm, and the product R is 29,96 mm. Positive control and negative control used ceftriaxone disc 30 µg the inhibition zone diameter was obtained 18,1 mm and the disc paper was dripped with sterile aquadest. This is because the amount of ceftriaxone injection test substance in the disk is greater than the positive control ceftriaxone level. In the test sample there are 1000 µg/disc while the positive control had 30 µg/disc, it means that the number of Ceftriaxone test substances was 33,3 time greater than the positive control. The test results show that ceftriaxone injection has an inhibitory power with a strong category based on the Clinical Laboratory Standards Institute (2017), and positive control using ceftriaxone 30 µg disc showed moderate inhibition.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85603094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0