Antibacterial Sensitivity Test of Generic Ceftriaxone Injection Against Salmonella typhi

Research on antibacterial sensitivity test of several generic ceftriaxone injection preparations against Salmonella typhi  have been conducted. The purpose of this study was to determine the antibacterial sensitivity of several generic ceftriaxone injection preparations against Salmonella typhi using the Agar diffusion method, with 3 samples taken from 3 different manufacturers in hospital S Pekanbaru. The result of inhibition zone diameter obtained by product P is 27,76 mm, product Q is 28,83 mm, and the product R is 29,96 mm. Positive control and negative control used ceftriaxone disc 30 µg the inhibition zone diameter was obtained 18,1 mm and the disc paper was dripped with sterile aquadest. This is because the amount of ceftriaxone injection test substance in the disk is greater than the positive control ceftriaxone level. In the test sample there are 1000 µg/disc while the positive control had 30 µg/disc, it means that the number of Ceftriaxone test substances was 33,3 time greater than the positive control. The test results show that ceftriaxone injection has an inhibitory power with a strong category based on the Clinical Laboratory Standards Institute (2017), and positive control using ceftriaxone 30 µg disc showed moderate inhibition.