Journal of studies on alcohol and drugs最新文献

{"title":"Age Differences in Opioid Overdose Risk Factors Among Black Men: A Brief Report.","authors":"Brittany Miller-Roenigk, Paris Wheeler, Danelle Stevens-Watkins","doi":"10.15288/jsad.25-00073","DOIUrl":"10.15288/jsad.25-00073","url":null,"abstract":"<p><strong>Objective: </strong>Opioid overdose deaths continue to increase among Black Americans, despite decreases in deaths overall nationwide. Older Black men (beginning in their 50s) have a heightened risk, dying from opioid overdoses at a five-fold increase from 2015-2023. However, research identifying differences in risk factors for opioid overdose among older Black men compared to younger Black men is limited.</p><p><strong>Method: </strong>The current study is a secondary analysis of survey data from a study highlighting drug misuse and treatment among Black adults in Kentucky, and compares Black men 51 and older (<i>n</i> = 125) to Black men 50 and younger (<i>n</i> = 271) on the following overdose risk factors: opioid use, stimulant use, polydrug use, stimulant and opioid co-use, injection drug use, pain, and having a doctor deny pain medication. The sample includes Black men residing in Kentucky, a state with the fourth highest opioid overdose rates in the U.S.</p><p><strong>Results: </strong>Results indicate that Black men 51 and older report more stimulant use, <i>U</i> = 10740.50, <i>p</i> < .001, <i>r</i> = -.35; stimulant/opioid co-use, <i>B</i> = -1.23, <i>p</i> < .001; <i>OR</i> = .29, 95% <i>CI</i> = .18 - .47; polydrug use, <i>t</i>(223.14) = 2.46, <i>p</i> = .02; and pain, <i>B</i> = -.62, <i>p</i> = .008; <i>OR</i> = .54, 95% <i>CI</i> = .34 - .85; than men 50 and younger.</p><p><strong>Conclusions: </strong>Findings illustrate differential prevalence of overdose risk factors among Black men 51 and older compared to men 50 and younger. Opioid overdose prevention considerations are discussed, including assessing identified risk factors among older Black men.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction, Addition of Author to: Order of Cannabis and Alcohol Use on Pregaming and Non-Pregaming Days Among College Students.","authors":"Eric R Pedersen, Reagan E Fitzke, Toni Atieh, Denise D Tran, Jordan P Davis, Rachel L Gunn, Lauren Micalizzi, Justin F Hummer, Mark A Prince","doi":"10.15288/jsad.26-01001","DOIUrl":"10.15288/jsad.26-01001","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Models of Alcohol Use and Alcohol-Induced Neurotoxicity: Behavioral, Cognitive, and Developmental Perspectives.","authors":"Maliheh Rastgoo, Babak Keshvari, Fahimeh Mohseni","doi":"10.15288/jsad.26-00200","DOIUrl":"https://doi.org/10.15288/jsad.26-00200","url":null,"abstract":"<p><strong>Objective: </strong>This review conceptualizes ethanol and methanol neurotoxicity through a tri-domain framework encompassing motivational, degenerative, and developmental mechanisms, and integrates decades of rodent research into a multidimensional map of how alcohol reshapes the brain. It emphasizes exposure route-specific paradigm, oral gavage, vapor inhalation, and intraperitoneal administration, as translational anchors linking behavioral, metabolic, and molecular signatures.</p><p><strong>Method: </strong>A literature search was conducted across PubMed, Scopus, and Web of Science databases for articles published between June 1999 and May 2026. Search terms integrated keywords related to alcohol exposure routes and neurotoxicity (e.g., ethanol, methanol, neurodegeneration, prenatal/adolescent exposure, oral gavage, vapor, and injection paradigms). Boolean operators and manual citation tracking were utilized. Out of 205 initially identified articles, 182 studies meeting selection criteria were included in the final synthesis.</p><p><strong>Results: </strong>Chronic gavage models effectively capture nutrient-metabolic interactions under sustained drinking, vapor inhalation isolates central oxidative and inflammatory cascades under stress-neutral conditions, and injection paradigms offer mechanistic precision for acute mitochondrial dysfunction. Hybrid protocols reveal time-coded dynamics of degeneration and recovery. Developmental studies demonstrate that prenatal and adolescent alcohol exposure drives epigenetic remodeling, DNA methylation drift, histone acetylation, and microRNA dysregulation, leading to long-term deficits in cortical maturation and cognitive control. Methanol models extend this neuroenergetic spectrum through formate-driven mitochondrial failure and optic-cerebellar injury.</p><p><strong>Conclusions: </strong>The tri-domain framework integrates diverse rodent paradigms across exposure routes and life stages. To enhance clinical translation, future research should leverage multi-omics, connectomic mapping, and bioengineered platforms (e.g., organoids and brain-on-chip) to identify early molecular markers and targeted neuroprotective interventions.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Event-Level Patterns of Cannabis-Impaired Driving.","authors":"Jenni B Teeters, Sidney M Traxler, Flynn Harris","doi":"10.15288/jsad.25-00378","DOIUrl":"10.15288/jsad.25-00378","url":null,"abstract":"<p><strong>Objective: </strong>Cannabis-impaired driving (CID) is an increasing public health concern, particularly among emerging adults. Despite growing prevalence, little is known about episode-level patterns of use and impairment before driving. This study examined detailed features of recent and heaviest CID episodes to better understand high-risk driving contexts.</p><p><strong>Method: </strong>Participants were 149 emerging adult cannabis users (ages 18-29) reporting ≥3 instances of driving after cannabis use in the past 3 months. Event-level data were collected via retrospective self-report of the most recent and heaviest CID occasions. Participants reported method of use, amount consumed, wait time before driving, subjective intoxication, driving distance, alcohol co-use, and the presence of passengers. Paired-sample <i>t</i> tests examined within-person differences between episodes.</p><p><strong>Results: </strong>More than 60% reported actively using cannabis while driving, and more than one third reported driving after simultaneous cannabis and alcohol use. Passengers were present in 46% of the most recent driving episodes and 35% of the heaviest driving episodes. Subjective intoxication ratings were significantly higher during the heaviest episodes (<i>M</i> = 6.96) compared with the most recent episodes (<i>M</i> = 4.71, <i>p</i> < .001), yet wait time before driving and distance driven did not differ.</p><p><strong>Conclusions: </strong>Findings highlight high-risk contexts in CID, including simultaneous substance use and driving while intoxicated, often with passengers present. Retrospective event-level analysis offers a nuanced understanding of CID behaviors and underscores the need for prevention strategies that address situational risk factors.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"970-975"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12994868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coenzyme Q10 Mitigates Anxiety- and Depression-Like Behaviors in a Fetal Alcohol Spectrum Disorder Model by Suppressing Hippocampal Astrocytic Reactivity, Oxidative Stress, and Neuronal Cell Death.","authors":"Razieh Adabi, Fahimeh Mohseni, Alireza Masoudi, Raheleh Rafaiee","doi":"10.15288/jsad.25-00290","DOIUrl":"10.15288/jsad.25-00290","url":null,"abstract":"<p><strong>Objective: </strong>Fetal alcohol spectrum disorder (FASD) results from prenatal alcohol exposure and is associated with long-term neurobehavioral deficits, including anxiety and depression. Ethanol-induced oxidative stress, neuroinflammation, and hippocampal damage are key contributors to these outcomes. Coenzyme Q10 (CoQ10), a mitochondrial antioxidant, may offer neuroprotection against such ethanol-induced damage. This study aimed to investigate the potential therapeutic effects of CoQ10 on anxiety- and depression-like behaviors and hippocampal neurotoxicity in a neonatal rat model of FASD.</p><p><strong>Method: </strong>Neonatal Wistar rats were exposed to ethanol (5.25 g/kg/day) via oral gavage from postnatal day (PD) 2 to PD10 (corresponding to the third trimester of human brain development). CoQ10 (30 mg/kg, intraperitoneal [i.p.]) was administered daily after ethanol exposure. Behavioral testing was performed on PD38-39 using the Elevated Plus Maze (EPM) and Forced Swim Test (FST). On PD40, biochemical assays measured malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Immunohistochemistry assessed glial fibrillary acidic protein (GFAP) and cleaved caspase-3 expression, and Nissl staining evaluated necrotic cell death in the CA1 hippocampal region.</p><p><strong>Results: </strong>CoQ10 significantly improved anxiety- and depression-like behaviors in ethanol-exposed rats (EPM: <i>p</i> = .0001-.0099; FST: <i>p</i> = .0021). It markedly reduced MDA levels (<i>p</i> = .0010) to near-control values (<i>p</i> = .4614, N.S.) and partially restored antioxidant enzyme activities (SOD: <i>p</i> = .0112 vs. control <i>p</i> = .0108; GSH: <i>p</i> = .0092 vs. control <i>p</i> = .3643, N.S.; CAT: <i>p</i> = .0003 vs. control <i>p</i> = .0769, N.S.). CoQ10 largely normalized astrocytic activation (GFAP: ethanol vs. CoQ10 <i>p</i> < .0001; CoQ10 vs. control <i>p</i> = .0196) and reduced cleaved caspase-3 expression (ethanol vs. CoQ10 <i>p</i> = .0407; CoQ10 vs. control <i>p</i> = .8940, N.S.). Furthermore, CoQ10 significantly decreased hippocampal necrotic cell death (ethanol vs. CoQ10 <i>p</i> = .0074), although a difference persisted versus controls (<i>p</i> < .0001).</p><p><strong>Conclusions: </strong>CoQ10 administration mitigates behavioral and cellular manifestations of FASD by counteracting oxidative stress, astrocytic reactivity, and neuronal apoptosis/necrosis, thereby contributing to hippocampal functional recovery.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"976-989"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Wonderful Panoramic View From Griffith Edwards' Window.","authors":"Tim Stockwell","doi":"10.15288/jsad.26-00243","DOIUrl":"10.15288/jsad.26-00243","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"871-872"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Seeing Addiction</i> in the Context of the Modern History of Addiction Science.","authors":"William Bejarano, Judit H Ward","doi":"10.15288/jsad.26-00249","DOIUrl":"10.15288/jsad.26-00249","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"875-876"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Griffith Edwards, the World Health Organization, and the Globalization of Alcohol Problems.","authors":"Robin Room","doi":"10.15288/jsad.26-00212","DOIUrl":"10.15288/jsad.26-00212","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"884-886"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Policy and the Science/Policy Connections.","authors":"Sally Casswell","doi":"10.15288/jsad.26-00251","DOIUrl":"10.15288/jsad.26-00251","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"877-879"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Sales Taxes Are Associated With Reduced Preterm Birth and Low Birthweight in the United States.","authors":"Meenakshi S Subbaraman, Sue Thomas, Ryan Treffers, Sarah C M Roberts","doi":"10.15288/jsad.25-00305","DOIUrl":"10.15288/jsad.25-00305","url":null,"abstract":"<p><strong>Objective: </strong>Historically, alcohol taxation has been one of the best strategies to reduce drinking and related harms in the general population, and prior analyses support that increased alcohol taxes are associated with fewer harms related to drinking during pregnancy. Here, we examine how alcohol taxes are related to preterm and low birthweight births.</p><p><strong>Method: </strong>Birth certificate data for 101,191,080 births conceived between January 1993 and March 2019 come from the U.S. National Vital Statistics System. Outcomes were preterm birth (<37 weeks) and low birthweight (<2,500 g). Time-varying state-level alcohol tax policies were beverage-specific volume-based, sales, and ad valorem taxes. Final regression models adjusted for individual and state covariates, state trends, and clustered standard errors by state.</p><p><strong>Results: </strong>Only sales taxes were consistently related to birth outcomes. Having a beer sales tax was significantly related to lower odds of preterm birth (odds ratio [OR] = 0.94, 95% CI [0.90, 0.98]) and lower odds of low birthweight (OR = 0.98, 95% CI [0.96, 0.99]). Similarly, having a wine sales tax was significantly related to lower odds of preterm birth (OR = 0.94, 95% CI [0.90, 0.98]) and lower odds of low birthweight (OR = 0.97, 95% CI [0.95, 0.99]). Finally, having a spirits sales tax was also significantly related to lower odds of preterm birth (OR = 0.95, 95% CI [0.91, 0.98]) and lower odds of low birthweight (OR = 0.97, 95% CI [0.95, 0.99]).</p><p><strong>Conclusions: </strong>State-level beverage-specific sales taxes are associated with fewer adverse birth outcomes. This study provides additional evidence that increased alcohol taxes may be relevant for reducing adverse effects related to pregnant people's alcohol consumption.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"1027-1035"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}