Ramin Khoramnia, Tadas Naujokaitis, Maximilian Friedrich, Hyeck-Soo Son, Gerd U Auffarth, Victor A Augustin
{"title":"Severity-Graded Repeatability of AS-OCT Including Epithelial and Stromal Metrics in Patients With Keratoconus Versus Healthy Individuals.","authors":"Ramin Khoramnia, Tadas Naujokaitis, Maximilian Friedrich, Hyeck-Soo Son, Gerd U Auffarth, Victor A Augustin","doi":"10.3928/1081597X-20260504-03","DOIUrl":"https://doi.org/10.3928/1081597X-20260504-03","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the repeatability of corneal parameters measured by anterior segment optical coherence tomography (AS-OCT) in patients with keratoconus and healthy individuals.</p><p><strong>Methods: </strong>This monocentric cross-sectional study included 136 individuals in total: 95 patients with keratoconus and 41 healthy individuals. Three AS-OCT measurements were performed on the same day using the Anterion (Heidelberg Engineering). One eye per patient was randomly selected and repeatability coefficients (RCs) with two-sided 95% CIs were calculated for anterior and posterior keratometry, as well as corneal pachymetric, epithelial, and stromal parameters. The repeatability of measured parameters was compared between patients with keratoconus and healthy individuals and in different keratoconus severity groups using intra-subject variance.</p><p><strong>Results: </strong>The RC of maximum keratometry (Kmax) (two-sided 95% CI) was 0.33 diopters (D) (range: 0.29 to 0.39 D) in healthy eyes and 0.68 D (range: 0.62 to 0.76 D) in eyes with keratoconus. The RC of anterior Kmean was 0.19 D (range: 0.17 to 0.23 D) and 0.37 D (range: 0.33 to 0.41 D), the RC of anterior corneal astigmatism was 0.28 D (range: 0.24 to 0.33 D) and 0.43 D (range: 0.39 to 0.48 D), and the RC of minimum corneal thickness was 1.98 µm (range: 1.72 to 2.34 µm) and 2.15 µm (range: 1.96 to 2.39 µm) in healthy eyes and eyes with keratoconus, respectively. Patients with keratoconus had a lower measurement repeatability for most measured parameters, including Kmax (<i>P</i> < .001, Mann-Whitney <i>U</i> test, two-tailed) compared to the healthy individuals. Repeatability tended to worsen with increasing keratoconus severity.</p><p><strong>Conclusions: </strong>Although the AS-OCT demonstrated a high measurement repeatability in both healthy eyes and eyes with keratoconus, the repeatability of most evaluated parameters was slightly lower in patients with keratoconus and tended to worsen with increasing keratoconus severity.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e677-e686"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Z Chen, Krystal Hui, Angeline Lai, Jocelyn Yeo, Liang Shen
{"title":"The Effect of Pupil Dilation on Preoperative Optical Biometry Results for Phacoemulsification: A Meta-analysis.","authors":"David Z Chen, Krystal Hui, Angeline Lai, Jocelyn Yeo, Liang Shen","doi":"10.3928/1081597X-20260427-01","DOIUrl":"10.3928/1081597X-20260427-01","url":null,"abstract":"<p><strong>Purpose: </strong>To summarize the effects of pupil dilation on optical biometry results and evaluate its impact on intraocular lens (IOL) power calculations.</p><p><strong>Methods: </strong>A systematic literature search was conducted in PubMed, EMBASE, and Cochrane Library on December 5, 2024. Original studies published from 2010 onward that measured ocular parameters before and after dilation were included. The primary outcome was the change in ocular parameters after dilation; secondary outcomes included the impact of dilation on predicted and postoperative refractive outcomes based on various IOL formulas.</p><p><strong>Results: </strong>Pupil dilation significantly increased anterior chamber depth (ACD) by 0.08 mm (<i>P</i> < .001), reduced lens thickness (LT) by 0.02 mm (<i>P</i> < .001), and increased white-to-white distance (WTW) by 0.12 mm (<i>P</i> < .001). When compared to using tropicamide, cyclopentolate resulted in a greater increase in ACD (0.03 mm, <i>P</i> = .03) and greater reduction in LT (0.04 mm, <i>P</i> = .001), whereas phenylephrine resulted in less increase in ACD by 0.06 mm (<i>P</i> = .001). There was no significant change in predicted IOL power for third generation formulas, but dilation resulted in a significant increase for the Barrett Universal II and Haigis formulas (both by 0.05 diopters, <i>P</i> = .02 and <i>P</i> < .001, respectively).</p><p><strong>Conclusions: </strong>Pupil dilation significantly increases ACD and reduces LT, which in turn significantly increases IOL power recommendations by later generation IOL calculation formulas. It would be prudent to consider performing biometry without dilation to avoid its impact on IOL calculation and subsequently final refractive outcome.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e729-e741"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lan Wang, Jiaqi Meng, Kaiwen Cheng, Limei Zhang, Wenwen He, Haike Guo, Yi Lu, Xiangjia Zhu
{"title":"Comparison of Visual Outcomes Between Bilateral Implantation of Multifocal Intraocular Lens and Mix-and-Match Strategy.","authors":"Lan Wang, Jiaqi Meng, Kaiwen Cheng, Limei Zhang, Wenwen He, Haike Guo, Yi Lu, Xiangjia Zhu","doi":"10.3928/1081597X-20260504-04","DOIUrl":"10.3928/1081597X-20260504-04","url":null,"abstract":"<p><strong>Purpose: </strong>To compare postoperative visual outcomes between bilateral multifocal intraocular lens (IOL) implantation and mix-and-match strategies.</p><p><strong>Methods: </strong>This prospective multicenter observational study enrolled 156 patients (312 eyes) who underwent uneventful cataract surgery with IOL implantation in both eyes. Patients were divided into five groups based on binocular IOL strategy: mix-and-match of monofocal and bifocal IOLs (MB group), bilateral bifocal IOLs (BB group), monofocal and trifocal IOLs (MT group), bifocal and trifocal IOLs (BT group), and bilateral trifocal IOLs (TT group). Binocular visual outcomes, including visual acuity, defocus curves, contrast sensitivity, stereoacuity, and subjective visual quality measures such as Visual Function Index 14 scores, spectacle independence, and patient satisfaction were assessed at 6 months after surgery.</p><p><strong>Results: </strong>All patients showed significant improvement in binocular visual acuity after surgery. Binocular distance visual acuity, contrast sensitivity, Visual Function Index 14 scores, spectacle independence, and satisfaction were comparable between the MB and BB groups and among the MT, BT, and TT groups. BB yielded slightly better binocular near visual acuity than MB. TT achieved mildly superior intermediate and near visual acuity than MT. Near stereoacuity was significantly better for BB than MB and for BT than MT. TT showed superior intermediate and near stereoacuity than MT. Patients who had MT and BT were more likely to report difficulty with distance perception than those who had TT. Photic disturbances were relatively more common in the BB and TT groups compared to the mix-and-match groups.</p><p><strong>Conclusions: </strong>The mix-and-match strategy provided comparable binocular distance visual acuity, contrast sensitivity, and subjective visual quality to bilateral multifocal IOL implantation. Intermediate and near visual acuity and stereoacuity may be compromised in monofocal-multifocal combinations.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e687-e694"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Sella, Itay Lavy, Benjamin Stern, Jamel Corredores, David Smadja
{"title":"Visual and Refractive Outcomes of High Myopia Photorefractive Keratectomy With the Alcon Wavelight EX500 Platform Using an Optimized Nomogram: The \"Hadassah\" Nomogram.","authors":"Sara Sella, Itay Lavy, Benjamin Stern, Jamel Corredores, David Smadja","doi":"10.3928/1081597X-20260511-02","DOIUrl":"https://doi.org/10.3928/1081597X-20260511-02","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the 12-month visual, refractive, and astigmatic outcomes of a laser vision correction procedure employing an adjusted nomogram in high myopia and explored predictors of success.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled 66 eyes of 66 patients with manifest refraction of ≥-6.50 diopters (D) who underwent photorefractive keratectomy surgery; 50 eyes completed 12 months of follow-up. Standardized nine graphs reporting analyzed efficacy, safety, predictability, stability, and astigmatic vector parameters. Multivariable regression assessed the predictive value of baseline refractive and anatomical factors and ablation depth.</p><p><strong>Results: </strong>At 12 months, the uncorrected distance visual acuity was 20/20 or better in 92% of eyes, 20/25 or better in 98%, and 20/32 or better in 100%. Seventy-six percent gained one or more line of uncorrected distance visual acuity. Efficacy and safety indices were 1.16 ± 0.24 and 1.18 ± 0.23, respectively. Predictability was high: 96% and 100% of eyes were within ± 0.50 D and ±1.00 D of target, respectively, with no overcorrection. Refractive stability was achieved within 3 months and maintained thereafter (mean Δ spherical equivalent < 0.10 D). Mean cylinder decreased from 0.66 ± 0.50 to 0.06 ± 0.15 D (<i>P</i> < .001), and 94% had 0.25 D residual cylinder. Vector analysis showed close correspondence between intended and achieved astigmatic correction with excellent axis alignment. In this sample, multivariable analysis did not identify independent baseline predictors of outcome.</p><p><strong>Conclusions: </strong>The Hadassah nomogram demonstrated favorable 12-month efficacy, safety, predictability, and stability in patients with high to very high myopia and astigmatism. Although further validation is required, its simplicity and ease of implementation make it a practical approach that may help improve the accuracy of correction of high myopia with the Wavelight EX500 platform (Alcon Laboratories, Inc).</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e710-e718"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Machine Learning-Based Prediction of LASIK Console Inputs for Aspheric Planning (Q-factor, Defocus, Astigmatism): A Translational Methods Study.","authors":"Steven Garnier","doi":"10.3928/1081597X-20260415-02","DOIUrl":"https://doi.org/10.3928/1081597X-20260415-02","url":null,"abstract":"<p><strong>Purpose: </strong>To frame aspheric laser refractive planning as the supervised prediction of console-programmable inputs (Defocus, Astigmatism, and Q-factor) and to benchmark competing regression models; this is a translational methods proof-of-concept, not a clinical effectiveness study.</p><p><strong>Methods: </strong>An anonymized, retrospective, single-platform dataset of 2,448 complete-case treatments was analyzed. Multi-output regressors (linear and nonlinear) were trained and compared using prespecified metrics (<i>R</i><sup>2</sup>, MAE/MSE) and residual-distribution visualization/calibration. Actuator-response checks related programmed inputs to changes in Defocus (Z<sub>2</sub><sup>0</sup>) and primary spherical aberration (Z<sub>4</sub><sup>0</sup>). External validation used a temporally later, device-shift cohort (n = 147).</p><p><strong>Results: </strong>Linear regression predicted Defocus and astigmatism well (eg, Defocus <i>R</i><sup><i>2</i></sup> = 0.98) but degraded for Q-factor (<i>R</i><sup>2</sup> = 0.47), whereas nonlinear models improved Q-factor error and calibration. Actuator-response analyses showed strong coupling for Defocus input (<i>R</i><sup>2</sup> = 0.97), moderate coupling of Q-factor to ΔZ<sub>4</sub><sup>0</sup> (<i>R</i><sup>2</sup> = 0.51), and a weak Q→Defocus cross-effect (<i>R</i><sup>2</sup> = 0.12). On external validation, the best model generalized: Defocus MAE 0.22 D (<i>R</i><sup>2</sup> = 0.98) and Q-factor MAE 0.21 (<i>R</i><sup>2</sup> = 0.81).</p><p><strong>Conclusions: </strong>Supervised nonlinear multi-output models achieve lower error and better calibration for Q-factor than linear baselines, supporting a metric-driven pathway toward more reliable control of low-order refractive targets and primary asphericity. Potential clinical implications include tissue sparing, improved contrast, and near-vision gains. Prospective, human-in-the-loop evaluation with safety and patient-reported endpoints is warranted.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e719-e728"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First Report of Circular Rainbow Glare After Femtosecond Laser-Assisted LASIK.","authors":"Sarah Partouche, Damien Gatinel","doi":"10.3928/1081597X-20260505-02","DOIUrl":"https://doi.org/10.3928/1081597X-20260505-02","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the first documented case of circular rainbow glare following laser in situ keratomileusis (LASIK) with a spiral flap creation pattern.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 62-year-old woman presented with visual discomfort after undergoing monovision LASIK at an external center. Incorrect eye dominance selection resulted in unintended myopization of the dominant eye. The patient reported difficulty with distance vision and described multi-colored rings surrounding the point light sources in dim environments. LASIK enhancement was planned by relifting the stromal flap to achieve emmetropia in the dominant eye. Intraoperative findings revealed a concentric pattern of femtosecond laser impacts on the posterior surface of the flap and the stromal bed. The patient reported complete resolution of rainbow glare symptoms in the treated eye and an improvement in uncorrected distance visual acuity.</p><p><strong>Conclusions: </strong>This case represents the first reported instance of circular rainbow glare, supporting a diffractive etiology related to the periodic arrangement of femtosecond laser spot placement.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e742-e744"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianze Huang, Yuchen Wang, Yuexin Wang, Ying Li, Yan Luo
{"title":"Changes of Dynamic Visual Acuity and Higher Order Aberrations After Implantable Collamer Lens (ICL V4c) Implantation for Myopia Correction.","authors":"Tianze Huang, Yuchen Wang, Yuexin Wang, Ying Li, Yan Luo","doi":"10.3928/1081597X-20260421-02","DOIUrl":"https://doi.org/10.3928/1081597X-20260421-02","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the changes in dynamic visual acuity (DVA) following Implantable Collamer Lens (ICL) implantation for myopia treatment.</p><p><strong>Methods: </strong>This prospective cohort study included participants receiving ICL implantation at Peking Union Medical College Hospital between May 2021 and March 2022. Preoperative and postoperative data, including static visual acuity (SVA) in logarithm of the minimum angle of resolution (logMAR) format, refractive error, higher order aberrations, and dynamic visual acuity (DVA) at 40 and 80 degrees per second (dps), were collected preoperatively and at 1 week, 1 month, and 3 months postoperatively.</p><p><strong>Results: </strong>The study comprised 56 eyes from 56 patients with myopia (83.9% women) who had an average age of 28.54 ± 5.23 years. Sample sizes at each time point were 56 preoperatively and at 1 week, 45 at 1 month, and 34 at 3 months. After ICL implantation, both SVA and DVA significantly improved. SVA improved from 0.01 ± 0.03 preoperatively to -0.07 ± 0.05 at 3 months postoperatively (<i>P</i> < .001), DVA40 improved from 0.05 ± 0.09 to -0.03 ± 0.07 (<i>P</i> < .001), and DVA80 improved from 0.09 ± 0.09 to -0.02 ± 0.08 (<i>P</i> < .001). A stepwise multiple linear regression model revealed a significant linear correlation between DVA and SVA, spherical equivalent, and trefoil aberration.</p><p><strong>Conclusions: </strong>Significant improvements in DVA were observed postoperatively in patients with myopia receiving ICL implantation. The improvement in DVA may be correlated with the enhancement of SVA, spherical equivalent, and higher order aberrations.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e652-e661"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carel Bustos-Ampudia, Jair Maldonado-Aparicio, Isabel De La Fuente-Batta, Daniela A Peimbert-Franco, Guillermo E Yáñez-Oviedo, Azyadeh Camacho-Ordonez, Eduardo Chávez-Mondragón, Leire Irusteta-Jimenez
{"title":"Machine Learning Prediction Models for Classifying Myopic Versus Hyperopic Ablation Patterns in Eyes With Previous Refractive Surgery Undergoing Cataract Surgery.","authors":"Carel Bustos-Ampudia, Jair Maldonado-Aparicio, Isabel De La Fuente-Batta, Daniela A Peimbert-Franco, Guillermo E Yáñez-Oviedo, Azyadeh Camacho-Ordonez, Eduardo Chávez-Mondragón, Leire Irusteta-Jimenez","doi":"10.3928/1081597X-20260504-01","DOIUrl":"10.3928/1081597X-20260504-01","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a machine learning model to classify myopic or hyperopic ablation patterns in eyes that had previous refractive surgery and are now having cataract surgery using corneal topographic and tomographic parameters.</p><p><strong>Methods: </strong>This retrospective observational study was conducted at the Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico. Machine learning analyses were performed using Orange Data Mining software (Biometrics Laboratory, University of Ljubljana, Slovenia) with a 70/30 training-testing split. Predictive variables included corneal asphericity (Q-value), posterior-to-anterior curvature ratio (P/A ratio), sagittal map morphology, spherical aberration (Z<sup>0</sup><sub>4</sub>), mean keratometry, central corneal thickness, and thinnest pachymetry. Random Forest, Decision Tree, and Logistic Regression models were trained and compared. Model performance was assessed using area under the receiver operating characteristic curve (AUC), accuracy, precision, recall, F1 score, and Matthews correlation coefficient (MCC).</p><p><strong>Results: </strong>Seventy-two eyes with a history of refractive surgery were analyzed: 16.67% (n = 12) had hyperopic and 83.33% (n = 60) had myopic ablations. P/A ratio and Z<sup>0</sup><sub>4</sub> showed a strong negative correlation (<i>r</i> = -0.793, <i>P</i> < .001) for classifying the ablation type. The Random Forest model achieved the highest discriminative performance (AUC = 0.933), followed by Logistic Regression (AUC = 0.881) and Decision Tree (AUC = 0.828). Decision Tree modeling identified clinically interpretable cut-off values for classification, with a P/A ratio of 82.7% and a Z<sup>0</sup><sub>4</sub> value of -0.144 emerging as key decision nodes for differentiating myopic from hyperopic ablation patterns.</p><p><strong>Conclusions: </strong>Machine learning-based classification models distinguished myopic from hyperopic ablation patterns, with the Random Forest model demonstrating the highest performance using corneal topographic data. These models may serve as valuable adjuncts for intraocular lens power calculation in cataract surgery in eyes that had previous refractive surgery, especially when prior surgical records are unavailable.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"42 7","pages":"e662-e667"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}