Journal of Radiation Research and Applied Sciences最新文献

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Analysis of flow and heat transfer in magnetized nanofluids between two rotating disks in the presence of thermal radiation 热辐射作用下磁化纳米流体在两个旋转圆盘间的流动和传热分析
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-23 DOI: 10.1016/j.jrras.2025.101643
Muhammad Imran , Shan Ali Khan , Sumeira Yasmin , Syeda Zunaira , Abdullah Alhushaybari , Dennis Ling Chuan Ching , Ilyas Khan
{"title":"Analysis of flow and heat transfer in magnetized nanofluids between two rotating disks in the presence of thermal radiation","authors":"Muhammad Imran ,&nbsp;Shan Ali Khan ,&nbsp;Sumeira Yasmin ,&nbsp;Syeda Zunaira ,&nbsp;Abdullah Alhushaybari ,&nbsp;Dennis Ling Chuan Ching ,&nbsp;Ilyas Khan","doi":"10.1016/j.jrras.2025.101643","DOIUrl":"10.1016/j.jrras.2025.101643","url":null,"abstract":"<div><div>This comparative investigation effects of steady, incompressible <em>MHD</em> mono nanofluids flow with distinct nanoparticles (<span><math><mrow><mi>C</mi><mi>u</mi><mi>O</mi><mo>&amp;</mo><mi>A</mi><msub><mi>l</mi><mn>2</mn></msub><msub><mi>O</mi><mn>3</mn></msub></mrow></math></span>) are utilized with their physical properties and Ethylene glycol/water (50 %:50 %) is mentioned as a base fluid under the thermal radiation between two rotational stretching disks. The porous medium is considered among the both disks under Darcy-Forchheimer phenomenon. The upper and lower disks are stretchable and rotate able with different rates and angular frequencies. The heat source and joule dissipation irreversibility are taken into account in current model. The nanomaterials are dispersed in a 50 %:50 % mixture of Ethylene glycol-water. The advantages of using the nanofluids, as well as the parameters involved with them, have been mathematically described. This problem is extremely significant in many fields of engineering and technology. Moreover, in segment of mathematical modeling the partial differential system are presented with the suitable boundary conditions. Theses governing partial differential (PDEs) structures through the similarities are transformed into ordinary differential equations. Further, to find our numerically results we use the shooting technique via bvp4c solver with Lobatto IIIA formula in MATLAB software. Additionally, the pictorial assistance and the tabular behavior of the momentum and temperature field have been examined under the achievement of different parameters. From the results it is concluding that tangential velocity is reduced with variation in porosity parameter and magnetic parameter. The Reynolds number causes an increment in radial velocity while decrement in tangential flow of fluid. The thermal field is enhanced with radiation parameter and thermal Biot number.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101643"},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermal radiation effect on SiC-Co3O4+Diamond/H2O trihybrid nanofluid with Stefan blowing and LTNE effects using classical and modified Hamilton-crosser models 采用经典和改进的Hamilton-crosser模型研究具有Stefan吹风和LTNE效应的SiC-Co3O4+Diamond/H2O三杂化纳米流体的热辐射效应
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-23 DOI: 10.1016/j.jrras.2025.101638
Ahmed M. Galal , Mostafa Mohamed Okasha , Dana Mohammad Khidhi , Kholoud Saad Albalawi , Nouf Abdulrahman Alqahtani , Mustafa Bayram , Munawar Abbas , Ilyas Khan
{"title":"Thermal radiation effect on SiC-Co3O4+Diamond/H2O trihybrid nanofluid with Stefan blowing and LTNE effects using classical and modified Hamilton-crosser models","authors":"Ahmed M. Galal ,&nbsp;Mostafa Mohamed Okasha ,&nbsp;Dana Mohammad Khidhi ,&nbsp;Kholoud Saad Albalawi ,&nbsp;Nouf Abdulrahman Alqahtani ,&nbsp;Mustafa Bayram ,&nbsp;Munawar Abbas ,&nbsp;Ilyas Khan","doi":"10.1016/j.jrras.2025.101638","DOIUrl":"10.1016/j.jrras.2025.101638","url":null,"abstract":"<div><div>This study proposes to examine the effects of Stefan blowing and thermal radiation on the Marangoni convective velocity of a trihybrid nanofluid across a disk by using LTNE (local thermal non-equilibrium) effect and heat generation. Thermal and mass transfer properties are studied utilizing the Cattaneo-Christov mass and heat flux model. Nanoparticles of silicon carbide <span><math><mrow><mo>(</mo><mrow><mi>S</mi><mi>i</mi><mi>C</mi></mrow><mo>)</mo></mrow></math></span>, cobalt oxide (<span><math><mrow><mrow><mi>C</mi><msub><mi>o</mi><mn>3</mn></msub><msub><mi>O</mi><mn>4</mn></msub></mrow><mo>)</mo></mrow></math></span>, and diamond <span><math><mrow><mo>(</mo><mrow><mi>N</mi><mi>D</mi></mrow><mo>)</mo></mrow></math></span> dissolved in water <span><math><mrow><mo>(</mo><mrow><msub><mi>H</mi><mn>2</mn></msub><mi>O</mi></mrow><mo>)</mo></mrow></math></span> make up the trihybrid nanofluid flow model. In this work, the trihybrid nanofluid's rate of heat transfer based on diamond <span><math><mrow><mo>−</mo><mi>S</mi><mi>i</mi><mi>C</mi><mo>−</mo><mi>C</mi><msub><mi>o</mi><mn>3</mn></msub><msub><mi>O</mi><mn>4</mn></msub><mo>/</mo></mrow></math></span> water is investigated by c contrasting the improved model with the Hamilton-Crosser model in its classical form. Thermal transmission efficiency in nuclear reactors, energy storage devices, and microelectronic cooling is improved by the investigation of Cattaneo-Christov flux in trihybrid nanofluids with LTNE effects. The design of effective cooling mechanisms in the automotive and aerospace industries is also aided by the optimization of thermal conductivity predictions through the use of classical and improved Hamilton-Crosser models. The system of PDEs is converted into a non-linear ODE system by applying the required transformations. The Bvp4c method is applied to solve this problem mathematically. When the values of the thermal and solutal relaxation parameters increase, the thermal and solutal distributions decrease.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101638"},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional speckle tracking imaging-based evaluation of influences of systematic cardiac rehabilitation nursing on cardiac function after interventional treatment of acute myocardial infarction 基于三维散斑跟踪成像评价系统心脏康复护理对急性心肌梗死介入治疗后心功能的影响
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-23 DOI: 10.1016/j.jrras.2025.101623
Suqiong Yi , Hongyin Yi
{"title":"Three-dimensional speckle tracking imaging-based evaluation of influences of systematic cardiac rehabilitation nursing on cardiac function after interventional treatment of acute myocardial infarction","authors":"Suqiong Yi ,&nbsp;Hongyin Yi","doi":"10.1016/j.jrras.2025.101623","DOIUrl":"10.1016/j.jrras.2025.101623","url":null,"abstract":"<div><h3>Background/objective</h3><div>Acute myocardial infarction (AMI) is a life-threatening condition that requires effective post-intervention care. This study aimed to assess the impact of systematic cardiac rehabilitation nursing on heart function and mental health in patients following AMI intervention.</div></div><div><h3>Methods</h3><div>A total of 200 AMI patients were assigned to the control group (routine nursing) and the observation group (systematic cardiac rehabilitation nursing). Heart function was evaluated before and after the intervention using three-dimensional speckle tracking imaging (3D-STI). Additionally, the effects of different nursing approaches on AMI patients undergoing intervention were analyzed.</div></div><div><h3>Results</h3><div>Systematic cardiac rehabilitation nursing led to significant improvements in clinical indicators and notable lipid-lowering effects. Compared to routine nursing, systematic cardiac rehabilitation nursing markedly (<em>p &lt;</em> 0.05) reduced the SAS score, improved the SF-36 score, and led to a 15.2 % reduction in LDL levels. Furthermore, 3D-STI showed a notable (<em>p &lt;</em> 0.05) improvement in radial strain and a reduction in area strain in observation group.</div></div><div><h3>Conclusion</h3><div>Systematic cardiac rehabilitation nursing markedly improved heart function and mental health in patients following AMI, as demonstrated by 3D-STI, though further multicenter studies are needed to confirm generalizability.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101623"},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical value of contrast-enhanced ultrasound and contrast-enhanced CT in the diagnosis of HBV-infected hepatocellular carcinoma 超声增强和CT增强对乙型肝炎感染的肝细胞癌的诊断价值
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-23 DOI: 10.1016/j.jrras.2025.101615
Jun Liu, Jinhong Cao, Lingling Ye, Xiaoding Hu
{"title":"Clinical value of contrast-enhanced ultrasound and contrast-enhanced CT in the diagnosis of HBV-infected hepatocellular carcinoma","authors":"Jun Liu,&nbsp;Jinhong Cao,&nbsp;Lingling Ye,&nbsp;Xiaoding Hu","doi":"10.1016/j.jrras.2025.101615","DOIUrl":"10.1016/j.jrras.2025.101615","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the diagnostic value of contrast-enhanced ultrasound (CEUS) and contrast-enhanced CT (CECT) in hepatitis B virus (HBV)-infected hepatocellular carcinoma (HCC).</div></div><div><h3>Methods</h3><div>A retrospective collection was conducted to HBV-infected patients who were treated at our hospital from February 2020 to January 2023. The included patients presented with liver space-occupying lesions based on routine examinations. In addition, they received CEUS and CECT examinations within four weeks after the detection of lesions, and subsequent pathological diagnoses were obtained. CEUS was performed using sulfur hexafluoride microbubble contrast agents for real-time vascular imaging, while CECT involved iodinated contrast imaging during arterial, portal, and delayed phases. Statistical analysis included ROC curve construction to assess diagnostic performance. The medical records of 81 patients were included in this study. Among the collected cases, 31 were pathologically diagnosed as HCC, while 50 cases were diagnosed with other benign lesions. The LI-RADS results of both diagnostic methods, CEUS and CECT, were observed and compared against the pathological results, which served as the gold standard. ROC curves were then constructed to evaluate the diagnostic efficiency of CEUS and CECT in detecting HCC. Finally, a receiver operating characteristic (ROC) curve was created to assess the diagnostic performance of joint diagnosis with CEUS and CECT in HCC.</div></div><div><h3>Results</h3><div>The area under the curve (AUC), specificity, and sensitivity of CECT were 0.859, 80.65 %, and 80.00 %, respectively, and those of CEUS were 0.796, 70.97 % and 80.00 %, respectively. The AUC, specificity and sensitivity of joint diagnosis were 0.934, 93.55 % and 80.00 %, respectively.</div></div><div><h3>Conclusion</h3><div>Both CEUS and CECT have high diagnostic value for HCC, each of which has its own advantages. The combination use of these two different imaging techniques significantly improves the diagnostic ability in detecting HCC.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101615"},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mathematical simulation of radiative nanofluid flow and heat transfer past a stretching surface: A parametric study 辐射纳米流体通过拉伸表面流动和传热的数学模拟:参数研究
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-22 DOI: 10.1016/j.jrras.2025.101620
Sidra Jubair , Sajida Raz Bhutto , Ioan-Lucian Popa , Umar Ishtiaq , Md Irfanul Haque Siddiqui
{"title":"Mathematical simulation of radiative nanofluid flow and heat transfer past a stretching surface: A parametric study","authors":"Sidra Jubair ,&nbsp;Sajida Raz Bhutto ,&nbsp;Ioan-Lucian Popa ,&nbsp;Umar Ishtiaq ,&nbsp;Md Irfanul Haque Siddiqui","doi":"10.1016/j.jrras.2025.101620","DOIUrl":"10.1016/j.jrras.2025.101620","url":null,"abstract":"<div><div>Numerically the nanofluid flow (NFF) over a spinning stretching/shrinking surface subject to the magnetic field is examined in the current study. The NF is prepared by the dispersion of aluminum alloys (Ti<sub>6</sub>Al<sub>4</sub>V) nanoparticles (NPs) in the base fluid (EG + water). Ti<sub>6</sub>Al<sub>4</sub>V-NPs have unique properties such as biologic compatibility, high durability, high boiling point (1604–1660 °C), and erosion resistance, making them more suitable for the automotive industry and other engineering purposes. The current study aims to address and provide remarkable insights into the aforementioned physical parameters. The modeled equations of NFF are transformed into nonlinear DEs (differential equations) independent of dimension, and they are computationally solved by using the widely used parametric continuation method (PCM). The numerical outcomes are compared to published results. The relative error with the published work is 0.00404 %, which ensure the accuracy of the results. The impact of physical fluid parameters on the fluid motion, thermal energy, and mass distribution profiles are studied. The values and ranges of these parameters have been considered based on the better convergence of the flow equations. It has been determined that the fluid velocity fall offs with the impact of magnetic field and rising numbers of Ti<sub>6</sub>Al<sub>4</sub>V NPs. The skin friction rises with variations in the aligned magnetic field and sheet stretching ratio factor. In addition, the radiation absorption factor increases the energy distribution rate.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101620"},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing medical imaging with Ghost-ResNeXt and locust-inspired optimization: A case study on diabetic retinopathy 利用Ghost-ResNeXt和蝗虫启发优化增强医学成像:糖尿病视网膜病变的案例研究
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-22 DOI: 10.1016/j.jrras.2025.101622
Ibrahim Alrashdi, Rasha M. Abd El-Aziz, Ahmed I. Taloba
{"title":"Enhancing medical imaging with Ghost-ResNeXt and locust-inspired optimization: A case study on diabetic retinopathy","authors":"Ibrahim Alrashdi,&nbsp;Rasha M. Abd El-Aziz,&nbsp;Ahmed I. Taloba","doi":"10.1016/j.jrras.2025.101622","DOIUrl":"10.1016/j.jrras.2025.101622","url":null,"abstract":"<div><div>Diabetic Retinopathy (DR) is a global cause of vision impairment, necessitating early detection for effective treatment. Previous works on deep learning architectures like ResNet and DenseNet exhibit promising efficiency in DR detection. However, they're typically computationally expensive and sluggish, rendering them relatively unsuitable for real-time scientific purposes. Also, there are challenges associated with the existing models of displaying normality and the normal distributions to enhance hyperparameters, which often result in the models' generally poor performance. To lower the version complexity and maintain higher accuracy in low-light situations, this examines the cost of the significant GhostNet structure with the former high-throughput ResNeXt model to establish Ghost-ResNeXt. To improve the model performance even more, we propose a new algorithm called Locust-Inspired Optimization, which belongs to swarm intelligence inspired by biological processes. These rules pleasantly tune the model's hyperparameters by emulating the swarm behavior of locusts for the best feature selection and classification. The proposed method entailed training the Ghost-ResNeXt model on a large data set of retinal images. At the same time, the parameters were optimized with the aid of a locust-inspired optimization algorithm. The model design prevents intricate patterns of DR from overshadowing the computational burden while optimally retaining valuable diagnostic information. Experimental outcomes proved that the Ghost-ResNeXT is superior to the conventional architectures in terms of accuracy and pace, which resulted in a remarkable improvement in DR detection accuracy within a comparatively reduced range of parameters. The Locust-Inspired Optimization enhances model stability, achieving higher precision and recall than conventional optimization techniques. This paper provides a novel and useful resource-saving approach to DR identification, which can be applied in ‘live’ diagnostics and telemedicine.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101622"},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of heat transfer and flow properties of penta hybrid nanofluid in magnetized squeezing flow of Boger-micropolar 博格-微极磁化挤压流中五杂化纳米流体的传热与流动特性分析
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-21 DOI: 10.1016/j.jrras.2025.101633
Fateme Nadalinia Chari, Mehdi Mahboobtosi, Davood Domiri Ganji
{"title":"Analysis of heat transfer and flow properties of penta hybrid nanofluid in magnetized squeezing flow of Boger-micropolar","authors":"Fateme Nadalinia Chari,&nbsp;Mehdi Mahboobtosi,&nbsp;Davood Domiri Ganji","doi":"10.1016/j.jrras.2025.101633","DOIUrl":"10.1016/j.jrras.2025.101633","url":null,"abstract":"<div><div>This study investigates the unsteady flow and heat characteristics of penta hybrid Boger-micropolar magnetohydrodynamic (MHD) nanofluid between parallel disks, its heat performance, which has drawn significant interest because of its promising application in heat exchangers. The penta hybrid nanofluid consists of blood as the base fluid and five different nanoparticles of Al<sub>2</sub>O<sub>3</sub>, ZrO<sub>2</sub>, Fe<sub>3</sub>O<sub>4</sub>, Ag and MoS<sub>2</sub>. The main goal of this study is to examine the laminar, time-dependent, and incompressible flow of a penta-hybrid nanofluid under the influence of a magnetic field, focusing on the squeezing flow of a Boger micropolar nanofluid between both porous and non-porous disks, while also analyzing its thermal properties. The fluid is subjected to squeezing at the top disk, which is in motion in the axial direction, and a uniform suction/injection at the bottom disk. Energy and velocity slip effects are also considered at the fixed bottom disk. For the analysis of the flow, appropriate similarity transformations are utilized to reduce the governing partial differential equations (PDEs) to nonlinear ordinary differential equations (ODEs), which are then solved numerically using Python. The analysis demonstrates that an increase in the solvent fraction factor (<em>β</em><sub>1</sub>) improves the heat transfer and flow velocity, and higher values of the relaxation time ratio (<em>β</em><sub>2</sub>) decrease the thermal conductivity. Also, an increase in the magnetic parameter (M) and microrotation (K) increases the resistance to flow and decreases the heat transfer efficiency. The results are presented graphically, illustrating the impact of microrotation, velocity, and temperature profiles, and providing useful information on the thermal performance of the fluid. The results have potential applications in advanced cooling systems, environmental purification, biomedical devices, and energy-efficient heat exchangers, where high heat transfer and control of the fluid are required.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101633"},"PeriodicalIF":1.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of glucose and lipid metabolic parameters in patients with metabolic syndrome on the treatment response of glioblastoma: A retrospective case-control study 代谢综合征患者糖脂代谢参数对胶质母细胞瘤治疗反应的影响:一项回顾性病例对照研究
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-21 DOI: 10.1016/j.jrras.2025.101589
Dingning Zhang , Ping Liang , Jintuo Yin , Luya Li , Yajing Wang , Rui Feng , Ying Zheng
{"title":"The impact of glucose and lipid metabolic parameters in patients with metabolic syndrome on the treatment response of glioblastoma: A retrospective case-control study","authors":"Dingning Zhang ,&nbsp;Ping Liang ,&nbsp;Jintuo Yin ,&nbsp;Luya Li ,&nbsp;Yajing Wang ,&nbsp;Rui Feng ,&nbsp;Ying Zheng","doi":"10.1016/j.jrras.2025.101589","DOIUrl":"10.1016/j.jrras.2025.101589","url":null,"abstract":"<div><h3>Background</h3><div>Glioblastoma (GBM) is an aggressive brain malignancy with a poor prognosis. The metabolic syndrome, characterized by aberrant glucose and lipid metabolism, may influence GBM treatment outcomes. This study aimed to explore the impact of glucose and lipid metabolic parameters in patients with metabolic syndrome on the therapeutic response of GBM.</div></div><div><h3>Methods</h3><div>A retrospective case-control study was conducted, involving 228 GBM patients with metabolic syndrome treated from January 2019 to January 2022. Patients were categorized into good and poor response groups based on survival beyond or below 15 months post-treatment. Demographic, clinical, and metabolic data were collected, including blood glucose, lipid profiles, and inflammatory markers. Univariate and multivariate logistic regression analyses identified predictors of treatment response.</div></div><div><h3>Results</h3><div>Elevated glucose and lipid parameters were associated with poor treatment responses. Mean serum glucose, glycated hemoglobin (HbA1c), and homeostatic model assessment of insulin resistance (HOMA-IR) were higher in the poor response group (<em>P</em> = 0.01, <em>P</em> &lt; 0.001, <em>P</em> = 0.022, respectively), correlating positively with poor outcomes in multivariate analysis. Dyslipidemia, characterized by high triglycerides (TG) and high-density lipoprotein cholesterol (HDL), and low low-density lipoprotein cholesterol (LDL) levels, significantly predicted poorer responses (TG <em>P</em> &lt; 0.001; LDL <em>P</em> = 0.012; HDL <em>P</em> &lt; 0.001). Elevated C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) levels were also linked to worse outcomes, indicating a role of systemic inflammation. Epidermal growth factor receptor (EGFR) amplification was more common in poor responders, while O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation was linked to better outcomes (<em>P</em> = 0.002 and <em>P</em> = 0.001, respectively).</div></div><div><h3>Conclusion</h3><div>Dysregulated glucose and lipid metabolism in metabolic syndrome adversely affects GBM treatment response.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101589"},"PeriodicalIF":1.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soy isoflavones protect against gamma radiation-induced kidney and liver damage in male albino rats 大豆异黄酮保护雄性白化大鼠免受γ辐射引起的肾脏和肝脏损伤
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-21 DOI: 10.1016/j.jrras.2025.101626
Wafa S. Alansari
{"title":"Soy isoflavones protect against gamma radiation-induced kidney and liver damage in male albino rats","authors":"Wafa S. Alansari","doi":"10.1016/j.jrras.2025.101626","DOIUrl":"10.1016/j.jrras.2025.101626","url":null,"abstract":"<div><div>We determined whether soy isoflavones could enhance the recovery of adult rats from the harmful effects of gamma radiation on the liver and kidney. Male Albino rats were subjected to whole-body gamma irradiation and fed a balanced diet supplemented with various amounts of soy isoflavones. Radiation exposure negatively affected liver and kidney functional markers, including albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, sodium, potassium, and total protein (TP) as well as markers of oxidative stress (MDA, GSH, and PC) and inflammation (TNF-α and NF-κB) compared with nonirradiated balanced diet-fed rats. Isoflavone-supplemented standard diets improved all of the markers in irradiated rats in a dose-dependent manner compared with standard diet-only fed irradiated rats. These findings highlight the protective effects of isoflavones against radiation-induced liver and kidney damage, possibly by blunting oxidative stress and inflammation.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101626"},"PeriodicalIF":1.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of thermal radiation on ternary hybrid nanofluid with thermal non-equilibrium effects and activation energy: Implications for biomedical applications 热辐射对具有热非平衡效应和活化能的三元杂化纳米流体的影响:生物医学应用的意义
IF 1.7 4区 综合性期刊
Journal of Radiation Research and Applied Sciences Pub Date : 2025-05-21 DOI: 10.1016/j.jrras.2025.101627
Munawar Abbas , Nidhal Becheikh , Samira Elaissi , Talib K. Ibrahim , Mustafa Bayram , Boutheyna Belhaj Bettaieb , Ilyas Khan , Hafiz Muhammad Ghazi
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