Journal of Radiation Research and Applied Sciences最新文献

{"title":"Generalized class of estimators under PPS Sampling: Application on solar radiation","authors":"Mohammed Alquraish","doi":"10.1016/j.jrras.2025.101903","DOIUrl":"10.1016/j.jrras.2025.101903","url":null,"abstract":"<div><div>The estimation of the population means is a crucial aspect of environmental studies in many cases including situations where the population is skewed or there is a high variability of the auxiliary data. Solar radiation is a major parameter in renewable energy planning and climate model, which tends to be spatially and temporally heterogeneous. This variability can be inefficiently estimated under Probability Proportional to Size (PPS) sampling due to inefficiencies caused by a biased ineffective estimator. In this work article we find the finite population mean of solar radiation by use of probability proportional to size (PPS) sampling. The estimators incorporate the auxiliary information into the computations in a more flexible way to increase the estimation of the population mean in PPS sampling schemes. The foremost objective of the study is to formulate, generalized and boosted estimators to attain the minimum mean squared error (MSE) and higher percentage relative efficiency (PRE) than conventional estimators. The real application to focus on is solar radiation data where the range of the auxiliary variables location, altitude, and atmospheric conditions, has a considerable impact on the value. The results show that the estimators consistently given by the generalized boosted estimators have minimum MSE and drastically high PRE as compared to their standard existing estimators. This implies that the suggested class of estimators provides a better and more efficient tool of means estimation in complex populations. Finally, the paper has added a highly flexible and valid estimation procedure in the context of a PPS sample, an application of which can be found in environmental monitoring, assessment of solar energy, and statistical surveys.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101903"},"PeriodicalIF":2.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOK5 as an oncogenic mediator in gastric cancer: Mechanistic insights through bioinformatics and clinical validation","authors":"Kun Tao ,&nbsp;Junqin Ge ,&nbsp;Zihao Ge ,&nbsp;Chungen Xing","doi":"10.1016/j.jrras.2025.101896","DOIUrl":"10.1016/j.jrras.2025.101896","url":null,"abstract":"<div><h3>Objective</h3><div>Gastric cancer (GC) exhibits metastasis-driven mortality, necessitating novel biomarkers. Although Docking Protein 5 (<em>DOK5</em>), a tyrosine kinase substrate previously implicated in neuronal development and signaling cascades, remains mechanistically uncharacterized in GC.</div></div><div><h3>Methods</h3><div><em>DOK5</em>'s diagnostic and prognostic potential was evaluated via integrated The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data mining. Utilizing 93 surgically resected specimens (2011–2015 retrospective cohort), we correlated <em>DOK5</em> immunoreactivity with clinicopathological variables. Gene Set Enrichment Analysis (GSEA) elucidated pathway associations.</div></div><div><h3>Results</h3><div><em>DOK5</em> demonstrated significant tumoral overexpression versus normal mucosa, prognosticating reduced survival. Clinical validations confirmed diagnostic capabilities and TNM-stage associations. GSEA revealed that <em>DOK5</em> expression positively correlated with epithelial-mesenchymal transition (EMT) and Notch signaling.</div></div><div><h3>Conclusion</h3><div><em>DOK5</em> functions as a tumor-promoting factor in GC carcinogenesis, mechanistically facilitating malignant progression through EMT program activation and Notch signaling pathway engagement. Critically, <em>DOK5</em> immunohistochemistry may serve as a clinically feasible biomarker to stratify high-risk gastric cancer patients during routine histopathology assessment. This establishes <em>DOK5</em> as both a prognostic indicator and a therapeutic target in GC therapeutics.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101896"},"PeriodicalIF":2.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of cetylpyridinium chloride buccal tablets combined with Xipayi gingival rinse in the postoperative infections after dental implant based on cone beam computed tomography imaging","authors":"Xiaodong Liu,&nbsp;Guangshu Chen,&nbsp;Man Lu,&nbsp;Peng Sun,&nbsp;Yuzeng Li","doi":"10.1016/j.jrras.2025.101875","DOIUrl":"10.1016/j.jrras.2025.101875","url":null,"abstract":"<div><h3>Background and objective</h3><div>Prophylactic application of antibiotics can effectively prevent and treat peri implant infection after oral implant surgery. This study aimed to explore the therapeutic effect of cetylpyridinium chloride buccal tablets (CCBT) combined with Xipayi gingival rinse (XGR) in the postoperative infections after dental implant based on cone beam computed tomography (CBCT) imaging.</div></div><div><h3>Methods</h3><div>Two hundred and seven patients who underwent elective implantation were randomly grouped: CCBT group, XGR group, XGR + CCBT group, and saline group. Visual analogue scale (VAS) was used to evaluate the degree of postoperative pain and check the wound healing. The periodontal status was evaluated by modified plaque index (mPLI), modified gingival index (mGI), and modified sulcus bleeding (mSBI). The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-8 (MMP-8) in the gingival crevicular fluid were detected. In addition, CBCT scans were performed to assess bone density and marginal bone resorption.</div></div><div><h3>Results</h3><div>As against saline group, the pain proportion, mPLI, mGI, and mSBI scores, the number of <em>obligate anaerobes</em> around the implant, the levels of IL-6, TNF-α, and MMP-8 in gingival crevicular fluid, and the proportion of peri implant infection were markedly decreased, and the wound healing proportion was markedly increased in CCBT group, XGR group, and XGR + CCBT group (<em>P &lt;</em> 0.05). Moreover, following remedy, as against CCBT group and XGR group, all indicators were markedly improved, and the proportion of postoperative peri implant infection was lower in XGR + CCBT group (<em>P &lt;</em> 0.05). CBCT analysis showed that, compared to other groups, XGR + CCBT group exhibited increased bone density and reduced bone resorption at four and six months postoperatively (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Based on CBCT imaging, CCBT combined with XGR significantly reduces the short-term risk of infection following dental implant surgery, and promote osseointegration and reducing bone loss, demonstrating a synergistic advantage over monotherapy.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101875"},"PeriodicalIF":2.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based magnetic resonance imaging image reconstruction in the assessment of brain microstructural changes in Parkinson's disease patients","authors":"Jinyan Shao,&nbsp;Fang Wang","doi":"10.1016/j.jrras.2025.101876","DOIUrl":"10.1016/j.jrras.2025.101876","url":null,"abstract":"<div><h3>Objective</h3><div>This study was aimed to investigate the application value of deep learning-based magnetic resonance imaging (MRI) image reconstruction technology in the assessment of brain microstructural changes in patients with Parkinson's disease (PD).</div></div><div><h3>Methods</h3><div>A total of 78 early-stage PD patients and 78 healthy controls were enrolled. Diffusion tensor imaging (DTI) was performed using MRI, and images were reconstructed using a multi-object interactive neural network-based brain MRI segmentation model. Parameters including fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) were calculated to assess microstructural changes in brain regions such as the substantia nigra, basal ganglia, and hippocampus. Pearson correlation analysis was employed to examine the association between regional parameters and Montreal cognitive assessment (MoCA) scores, while receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of these parameters for PD.</div></div><div><h3>Results</h3><div>The constructed segmentation model achieved a Dice similarity coefficient (DSC) of 0.922, with relative volume difference (RVD) and root mean square (RMS) values of 0.042 and 0.46, respectively, outperforming related algorithms. The PD group exhibited significantly reduced FA and increased RD in the substantia nigra, hippocampus, and thalamus. Hippocampal RD demonstrated a strong negative correlation with MoCA scores (<em>r=</em>-0.67, <em>P&lt;</em>0.001). ROC analysis indicated that hippocampal RD had the best diagnostic efficacy for PD [area under the curve (AUC) = 0.90, sensitivity 88 %/specificity 87 %], followed by substantia nigra RD (AUC = 0.88) and thalamic RD (AUC = 0.87).</div></div><div><h3>Conclusion</h3><div>Deep learning-based MRI reconstruction technology can accurately quantify early brain microstructural damage in PD patients. The RD of the hippocampus and substantia nigra are sensitive biomarkers for diagnosing PD and screen cognitive impairment, providing a new imaging strategy for the early precise diagnosis and treatment of PD.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101876"},"PeriodicalIF":2.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solar radiation-driven MHD Maxwell nanofluid flow with gyrotactic microorganisms and Soret–Dufour effects: A thermal engineering study","authors":"Mohamed Bechir Ben Hamida ,&nbsp;Muhammad Irfan ,&nbsp;Muhammad Shoaib Anwar ,&nbsp;Mubashar Javed","doi":"10.1016/j.jrras.2025.101887","DOIUrl":"10.1016/j.jrras.2025.101887","url":null,"abstract":"<div><h3>Background</h3><div>In recent progress the fluid with bio-magnetic is biotic fluid that occurs in existing mortals under magnetic field impact. Plasma is the best specimen of a bio-magnetic fluid. The studies on bio-magnetic fluid in the former limited spans, have established extra devotion from scientists, because of its significant uses in medicinal disciplines and bio-engineering, for instance dipping blood loss in operations, in magnetic stratagem expansion for cell parting and the battered remedies transport. Furthermore, magnetic particles are utilized for MRI (magnetic resonance imaging) of detailed materials of the cancer treatment or human structure.</div></div><div><h3>Objective</h3><div>This work elaborates the combine influences of variable conductivity and soret-doufour aspects on bioconvection magnetite Maxwell nanofluid with motile microorganism along a stretching cylinder. The impact of heat source/sink with chemical reaction is also considered in this scientific modeling in stagnation reagion. The theoretically study describes the Brownian motion and thermophoretic dispersal thought exhausting Buongiorno model.</div></div><div><h3>Methodology</h3><div>The homotopic tactic describes a broad uses of nonlinear problems in physics, production and applied mathematics. The suitable scaling conversions are subjugated to alter the partial differential (PDEs) into ordinary differential equations (ODEs). The homotopic analysis tactic is a semi-analytical process which is exploited for solutions of ODEs by forming a series solution constructed on the thought of homotopy.</div></div><div><h3>Major findings</h3><div>The outstanding physical features of flow factors on temperature, concentration and microbe concentration fields are observed and clarified tabular and graphical shape. The various physical influences performance of heat transport and density of the motile microbes are also presented. The doufour and variable conductivity factors raise the temperature field. The work exposes that the thermophoretic dispersion and Soret factors exaggerate the concentration field, whereas diminish for Brownian factor. Furthermore, the picture specifies that the growing of Peclet factor falloff the motile density field of microbe. The modern theoretic exertion has been utilized to intensify the performance of thermal energy, industrial and heat transport.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101887"},"PeriodicalIF":2.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of non-linear radiative flux in thermal and entropy optimization of hybrid Casson nanofluid over a spinning permeable sphere","authors":"S. Bilal ,&nbsp;Enio Pedone Bandarra Filho ,&nbsp;Tomas kozubek ,&nbsp;Muhammad Bilal Riaz ,&nbsp;M. Yasir","doi":"10.1016/j.jrras.2025.101833","DOIUrl":"10.1016/j.jrras.2025.101833","url":null,"abstract":"<div><div>Transmission of energy in flow over spinning sphere or rotating objects has outstanding utilization in various engineering and scientific disciplines. For instance, reactors safety, aerosol cooling, heat exchangers, lubrication, water contaminants removal and many more. So, taking motivation from these applications, a multipurpose investigation to optimize energy proficiency by adding amalgamation of Penta-hybridized nanoparticles in viscoelastic material flow over a rotating sphere is adhered in current artifact. Effectiveness of periodically variant magnetic field instead of considering it uniformly has been employed to make problem more realistic to real world applications. To explore hydrothermal attributes of flow accounted in domain, Casson rheological model is introduced. Catalytic reactions subjected to homogeneity/heterogeneity has been used to enhance exchange in energy among fluid layers. Mathematical formulation of problem concerned with empirical relations of considered nanocomposites along with physical factors is modelled in the form of ordinary differential setup after using similarity approach. Numerical simulations are performed by using finite element method. Results are drawn in the view of pictorial and tabulated formats.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101833"},"PeriodicalIF":2.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color changes and optical properties of gamma irradiated polycarbonate/poly(methyl methacrylate)/polyvinyl chloride blended polymers: Linear and nonlinear optical parameters","authors":"Samir A. Nouh ,&nbsp;M.A. Ellabban ,&nbsp;Merfat Algethami ,&nbsp;F.A. Alsomali ,&nbsp;Mai M.E. Barakat","doi":"10.1016/j.jrras.2025.101893","DOIUrl":"10.1016/j.jrras.2025.101893","url":null,"abstract":"<div><div>The casting approach was applied to create blended polymers of polycarbonate, poly(methyl methacrylate) and polyvinyl chloride (PC/PMMA/PVC). Several gamma radiation doses (20–150 kGy) were utilized to irradiate samples from the produced PC/PMMA/PVC films. The consequent influences of the gamma radiation on the color changes, linear and nonlinear optical parameters of the created films were explored by means of UV-spectroscopy. Also, the International Commission on Illumination (CIE) color differences approach was utilized to evaluate the color shifts amongst the films irradiated with different doses and the non-irradiated one. The gamma irradiation with doses ranging between 20 and 150 kGy caused noticeable color modifications to the colorless pristine film due to the tendency of the green and blue color components to be converted into red and yellow, respectively. This caused an increase in the color intensity to 28.32 indicating significant color changes. Moreover, the blended polymers’ absorbance increased when irradiated with gamma doses up to 150 kGy. Also, the values of Urbach energy were enhanced from 0.11 to 0.26 eV. Additionally, the direct and indirect bandgaps decreased from 4.72 to 4.25 eV and from 4.52 to 4.05 eV, respectively. Furthermore, we identified the kind of microelectronic transitions for the PC/PMMA/PVC blended polymers utilizing the optical dielectric loss function (<em>ε</em>\"). We detected that the type of transition is a direct allowed. Moreover, the refractive index increased from 2.043 to 2.123 upon γ irradiation up to 150 kGy. The resulting improvements in optical characteristics of the PC/PMMA/PVC blended polymers introduce the basis that can be used in constructing optoelectronic devices.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101893"},"PeriodicalIF":2.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonketotic hyperglycemic hemichorea: white shadows on CT and T1-weighted MRI","authors":"Zhihui Zhou ,&nbsp;Juan Peng ,&nbsp;Wenxiao Zhang ,&nbsp;Jinming Deng ,&nbsp;Libin Liu","doi":"10.1016/j.jrras.2025.101890","DOIUrl":"10.1016/j.jrras.2025.101890","url":null,"abstract":"<div><div>Nonketotic hyperglycemic hemichorea (NHH) is a rare movement disorder, most commonly observed in elderly female patients with poorly controlled diabetes. We describe a 55-year-old male patient with diabetes who was admitted due to involuntary movements of the right limbs for five days. CT revealed a hyperdense lesion in the left putamen and caudate nucleus, while MRI showed hyperintensity on T1WI and hypointensity on both T2WI and diffusion-weighted imaging. The patient was treated with oral haloperidol and insulin for blood glucose control, leading to gradual symptom improvement. Follow-up imaging showed resolution of the lesions, correlating with clinical improvement. NHH has characteristic imaging findings and should be differentiated from cerebral hemorrhage, basal ganglia calcification, and hepatic encephalopathy.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101890"},"PeriodicalIF":2.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of lncRNA NEAT1 suppresses multiple myeloma progression via the miR-133a-3p/ARPC5 axis","authors":"Xin Li ,&nbsp;Peng Zhang ,&nbsp;Zhenzhen Meng ,&nbsp;Shanshan Luo","doi":"10.1016/j.jrras.2025.101878","DOIUrl":"10.1016/j.jrras.2025.101878","url":null,"abstract":"<div><h3>Background</h3><div>Long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) has been implicated in multiple myeloma (MM) pathogenesis, with elevated expression correlating with disease progression and poor clinical outcomes. This study systematically investigated the molecular pathways through which NEAT1 contributes to MM pathogenesis.</div></div><div><h3>Methods</h3><div>We first characterized NEAT1 expression patterns in MM patients and MM cell lines. Functional studies were performed in NCIH929 and U266 cell lines through gain-of-function (overexpression plasmids) and loss-of-function (small interfering RNA -mediated knockdown) approaches, with assessment of proliferation, invasion and apoptosis. Mechanistic studies employed dual-luciferase reporter assays to validate direct interactions between NEAT1/miR-133a-3p and miR-133a-3p/ARPC5. Rescue experiments elucidated functional relationships within this regulatory axis. Therapeutic potential was evaluated in xenograft models using NEAT1-depleted NCIH929 cells.</div></div><div><h3>Results</h3><div>Expression analysis revealed that NEAT1 was upregulated 2.2-fold in MM patients (<em>P</em> &lt; 0.01), while miR-133a-3p was downregulated 3.1-fold (<em>P</em> &lt; 0.01) and ARPC5 mRNA levels was increased 2.0-fold (<em>P</em> &lt; 0.01). NEAT1 overexpression notably enhanced MM cell proliferation and invasion, and suppressed apoptosis (<em>P</em> &lt; 0.01). Conversely, NEAT1 knockdown yielded opposite effects (all <em>P</em> &lt; 0.01). Mechanistically, miR-133a-3p was a target gene of NEAT1 and negatively regulated by NEAT1. The inhibition of miR-133a-3p counteracted the tumor-suppressive effect of NEAT1 knockdown on MM cell progression. Furthermore, ARPC5 was validated as a downstream target of miR-133a-3p, and the overexpression of ARPC5 nullified the inhibitory effect of miR-133a-3p overexpression on MM cell progression (<em>P</em> &lt; 0.01). Additionally, NEAT1 knockdown inhibited ARPC5 expression in MM cells (<em>P</em> &lt; 0.01). ARPC5 overexpression abrogated the inhibitory effects of NEAT1 knockdown on MM cell progression (<em>P</em> &lt; 0.01). Additionally, NEAT1 depletion significantly suppressed tumor growth in vivo (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>LncRNA NEAT1 knockdown suppressed proliferation and invasion, and facilitated apoptosis of MM cells <em>via</em> targeting the miR-133a-3p/ARPC5 pathway. This study is the first to demonstrate that NEAT1 promotes MM progression by sponging miR-133a-3p to upregulate ARPC5, revealing a novel therapeutic axis.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101878"},"PeriodicalIF":2.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric characteristics of IMRT and VMAT techniques for spatially fractionated radiation therapy","authors":"Shuangtong Liu ,&nbsp;Xin Huang ,&nbsp;Shanshan Yin ,&nbsp;Minghan Qiu ,&nbsp;Zhitao Dai ,&nbsp;Hui Wang","doi":"10.1016/j.jrras.2025.101898","DOIUrl":"10.1016/j.jrras.2025.101898","url":null,"abstract":"<div><h3>Object</h3><div>This study aimed to evaluate the differences in plan quality metrics between three main methods of radiotherapy: Volumetric Modulated Arc Therapy (VMAT), Intensity-Modulated Radiation Therapy - Sliding Window (IMRT-SW), and Intensity-Modulated Radiation Therapy - Multiple Static Segments (IMRT-MSS) for spatially fractionated radiation therapy (SFRT) planning in the radiotherapy department of Tianjin Union Medical Center using the Eclipse 15.5 treatment planning system.</div></div><div><h3>Methods</h3><div>SFRT plans of ten Patients were designed using coplanar IMRT-MSS,IMRT-SW and VMAT techniques, A total of 45 plans were created with collimator angles set to 315°, 0°, 45°, and 90°, utilizing evenly distributed fields within 360°. VMAT plans employed four full arc, while IMRT plan were divided into four groups based on field spacing of 30°, 22.5°, 15°, and 10°.Plan quality was assessed and compared using metrics include Peak-to-valley dose ratio (PVDR), peak dose, lattice spheres coefficient of variation(CV), Conformity Index(CI), Gradient Measure(GM), Mean Dose to Normal Tissue(D_mean,NT), gamma passing rates(GPR), monitor units (MU), and the MU Percentage for each Collimator Angle.</div></div><div><h3>Results</h3><div>VMAT group exhibited a significantly elevated PVDR and peak dose, with the worst-case CV values. VMAT demonstrates a progressive enhancement in PVDR superiority compared to IMRT as the lattice point number decrease(≤10–15 points). The IMRT-MSS group generally shows higher PVDR than the IMRT-SW group. VMAT group demonstrated significant advantages in CI, GM, MU efficiency, and acceptable GPR, while the IMRT-MSS cohort outperformed IMRT-SW in these parameters. Collimator angles of 45° and 315° were found to be particularly significant in SFRT plan.</div></div><div><h3>Conclusion</h3><div>VMAT demonstrates overall superior performance compared to IMRT, particularly with reduced lattice point density or in superficial convex-shaped tumors. For SFRT of large-volume tumors (lattice point counts&gt;15), we recommend VMAT implementation with controlled lattice points for improved PVDR.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101898"},"PeriodicalIF":2.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}