Journal of Radiation Research and Applied Sciences最新文献

{"title":"Impact of computed tomography radiomics-based predictive model for immunotherapy efficacy in non-small cell lung cancer on predictive nursing outcomes","authors":"Yajing Lin , Xiaowan Zeng , Xiaoyan Li","doi":"10.1016/j.jrras.2026.102170","DOIUrl":"10.1016/j.jrras.2026.102170","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the feasibility of predicting the efficacy of immunotherapy in non-small cell lung cancer (NSCLC) patients using computed tomography (CT) radiomics, and to evaluate the impact of predictive nursing interventions on the quality of life (QOL) and complication rates in these patients.</div></div><div><h3>Methods</h3><div>A total of 68 NSCLC patients treated in hospital were included and randomly assigned into two groups: control group (routine care) and intervention group (predictive nursing intervention in addition to routine care), with 34 patients in each group. All patients underwent contrast-enhanced CT scanning, with the tumor region of interest (ROI) delineated. Intensity, morphological features (sphericity), and texture characteristics (gray-level co-occurrence matrix) were extracted. A predictive model for immunotherapy efficacy was established, and the performance of logistic regression (LR), support vector machine (SVM), K-nearest neighbor (KNN), and Boosting algorithms was compared in terms of accuracy, specificity, precision, recall, and F-score. Additionally, the time of drain removal, hospital stay, post-care QOL scores (including physical function, psychological function, social function, and material life), and complication rates were recorded for both groups.</div></div><div><h3>Results</h3><div>In the prediction model, the LR model performed better on multiple key indicators, with higher accuracy (0.787 vs. 0.771/0.752/0.754), specificity (0.525 vs. 0.352/0.256/0.236), precision (0.895 vs. 0.753/0.761/0.778), recall (0.889 vs. 0.762/0.858/0.793), and F1 score (0.892 vs. 0.757/0.807/0.785) than SVM, KNN, and AdaBoost algorithms. Regarding nursing interventions, the intervention group had significantly shorter drain removal time (52.39 ± 4.32 h) and hospital stay (11.82 ± 1.84 days) compared to the control group (67.93 ± 5.76 h and 17.92 ± 2.91 days, respectively), with statistically significant differences (<em>P</em> < 0.05). Regarding nursing interventions, no significant difference was observed in the baseline QOL scores between the two patient groups at enrollment (<em>P</em> > 0.05), indicating comparability. Post-care, the intervention group showed significantly higher scores in physical function, psychological function, social function, and material life quality compared to the control group (<em>P</em> < 0.05). The incidence of complications in the intervention group (2.94 %) was lower than that in the control group (17.65 %), but the difference did not reach statistical significance (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>CT imaging omics technology has shown potential as an auxiliary tool for predicting the efficacy of immunotherapy in NSCLC patients. The predictive nursing model studied in parallel within the same cohort indicates that this prospective nursing approach can significantly improve patient outcomes. This int","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102170"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging semi-quantitative evaluation of cartilage damage in patients with knee osteoarthritis","authors":"Songbin Yang ,&nbsp;Xu Cui ,&nbsp;Maohua Pang ,&nbsp;Dandan Lv ,&nbsp;Jichun Wu ,&nbsp;Ying Li ,&nbsp;Juhua Zhang","doi":"10.1016/j.jrras.2026.102173","DOIUrl":"10.1016/j.jrras.2026.102173","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop and validate an improved U-Net model for optimizing knee MRI reconstruction and used these optimized images to perform semi-quantitative assessments of cartilage damage severity in patients with knee osteoarthritis (KOA), as well as to explore the association between cartilage damage and subchondral bone marrow edema.</div></div><div><h3>Methods</h3><div>The improved U-shaped network (U-net) was utilized for optimizing the MRI images, and the network reconstruction time, structural similarity index measure (SSIM), and peak signal-to-noise ratio (PSNR) were analyzed. 108 patients with KOA who underwent magnetic resonance examination were included as the research objects. After the patients were divided into normal, mild, and severe groups, their grades of semi-quantitative evaluation of cartilage damage were analyzed.</div></div><div><h3>Results</h3><div>The SSIM of the improved U-net was significantly higher than that of the original U-net, and the difference between the reconstructed images and the original images was highly reduced. MRI could show the types of cartilage damage in the knee joint. An MRI system with the improved U-net model improved the quality of MRI images of KOA patients. The improved U-net achieved a mean PSNR of 42.7 dB and SSIM of 0.94 at a 20 % sampling rate, representing a 15 % and 10 % improvement over the standard U-net, respectively. After the improvement, the reconstruction time of the U-net became shorter. There was a statistically significant difference in the probability of cartilage injury grades I–IV occurring among subchondral bone marrow edema grades 1–3 (<em>Z</em> = 5.098, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The semi-quantitative MRI assessment facilitated by the improved U-net shows promise for accurately displaying and grading articular cartilage damage in KOA. Further validation against arthroscopic findings and in multi-center cohorts is warranted before clinical adoption can be considered. In conclusion, the improved U-net provided knee MRI reconstructions with superior quantitative quality and speed. Using these images, semi-quantitative assessment revealed a significant association between the severity of subchondral bone marrow edema and cartilage injury grade, demonstrating the method's potential for structured image evaluation in KOA.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102173"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption of magnetic resonance image-based comfort nursing in patients with chronic rhinosinusitis","authors":"Jie Yang ,&nbsp;Rong Lin ,&nbsp;Jiaojiao Wu ,&nbsp;Hongyuan Zhu ,&nbsp;Lina Fang","doi":"10.1016/j.jrras.2026.102172","DOIUrl":"10.1016/j.jrras.2026.102172","url":null,"abstract":"<div><h3>Objective</h3><div>This research aimed to evaluate the clinical efficacy of magnetic resonance image (MRI)-based comfort care in patients with chronic rhinosinusitis (CRS) and analyze its impact on hospital stay, symptom relief, and nursing satisfaction.</div></div><div><h3>Methods</h3><div>A total of 300 patients with CRS who had received MRI examination to clarify the pathological features were retrospectively included and divided into a control group (n = 150) and an intervention group (n = 150) based on the nursing protocol they received. The control group received routine nursing care. While the intervention group received additional comfort care interventions (psychological support, posture guidance, dietary management) that were personalized based on individual MRI characteristics such as mucosal thickening and sinus obstruction. The data of hospital stay, time to complication resolution, medication/lifestyle/diet compliance score, and nursing satisfaction of the two groups were collected retrospectively and statistically analyzed.</div></div><div><h3>Results</h3><div>Based on MRI characteristics (e.g.<em>,</em> mucosal thickening, calcifications), the intervention group received personalized care tailored to lesion severity and location. Their hospital stay (9.85 ± 1.63 days) and time to complication resolution (8.17 ± 1.29 days) were notably shorter than those of the control group (16.18 ± 2.24 days, 15.09 ± 1.83 days, <em>P</em> &lt; 0.05). MRI assessment revealed that patients with more extensive inflammation received more targeted interventions, which was associated with higher compliance scores (r = −0.42, <em>P</em> &lt; 0.05), suggesting imaging helped tailor effective care. The intervention group exhibited greatly higher medication, lifestyle, and dietary compliance scores (23.71 ± 4.39, 24.31 ± 4.62, 21.93 ± 3.67) versus the control group (15.85 ± 5.05, 15.23 ± 3.77, 14.88 ± 4.55, <em>P</em> &lt; 0.05). Nursing satisfaction was also markedly higher in the intervention group (90.67 %) than in the control group (76.67 %, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This retrospective analysis showed that MRI-based comfort care enables precise disease assessment and personalized interventions, effectively reducing hospital stay, improving treatment compliance, and enhancing nursing satisfaction in CRS patients, demonstrating promising clinical value that warrants further investigation and validation.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102172"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147394340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hamilton-crosser thermal conductivity model in the quaternary nanofluid flow with second-order slip condition","authors":"Hazirah Mohd Azmi ,&nbsp;Norihan Md Arifin ,&nbsp;Haliza Rosali ,&nbsp;Siti Suzilliana Putri Mohamed Isa","doi":"10.1016/j.jrras.2025.102142","DOIUrl":"10.1016/j.jrras.2025.102142","url":null,"abstract":"<div><div>Nanofluids, formed by dispersing nanoparticles into conventional base fluids, have gained significant attention as advanced heat transfer media in various sectors, including automotive, aerospace, nuclear reactors, biomedical systems, etc. Their enhanced thermophysical properties and particularly improved thermal conductivity, which make them superior to traditional fluids for high-efficiency thermal management. To accurately estimate the thermal conductivity of nanofluids, several theoretical models have been proposed, among which the Hamilton-Crosser (HC) model is widely adopted. This model extends Maxwell's classical theory by incorporating particle shape factors, providing more accurate predictions for fluids containing non-spherical or clustered nanoparticles. In the field of fluid mechanics, boundary layer flows influenced by magnetohydrodynamics (MHD) and thermal radiation are of increasing relevance in systems subjected to magnetic fields and high heat loads, such as in magnetic cooling, plasma processing and solar energy applications. According to this problem statement, this paper provides a numerical solution for the mathematical modelling of the MHD radiative water-based nanofluid flow. This nanofluid contains a combination of four nanoparticles: alumina, copper, graphene and silicon dioxide, which represents a quaternary hybrid nanofluid system. The mathematical modelling was initiated with the partial differential equations (PDEs) and finalised by ordinary differential equations (ODEs). The transformations from PDEs to ODEs simplify the mathematical model for numerical analysis, which can be done by using similarity transformations. The resulting ODEs are solved using MATLAB's built-in bvp4c solver. Key physical quantities for the profiles (velocity and temperature) and the quantities measured for the flow and thermal characteristics (skin friction coefficient and local Nusselt number) are graphically illustrated and described. The results show that the quaternary case produces the highest heat transfer rate compared to the nanofluid case, which has the lowest number of nanoparticle types (nanofluid case). In addition, the cylindrical shape is proven to have the highest local Nusselt number value for the stretching boundary case, while the spherical shape produces the highest local Nusselt number value for the shrinking boundary. Meanwhile, the magnetic field, thermal radiation, slip condition and projected angle at the sheet influence the distribution of the profile and physical parameters.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102142"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coptisine suppresses pulmonary nodule carcinogenesis by inducing CAFs mitochondrial apoptosis via Sirt3/YME1L1","authors":"Jin-Liang Hu ,&nbsp;Kun Lv ,&nbsp;Jie-Zhong Hu ,&nbsp;Zheng Tang ,&nbsp;Pia Vanessa C. Basilio","doi":"10.1016/j.jrras.2025.102148","DOIUrl":"10.1016/j.jrras.2025.102148","url":null,"abstract":"<div><div>Coptisine, an active alkaloid from <em>Coptis chinensis</em>, exhibits potent anticancer effects by targeting cancer-associated fibroblasts (CAFs) in the tumor microenvironment. This study investigates its mechanism in attenuating lung via Sirt3-mediated deacetylation of YME1L1, regulating mitochondrial apoptosis in CAFs. Orthotopic lung cancer models were established in C57BL/6 mice using SCLC-2 cells, treated with Coptisine (60 or 120 mg/kg/day). In vitro, primary pulmonary fibroblasts (CAFs) co-cultured with SCLC-2 cells were assessed for proliferation (CCK-8), metastasis (Transwell), apoptosis (ELISA), mitochondrial potential (JC-1), and ROS (DCFH-DA). Coptisine inhibited tumor growth, improved lung function, and reduced myofibroblast markers (α-SMA, FAP). It upregulated Bax and Sirt3 while downregulating YME1L1, BCL-2, and EMT proteins (e.g., Vimentin), damaging to mitochondrial function. Mechanistically, Coptisine activated Sirt3 to deacetylate YME1L1, inducing mitochondrial fragmentation in CAFs. These findings highlight Coptisine's potential as a lung cancer therapy by targeting the Sirt3/YME1L1 pathway in CAFs.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102148"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC01123 drives autophagy-mediated promotion of ovarian tumor metastasis through the p65/ATG13 pathway","authors":"Xiao Yan ,&nbsp;Shuang Miao ,&nbsp;Bozhen Fan ,&nbsp;Zeyu Xu ,&nbsp;Yunzhi Zhao ,&nbsp;Chenyue Yuan ,&nbsp;Ziliang Wang ,&nbsp;Yongning Sun","doi":"10.1016/j.jrras.2025.102118","DOIUrl":"10.1016/j.jrras.2025.102118","url":null,"abstract":"<div><h3>Background</h3><div>Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regualtors in cancer biology, including ovarian cancer (OC). Analysis of the OC cohort in the Cancer Genome Atlas (TCGA) revealed that LINC011123 is significantly upregulated in OC compared to normal ovarian tissue. Nonetheless, the functional consequence of this upregulation and the underlying mechanism of LINC01123 in OC remain unclear. We hypothesized that elevated LINC01123 exerts an oncogenic function.</div></div><div><h3>Methods</h3><div>RNA sequencing datasets from TCGA were analyzed to identify the RNAs with differential expression in OC tissues relative to standard ovarian tissue. The role of LINC01123 in regulating cell proliferation, migration, and autophagy was defined through functional experiments including wound healing, transwell, and western blotting <em>in vitro</em>, and a xenograft mouse model <em>in vivo</em>. LINC01123 regulation underwent investigation using RNA pulldown and mass spectrometry, RNA immunoprecipitation, luciferase reporter assays, and so on.</div></div><div><h3>Results</h3><div>LINC01123 is one of the most highly increased lncRNAs in OC specimens compared to non-cancerous ovarian tissue. Downregulation of LINC01123 functioned to suppress proliferation and cellular migration. RNA pulldown and gene set enrichment analysis suggested that the amount of LINC01123 positively correlated with genes involved in autophagy. LINC01123 promoted autophagy by promoting ATG13 expression. Further mechanistic studies showed that LINC01123 directly binds to p65 to activate ATG13 transcription, promoting autophagy and facilitating OC tumorigenesis.</div></div><div><h3>Conclusion</h3><div>Our results uncovered the oncogenic function and mechanism of LINC01123 in OC. LINC01123 associates with p65, augmenting autophagy, which in turn facilitates tumor metastasis within OC cells by increasing ATG13 expression. LINC01123 is a potential therapeutic target for OC patients.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102118"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringenin attenuates inflammation and apoptosis in lipopolysaccharide-induced H9c2 cardiomyocytes","authors":"Fang Wang ,&nbsp;Rui Dai","doi":"10.1016/j.jrras.2025.102115","DOIUrl":"10.1016/j.jrras.2025.102115","url":null,"abstract":"<div><h3>Background</h3><div>Naringenin, a natural flavonoid, has various pharmacological effects. However, the function of naringenin in cardiac inflammation remains unclear. This study investigated whether naringenin alleviates cardiac inflammatory induced by lipopolysaccharide (LPS).</div></div><div><h3>Methods</h3><div>Naringenin's regulatory targets in inflammation and apoptosis were investigated using network pharmacology and molecular docking. LPS activated H9c2 cardiomyocytes, which were then treated with naringenin.</div></div><div><h3>Results</h3><div>Naringenin (20 or 40 μM) reduced the expression of cytokine induced by LPS (P &lt; 0.05). In LPS-induced cells treated with naringenin (20 μM), the nuclear translocation of p65 was inhibited, concomitantly with a significant reduction in IκBα degradation. TUNEL staining revealed that naringenin (20 μM) significantly reduced apoptosis triggered by LPS (P &lt; 0.05). Naringenin (20 μM) also significantly decreased the expression level of Bax and cleaved-caspase 3, and significantly elevated Bcl-2 expression.</div></div><div><h3>Conclusion</h3><div>Naringenin may be able to attenuate H9c2 cardiomyocyte inflammation and apoptosis induced by LPS.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102115"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated bioinformatic analysis and experimental validation identify IDH2 as a key mitochondrial energy metabolism-ferroptosis biomarker in ischemic stroke","authors":"Mingqin Zhang ,&nbsp;Jin Xu ,&nbsp;Dongyi Yang ,&nbsp;Jiabin Wang ,&nbsp;Sha Luo ,&nbsp;Yiping Wang","doi":"10.1016/j.jrras.2025.102140","DOIUrl":"10.1016/j.jrras.2025.102140","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic stroke (IS) is implicated in disruptions of mitochondrial energy metabolism and ferroptosis. However, the underlying mechanisms remain elusive.</div></div><div><h3>Methods</h3><div>Three stroke-related transcriptome datasets (GSE22255, GSE58294, and GSE16561) were retrieved from the GEO database. A series of bioinformatic analyses were conducted, including differential expression analysis, functional enrichment, and protein–protein interaction (PPI) network construction. We further applied random forest modeling and single-cell sequencing to screen mitochondrial energy metabolism- and ferroptosis-related genes. The diagnostic value and immune correlations of these genes were further validated. We constructed an IS model in HT22 cells with OGD/R induction and employed IDH2 overexpression by transfection for subsequent functional validation.</div></div><div><h3>Results</h3><div>8 differentially expressed genes (DEGs) were identified (MGST1, ACSL1, PDK4, IDH2, ECH1, GPX4, BCAT2, PARK7). Functional enrichment analysis revealed their involvement in pathways like pyruvate metabolism and immune response regulation. In the random forest model, IDH2 showed a promising diagnostic value in the external validation set (AUC = 0.682). Single-cell analysis identified specific expression of IDH2 in glial cells and MGST1 in astrocytes, with both genes showing a notable correlation to macrophage infiltration. Notably, IDH2 expression was markedly reduced in IS cell models, and its overexpression significantly improved mitochondrial energy metabolism and inhibited ferroptosis.</div></div><div><h3>Conclusion</h3><div>This study elucidated the critical roles of mitochondrial energy metabolism–ferroptosis–related genes in IS and highlights IDH2 as a key candidate for disease diagnosis and potential therapeutic intervention. And its overexpression significantly improved mitochondrial energy metabolism and inhibited ferroptosis, suggesting a protective mechanistic role.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102140"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced indirect sealing of cerebrospinal fluid leaks in anterior cervical surgery using plate mechanical pressure","authors":"Dong Liu,&nbsp;Leisheng Wang,&nbsp;Xiaoguang Fan","doi":"10.1016/j.jrras.2026.102196","DOIUrl":"10.1016/j.jrras.2026.102196","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the effectiveness and safety of the “indirect sealing method” for managing cerebrospinal fluid leakage (CSFL) during anterior cervical spine surgery (ACSS), using magnetic resonance imaging (MRI) imaging.</div></div><div><h3>Methods</h3><div>A retrospective analysis included 30 patients with CSFL during ACSS for ossification of the posterior longitudinal ligament. Patients were divided into the Patch group (application of an artificial dura mater patch + hemostatic gelatin on the dura surface, n = 15) and the Patch + Plate group (artificial dura patch positioned between the vertebral body and the titanium plate, n = 15). Effectiveness was assessed via total CSFL drainage volume, drainage tube duration, and CSFL incidence on MRI at 3 days, 1 month, and 3 months postoperatively. Safety was evaluated based on sealing-related and surgery-related complications. Surgical efficacy was measured using modified Japanese orthopedic association score (mJOA), visual analog scale (VAS), and neck disability index (NDI) scores preoperatively and at 3 months, along with time to ambulation and total hospital stay.</div></div><div><h3>Results</h3><div>The Patch + Plate group had significantly lower total CSFL drainage volume (P = 0.004) and shorter drainage tube duration (P = 0.005). CSFL incidence was lower in the Patch + Plate group at 3 days (P = 0.003), 1 month (P = 0.015), and 3 months (P = 0.015). Low intracranial pressure headache (P = 0.002) was lower in the Patch + Plate group. At 3 months, the Patch + Plate group showed better mJOA (P = 0.038), VAS (P = 0.025), and NDI (P = 0.044) scores, as well as shorter time to ambulation (P = 0.041) and total hospital stay (P = 0.031).</div></div><div><h3>Conclusion</h3><div>Placing the patch between the titanium plate and the vertebral body to achieve a tight seal using the mechanical pressure of the titanium plate can improve sealing effectiveness, reduces CSFL-related complications, and enhances postoperative recovery in ACSS.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102196"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of MgO on the structural, optical, and radiation shielding behavior of multi-component borate glass","authors":"Samar Al-Shehri ,&nbsp;Nawal K. Almaymoni ,&nbsp;Nuha Al-Harbi ,&nbsp;Mona Mahmoud ,&nbsp;Kottakkaran Sooppy Nisar ,&nbsp;Wedad R. Alharbi ,&nbsp;Hosam M.G. Al-Qatlawi ,&nbsp;Sarah M. Kamil ,&nbsp;Ahmad S. Abu-Khadra ,&nbsp;A.M. Abdel-Ghany","doi":"10.1016/j.jrras.2025.102110","DOIUrl":"10.1016/j.jrras.2025.102110","url":null,"abstract":"<div><div>This study investigates the influence of the replacement of B₂O₃ with MgO on the structural, optical, and radiation shielding properties of borate-based glasses. Three samples were prepared based on the chemical formula (77.5 – x) mol% B₂O₃ + 2.5 mol% V₂O₅ + 2.5 mol% CeO₂ + 10 mol% PbO + 7.5 mol% Na₂O + x mol% MgO (x = 0, 1.25, and 2.5). As the content of MgO increased, it was observed an enhancement in glass transparency and improved surface uniformity. Based on the Fourier transform inferred, FTIR, spectral analysis the network polymerization has been confirmed. Also, a conversion of BO₃ to BO₄ has been observed. Optical sherardization has been achieved using the UV–Vis spectra measurements. The results showed a reduction in both transmittance and optical energy gap as the MgO content increased. While the value experimental measured density increased from 1.78 to 2.16 g/cm³. Also, the glass packing efficiency increased from 54 % to &gt;65 %, which confirmed improved structural compactness. Radiation shielding parameters, calculated using XCOM at 0.662, 1.173, and 1.333 MeV, showed enhanced LAC and reduced HVL. It was found that, the sample with 2.5 mol% MgO exhibited the best shielding performance. In general, while these glasses do not surpass lead or commercial high-density glasses in shielding efficiency, they significantly outperform concrete. based on the findings, the prepared samples show competitive performance relative to some polymer-based shields. This supports the MgO-containing borate glasses for use in optical, radiation shielding, and biomedical applications.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102110"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}