Therapeutic effect of cetylpyridinium chloride buccal tablets combined with Xipayi gingival rinse in the postoperative infections after dental implant based on cone beam computed tomography imaging

Abstract

Background and objective

Prophylactic application of antibiotics can effectively prevent and treat peri implant infection after oral implant surgery. This study aimed to explore the therapeutic effect of cetylpyridinium chloride buccal tablets (CCBT) combined with Xipayi gingival rinse (XGR) in the postoperative infections after dental implant based on cone beam computed tomography (CBCT) imaging.

Methods

Two hundred and seven patients who underwent elective implantation were randomly grouped: CCBT group, XGR group, XGR + CCBT group, and saline group. Visual analogue scale (VAS) was used to evaluate the degree of postoperative pain and check the wound healing. The periodontal status was evaluated by modified plaque index (mPLI), modified gingival index (mGI), and modified sulcus bleeding (mSBI). The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-8 (MMP-8) in the gingival crevicular fluid were detected. In addition, CBCT scans were performed to assess bone density and marginal bone resorption.

Results

As against saline group, the pain proportion, mPLI, mGI, and mSBI scores, the number of obligate anaerobes around the implant, the levels of IL-6, TNF-α, and MMP-8 in gingival crevicular fluid, and the proportion of peri implant infection were markedly decreased, and the wound healing proportion was markedly increased in CCBT group, XGR group, and XGR + CCBT group (P < 0.05). Moreover, following remedy, as against CCBT group and XGR group, all indicators were markedly improved, and the proportion of postoperative peri implant infection was lower in XGR + CCBT group (P < 0.05). CBCT analysis showed that, compared to other groups, XGR + CCBT group exhibited increased bone density and reduced bone resorption at four and six months postoperatively (P < 0.05).

Conclusion

Based on CBCT imaging, CCBT combined with XGR significantly reduces the short-term risk of infection following dental implant surgery, and promote osseointegration and reducing bone loss, demonstrating a synergistic advantage over monotherapy.