Journal of Radiation Research and Applied Sciences最新文献

{"title":"Radiological safety assessment of packaged bottle drinking water in India – Age dependent analysis","authors":"Mahasin Gazi ,&nbsp;Arindam Kumar Naskar ,&nbsp;Argha Deb","doi":"10.1016/j.jrras.2025.102128","DOIUrl":"10.1016/j.jrras.2025.102128","url":null,"abstract":"<div><div>Radioactive radon (²²²Rn) concentrations in 121 different brands of packaged bottle drinking water (PBDW) samples from different states of India have been assessed in the present study using a potable AlphaGUARD radon monitor along with AlphaGUARD aqua kit. Among the collected samples, the production sites of 72 number of PBDW samples are different places of West Bengal and the remaining 49 samples are different places of other different states of India. Thus, assessing the radon levels in different brands of packaged drinking water that are accessed from most parts of India gives a general picture of the ²²²Rn concentrations in packaged bottled drinking water throughout India.</div><div>Measured radon concentration levels vary between 0.19 and 5.81 Bq/l with an average value of 1.36 Bq/l. Radon concentration of no sample has exceeded the WHO, IAEA and EU Commission prescribed reference level of 100 Bq/l or even USEPA's proposed MCL (11.11 Bq/l).</div><div>The measured radon concentrations of the collected samples manifest no significant correlation with either Total Dissolved Solids (TDS) or pH values of the samples.</div><div>Annual effective dose (AED) due to radon from these bottled drinking water for three age groups namely infants, children and adults are found to vary between 0.66 and 20.00 μSv/y with a mean of 4.68 ± 0.29 μSv/y, 0.82–25.00 μSv/y with a mean of 5.84 ± 0.36 μSv/y and 0.73–22.30 μSv/y with a mean of 5.21 ± 0.32 μSv/y respectively. Assessment of dose shows that total annual effective dose to the children is the highest among the age groups. No sample has exceeded the WHO, ICRP and the EU commission proposed reference dose limit of 100 μSv/y.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102128"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LRG1 protein is a novel prognostic indicator for patients with non-small cell lung cancer","authors":"Yingjia Mao ,&nbsp;Hao Yu ,&nbsp;Rong Yu ,&nbsp;Hongmei Niu ,&nbsp;Xin Deng ,&nbsp;Qing Qi ,&nbsp;Xiang Li ,&nbsp;Fuqian Zhao ,&nbsp;Daofu Shen ,&nbsp;Lei Wang","doi":"10.1016/j.jrras.2025.102154","DOIUrl":"10.1016/j.jrras.2025.102154","url":null,"abstract":"<div><h3>Background</h3><div>The lack of early diagnostic markers often leads to the late diagnosis of lung cancer. Although LRG1 was identified in the serum of metastatic patients, its functional role and diagnostic potential remain largely unexplored. We hypothesize that LRG1 promotes lung cancer progression via immune modulation and enhances metastatic potential.</div></div><div><h3>Methods</h3><div>We analyzed the relationship between LRG1 expression and survival outcomes using TCGA data. Immune cell relevance was assessed using the TIMER and TISCH databases. The functional effects of LRG1 on lung cancer cell proliferation and migration were investigated using CCK-8, EdU, scratch assays, and Western blot. Peripheral serum was collected from healthy controls (n = 15), non-metastatic groups (n = 13), and metastatic groups (n = 56). Serum LRG1 levels were detected by ELISA, and its diagnostic value was evaluated using ROC curve analysis.</div></div><div><h3>Results</h3><div>High LRG1 expression is associated with poor prognosis and is linked to macrophage and neutrophil infiltration. In vitro functional studies have shown that LRG1 promotes lung cancer cell proliferation and migration. Furthermore, serum LRG1 levels are significantly elevated in patients with metastatic lung cancer, and LRG1 demonstrates high diagnostic accuracy across all disease stages. In metastatic patients, LRG1 showed promising potential for early detection in LUAD patients (AUC = 0.74) and LUSC patients (AUC = 0.69), showing high levels in LUAD patients (AUC = 0.75) and LUSC patients (AUC = 0.73).</div></div><div><h3>Conclusion</h3><div>Our study has revealed the potential of LRG1 as a novel biomarker for early diagnosis and recurrence monitoring of lung cancer. It has diagnostic value in early-stage disease and prognostic value in late-stage disease. However, further investigation into its mechanistic role is warranted.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102154"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-effect analysis of 60Co-γ radiation on Astragalus membranaceus across life cycle and creation of high-flavonoid/super-biomass germplasm","authors":"Ming Jiang ,&nbsp;Zun Lv ,&nbsp;Jiajia Chen ,&nbsp;Yue Pan ,&nbsp;Ying Yu ,&nbsp;Kanchao Yu ,&nbsp;Lijuan Xia ,&nbsp;Jicheng Liu ,&nbsp;Hui Li ,&nbsp;Keyong Zhang","doi":"10.1016/j.jrras.2025.102149","DOIUrl":"10.1016/j.jrras.2025.102149","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to systematically investigate the dose-dependent effects of ⁶⁰Co-γ radiation on the entire growth cycle of <em>Astragalus membranaceus</em>, using a dose gradient ranging from 50 to 400 Gy. The specific objectives were to evaluate its impacts on seed germination, seedling physiology, agronomic traits of one-year-old plants, and the accumulation of medicinal components.</div></div><div><h3>Methods</h3><div>A radiation dose gradient of 50–400 Gy was applied to <em>Astragalus membranaceus</em> seeds. Assessments included seed germination and seedling emergence rates, physiological and biochemical markers (e.g., antioxidant enzyme activities and secondary metabolites), agronomic traits, and medicinal compound accumulation. The median lethal dose (LD₅₀) was calculated, and a multi-trait weighted index (I) was used to screen superior germplasm lines.</div></div><div><h3>Results</h3><div>Low-dose radiation (50–100 Gy) significantly improved seed germination and emergence rates, while high doses (≥200 Gy) were inhibitory, with an LD₅₀ of 201.95 Gy. At 50 Gy, antioxidant defense mechanisms were activated, indicated by increased CAT and APX activities, and flavonoid content rose by 48.2 %. Doses≥300 Gy caused severe damage, including a 57.8 % reduction in thylakoid density. In one-year-old plants, 50 Gy synergistically improved biomass and active compound content. Doses of 100–300 Gy induced transgressive segregation: one line (300 Gy-2) showed a root dry weight 4.63 times that of the control. Using a multi-trait index, seven superior lines were selected. Line 100 Gy-8 exhibited a 1.54-fold increase in total flavonoids (93.03 mg/g), while line 400 Gy-12 showed a threefold enhancement.</div></div><div><h3>Conclusion</h3><div>The results indicate that 50 Gy is an optimal dose for simultaneously improving yield and quality in <em>Astragalus membranaceus</em>, whereas the 100–300 Gy range serves as a promising mutagenic window for generating high-flavonoid or high-biomass variants. This study provides theoretical support and core germplasm resources for targeted breeding strategies.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102149"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell toxicity test, biocompatibility study and clinical study of juguang®-18HF polysulfone membrane dialyzer","authors":"Chen Yun ,&nbsp;Xiaofan He ,&nbsp;Lifeng Yang ,&nbsp;Suhua Xu ,&nbsp;Yunyi Li ,&nbsp;Huiyi Zeng ,&nbsp;Xianggeng Chi ,&nbsp;Ao-ieong Chi-Wa ,&nbsp;Boxun Wang ,&nbsp;Zhuoheng Song ,&nbsp;Zhangzhang Xiao ,&nbsp;Wenyu Gong ,&nbsp;Jingxian Huang ,&nbsp;Donghao He ,&nbsp;Ting Xie ,&nbsp;Yong Dai ,&nbsp;Donge Tang ,&nbsp;Hongming Zhou ,&nbsp;Zigan Xu ,&nbsp;Lianghong Yin ,&nbsp;Aiyun Zha","doi":"10.1016/j.jrras.2025.102075","DOIUrl":"10.1016/j.jrras.2025.102075","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to investigate the cytotoxicity and biocompatibility of polysulfone hollow fiber dialyzers, while observing clinical efficacy, in order to provide a basis for preclinical and clinical research on polyethersulfone hollow fiber dialyzers for clinical application.</div></div><div><h3>Methods</h3><div>Twenty-four JUGUANG®-18HF dialyzers produced by polyether sulfone hollow fiber dialysis membrane produced by 3M Company were used for cytotoxicity test, in vitro mammalian cell chromosome aberration test, subchronic systemic toxicity test and clinical test. And observe clinical biocompatibility and efficacy through self-cross-validation non-inferiority verification.</div></div><div><h3>Results</h3><div>All animal and cell experiments showed that the cytotoxicity score of the treatment group was 0 points compared to the control group. According to the standard, the cytotoxicity and reaction degree were deemed as non-cytotoxic. Biochemical tests showed no statistical differences in any indicators. Clinical observations noted that blood samples were drawn from the arterial end of the vascular access before dialysis, 15 min after the start of dialysis, and at the end of dialysis. Routine blood tests, fragmented red blood cell analysis, and changes in CRP and liver function before and after dialysis were all found to be normal. The clearance and decline rates of BUN and Cr, as well as changes in electrolytes, showed no statistically significant difference compared to the control group in Parazacco spilurus subsp. spilurus.</div></div><div><h3>Conclusions</h3><div>The JUGUANG®-18HF hollow fiber dialyzer with polyether sulfone membrane produced by 3M company showed that it was in compliance with the regulations in cytotoxicity, chromosomal aberration of mammalian cells in vitro and subchronic systemic toxicity test. Clinical studies showed that it had good biocompatibilityand clinical efficacy.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102075"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of NORM and heavy metal risks from breakfast cereals consumed in the Kurdistan Region, Iraq","authors":"Halmat J. Hassan ,&nbsp;Farhad A. Hama Hassan","doi":"10.1016/j.jrras.2026.102186","DOIUrl":"10.1016/j.jrras.2026.102186","url":null,"abstract":"<div><div>This study analyses 22 commercially available cereal samples containing naturally occurring radioactive materials, imported and sold in major retailers within the Kurdistan Region, Iraq. Gamma-ray spectrometry and X-ray fluorescence were employed to assess radiological risk associated with cereal consumption. The activity concentrations of radionuclides ranged from 1.6 ± 0.35 to 68.5 ± 11.5 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³⁸U, 2.3 ± 0.24 to 96.4 ± 7.5 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³²Th, and 67.8 ± 5.2 to 1448 ± 92 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ⁴⁰K. Estimated annual effective doses were 59.07, 365.9, and 30.055 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³⁸U, ²³²Th, and ⁴⁰K, respectively, based on an assumed annual cereal intake of 5 kg for adults and 3.7 kg for children. Samples S4 and S5 exhibited the highest total AED, at 388.3 and 331.8 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, respectively. The total effective dose of these samples surpasses the general public reference level of 290 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, indicating unsuitability for consumption. The Pb concentrations in samples S8 and S17 markedly exceed the Codex international limit of 6 mg <span><math><mrow><msup><mtext>kg</mtext><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, reaching 25.6 and 31.7 mg <span><math><mrow><msup><mtext>kg</mtext><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, respectively. These findings suggest that food regulations should address potential radiation exposure from cereals to mitigate public health risks.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102186"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CALB1 inhibits ferroptosis in laryngeal carcinoma via targeting Ca2+-IP3R on mitochondria-associated membranes","authors":"Zhihai Li ,&nbsp;Qiaozhi Jin ,&nbsp;Yana Sun ,&nbsp;Yilong Wang ,&nbsp;Jisheng Liu","doi":"10.1016/j.jrras.2026.102209","DOIUrl":"10.1016/j.jrras.2026.102209","url":null,"abstract":"<div><h3>Background</h3><div>Laryngeal cancer, a malignancy arising from the laryngeal mucosal epithelium, threatens human health; hoarseness is often an early sign. Ferroptosis, defined by iron-dependent lipid peroxidation, has emerged as a key cell death modality in cancer. This study investigated whether CALB1 regulates ferroptosis in laryngeal cancer by targeting Ca²⁺-IP3R signaling at mitochondria-associated membranes (MAMs).</div></div><div><h3>Methods</h3><div>Normal laryngeal epithelial (16HBE) and laryngeal carcinoma (TU177) cells were used. CALB1 expression and its impact on chemosensitivity were assessed by Western blotting, qRT-PCR, CCK-8, and flow cytometry. Ferroptosis was evaluated by measuring intracellular Fe²⁺, malondialdehyde (MDA), and reactive oxygen species (ROS). ELISA and co-immunoprecipitation (Co-IP) were employed to examine CALB1 modulation of the Ca²⁺-IP3R pathway. Mitochondrial function and antioxidant status were analyzed by mitochondrial membrane potential and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)</div></div><div><h3>Results</h3><div>CALB1 was upregulated in TU177 versus 16HBE cells and conferred chemoresistance: following cisplatin, CALB1-high cells showed increased survival with reduced apoptosis. CALB1 knockdown decreased GPX4 and enhanced ferroptosis, evidenced by elevated intracellular Fe²⁺, MDA, and ROS; these changes were reversed by the ferroptosis inhibitor Fer-1, which restored protein expression and reduced oxidative damage. Co-IP revealed CALB1–IP3R interaction. Loss of CALB1 disrupted mitochondrial membrane potential and diminished SOD and GSH-Px activities, effects alleviated by the IP3R inhibitor 2-APB, supporting a role for IP3R-mediated Ca²⁺ flux in CALB1-dependent ferroptosis control.</div></div><div><h3>Conclusions</h3><div>CALB1 inhibits ferroptosis in laryngeal cancer cells by suppressing IP3R-mediated Ca²⁺ signaling and maintaining the homeostasis of mitochondrial function, iron metabolism, and antioxidant system. These findings suggest that the CALB1–IP3R regulatory axis may serve as a potential therapeutic target for enhancing ferroptosis-based treatments in laryngeal cancer.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102209"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147394330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring thermodynamic processes through CFD of free convection of Bingham fluids in innovative hexagonal enclosure (Papanastasiou model)","authors":"Benhanifia Kada ,&nbsp;Mebarki Brahim ,&nbsp;Ahmed Remlaoui ,&nbsp;Keddar Mohammed ,&nbsp;Syed M. Hussain ,&nbsp;Hijaz Ahmad ,&nbsp;Neissrien Alhubieshi ,&nbsp;Assmaa Abd-Elmonem ,&nbsp;Bandar M. Fadhl ,&nbsp;Basim M. Makhdoum","doi":"10.1016/j.jrras.2026.102161","DOIUrl":"10.1016/j.jrras.2026.102161","url":null,"abstract":"<div><div>This research presents a unique enclosure geometry, namely, a hexagonal finned cavity, for the analysis of Bingham–Papanastasiou fluid natural convection, which is examined numerically through COMSOL Multiphysics. The momentum and energy equations that govern the phenomena are solved via the Galerkin approach. The external walls have been assumed to be cold, while the inner wall has been taken as hot. A thorough investigation of the thermo-hydrodynamic flow is carried out considering the nominal value of the Rayleigh number (Ra), the range of plasticity Bn (1–50), and the obstacle lengths L (0.1, 0.4). The findings demonstrate that the rate of heat transfer (<em>Nu</em>) is positively correlated with the buoyancy parameter (Ra) while it is inversely related to the plasticity parameter (Bn), with larger values of the latter resulting in lesser heat transfer. This reduction seems to occur due to lame yield stress at a bigger Bn, damping the fluid flow inside the enclosure. The streamline patterns further confirm this trend, showing a significant weakening of circulation at high plasticity levels, particularly for Bn = 50. The effect of obstacle length can be seen on the streamline and isotherm contours, which may indicate the intermediate fin length (L = 0.2) for Rayleigh Number (Ra) as the best, as it increases vortex creation and supports good circulation in the cavity, thus enhancing the heat transfer performance.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102161"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new heavy-tailed distribution: Its heavy-tailed characteristics with implementations in the radiation and music engineering","authors":"Yuyun Huang ,&nbsp;Salah Eldden Omer Ali","doi":"10.1016/j.jrras.2025.102104","DOIUrl":"10.1016/j.jrras.2025.102104","url":null,"abstract":"<div><div>Recognizing the significant influence that data analysis tools have in diverse fields, we present an innovative analytical approach to enhance and expand the existing variety of distribution methods. Our work centers on combining the inverse Lomax distribution with a recognized distributional approach, leading to what we call the new heavy-tailed inverse Lomax (NHTI-Lomax) distribution. The NHTI-Lomax distribution is able to capture the key characteristics linked to heavy-tailed distributions. This fact is supported by both visual illustrations and thorough mathematical proof. The identifiability features and the heavy-tailed characteristics of the NHTI-Lomax distribution are thoroughly examined and mathematically verified. Furthermore, we obtain the maximum likelihood estimators relevant to this distribution. Additionally, we conduct an analysis of the NHTI-Lomax distribution’s effectiveness with simulated data, allowing us to assess its practical relevance and performance across different situations. In practical terms, the significance of the NHTI-Lomax distribution is evaluated using perspectives from real-world data. The first application pertains to music engineering. While, the second application focuses on the field of radiation sciences. By employing certain established information criteria, we show that the NHTI-Lomax distribution outperforms certain alternative distributions.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102104"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nanobismuth-loaded hydroxyapatite coating on titanium surface and its antibacterial-osteogenic performance study","authors":"Xue Zhong,&nbsp;Yuhang Song,&nbsp;Zhen Wang","doi":"10.1016/j.jrras.2026.102179","DOIUrl":"10.1016/j.jrras.2026.102179","url":null,"abstract":"<div><h3>Objectives</h3><div>Peri-implantitis and early osseointegration at the implant interface are critical challenges in dental implantation. An effective strategy to tackle these issues involves loading bioactive components onto the titanium surface and controlling their release. This research utilizes phase-transited lysozyme (PTL)to functionalize implant titanium surfaces, with the objective of fabricating a hydroxyapatite coating infused with bismuth nanoparticles to inhibit bacterial colonization and promote osteogenesis in vitro, thereby addressing key factors in the prevention of peri-implantitis.</div></div><div><h3>Methods</h3><div>First, use PTL to modify the surface of pristine titanium. On this basis, prepare a hydroxyapatite coating through the biomimetic mineralization method. Then, load the bismuth nanoparticles onto the titanium sheet by electrostatic adsorption. Finally, obtain a bismuth-loaded hydroxyapatite composite coating.</div></div><div><h3>Results</h3><div>Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) analyses confirmed that hydroxyapatite and bismuth nanoparticle composite coatings had been successfully laid down on modified titanium substrates with PTL treatment. SEM and transmission electron microscope (TEM) images revealed the microstructural characteristics of the coatings and the size distribution of the spherical BiNPs (approximately 20–30 nm). Bacterial assays and confocal microscopy observations demonstrated that the bismuth-loaded samples possessed potent early-stage antibacterial activity, effectively inhibiting both planktonic and adherent bacterial viability over a 5-day period, though efficacy gradually decreased over time. Laboratory cell tests indicated the coated titanium discs demonstrated minimal cytotoxicity and positively influenced osteoblast proliferation and adhesion, indicative of favorable biocompatibility.</div></div><div><h3>Conclusion</h3><div>The resultant Ti-HA-BiNPs coating conferred both enhanced antibacterial properties (&gt;90 % initial inhibition) and osteogenic promotion, offering a promising dual-functional strategy for the prevention of peri-implantitis and enhancement of implant stability in the early postoperative period.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102179"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new three-parameter statistical distribution with applications to biomedical and radiation data","authors":"Mohammed Ibrahim AlTwijri ,&nbsp;Norah D. Alshahrani ,&nbsp;Mohammed Elgarhy ,&nbsp;Mahmoud Elsehetry ,&nbsp;Bassant Elkalzah","doi":"10.1016/j.jrras.2026.102167","DOIUrl":"10.1016/j.jrras.2026.102167","url":null,"abstract":"<div><div>In this paper, we present a new extension of the power Komal distribution (PKD), an original modification of the PKD. The new suggested model is called the half-logistic power Komal distribution (HLPKD). This modified distribution keeps the original PKD simple while providing more flexibility and accuracy when modeling data. The HLPKD has numerous statistical characteristics, including right-skewed, decreased and unimodal probability density functions, skewness, kurtosis moments, incomplete moments, and order statistics. We illustrate the HLPKD’s effectiveness and dependability using the maximum likelihood standard parameter estimate technique and a complete simulation exercise. From the simulation results, we can note that the bias, relative bias, mean square error, root mean square error and average length values decrease as the sample size increases Furthermore, implementing the HLPKD to two real-life biomedical/radiation datasets illustrates its usefulness. It can outperform well-known models as power Komal, Komal, power length-biased new xLindley, power Lindley, power Zeghdoudi, half-logistic new Weibull Pareto, half logistic Weibull, and half logistic exponential distributions.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102167"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}