Journal of psychoactive drugs最新文献_第5页

Prevalence of Potential Contraindications and Risk Factors Relevant to MDMA-Assisted Therapy Among U.S. Veterans with Posttraumatic Stress Disorder. 美国退伍军人创伤后应激障碍mdma辅助治疗相关的潜在禁忌症和危险因素

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-08-05 DOI: 10.1080/02791072.2026.2710059

Catherine S Hwang, David C Cameron, Allison C O'Neill, Benjamin J Morasco, Steven K Dobscha, P Todd Korthuis, Christopher S Stauffer

{"title":"Prevalence of Potential Contraindications and Risk Factors Relevant to MDMA-Assisted Therapy Among U.S. Veterans with Posttraumatic Stress Disorder.","authors":"Catherine S Hwang, David C Cameron, Allison C O'Neill, Benjamin J Morasco, Steven K Dobscha, P Todd Korthuis, Christopher S Stauffer","doi":"10.1080/02791072.2026.2710059","DOIUrl":"https://doi.org/10.1080/02791072.2026.2710059","url":null,"abstract":"3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy has emerged as a potential strategy to treat posttraumatic stress disorder (PTSD). We conducted a national serial cross-sectional study of U.S. Veterans with PTSD from January 1, 2018, to December 31, 2023, to quantify the prevalence of potential contraindications, risk factors, and drug-drug interactions relevant to MDMA-assisted therapy. Participants were required to have at least two diagnostic codes for PTSD within a calendar year. Each year, 303,451 to 326,315 participants received care for PTSD. The annual proportion of individuals with at least one contraindication for MDMA-assisted therapy ranged from 15.3% to 17.3%, and the annual proportion with at least one conditional or modifiable risk factor ranged from 55.2% to 58.2%. Each year, 85.7% to 87.5% of participants filled at least one prescription for another medication that potentially interacts with MDMA. Many individuals with PTSD have contraindications or conditional risk factors that may require additional evaluation prior to receiving MDMA-assisted therapy, but many may be eligible with careful management of modifiable conditions and potential drug-drug interactions. Our results have important implications for policymakers and clinicians as studies examining the safety and efficacy of MDMA-assisted therapy continue to evolve toward potential implementation.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Perceived Value of Risk Reduction Programs in High-Risk Areas in Malaysia. 马来西亚高风险地区降低风险计划的感知价值。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-08-02 DOI: 10.1080/02791072.2026.2712399

Seuk Yen Phoong, Seuk Wai Phoong, Xi Zhu

{"title":"The Perceived Value of Risk Reduction Programs in High-Risk Areas in Malaysia.","authors":"Seuk Yen Phoong, Seuk Wai Phoong, Xi Zhu","doi":"10.1080/02791072.2026.2712399","DOIUrl":"https://doi.org/10.1080/02791072.2026.2712399","url":null,"abstract":"This paper aims to evaluate the perceived value of the drug prevention activities in Malaysia's high-risk areas. The drug prevention activities involved are counseling, outreach, workshop, and program. A quantitative method is employed in this study to investigate the participants' perception on the programs. A cross-sectional survey of 332 participants across seven selected high-risk regions in Peninsular Malaysia were selected for their proximity to international borders and high drug-related crime statistics. The results revealed compelling insights, showing that emotional and social values were strongly correlated with program effectiveness, while functional value showed only marginal influence. These findings challenge conventional policy approaches by demonstrating that community-based interventions fostering emotional support networks and social cohesion yield substantially greater impact than traditional information-driven or enforcement-focused strategies. The study also has theoretical contributions by validating the applicability of perceived value theory in substance abuse prevention contexts, while offering practical recommendations for policymakers to redesign interventions with greater emphasis on psychosocial support mechanisms. Limitations include the cross-sectional design and regional focus, suggesting opportunities for future longitudinal studies across broader geographical areas to assess program sustainability and cultural adaptability.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mystical Experiences as Catalysts in Ketamine-Assisted Psychotherapy: A Case Study. 神秘体验作为氯胺酮辅助心理治疗的催化剂：一个案例研究。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-03 DOI: 10.1080/02791072.2026.2696253

Miguel Joaquim Soares Teles Couceiro, Victor José da Conceição Teixeira Amorim Rodrigues, Nuno Manuel Correia Torres

引用次数: 0

Shame, Guilt and Psychedelic Experience: Results from a Prospective, Longitudinal Survey of Real-World Psilocybin Use. 羞耻，内疚和迷幻体验：来自真实世界裸盖菇素使用的前瞻性纵向调查的结果。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-01 Epub Date: 2025-02-07 DOI: 10.1080/02791072.2025.2461997

David S Mathai, Daniel E Roberts, Sandeep M Nayak, Nathan D Sepeda, Amy Lehrner, Matthew W Johnson, Matthew X Lowe, Heather Jackson, Albert Garcia-Romeu

{"title":"Shame, Guilt and Psychedelic Experience: Results from a Prospective, Longitudinal Survey of Real-World Psilocybin Use.","authors":"David S Mathai, Daniel E Roberts, Sandeep M Nayak, Nathan D Sepeda, Amy Lehrner, Matthew W Johnson, Matthew X Lowe, Heather Jackson, Albert Garcia-Romeu","doi":"10.1080/02791072.2025.2461997","DOIUrl":"10.1080/02791072.2025.2461997","url":null,"abstract":"The classic psychedelic psilocybin has attracted special interest across clinical and non-clinical settings as a potential tool for mental health. Despite increasing attention to challenging psychedelic experiences, few studies have explored the relevance of shame-related processes with psychedelic use. This prospective, longitudinal study involved sequential, automated, web-based surveys that collected data from 679 adults planning to use psilocybin in naturalistic settings at timepoints before and after psilocybin use. State and trait shame and feelings of guilt were collected using validated measures and assessed alongside other measurements of psychological health. Acute feelings of shame or guilt during psilocybin experiences were commonly reported (68.2% of users) and difficult to predict. Ratings of participant ability to constructively work through these feelings predicted wellbeing 2-4 weeks after psilocybin use. Psilocybin on average produced a small but significant decrease in trait shame that was maintained 2-3 months after use (Cohen's dz = 0.37). Trait shame increased in a notable minority of participants (29.8%). The activation of self-conscious emotions with psychedelics deserves further attention as a challenging experience subcategory that may be relevant to psychological outcomes. Such experiences could pose a unique and context-dependent learning condition for both therapeutic and detrimental forms of shame-related memory reconsolidation.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"286-297"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabis Dependence Among Georgian Small-Scale Cannabis Growers: Results of a Cross-Sectional Online Survey. 格鲁吉亚小型大麻种植者对大麻的依赖：一项横断面在线调查的结果。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-01 Epub Date: 2025-02-07 DOI: 10.1080/02791072.2025.2463514

Tamar Mgebrishvili, Irma Kirtadze, Ali Mirzazadeh, David Otiashvili

{"title":"Cannabis Dependence Among Georgian Small-Scale Cannabis Growers: Results of a Cross-Sectional Online Survey.","authors":"Tamar Mgebrishvili, Irma Kirtadze, Ali Mirzazadeh, David Otiashvili","doi":"10.1080/02791072.2025.2463514","DOIUrl":"10.1080/02791072.2025.2463514","url":null,"abstract":"The study aims to assess cannabis dependency among individuals who cultivate cannabis for medical and/or recreational purposes. Participants included growers who cultivated cannabis for personal use, social supply, caregiving activities, or illegal sales. Between December 2020 and August 2021, we conducted an online cross-sectional survey among Georgian cannabis growers. We used the International Cannabis Cultivation Questionnaire to measure the purpose of growing cannabis and the Severity of Dependence Scale (SDS). Logistic regression analysis was used to assess factors associated with cannabis dependency. Out of 218 cannabis growers, 193 (88.5%) grew cannabis for their personal use. Among participants, 132 (68%) used cannabis for recreational and 61 (32%) used it for medical purposes. The overall prevalence of cannabis use dependency was 37.7%. In multiple logistic regression analysis, medical users (AOR 0.39, P-value < .05) had lower odds of developing dependency compared to recreational users. Growers who used cannabis for medical purposes were more likely to consume it on a daily or almost daily basis. The majority of Georgian (illegal) cannabis growers use their products for their personal consumption, mostly for recreational purposes. This group had a higher odd of developing cannabis dependency compared to those growers who use cannabis for the medical purposes.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"361-370"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Dual Dependencies: A Case Study of Concurrent Low-Dose Buprenorphine Induction and Rapid Phenobarbital Taper. 管理双重依赖：同时低剂量丁丙诺啡诱导和快速苯巴比妥逐渐减少的案例研究。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-01 Epub Date: 2025-01-14 DOI: 10.1080/02791072.2024.2446448

Brent Schnipke, Gayane Archer, Veronika Hanko, Brandon Hamm

引用次数: 0

The Index of Cannabis Equivalence (ICE): A User-Centered Approach to Standardization of Cannabis Dose-Response. 大麻等效指数（ICE）：以用户为中心的大麻剂量反应标准化方法。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-01 Epub Date: 2025-01-09 DOI: 10.1080/02791072.2025.2449932

Michelle St Pierre, Stacey Squires, Sarah Daniels, Tatiana Sanchez, Zach Walsh

{"title":"The Index of Cannabis Equivalence (ICE): A User-Centered Approach to Standardization of Cannabis Dose-Response.","authors":"Michelle St Pierre, Stacey Squires, Sarah Daniels, Tatiana Sanchez, Zach Walsh","doi":"10.1080/02791072.2025.2449932","DOIUrl":"10.1080/02791072.2025.2449932","url":null,"abstract":"The increasing acceptance of cannabis use, and policy changes in several jurisdictions has led researchers and public health experts to call for a standard cannabis dose. Standard dosing units are useful tools for regulation, substance use guidelines, data collection, consistency of research, as a means of communicating low-risk recommendations and dose-related effects, and for self-monitoring. Efforts to standardize cannabis dose have focused on cannabinoid content without considering tolerance or mode. Cannabis users with diverse motivations for use and varying experience rated low, medium, and high doses across seven modes of use. The participants (N = 1368; 42% female) were 18-93 years of age (M = 31.64, SD = 14.70) who had a cannabis use history. The Index of Cannabis Equivalence (ICE) identified the following low-dose cannabis equivalencies: two puffs on a joint, pipe, herbal or concentrate vaporizer is equivalent to one hit on a bong, a 5 mg/THC edible, and ¼ dab of a concentrate. These findings are based on responses from users with lower tolerance, which may limit generalizability to those with higher tolerance. The ICE proposes standardized cannabis doses through user-derived ratings across different administration routes. The meaningful standardization of units of cannabis products in a manner similar to what has been achieved for alcohol represents a valuable step in establishing standard doses across different modes of cannabis administration.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"371-376"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Down the Rabbit Hole: A Large-Scale Survey of Psychedelic Users' Patterns of Use and Perceived Effects. 掉进兔子洞：对迷幻药使用者使用模式和感知效果的大规模调查。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-01 Epub Date: 2025-01-29 DOI: 10.1080/02791072.2025.2452226

Carrie Cuttler, Amanda Stueber, Jonathan Simone, Leah M Mayo

{"title":"Down the Rabbit Hole: A Large-Scale Survey of Psychedelic Users' Patterns of Use and Perceived Effects.","authors":"Carrie Cuttler, Amanda Stueber, Jonathan Simone, Leah M Mayo","doi":"10.1080/02791072.2025.2452226","DOIUrl":"10.1080/02791072.2025.2452226","url":null,"abstract":"The ever-changing landscape surrounding legality and accessibility of psychedelics and their increasing popularity make it imperative to better understand the nature of psychedelic use by the general population. To this end, 1,486 eligible respondents (Mage = 29.58, 67.1% male) residing in the United States completed an online survey designed to assess the types of psychedelics used, methods of administration and dosing, frequency of use, intentions for use, context/environments in which they are used, perceived acute effects, frequency of those effects and distress about them, and their perceived residual effects and distress about them. Respondents predominantly endorsed using MDMA, LSD, DMT, and psilocybin. The predominant methods of administration were oral. Most reported using psychedelics for recreational purposes. The most endorsed acute effects were hallucinations, increased heart rate, positive mood, and visual tracers, while the most endorsed residual effects were headaches/migraine, dry mouth, nausea, hallucinations, and anxiety. Participants were most distressed by negative mood states, vomiting, and nausea when under the acute effects of psychedelics, but mean distress ratings were low. These results can help inform clinical trials, reform policy regarding legal access to psychedelics, and track changes in these metrics as sociocultural and legal landscapes continue to shift.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"265-277"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketamine-Assisted Psychotherapy for Antisocial Personality Disorder: A Case Report. 氯胺酮辅助治疗反社会型人格障碍1例报告。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-01 Epub Date: 2025-01-07 DOI: 10.1080/02791072.2025.2449911

Matthew R Hicks, Heather Zwickey, Ryan Bradley

引用次数: 0

Psychotic-Like Experiences in Young Recreational Users of Ketamine: A Case Study. 青少年娱乐性氯胺酮使用者的精神病样经验：个案研究。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-07-01 Epub Date: 2025-01-08 DOI: 10.1080/02791072.2025.2449909

Valerio Ricci, Domenico De Berardis, Sheikh Shoib, Giovanni Martinotti, Giuseppe Maina

{"title":"Psychotic-Like Experiences in Young Recreational Users of Ketamine: A Case Study.","authors":"Valerio Ricci, Domenico De Berardis, Sheikh Shoib, Giovanni Martinotti, Giuseppe Maina","doi":"10.1080/02791072.2025.2449909","DOIUrl":"10.1080/02791072.2025.2449909","url":null,"abstract":"This study explores the psychotic-like experiences (PLEs) associated with recreational ketamine use among young adults. Ketamine, initially introduced as an anesthetic, is now widely used recreationally for its dissociative effects, raising concerns about its impact on mental health. Ten participants aged 18-24, who used ketamine recreationally multiple times a week, were assessed using the Community Assessment of Psychic Experiences (CAPE-42). Results showed a significant positive correlation between the frequency of ketamine use and PLEs, with no significant impact from other substances like THC, MDMA, and alcohol. These findings confirm ketamine's potential to induce psychotic-like symptoms by antagonizing NMDA receptors, similar to schizophrenia. The study underscores the need for preventive measures and targeted interventions to address the mental health risks of frequent ketamine use, particularly among young adults. However, limitations such as the small sample size and reliance on self-reported data suggest that further research is needed to establish causality and examine long-term effects. Overall, this study highlights the significant association between recreational ketamine use and increased PLEs, emphasizing the importance of early detection and intervention strategies.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"226-235"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0