迷幻药的使用和行为成瘾。

IF 2.1 4区 医学 Q2 PSYCHOLOGY, CLINICAL
Trey Brasher, David Rosen, Marcello Spinella
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引用次数: 0

摘要

最近对经典致幻剂治疗抑郁和焦虑的临床试验引发了人们对其治疗其他精神疾病的潜力的质疑。来自临床前和临床研究的证据表明,迷幻药可能有助于药物使用障碍,正在进行的注册试验。行为成瘾与物质成瘾有共同的特点,也可能对迷幻药治疗有反应。本研究调查了社区样本(N = 1107)中自我报告的问题赌博、性成瘾、强迫性购买和饮食失调的症状,以及幸福感(自我超越、个人成长、抑郁/焦虑等)和使用致幻剂和其他精神活性药物的情况。幸福感指标与行为成瘾症状之间存在显著的正相关,幸福感与行为成瘾之间存在负相关。即使在控制了人口统计和其他药物使用之后,迷幻药使用者报告的幸福感更高,行为成瘾症状更低。主成分分析表明,行为成瘾形成一个单一因素,并将其合并成一个综合得分。多元回归分析显示,使用主要兴奋剂、酒精和尼古丁电子烟可以预测更高的行为成瘾分数,而使用致幻剂可以预测更低的分数。这些发现表明,迷幻药可能有助于治疗行为成瘾。有必要进行对照试验或临床试验来进一步探索这种治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psychedelic Use and Behavioral Addictions.

Recent clinical trials on classic psychedelics for depression and anxiety have raised questions about their potential to treat other psychiatric conditions. Evidence from pre-clinical and clinical research suggests psychedelics may help with substance use disorders, with ongoing registered trials. Behavioral addictions, sharing features with substance addictions, may also respond to psychedelic treatment. This study examined self-reported symptoms of problem gambling, sexual addiction, compulsive buying, and eating disorders in a community sample (N = 1107), alongside measures of well-being (self-transcendence, personal growth, depression/anxiety, etc.), and use of psychedelics and other psychoactive drugs. Significant positive correlations emerged among well-being measures and among behavioral addiction symptoms, with inverse correlations between well-being and behavioral addictions. Psychedelic users reported greater well-being and lower behavioral addiction symptoms, even after controlling for demographics and other drug use. Principal components analysis showed that behavioral addictions formed a single factor, which was combined into a composite score. Multiple regression analyses revealed that major stimulant, alcohol, and nicotine vaping use predicted higher behavioral addiction scores, while psychedelic use uniquely predicted lower scores. These findings suggest psychedelics may aid in treating behavioral addictions. A controlled pilot study or clinical trial is warranted to explore this therapeutic potential further.

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来源期刊
CiteScore
5.30
自引率
7.10%
发文量
62
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