Journal of Physiological Sciences最新文献_第8页

Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells. 肾上腺素受体表达水平的变化与胶质母细胞瘤细胞的可塑性有关。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-03-28 DOI: 10.1016/j.jphyss.2025.100016

Yutaro Asaka, Toshio Masumoto, Atsuhito Uneda, Vanessa D Chin, Yusuke Otani, Tirso Peña, Haruyoshi Katayama, Takuto Itano, Teruhiko Ando, Rongsheng Huang, Atsushi Fujimura

{"title":"Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.","authors":"Yutaro Asaka, Toshio Masumoto, Atsuhito Uneda, Vanessa D Chin, Yusuke Otani, Tirso Peña, Haruyoshi Katayama, Takuto Itano, Teruhiko Ando, Rongsheng Huang, Atsushi Fujimura","doi":"10.1016/j.jphyss.2025.100016","DOIUrl":"10.1016/j.jphyss.2025.100016","url":null,"abstract":"Glioblastoma cells are known to regulate their cellular plasticity in response to their surrounding microenvironment, but it is not fully understood what factors contribute to the cells' changing plasticity. Here, we found that glioblastoma cells alter the expression level of adrenoreceptors depending on their differentiation stage. Catecholamines are abundant in the central nervous system, and we found that noradrenaline, in particular, enhances the stemness of glioblastoma cells and promotes the dedifferentiation potential of already differentiated glioblastoma cells. Antagonist and RNAi experiments revealed that signaling through α1D-adrenoreceptor is important for noradrenaline action on glioblastoma cells. We also found that high α1D-adrenoreceptor expression was associated with poor prognosis in patients with gliomas. These data suggest that glioblastoma cells increase the expression level of their own adrenoreceptors to alter the surrounding tumor microenvironment favorably for survival. We believe that our findings will contribute to the development of new therapeutic strategies for glioblastoma.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100016"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction between thermosensitive TRP channels and anoctamin 1. 热敏TRP通道与氨基辛胺的相互作用

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-03-22 DOI: 10.1016/j.jphyss.2025.100015

Yasunori Takayama

引用次数: 0

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-03-24 DOI: 10.1016/j.jphyss.2025.100018

Benjamin Provencher, Mathieu Piché

引用次数: 0

New indicator of small intestinal ageing in senescence-accelerated mice. 衰老加速小鼠小肠衰老的新指标。

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-06-20 DOI: 10.1016/j.jphyss.2025.100030

Fumiya Kurihara, Wendy Hempstock, Noriko Ishizuka, Hisayoshi Hayashi

引用次数: 0

Acute transcutaneous CO₂ exposure: A feasibility study for the future investigation of CO₂-specific exercise adaptations. 急性经皮二氧化碳暴露：未来研究二氧化碳特异性运动适应的可行性研究。

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-03 DOI: 10.1016/j.jphyss.2025.100021

Kyle M A Thompson, Avery Bendell, Jamie F Burr

{"title":"Acute transcutaneous CO2 exposure: A feasibility study for the future investigation of CO2-specific exercise adaptations.","authors":"Kyle M A Thompson, Avery Bendell, Jamie F Burr","doi":"10.1016/j.jphyss.2025.100021","DOIUrl":"10.1016/j.jphyss.2025.100021","url":null,"abstract":"Blood flow restricted (BFR) exercise induces musculoskeletal adaptations at reduced exercise loads. The role of hypercapnia during BFR remains unclear, due to difficulties in isolating this factor in vivo. We evaluated a hypercapnic model designed to raise CO2 levels similar to low-intensity exercise, while minimizing other exercise-induced effects (e.g. hypoxia, lactate accumulation). In a crossover design, 18 participants were administered pure CO₂ (EXP) or room air (CON) transcutaneously from the neck down for 90 min. Ventilatory and blood markers (V̇CO2, ETCO2, V̇E, pH, and PCO2) were measured throughout. The area under the curve of ETCO2 was higher during EXP compared to CON (75.5 ± 83.7 vs. 32.8 ± 57.5 a.u., p = 0.05), confirming successful CO2 administration. However, there was no significant effect on PCO2 (p = 0.09), despite a trend toward reduced pH (p = 0.059). CONCLUSION: While transcutaneous CO2 absorption induced a physiological response, the magnitude was small, and this model shows limited ecological validity to simulate exercise-like conditions.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100021"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium response via CRAC channels in human synovial cells induced by shear stress in rheumatoid arthritis. 类风湿性关节炎中剪切应力诱导滑膜细胞通过CRAC通道的钙反应。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-03-06 DOI: 10.1016/j.jphyss.2025.100013

Yu Okumura, Kanya Honoki, Yasuhito Tanaka, Miyako Takaki, Keiji Asada

引用次数: 0

Pupil dilation evoked by painful electrical stimulation is abolished during pain inhibition by distraction. 由疼痛电刺激引起的瞳孔扩张在分心抑制疼痛时被消除。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI: 10.1016/j.jphyss.2025.100026

Alice Wagenaar-Tison, Zoha Deldar, Antoine Bergeron, Benjamin Provencher, Stéphane Northon, Nabi Rustamov, Isabelle Blanchette, Sylvain Sirois, Mathieu Piché

{"title":"Pupil dilation evoked by painful electrical stimulation is abolished during pain inhibition by distraction.","authors":"Alice Wagenaar-Tison, Zoha Deldar, Antoine Bergeron, Benjamin Provencher, Stéphane Northon, Nabi Rustamov, Isabelle Blanchette, Sylvain Sirois, Mathieu Piché","doi":"10.1016/j.jphyss.2025.100026","DOIUrl":"10.1016/j.jphyss.2025.100026","url":null,"abstract":"The aim of the present study was to examine the contribution of spinal and supraspinal processes to pain modulation by attention. It is hypothesized that pain inhibition by distraction is accompanied by reduced pain-evoked pupil dilation and cerebral activity, but no inhibition of the nociceptive flexion reflex (NFR), while pain anticipation is expected to increase pain perception and pain-related responses. Twenty healthy volunteers received 90 painful stimuli in control, distraction (mental arithmetic), and anticipation (visual cue) conditions. Anticipation did not modulate pain (p = .7), while distraction decreased pain significantly (p < .001). Moreover, pupil diameter increased 500-1000 ms post-stimulus in the control condition (p < .05), but this response was abolished by distraction. Distraction also decreased pain-related brain activity (high-gamma oscillations) (p = .004), but not the NFR (p = .3). These results suggest that pain inhibition by distraction is produced, in part, by supraspinal inhibition of nociceptive processes.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100026"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in the autonomic regulation of temperature in the lower lip and tongue during activation of the lingual nerve. 舌神经激活时下唇和舌头温度自主调节的差异。

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-06-04 DOI: 10.1016/j.jphyss.2025.100028

Syed Taufiqul Islam, Toshiya Sato, Hanako Ohke, Mari Shimatani, Hisayoshi Ishii

{"title":"Differences in the autonomic regulation of temperature in the lower lip and tongue during activation of the lingual nerve.","authors":"Syed Taufiqul Islam, Toshiya Sato, Hanako Ohke, Mari Shimatani, Hisayoshi Ishii","doi":"10.1016/j.jphyss.2025.100028","DOIUrl":"10.1016/j.jphyss.2025.100028","url":null,"abstract":"Orofacial temperature influences orofacial functions and is related to hemodynamics mediated by the autonomic nerves. Although the properties of autonomic vasomotor responses differ in orofacial tissues, differences in the autonomic regulation of orofacial temperature are unclear. We examined the differences in blood flow (BF) and temperature (Tm) between the extraoral (lower lip) and intraoral tissues (tongue) of urethane-anesthetized rats. Noncholinergic parasympathetic vasodilation evoked by trigeminal-mediated reflex elicited significant increases in BF and Tm in both tissues, and these increases were larger in the tongue than in the lower lip. Activation of cervical sympathetic nerves significantly decreased BF and Tm in both tissues. These decreases were restored by parasympathetic reflex vasodilation; the effects were larger in the tongue than in the lower lip. Our results suggest that parasympathetic vasodilation is involved in the maintenance of BF and Tm, and that the effects may be greater in intraoral than in extraoral tissues.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100028"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistance training-induced dihydrotestosterone is blunted in aging rat skeletal muscle. 抗阻训练诱导的双氢睾酮在衰老大鼠骨骼肌中钝化。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-03-27 DOI: 10.1016/j.jphyss.2025.100019

Yung-Li Hung, Akihito Ishigami, Shuichi Machida

引用次数: 0

Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1. 低表达转化生长因子-β1的小鼠近端主动脉瘤。

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1016/j.jphyss.2025.100024

Masao Kakoki, John R Hagaman, Masahiko Terajima, Masako Nagasawa, Katsumi Uoshima, Mitsuo Yamauchi, Oliver Smithies, Kenji Kansaku

{"title":"Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1.","authors":"Masao Kakoki, John R Hagaman, Masahiko Terajima, Masako Nagasawa, Katsumi Uoshima, Mitsuo Yamauchi, Oliver Smithies, Kenji Kansaku","doi":"10.1016/j.jphyss.2025.100024","DOIUrl":"10.1016/j.jphyss.2025.100024","url":null,"abstract":"In humans, loss-of-function mutations in multiple component genes of transforming growth factor (TGF)-β signaling have been demonstrated to cause proximal aortic aneurysms. However, association of human variants in the prototype ligand TGFB1 with thoracic aortic aneurysms have not been reported to date. To delineate the consequences of genetically altered Tgfb1 expression on aortic phenotype in mammals, we studied aortic phenotype in mice with loss-of-functions or gain-of-function mutations in Tgfb1 (Tgfb1L/L and Tgfb1H/H). Tgfb1L/L mice spontaneously developed proximal aortic aneurysms and had markedly shortened lifespans as compared with wildtype, whereas Tgfb1H/Hmice did not develop aortic aneurysms and had comparable lifespans with wildtype. Aortic levels of collagen and elastin stable crosslinks, and the expression of their associated enzymes in Tgfb1L/L mice were significantly less than those in wildtype. These results suggest that TGF-β1 is protective against aortic aneurysms at least partly via increasing the cross-linking of collagen and elastin.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100024"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0