Journal of Physiological Sciences最新文献

Corrigendum to "Distinct molecular profiles in human aortic smooth muscle cells under cyclic stretch and hydrostatic pressure" [J Physiol Sci 76(2026):10090]. “人主动脉平滑肌细胞在循环拉伸和静水压力下的不同分子图谱”[J].生理科学，76(2026):10090。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-10-14 DOI: 10.1016/j.jphyss.2026.100108

Takahiro Kusume, Hana Inoue, Noriaki Arakawa, Kazuhiro Satomi, Utako Yokoyama

引用次数: 0

Anticonvulsant potential of tolfenamic acid in pentylenetetrazol-induced acute symptomatic seizures in male wistar rats. 甲苯胺酸对戊四唑致雄性wistar大鼠急性症状性癫痫的抗惊厥作用。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-10-13 DOI: 10.1016/j.jphyss.2026.100109

Saghi Hakimi Naeini, Vahid Azizi, Abdolkarim Hosseini

{"title":"Anticonvulsant potential of tolfenamic acid in pentylenetetrazol-induced acute symptomatic seizures in male wistar rats.","authors":"Saghi Hakimi Naeini, Vahid Azizi, Abdolkarim Hosseini","doi":"10.1016/j.jphyss.2026.100109","DOIUrl":"https://doi.org/10.1016/j.jphyss.2026.100109","url":null,"abstract":"Objectives: Epilepsy is a neurological disorder characterized by recurrent seizures, posing significant challenges to patients' quality of life. Novel therapeutic agents are continuously sought to enhance seizure management. This study investigates the anticonvulsant potential of tolfenamic acid in a model of pentylenetetrazol (PTZ)-induced acute symptomatic seizures in male Wistar rats.Methods: Male Wistar rats were administered tolfenamic acid prior to PTZ-induced seizure induction. The anticonvulsant effects were evaluated by assessing seizure onset, severity, and duration. Biochemical assays were performed to measure oxidative stress and inflammatory markers.Results: Tolfenamic acid treatment significantly delayed the onset of seizures and reduced both seizure severity and duration compared to the negative control group (p < 0.05). Biochemical analysis revealed a notable modulation of oxidative stress and inflammatory pathways in rats treated with tolfenamic acid, indicating its neuroprotective properties (p < 0.05).Conclusions: The findings demonstrate the significant anticonvulsant and neuroprotective properties of tolfenamic acid in a PTZ-induced seizure model. By delaying seizure onset, reducing severity and duration, and modulating oxidative stress and inflammation, tolfenamic acid shows promise as a potential therapeutic agent for seizure management. Additional clinical trials are necessary to confirm these results in human populations and to investigate the potential of tolfenamic acid as a new treatment for epilepsy and related disorders.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"76 3","pages":"100109"},"PeriodicalIF":3.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease-associated myeloid states in cardiac remodeling: A new era of cardiac inflammation research enabled by computational biology. 心脏重构中的疾病相关髓系状态：计算生物学使心脏炎症研究进入新时代。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-10-10 DOI: 10.1016/j.jphyss.2026.100107

Masanori Obana, Masashi Tomimatsu, Shota Tanaka, Keisuke Shirakura, Yoshiaki Okada, Yasushi Fujio

{"title":"Disease-associated myeloid states in cardiac remodeling: A new era of cardiac inflammation research enabled by computational biology.","authors":"Masanori Obana, Masashi Tomimatsu, Shota Tanaka, Keisuke Shirakura, Yoshiaki Okada, Yasushi Fujio","doi":"10.1016/j.jphyss.2026.100107","DOIUrl":"https://doi.org/10.1016/j.jphyss.2026.100107","url":null,"abstract":"Adverse cardiac remodeling involves cardiomyocyte dysfunction, fibrosis, vascular alterations, and inflammation, contributing to heart failure progression. Although myeloid cells are regulators of cardiac remodeling, therapeutic strategies targeting inflammation have shown limited clinical benefit, highlighting the need for a more precise understanding of myeloid cell functions. Recent advances in single-cell transcriptomics and computational approaches have revealed substantial heterogeneity among cardiac myeloid cells and identified multiple disease-associated myeloid states with distinct molecular and functional characteristics. These findings have shifted the field beyond conventional cell classification toward understanding how specific myeloid states emerge and influence tissue remodeling through interactions with neighboring cells. In this review, we summarize recent advances in disease-associated macrophage and neutrophil states during cardiac remodeling and highlight GARP-expressing myeloid (GEM) cells as a newly identified myeloid state that promotes adverse remodeling. Understanding how disease-associated myeloid states emerge and function within multicellular tissue environments may provide new insights into cardiac remodeling.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"76 3","pages":"100107"},"PeriodicalIF":3.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters. vegfr依赖性信号有助于叙利亚仓鼠出生后棕色脂肪组织的发育。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-10-07 DOI: 10.1016/j.jphyss.2026.100106

Khaled Mahmud Sujan, Yukino Tamakoshi, Bong Soo Seok, Zibo Yang, Shucheng Xu, Mohamed Elfeky, Mira Kato-Suzuki, Yuko Okamatsu-Ogura

引用次数: 0

STING deficiency differentially affects skeletal muscle responses to high-intensity interval training and mechanical overload. STING缺乏对骨骼肌对高强度间歇训练和机械负荷的反应有不同的影响。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-10-03 DOI: 10.1016/j.jphyss.2026.100105

Haiyu Zhao, Reima Onishi, Mayuko Oba, Ryota Iyama, Takumi Yokokawa, Ai Takemura, Tatsuya Hayashi, Tatsuro Egawa

{"title":"STING deficiency differentially affects skeletal muscle responses to high-intensity interval training and mechanical overload.","authors":"Haiyu Zhao, Reima Onishi, Mayuko Oba, Ryota Iyama, Takumi Yokokawa, Ai Takemura, Tatsuya Hayashi, Tatsuro Egawa","doi":"10.1016/j.jphyss.2026.100105","DOIUrl":"https://doi.org/10.1016/j.jphyss.2026.100105","url":null,"abstract":"Skeletal muscle adapts to mechanical stress through inflammatory, mitochondrial and translational responses, but upstream sensors remain unclear. Stimulator of interferon genes (STING) links cytosolic DNA sensing to inflammatory signaling. We examined its role using STING-knockout (KO) mice. The STING agonist diamidobenzimidazole (diABZI) elicited a genotype-dependent Tnfα response. During four-week high-intensity interval training (HIIT), KO mice showed lower absolute running performance, but changes from baseline did not differ between genotypes. Overload increased plantaris mass across genotypes without an interaction. Phosphorylated 4E-BP1 abundance showed a significant genotype × overload interaction, whereas the p-4E-BP1/total 4E-BP1 ratio showed an overall genotype difference without a significant interaction. The ratio was lower overall in KO muscle, while overload-induced p70S6K responses were preserved. Tnfα, Il-6 and TBK1 responses to HIIT and overload were stimulus dependent. These findings suggest that STING contributes selectively, rather than uniformly, to metabolic, translational and inflammatory regulation during skeletal muscle adaptation.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":" ","pages":"100105"},"PeriodicalIF":3.3,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogenous pyruvate protects IMS32 Schwann cells from impairing the maturation process under hyperglycemia. 外源性丙酮酸保护IMS32雪旺细胞免受高血糖状态下成熟过程的损害。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-10-03 DOI: 10.1016/j.jphyss.2026.100104

Hideji Yako, Sana Hattori, Sayaka Iwamoto, Tatsuya Ooki, Waraku Nagatani, Yuika Kaburaki, Yuki Miyamoto, Kazunori Sango, Junji Yamauchi

{"title":"Exogenous pyruvate protects IMS32 Schwann cells from impairing the maturation process under hyperglycemia.","authors":"Hideji Yako, Sana Hattori, Sayaka Iwamoto, Tatsuya Ooki, Waraku Nagatani, Yuika Kaburaki, Yuki Miyamoto, Kazunori Sango, Junji Yamauchi","doi":"10.1016/j.jphyss.2026.100104","DOIUrl":"10.1016/j.jphyss.2026.100104","url":null,"abstract":"Peripheral neuropathy is a chronic common complication of diabetes mellitus. Continuous hyperglycemia induces metabolic disturbances and elicits oxidative stress. However, the impact of hyperglycemia on the maturation of Schwann cells is not fully understood. Therefore, we examined whether hyperglycemia affects the maturation process of IMS32 Schwann cells treated with forskolin, a Schwann cell maturation enhancer, using promoter assays and immunoblotting of Schwann cell markers such as MBP, CNPase, and GFAP. IMS32 cells exposed to high-glucose conditions showed decreased expression of these markers. Exogenous pyruvate plays a crucial role in maintaining glucose metabolism and reducing oxidative stress under hyperglycemic conditions. These decreases were prevented by pyruvate supplementation. Pyruvate treatment also prevented IMS32 cells from producing reactive oxygen species and from impairing mitochondrial membrane potential. These results indicate that hyperglycemia impairs Schwann cell maturation accompanied by mitochondrial dysfunction and oxidative stress, contributing to the development and progression of diabetic peripheral neuropathy.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"76 3","pages":"100104"},"PeriodicalIF":3.3,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma-oryzanol promotes neurite extension in NGF-primed PC12 cells and enhances viability/process elongation in immortalized Schwann cells. γ -米扎酚促进ngf引发的PC12细胞的神经突延伸，并增强永生化雪旺细胞的活力/过程延伸。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-09-28 DOI: 10.1016/j.jphyss.2026.100103

Takeshi Shimizu

{"title":"Gamma-oryzanol promotes neurite extension in NGF-primed PC12 cells and enhances viability/process elongation in immortalized Schwann cells.","authors":"Takeshi Shimizu","doi":"10.1016/j.jphyss.2026.100103","DOIUrl":"10.1016/j.jphyss.2026.100103","url":null,"abstract":"Phytochemicals are natural compounds found in vegetables and fruits. Gamma-oryzanol (Orz) is present in rice bran generated during the milling process. Health effects of Orz have yet to be fully elucidated. We found that Orz treatment enhanced neurite/process extension in both nerve growth factor-primed PC12 pheochromocytoma cells and immortalized Schwann cells (IFRS1 cells). Orz also improved the viability of IFRS1 cells cultured under low-serum conditions. LY294002, a PI3K inhibitor, caused a polygonal cobblestone-like morphology in IFRS1 cells, while Orz treatment cancelled this effect. Although LY294002 increased the number of apoptotic IFRS1 cells, this effect was not influenced by Orz treatment, suggesting that the effects of Orz on Schwann cell morphology are mediated through downstream effectors of the PI3K pathway rather than through cell viability. Taken together, Orz promotes process extension of two types of neural cells and enhances Schwann cell viability, suggesting therapeutic potential for regeneration after peripheral nerve injury.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"76 3","pages":"100103"},"PeriodicalIF":3.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale interactions in cardiovascular homeostasis and remodeling: from molecular coupling to organelle and multicellular networks. 心血管稳态和重构中的多尺度相互作用：从分子偶联到细胞器和多细胞网络。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-09-14 DOI: 10.1016/j.jphyss.2026.100102

Motohiro Nishida

{"title":"Multiscale interactions in cardiovascular homeostasis and remodeling: from molecular coupling to organelle and multicellular networks.","authors":"Motohiro Nishida","doi":"10.1016/j.jphyss.2026.100102","DOIUrl":"10.1016/j.jphyss.2026.100102","url":null,"abstract":"Cardiovascular homeostasis is increasingly understood not as the output of isolated pathways, but as an emergent and history-dependent property of interactions across biological scales. Cutting-edge technologies have revealed coupling between transcription and metabolism, signaling within molecular microdomains, organelle networks, communication between cardiomyocytes and non-myocytes, neurovascular regulation, and interorgan interactions. This special issue brings together five perspectives that examine how such interactions preserve physiological function and, under stress, redirect the cardiovascular system toward adaptation or disease. As a representative multiscale example, this Editorial highlights hierarchical mitochondrial quality control. Biogenesis, fusion-fission dynamics, proteostasis, mitochondria-derived vesicles, organelle contacts, and mitophagy form a graded defense network that matches the response to the burden and location of damage. The same network connects mitochondrial dysfunction to innate immunity and tissue remodeling. Defining directionality, spatial context, temporal order, and flux within these interactions will be essential for converting descriptive interaction maps into causal physiology and selective therapies.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"76 3","pages":"100102"},"PeriodicalIF":3.3,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential roles of β3-adrenergic receptor in heart rate regulation via sinus node activity and local adipocyte metabolism. β3-肾上腺素能受体通过窦房结活动和局部脂肪细胞代谢在心率调节中的潜在作用。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-09-14 DOI: 10.1016/j.jphyss.2026.100101

Yukihiro Harada, Chih Chi Kao, Tomoe Ueyama, Alphonse Boché, Morshedul Alam Azad Khandaker, Shu Nakao, Teruhisa Kawamura

{"title":"Potential roles of β3-adrenergic receptor in heart rate regulation via sinus node activity and local adipocyte metabolism.","authors":"Yukihiro Harada, Chih Chi Kao, Tomoe Ueyama, Alphonse Boché, Morshedul Alam Azad Khandaker, Shu Nakao, Teruhisa Kawamura","doi":"10.1016/j.jphyss.2026.100101","DOIUrl":"10.1016/j.jphyss.2026.100101","url":null,"abstract":"β-Adrenergic signalling plays a central role in the regulation of diverse physiological processes, including cardiovascular function. In the heart, β1-adrenergic receptors (β1-ARs) mediate most sympathetic effects on contractility and heart rate, whereas the role of β3-ARs remains poorly understood. Here we investigated the expression and functional significance of β3-ARs in the sinus node (SN), the primary cardiac pacemaker. β3-AR expression showed a clear regional gradient, being highest in adipose tissue associated with the SN, modest in the SN itself, and minimal in atrial and ventricular myocardium. Single-nucleus RNA sequencing further demonstrated enriched β3-AR transcripts in adipocytes within the SN region and modest expression in SN and atrial myocytes. Pharmacological modulation of β3-AR activity influenced heart rate and altered spontaneous firing in isolated right atrial preparations containing the SN. These findings suggest that β3-AR signalling may influence pacemaker activity both directly within the SN and indirectly through local adipose tissue metabolism.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"76 3","pages":"100101"},"PeriodicalIF":3.3,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeated hypergravity training facilitates vestibular compensation associated with dorsal root ganglion remodeling. 重复的超重力训练促进前庭代偿与背根神经节重塑相关。

IF 3.3 4区医学

Journal of Physiological Sciences Pub Date : 2026-09-08 DOI: 10.1016/j.jphyss.2026.100100

Yuta Masuda, Kakeru Shimizu, Marina Khatun, Sajjad Hossain, Risa Shimane, Nanaka Tameike, Yukari Takeda, Chikara Abe

{"title":"Repeated hypergravity training facilitates vestibular compensation associated with dorsal root ganglion remodeling.","authors":"Yuta Masuda, Kakeru Shimizu, Marina Khatun, Sajjad Hossain, Risa Shimane, Nanaka Tameike, Yukari Takeda, Chikara Abe","doi":"10.1016/j.jphyss.2026.100100","DOIUrl":"10.1016/j.jphyss.2026.100100","url":null,"abstract":"Vestibular compensation relies on sensory reweighting, but whether repeated hypergravity training (HT) facilitates recovery after bilateral vestibular lesion (BVL) remains unclear. We investigated the effects of HT on motor function and dorsal root ganglion (DRG) transcriptomes in mice following BVL. Mice underwent sham surgery or BVL and were assigned to either HT (2 G, 60 min/day for 10 days) or no HT (NHT). Body weight, righting reflex, and rotarod performance were evaluated, and RNA sequencing of L5 DRGs was performed on day 7. HT did not improve body weight loss or vestibular-dependent righting reflex deficits. However, HT resulted in significantly better rotarod performance on Day 7 compared with NHT. RNA sequencing identified 397 candidate genes, with enrichment of muscle-related and myelination-related biological processes. These findings suggest that repeated HT facilitates vestibular compensation by promoting transcriptional changes in DRGs and enhancing peripheral somatosensory plasticity rather than restoring vestibular function itself.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"76 3","pages":"100100"},"PeriodicalIF":3.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0