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Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-28 DOI: 10.1016/j.jphyss.2025.100016
Yutaro Asaka, Toshio Masumoto, Atsuhito Uneda, Vanessa D Chin, Yusuke Otani, Tirso Peña, Haruyoshi Katayama, Takuto Itano, Teruhiko Ando, Rongsheng Huang, Atsushi Fujimura
{"title":"Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.","authors":"Yutaro Asaka, Toshio Masumoto, Atsuhito Uneda, Vanessa D Chin, Yusuke Otani, Tirso Peña, Haruyoshi Katayama, Takuto Itano, Teruhiko Ando, Rongsheng Huang, Atsushi Fujimura","doi":"10.1016/j.jphyss.2025.100016","DOIUrl":"https://doi.org/10.1016/j.jphyss.2025.100016","url":null,"abstract":"<p><p>Glioblastoma cells are known to regulate their cellular plasticity in response to their surrounding microenvironment, but it is not fully understood what factors contribute to the cells' changing plasticity. Here, we found that glioblastoma cells alter the expression level of adrenoreceptors depending on their differentiation stage. Catecholamines are abundant in the central nervous system, and we found that noradrenaline, in particular, enhances the stemness of glioblastoma cells and promotes the dedifferentiation potential of already differentiated glioblastoma cells. Antagonist and RNAi experiments revealed that signaling through α1D-adrenoreceptor is important for noradrenaline action on glioblastoma cells. We also found that high α1D-adrenoreceptor expression was associated with poor prognosis in patients with gliomas. These data suggest that glioblastoma cells increase the expression level of their own adrenoreceptors to alter the surrounding tumor microenvironment favorably for survival. We believe that our findings will contribute to the development of new therapeutic strategies for glioblastoma.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100016"},"PeriodicalIF":2.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resistance training-induced dihydrotestosterone is blunted in aging rat skeletal muscle.
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-27 DOI: 10.1016/j.jphyss.2025.100019
Yung-Li Hung, Akihito Ishigami, Shuichi Machida
{"title":"Resistance training-induced dihydrotestosterone is blunted in aging rat skeletal muscle.","authors":"Yung-Li Hung, Akihito Ishigami, Shuichi Machida","doi":"10.1016/j.jphyss.2025.100019","DOIUrl":"https://doi.org/10.1016/j.jphyss.2025.100019","url":null,"abstract":"<p><p>This study aimed to investigate the influence of aging on steroid hormone production in skeletal muscles in response to resistance training. Male F344 rats, aged 4 months (young) and 22 months (old), were randomized into the sedentary and training groups. The training group performed resistance training by climbing a ladder with a load every three days for eight weeks. After the training period, the flexor hallucis longus muscle was dissection, and muscle steroid hormone levels were analyzed using liquid chromatography-tandem mass spectrometry. We found that resistance training significantly increased muscle mass in young and old rats, although the increase was less pronounced in the latter. In young, trained rats, muscle dihydrotestosterone levels were approximately 35-fold higher compared to sedentary controls (p < 0.01); dihydrotestosterone levels did not differ significantly between sedentary and trained old rats. These findings indicate that resistance training-induced dihydrotestosterone production is blunted in aging rat skeletal muscle.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100019"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C-fiber-related brain responses evoked by laser heat pulses applied to the back.
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-24 DOI: 10.1016/j.jphyss.2025.100018
Benjamin Provencher, Mathieu Piché
{"title":"C-fiber-related brain responses evoked by laser heat pulses applied to the back.","authors":"Benjamin Provencher, Mathieu Piché","doi":"10.1016/j.jphyss.2025.100018","DOIUrl":"https://doi.org/10.1016/j.jphyss.2025.100018","url":null,"abstract":"<p><p>The aim of the present study was to examine C-fiber-related brain responses evoked by laser heat stimuli applied to the lumbar area, and to determine the stimulation protocol that produces the most reliable responses. Thirty healthy volunteers completed the study. Combinations of different stimuli (single pulses or trains of three pulses) with different pulse durations (7 or 14 ms) were used to compare C-fiber-related brain responses between protocols. The four protocols elicited comparable C-fiber-related brain responses to laser heat pulses. However, pulse trains of 7 ms pulses at 0.67 Hz elicited C-LEPs in the greatest proportion of participants (86.7 %). C-LEPs occurred within a 500 ms to 1500 ms post-stimulus time window, consistent with the perception associated with C-fiber activation. These results provide novel data on C-fiber-related brain responses to painful stimuli and a reliable stimulation protocol for future studies on low back pain.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100018"},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction between thermosensitive TRP channels and anoctamin 1.
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-22 DOI: 10.1016/j.jphyss.2025.100015
Yasunori Takayama
{"title":"Interaction between thermosensitive TRP channels and anoctamin 1.","authors":"Yasunori Takayama","doi":"10.1016/j.jphyss.2025.100015","DOIUrl":"https://doi.org/10.1016/j.jphyss.2025.100015","url":null,"abstract":"<p><p>Some thermosensitive transient receptor potential (TRP) channels form a protein complex with anoctamin 1 (ANO1, also called TMEM16A). TRP channels have high calcium permeability, and the calcium entering cells through TRP channel activation activates ANO1, a calcium-activated chloride channel, involved in many physiological and pathological conditions. The physiological significance of TRP channels is often mediated by their ability to activate ANO1, which controls chloride flux across the plasma membrane. This review summarizes the latest understanding on the interactions between ANO1 and thermosensitive TRP channels, including TRPV1, TRPV3, and TRPV4, which are involved in pain sensitization in primary sensory neurons, proliferation and migration of human keratinocytes, and fluid secretion such as sweat, respectively.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100015"},"PeriodicalIF":2.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcium response via CRAC channels in human synovial cells induced by shear stress in rheumatoid arthritis.
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-06 DOI: 10.1016/j.jphyss.2025.100013
Yu Okumura, Kanya Honoki, Yasuhito Tanaka, Miyako Takaki, Keiji Asada
{"title":"Calcium response via CRAC channels in human synovial cells induced by shear stress in rheumatoid arthritis.","authors":"Yu Okumura, Kanya Honoki, Yasuhito Tanaka, Miyako Takaki, Keiji Asada","doi":"10.1016/j.jphyss.2025.100013","DOIUrl":"10.1016/j.jphyss.2025.100013","url":null,"abstract":"<p><p>The role of calcium release-activated calcium channel (CRAC) inhibitors in the pathogenesis of rheumatoid arthritis (RA) is unclear. We focused on stromal interaction molecule 1 (STIM1) and Ca<sup>2+</sup> release-activated channel regulator 2 A (CRACR2A), which participate in CRAC activation, to understand the signaling mechanism of human RA fibroblast-like synovial (FLS) cells in response to shear stress (SS). Human normal and RA FLS cell cultures were studied. The rates of intracellular calcium release and extracellular calcium influx in response to SS differed, and the responses to the first and second stimuli were analyzed. In the RA FLS cells, CRAC inhibitor significantly decreased the second/first stimulus ratio compared with that of the normal cells, and STIM1 and CRACR2A exhibited significantly increased expression levels compared with those in the normal FLS cells. Therefore, STIM1 and CRACR2A expression and Ca<sup>2+</sup> influx in FLS cells are implicated in the pathogenesis of RA.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100013"},"PeriodicalIF":2.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRPV1 and thermosensitivity.
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-01 DOI: 10.1016/j.jphyss.2025.100009
Makoto Tominaga, Moe Iwata
{"title":"TRPV1 and thermosensitivity.","authors":"Makoto Tominaga, Moe Iwata","doi":"10.1016/j.jphyss.2025.100009","DOIUrl":"10.1016/j.jphyss.2025.100009","url":null,"abstract":"<p><p>The capsaicin receptor TRPV1 was identified as the first heat-activated ion channel in 1997. Since then, numerous studies have been performed on its physiological functions and structure-function relationship, and chemicals targeting TRPV1 have been developed. It has been more than 27 years since the initial cloning of the TRPV1 gene and more than 11 years since the clarification of its structure at the atomic level using cryo-EM. However, we still lack good chemical antagonists of TRPV1 as medicines. TRPV1 is involved in body temperature regulation, but how TRPV1 antagonists cause hyperthermia and how TRPV1 is involved in body temperature regulation are not yet clearly understood. More research is needed in the thermal biology field.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100009"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The interaction between orexin, sleep deprivation and Alzheimer's disease: Unveiling an Emerging Connection. 食欲素、睡眠剥夺和阿尔茨海默病之间的相互作用：揭示一种新兴的联系。
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-02 DOI: 10.1016/j.jphyss.2024.100004
Masoumeh Kourosh-Arami, Mahdi Ramezani, Alireza Komaki
{"title":"The interaction between orexin, sleep deprivation and Alzheimer's disease: Unveiling an Emerging Connection.","authors":"Masoumeh Kourosh-Arami, Mahdi Ramezani, Alireza Komaki","doi":"10.1016/j.jphyss.2024.100004","DOIUrl":"10.1016/j.jphyss.2024.100004","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Sleep-wake disorders are an extremely predominant and often disabling aspect of AD. Ox is vital in maintaining the sleep-wake cycle and promoting wakefulness. Dysfunction of Ox signaling has been associated with sleep disorders such as narcolepsy. In AD patients, the increase in cerebrospinal fluid Ox levels is related to parallel sleep deterioration. The relationship between AD and sleep disturbances has gained increasing attention due to their potential bidirectional influence. Disruptions in sleep patterns are commonly observed in AD patients, leading researchers to investigate the possible involvement of Ox in sleep disturbances characteristic of the disease. This review article explores the role of the Ox system in AD, and the intricate relationship between AD and sleep, highlighting the potential mechanisms, impact on disease pathology, and therapeutic interventions to improve sleep quality in affected individuals.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100004"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRPV3 in skin thermosensation and temperature responses. TRPV3在皮肤热感觉和温度反应中的作用。
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-08 DOI: 10.1016/j.jphyss.2025.100005
Jing Lei, Makoto Tominaga
{"title":"TRPV3 in skin thermosensation and temperature responses.","authors":"Jing Lei, Makoto Tominaga","doi":"10.1016/j.jphyss.2025.100005","DOIUrl":"10.1016/j.jphyss.2025.100005","url":null,"abstract":"<p><p>Human skin, as a sophisticated sensory organ, is able to detect subtle changes in ambient temperature. This thermosensory capability is primarily mediated by temperature-sensitive TRP channels expressed in both sensory neurons and keratinocytes. Among these, TRPV3, which responds to warm temperatures and plays a crucial role in various skin functions, is particularly notable. TRPV3 channels not only detect moderate warmth but are also sensitive to chemical ligands that evoke thermal sensations. The activation of TRPV3 by warm temperatures and compounds highlights its importance in the molecular mechanisms underlying skin thermosensation. This review mainly discusses the role of TRPV3, particularly its contribution to skin thermosensation and structural insights into its temperature sensitivity, providing an understanding of how TRPV3 modulates thermal perception at the molecular level.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100005"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian sleep-wake rhythm reversal in mice implanted with stomach cancer cell lines.
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1016/j.jphyss.2025.100007
Motohide Goto, Takashi Maruyama, Miki Nonaka, Yasuhito Uezono, Yoichi Ueta, Susumu Ueno
{"title":"Circadian sleep-wake rhythm reversal in mice implanted with stomach cancer cell lines.","authors":"Motohide Goto, Takashi Maruyama, Miki Nonaka, Yasuhito Uezono, Yoichi Ueta, Susumu Ueno","doi":"10.1016/j.jphyss.2025.100007","DOIUrl":"10.1016/j.jphyss.2025.100007","url":null,"abstract":"<p><p>The present study explored the phenotype and behavioral characteristics of mice implanted with the 85As2 human stomach cancer cell lines. Generally, mice are nocturnal; they are active during the dark phase and resting in the light phase. However, mice implanted with 85As2 cells demonstrated diurnal patterns, showing activity in the light phase. The similar light-dark behavioral reversal was noted in mice implanted with other cancer cell lines, such as the HCT116 human colon cancer cell lines. Furthermore, 85As2 implanted mice revealed significant shortening of the free-running period under constant dark conditions. To explore the underlying physiological mechanisms of this circadian rhythm reversal, diurnal variations in the suprachiasmatic nucleus (SCN) were analyzed with observation of c-Fos expression. Interestingly, no significant difference was found in the SCN activity between the control and 85As2-implanted mice, demonstrating rhythm reversal. It is suggested that the lesion causing this rhythm reversal exists downstream of the SCN.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100007"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involvement of ROS signal in aging and regulation of brain functions. ROS信号参与衰老和脑功能调节。
IF 2.6 4区 医学
Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2024-12-21 DOI: 10.1016/j.jphyss.2024.100003
Sho Kakizawa
{"title":"Involvement of ROS signal in aging and regulation of brain functions.","authors":"Sho Kakizawa","doi":"10.1016/j.jphyss.2024.100003","DOIUrl":"10.1016/j.jphyss.2024.100003","url":null,"abstract":"<p><p>Reactive oxygen species (ROS) are redox-signaling molecules involved in aging and lifestyle-related diseases. In the brain, in addition to the production of ROS as byproducts of metabolism, expression of ROS synthases has recently been demonstrated, suggesting possible involvement of ROS in various brain functions. This review highlights current knowledge on the relationship between ROS and brain functions, including their contribution to age-related decline in synaptic plasticity and cognitive function. While most studies demonstrate either the positive or negative effects of ROS on synaptic plasticity, the dual effects of ROS at individual synapses have been demonstrated recently in the mouse cerebellum. Furthermore, the cooperative interaction between these two effects determines the direction of synaptic plasticity. It is anticipated that further elucidation of both the positive and negative effects of ROS on brain function will lead to the development of more effective therapeutic strategies with fewer side effects for ROS-related brain dysfunction.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100003"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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