Journal of Physiological Sciences最新文献

Differences in the autonomic regulation of temperature in the lower lip and tongue during activation of the lingual nerve. 舌神经激活时下唇和舌头温度自主调节的差异。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-06-04 DOI: 10.1016/j.jphyss.2025.100028

Syed Taufiqul Islam, Toshiya Sato, Hanako Ohke, Mari Shimatani, Hisayoshi Ishii

{"title":"Differences in the autonomic regulation of temperature in the lower lip and tongue during activation of the lingual nerve.","authors":"Syed Taufiqul Islam, Toshiya Sato, Hanako Ohke, Mari Shimatani, Hisayoshi Ishii","doi":"10.1016/j.jphyss.2025.100028","DOIUrl":"10.1016/j.jphyss.2025.100028","url":null,"abstract":"Orofacial temperature influences orofacial functions and is related to hemodynamics mediated by the autonomic nerves. Although the properties of autonomic vasomotor responses differ in orofacial tissues, differences in the autonomic regulation of orofacial temperature are unclear. We examined the differences in blood flow (BF) and temperature (Tm) between the extraoral (lower lip) and intraoral tissues (tongue) of urethane-anesthetized rats. Noncholinergic parasympathetic vasodilation evoked by trigeminal-mediated reflex elicited significant increases in BF and Tm in both tissues, and these increases were larger in the tongue than in the lower lip. Activation of cervical sympathetic nerves significantly decreased BF and Tm in both tissues. These decreases were restored by parasympathetic reflex vasodilation; the effects were larger in the tongue than in the lower lip. Our results suggest that parasympathetic vasodilation is involved in the maintenance of BF and Tm, and that the effects may be greater in intraoral than in extraoral tissues.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100028"},"PeriodicalIF":2.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupil dilation evoked by painful electrical stimulation is abolished during pain inhibition by distraction. 由疼痛电刺激引起的瞳孔扩张在分心抑制疼痛时被消除。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-05-16 DOI: 10.1016/j.jphyss.2025.100026

Alice Wagenaar-Tison, Zoha Deldar, Antoine Bergeron, Benjamin Provencher, Stéphane Northon, Nabi Rustamov, Isabelle Blanchette, Sylvain Sirois, Mathieu Piché

{"title":"Pupil dilation evoked by painful electrical stimulation is abolished during pain inhibition by distraction.","authors":"Alice Wagenaar-Tison, Zoha Deldar, Antoine Bergeron, Benjamin Provencher, Stéphane Northon, Nabi Rustamov, Isabelle Blanchette, Sylvain Sirois, Mathieu Piché","doi":"10.1016/j.jphyss.2025.100026","DOIUrl":"10.1016/j.jphyss.2025.100026","url":null,"abstract":"The aim of the present study was to examine the contribution of spinal and supraspinal processes to pain modulation by attention. It is hypothesized that pain inhibition by distraction is accompanied by reduced pain-evoked pupil dilation and cerebral activity, but no inhibition of the nociceptive flexion reflex (NFR), while pain anticipation is expected to increase pain perception and pain-related responses. Twenty healthy volunteers received 90 painful stimuli in control, distraction (mental arithmetic), and anticipation (visual cue) conditions. Anticipation did not modulate pain (p = .7), while distraction decreased pain significantly (p < .001). Moreover, pupil diameter increased 500-1000 ms post-stimulus in the control condition (p < .05), but this response was abolished by distraction. Distraction also decreased pain-related brain activity (high-gamma oscillations) (p = .004), but not the NFR (p = .3). These results suggest that pain inhibition by distraction is produced, in part, by supraspinal inhibition of nociceptive processes.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100026"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of endurance versus resistance exercise training on central and peripheral chemoreflexes in young healthy individuals. 耐力和阻力运动训练对年轻健康个体中枢和外周化学反射的影响。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-05-15 DOI: 10.1016/j.jphyss.2025.100027

Thalia Babbage, Ana L C Sayegh, Jui-Lin Fan, Nicholas Gant, Julian F R Paton, James P Fisher

{"title":"Influence of endurance versus resistance exercise training on central and peripheral chemoreflexes in young healthy individuals.","authors":"Thalia Babbage, Ana L C Sayegh, Jui-Lin Fan, Nicholas Gant, Julian F R Paton, James P Fisher","doi":"10.1016/j.jphyss.2025.100027","DOIUrl":"10.1016/j.jphyss.2025.100027","url":null,"abstract":"Heightened central and peripheral chemoreflex sensitivity are associated with poor outcomes, but therapeutic approaches to target them are lacking. Endurance and resistance exercise training improve a multitude of physiological outcomes, but their effects on ventilatory chemoreflex sensitivity are unclear. Accordingly, the cardiorespiratory responses to steady-state isocapnic hypoxia (10 % O2, 5-minutes) and hyperoxic hypercapnic rebreathing (5 % CO2-95 % O2) were compared in endurance, resistance, and untrained groups. Central chemoreflex sensitivity was taken as the slope of the relationship between minute ventilation (V̇E) and end-tidal partial pressure of CO2. Peripheral chemoreflex sensitivity was determined from the absolute increase in V̇E from baseline to peak V̇E expressed relative to the fall in oxygen saturation. Neither central (P = 0.093) nor peripheral (P = 0.847) ventilatory chemoreflex sensitivities were different between groups. Future investigations should seek to understand whether exercise training modality influences central and peripheral chemoreflex sensitivity in older and clinical populations.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100027"},"PeriodicalIF":2.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1. 低表达转化生长因子-β1的小鼠近端主动脉瘤。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-05-14 DOI: 10.1016/j.jphyss.2025.100024

Masao Kakoki, John R Hagaman, Masahiko Terajima, Masako Nagasawa, Katsumi Uoshima, Mitsuo Yamauchi, Oliver Smithies, Kenji Kansaku

{"title":"Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1.","authors":"Masao Kakoki, John R Hagaman, Masahiko Terajima, Masako Nagasawa, Katsumi Uoshima, Mitsuo Yamauchi, Oliver Smithies, Kenji Kansaku","doi":"10.1016/j.jphyss.2025.100024","DOIUrl":"10.1016/j.jphyss.2025.100024","url":null,"abstract":"In humans, loss-of-function mutations in multiple component genes of transforming growth factor (TGF)-β signaling have been demonstrated to cause proximal aortic aneurysms. However, association of human variants in the prototype ligand TGFB1 with thoracic aortic aneurysms have not been reported to date. To delineate the consequences of genetically altered Tgfb1 expression on aortic phenotype in mammals, we studied aortic phenotype in mice with loss-of-functions or gain-of-function mutations in Tgfb1 (Tgfb1L/L and Tgfb1H/H). Tgfb1L/L mice spontaneously developed proximal aortic aneurysms and had markedly shortened lifespans as compared with wildtype, whereas Tgfb1H/Hmice did not develop aortic aneurysms and had comparable lifespans with wildtype. Aortic levels of collagen and elastin stable crosslinks, and the expression of their associated enzymes in Tgfb1L/L mice were significantly less than those in wildtype. These results suggest that TGF-β1 is protective against aortic aneurysms at least partly via increasing the cross-linking of collagen and elastin.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100024"},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective serotonin reuptake inhibitors (SSRIs) suppress Na⁺- dependent Mg²⁺ efflux in rat ventricular myocytes. 选择性血清素再摄取抑制剂（SSRIs）抑制大鼠心室肌细胞Na+依赖性Mg2+外排。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-05-12 DOI: 10.1016/j.jphyss.2025.100025

Michiko Tashiro, Masato Konishi, Hana Inoue, Utako Yokoyama

{"title":"Selective serotonin reuptake inhibitors (SSRIs) suppress Na+- dependent Mg2+ efflux in rat ventricular myocytes.","authors":"Michiko Tashiro, Masato Konishi, Hana Inoue, Utako Yokoyama","doi":"10.1016/j.jphyss.2025.100025","DOIUrl":"10.1016/j.jphyss.2025.100025","url":null,"abstract":"Na+/Mg2+ exchange transport, the Na+ gradient-driven Mg2+ extrusion system, plays a key role in cellular Mg2+ homeostasis. To date, the molecular entity and selective inhibitors of Na+/Mg2+ exchanger have not been fully explored. Intracellular free Mg2+ concentration ([Mg2+]i) was measured in ventricular myocytes acutely isolated from rat hearts. After soaking the cells in high-Mg2+ low-Na+ solution to increase [Mg2+]i, the addition of extracellular Na+ caused a decrease in [Mg2+]i. We analyzed the rate of decrease in [Mg2+]i as Na+/Mg2+ exchange transport activity. The suppression of the rate of decrease in [Mg2+]i caused by sertraline, a selective serotonin reuptake inhibitor (SSRI), was concentration dependent (IC50 8.9 μM) and reversible. Other SSRIs, namely paroxetine and fluvoxamine, were less effective than sertraline. In conclusion, sertraline inhibited Na+/Mg2+ exchange transport more effectively than any previously reported inhibitors of Na+/Mg2+ exchanger. Sertraline could be used as a tool to characterize the functions of Na+/Mg2+ exchanger.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100025"},"PeriodicalIF":2.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending wave propagation along muscle fibers originates from early local contraction at the end-plate region. 延伸波沿肌纤维的传播源于端板区域的早期局部收缩。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-05-09 DOI: 10.1016/j.jphyss.2025.100023

Tomonori Hayashi, Naoya Nakahara, Shigeru Morimoto, Maki Yamaguchi, Kazuhiro Hirano, Shigeru Takemori

引用次数: 0

Heart rate changes related to risky selections and outcomes in rat gambling tasks. 大鼠赌博任务中与风险选择和结果相关的心率变化。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-04-10 DOI: 10.1016/j.jphyss.2025.100022

Fumiya Fukushima, Atsushi Tamura, Nahoko Kuga, Takuya Sasaki

引用次数: 0

Acute transcutaneous CO₂ exposure: A feasibility study for the future investigation of CO₂-specific exercise adaptations. 急性经皮二氧化碳暴露：未来研究二氧化碳特异性运动适应的可行性研究。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-04-03 DOI: 10.1016/j.jphyss.2025.100021

Kyle M A Thompson, Avery Bendell, Jamie F Burr

{"title":"Acute transcutaneous CO2 exposure: A feasibility study for the future investigation of CO2-specific exercise adaptations.","authors":"Kyle M A Thompson, Avery Bendell, Jamie F Burr","doi":"10.1016/j.jphyss.2025.100021","DOIUrl":"https://doi.org/10.1016/j.jphyss.2025.100021","url":null,"abstract":"Blood flow restricted (BFR) exercise induces musculoskeletal adaptations at reduced exercise loads. The role of hypercapnia during BFR remains unclear, due to difficulties in isolating this factor in vivo. We evaluated a hypercapnic model designed to raise CO2 levels similar to low-intensity exercise, while minimizing other exercise-induced effects (e.g. hypoxia, lactate accumulation). In a crossover design, 18 participants were administered pure CO₂ (EXP) or room air (CON) transcutaneously from the neck down for 90 min. Ventilatory and blood markers (V̇CO2, ETCO2, V̇E, pH, and PCO2) were measured throughout. The area under the curve of ETCO2 was higher during EXP compared to CON (75.5 ± 83.7 vs. 32.8 ± 57.5 a.u., p = 0.05), confirming successful CO2 administration. However, there was no significant effect on PCO2 (p = 0.09), despite a trend toward reduced pH (p = 0.059). CONCLUSION: While transcutaneous CO2 absorption induced a physiological response, the magnitude was small, and this model shows limited ecological validity to simulate exercise-like conditions.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100021"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Special issue on thermosensitive TRP channels. 社论：关于热敏TRP通道的特刊。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-29 DOI: 10.1016/j.jphyss.2025.100020

Makoto Tominaga

引用次数: 0

Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells. 肾上腺素受体表达水平的变化与胶质母细胞瘤细胞的可塑性有关。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-28 DOI: 10.1016/j.jphyss.2025.100016

Yutaro Asaka, Toshio Masumoto, Atsuhito Uneda, Vanessa D Chin, Yusuke Otani, Tirso Peña, Haruyoshi Katayama, Takuto Itano, Teruhiko Ando, Rongsheng Huang, Atsushi Fujimura

{"title":"Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.","authors":"Yutaro Asaka, Toshio Masumoto, Atsuhito Uneda, Vanessa D Chin, Yusuke Otani, Tirso Peña, Haruyoshi Katayama, Takuto Itano, Teruhiko Ando, Rongsheng Huang, Atsushi Fujimura","doi":"10.1016/j.jphyss.2025.100016","DOIUrl":"10.1016/j.jphyss.2025.100016","url":null,"abstract":"Glioblastoma cells are known to regulate their cellular plasticity in response to their surrounding microenvironment, but it is not fully understood what factors contribute to the cells' changing plasticity. Here, we found that glioblastoma cells alter the expression level of adrenoreceptors depending on their differentiation stage. Catecholamines are abundant in the central nervous system, and we found that noradrenaline, in particular, enhances the stemness of glioblastoma cells and promotes the dedifferentiation potential of already differentiated glioblastoma cells. Antagonist and RNAi experiments revealed that signaling through α1D-adrenoreceptor is important for noradrenaline action on glioblastoma cells. We also found that high α1D-adrenoreceptor expression was associated with poor prognosis in patients with gliomas. These data suggest that glioblastoma cells increase the expression level of their own adrenoreceptors to alter the surrounding tumor microenvironment favorably for survival. We believe that our findings will contribute to the development of new therapeutic strategies for glioblastoma.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100016"},"PeriodicalIF":2.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0