Journal of Physiological Sciences最新文献_第10页

Acute effects of empagliflozin on open-loop baroreflex function and urine glucose excretion in Goto-Kakizaki diabetic rats. 恩格列净对后藤- kakizaki糖尿病大鼠开环压力反射功能和尿糖排泄的急性影响。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00861-9

Toru Kawada, Hiromi Yamamoto, Aimi Yokoi, Akitsugu Nishiura, Midori Kakuuchi, Shohei Yokota, Hiroki Matsushita, Joe Alexander, Keita Saku

{"title":"Acute effects of empagliflozin on open-loop baroreflex function and urine glucose excretion in Goto-Kakizaki diabetic rats.","authors":"Toru Kawada, Hiromi Yamamoto, Aimi Yokoi, Akitsugu Nishiura, Midori Kakuuchi, Shohei Yokota, Hiroki Matsushita, Joe Alexander, Keita Saku","doi":"10.1186/s12576-023-00861-9","DOIUrl":"https://doi.org/10.1186/s12576-023-00861-9","url":null,"abstract":"Although suppression of sympathetic activity is suggested as one of the underlying mechanisms for the cardioprotective effects afforded by sodium-glucose cotransporter 2 (SGLT2) inhibitors, whether the modulation of glucose handling acutely affects sympathetic regulation of arterial pressure remains to be elucidated. In Goto-Kakizaki diabetic rats, we estimated the open-loop static characteristics of the carotid sinus baroreflex together with urine glucose excretion using repeated 11-min step input sequences. After the completion of the 2nd sequence, an SGLT2 inhibitor empagliflozin (10 mg kg-1) or vehicle solution was administered intravenously (n = 7 rats each). Empagliflozin did not significantly affect the baroreflex neural or peripheral arc, despite significantly increasing urine glucose excretion (from 0.365±0.216 to 8.514±0.864 mg·min-1·kg-1, P < 0.001) in the 7th and 8th sequences. The possible sympathoinhibitory effect of empagliflozin may be an indirect effect associated with chronic improvements in renal energy status and general disease conditions.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"7"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats. 烟碱能对老龄大鼠嗅球血流反应的调节。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-022-00859-9

Sae Uchida, Jura Moriya, Daichi Morihara, Fusako Kagitani

引用次数: 0

Dogs showed lower parasympathetic activity during mutual gazing while owners did not. 狗在相互凝视时副交感神经活动较低，而主人则没有。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00863-7

Miho Nagasawa, Maaya Saito, Haruka Hirasawa, Kazutaka Mogi, Takefumi Kikusui

引用次数: 0

Relationships between feeding behaviors and emotions: an electroencephalogram (EEG) frequency analysis study. 进食行为与情绪的关系：脑电图频率分析研究。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-022-00858-w

Shintaro Kusunoki, Takako Fukuda, Saori Maeda, Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu, Hiroshi Yoshimura

{"title":"Relationships between feeding behaviors and emotions: an electroencephalogram (EEG) frequency analysis study.","authors":"Shintaro Kusunoki, Takako Fukuda, Saori Maeda, Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu, Hiroshi Yoshimura","doi":"10.1186/s12576-022-00858-w","DOIUrl":"https://doi.org/10.1186/s12576-022-00858-w","url":null,"abstract":"Feeding behaviors may be easily affected by emotions, both being based on brain activity; however, the relationships between them have not been explicitly defined. In this study, we investigated how emotional environments modulate subjective feelings, brain activity, and feeding behaviors. Electroencephalogram (EEG) recordings were obtained from healthy participants in conditions of virtual comfortable space (CS) and uncomfortable space (UCS) while eating chocolate, and the times required for eating it were measured. We found that the more participants tended to feel comfortable under the CS, the more it took time to eat in the UCS. However, the EEG emergence patterns in the two virtual spaces varied across the individuals. Upon focusing on the theta and low-beta bands, the strength of the mental condition and eating times were found to be guided by these frequency bands. The results determined that the theta and low-beta bands are likely important and relevant waves for feeding behaviors under emotional circumstances, following alterations in mental conditions.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal physiological calming responses to infant suckling at the breast. 母亲对婴儿吸吮乳房的生理镇静反应。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00860-w

Nami Ohmura, Lana Okuma, Anna Truzzi, Gianluca Esposito, Kumi O Kuroda

{"title":"Maternal physiological calming responses to infant suckling at the breast.","authors":"Nami Ohmura, Lana Okuma, Anna Truzzi, Gianluca Esposito, Kumi O Kuroda","doi":"10.1186/s12576-023-00860-w","DOIUrl":"https://doi.org/10.1186/s12576-023-00860-w","url":null,"abstract":"The mother-infant relation is key to infant physical, cognitive and social development. Mutual regulation and cooperation are required to maintain the dyadic system, but the biological foundation of these responses remains to be clarified. In this study, we report the maternal calming responses to infant suckling during breastfeeding. Using behavioral measures and a Holter electrocardiogram as a readout of the maternal autonomic nervous system, the maternal activities during resting, sitting with her infant on her lap, and breastfeeding were assessed. We found that during breastfeeding, mothers talked less and maternal heart rate was lower than during sitting with the infant without breastfeeding. Congruently, maternal heart rate variability measurements indicated a higher parasympathetic activity during breastfeeding. Time-locked analyses suggested that this maternal calming response was initiated by the tactile stimulation at the breast by the infant face or mouth latch, which preceded the perceived milk ejection. These findings suggest that somatosensory stimuli of breastfeeding activate parasympathetic activity in mothers. Just as how the infant Transport Response facilitates the carrying of infants, the maternal calming responses during breastfeeding may promote efficient milk intake by inhibiting spontaneous maternal activities.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"3"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case-control study. 血清CCN5/WISP2水平与妊娠期糖尿病发生风险呈正相关：一项病例对照研究

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00879-z

Mohammed Farhan Hamdan Alshganbee, Fariba Nabatchian, Vida Farrokhi, Reza Fadaei, Nariman Moradi, Reza Afrisham

{"title":"A positive association of serum CCN5/WISP2 levels with the risk of developing gestational diabetes mellitus: a case-control study.","authors":"Mohammed Farhan Hamdan Alshganbee, Fariba Nabatchian, Vida Farrokhi, Reza Fadaei, Nariman Moradi, Reza Afrisham","doi":"10.1186/s12576-023-00879-z","DOIUrl":"https://doi.org/10.1186/s12576-023-00879-z","url":null,"abstract":"Introduction: CCN5/WISP2 is prominently manifest in adipose tissue and has been linked to the pathogenesis of obesity, diabetes, and insulin resistance. However, discrepancies exist in previous studies, and little is known about its association with gestational diabetes mellitus (GDM). The current investigation is designed to examine the correlation of WISP2 with risk factors in GDM patients in comparison to healthy pregnant women for the first time.Methods: This case-control study measured serum levels of CCN5, TNF-α, IL-6, adiponectin, and fasting insulin using ELISA kits in 88 GDM patients and 88 pregnant women.Results: The GDM group had remarkably higher serum levels of CCN5 (379.41±83.078 ng/ml) compared to controls (212.02±77.935 ng/ml). In a similar vein, it was observed that patients diagnosed with GDM exhibited elevated levels of pro-inflammatory cytokines such as IL-6 and TNF-α; while conversely, adiponectin levels were found to be significantly lower than those observed in the control group (P < 0.0001). In women with GDM, a positive and significant correlation was observed between CCN5 and BMI, FBG, insulin, HOMA-IR, as well as IL-6 and TNF-α levels. In the adjusted model, the risk of GDM was significantly increased with elevated serum CCN5 level.Conclusion: Our research indicates a noteworthy and affirmative correlation between the levels of CCN5 in the serum and the risk of developing GDM, along with its associated risk factors such as BMI, insulin resistance index, FBG, and inflammatory cytokines (TNF-α and IL-6). These findings suggest that CCN5 could potentially play a role in the etiology of GDM.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"22"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice. 口服葡萄糖转运体的糖信号引发小鼠头期胰岛素释放。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00875-3

Mitsuhito Takamori, Yoshihiro Mitoh, Kengo Horie, Masahiko Egusa, Takuya Miyawaki, Ryusuke Yoshida

引用次数: 0

High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle. 高强度间歇训练可减轻运动诱导的hsp70辅助骨骼肌选择性自噬。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00884-2

Jiao Lu, Liu-Mei Zhang, Jing-Jing Liu, Yu-Ting Liu, Xiao-Ye Lin, Xue-Qi Wang, Yuan Zhang, Qiang Tang, Lin Liu

{"title":"High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle.","authors":"Jiao Lu, Liu-Mei Zhang, Jing-Jing Liu, Yu-Ting Liu, Xiao-Ye Lin, Xue-Qi Wang, Yuan Zhang, Qiang Tang, Lin Liu","doi":"10.1186/s12576-023-00884-2","DOIUrl":"https://doi.org/10.1186/s12576-023-00884-2","url":null,"abstract":"This study was designed to probe the effect of chaperone-assisted selective autophagy (CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the alteration of CASA in muscle fibers with pre-high-intensity interval training (HIIT) intervention-induced muscle adaptation in response to exhaustive exercise. Rats were randomly divided into a control group; an exhaustive exercise group; and an HIIT + exhaustive exercise group. Results show myofibril damage and BiP levels were increased after exhaustive exercise, and the levels of the HSP70, BAG3, ubiquitin, autophagy-related proteins, and their interactions were increased. HIIT intervention before exhaustive exercise could decrease myofibril injury and BiP levels, accompanied by down-regulation of HSP70/BAG3 complex and selective autophagy. In conclusion, exhaustive exercise promotes CASA to clear protein aggregation for keeping proteostasis in muscle fibers; pre-HIIT intervention improves myofibril injury and unfold protein response caused by exhaustive exercise, which might contribute to inhibit the augmentation of CASA.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"32"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cumulative effects of exercise training and consumption of propolis on managing diabetic dyslipidemia in adult women: a single-blind, randomized, controlled trial with pre-post-intervention assessments. 运动训练和蜂胶摄入对成年女性糖尿病血脂异常的累积影响：一项单盲、随机、对照试验，干预前后评估

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00872-6

Fatemeh Moayedi, Farzaneh Taghian, Khosro Jalali Dehkordi, Seyed Ali Hosseini

{"title":"Cumulative effects of exercise training and consumption of propolis on managing diabetic dyslipidemia in adult women: a single-blind, randomized, controlled trial with pre-post-intervention assessments.","authors":"Fatemeh Moayedi, Farzaneh Taghian, Khosro Jalali Dehkordi, Seyed Ali Hosseini","doi":"10.1186/s12576-023-00872-6","DOIUrl":"https://doi.org/10.1186/s12576-023-00872-6","url":null,"abstract":"Dyslipidemia is an imbalance of various lipids, and propolis, as a natural resinous viscos mixture made by Apis mellifera L. could improve in this condition. In this single-blind, randomized trial, 60 women with type 2 diabetes and dyslipidemia were divided into four groups: (1) the patients who did not apply the combined training and 500 mg propolis capsules supplement (Control group); (2) subjects performed combined training, including aerobic and resistance training (EXR); (3) subjects received the 500 mg propolis supplement capsules (SUPP); (4) Subjects performed combined training along with receiving the 500 mg propolis supplement capsules (EXR + SUPP). We evaluated the concentration of CTRP12, SFRP5, interleukin-6 (IL6), superoxide dismutase (SOD), malondialdehyde (MDA), adiponectin, and total antioxidant capacity (TAC) before and after the intervention. MDA, TAC, IL6, CTRP12, SFRP5 IL6, adiponectin, and lipid profile levels ameliorated in the EXR + SUPP group. We found that 8 weeks of treatment by combined exercise training and propolis supplement decreased inflammation activity and increased antioxidant defense in women with diabetic dyslipidemia. Trial registration This study was registered in the Iranian Registry of Clinical Trials; IRCT code: IRCT20211229053561N1.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"17"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism for exercise-mediated prevention against muscle wasting on extensor digitorum longus muscle in Spontaneously Diabetic Torii fatty rats. 运动介导预防自发性糖尿病Torii脂肪大鼠指长伸肌肌肉萎缩的机制。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00865-5

Hitoshi Kotake, Yuji Ogura, Shohei Yamada, Kazuho Inoue, Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Yasunori Natsuki, Seiko Hoshino, Minoru Watanabe, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori

{"title":"Mechanism for exercise-mediated prevention against muscle wasting on extensor digitorum longus muscle in Spontaneously Diabetic Torii fatty rats.","authors":"Hitoshi Kotake, Yuji Ogura, Shohei Yamada, Kazuho Inoue, Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Yasunori Natsuki, Seiko Hoshino, Minoru Watanabe, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori","doi":"10.1186/s12576-023-00865-5","DOIUrl":"https://doi.org/10.1186/s12576-023-00865-5","url":null,"abstract":"We previously reported the significant increase in limb muscle strength and cross-sectional area of the type IIb muscle fibers in the extensor digitorum longus (EDL) muscle in a type 2 diabetic animal model, with Spontaneously Diabetic Torii (SDT) fatty rats (n = 6) undergoing regular treadmill exercise from 8 to 16 weeks of age compared with sedentary SDT fatty rats (n = 6). This study investigated the mechanism by which exercise training prevented skeletal muscle wasting in the EDL muscle of the SDT fatty rats. The endurance exercise for 8 weeks downregulated the expression of muscle RING-finger protein-1 (an E3 ubiquitin ligase) and upregulated the expression of CD31, insulin receptor substrate-2, and phosphorylated endothelial nitric oxide synthase in the EDL muscle of 16-week-old SDT fatty rats. Endurance exercise training might reduce muscle wasting by preventing muscle degradation and increasing the angiogenic response in the EDL muscle in type 2 diabetes.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"5"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0