Journal of Physiological Sciences最新文献_第10页

Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat. 神经性疼痛模型大鼠杏仁核中央核对有害和非有害机械刺激的血清素释放反应的改变。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00910-x

Ryota Tokunaga, Hideshi Shibata, Mieko Kurosawa

引用次数: 0

An interactive simulator to deepen the understanding of Guyton's venous return curve. 交互式模拟器加深对盖顿静脉回流曲线的理解。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00912-9

Noritaka Mamorita, Akihiro Takeuchi, Hirotoshi Kamata

{"title":"An interactive simulator to deepen the understanding of Guyton's venous return curve.","authors":"Noritaka Mamorita, Akihiro Takeuchi, Hirotoshi Kamata","doi":"10.1186/s12576-024-00912-9","DOIUrl":"https://doi.org/10.1186/s12576-024-00912-9","url":null,"abstract":"Mean circulatory filling pressure, venous return curve, and Guyton's graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or understand them adequately. To deepen students' understanding of the graphical analysis, in place of having to perform live animal experiments, we developed an interactive cardiovascular simulator, as a self-learning tool, as a web application. The minimum closed-loop model consisted of a ventricle, an artery, resistance, and a vein, excluding venous resistance. The simulator consists of three modules: setting (parameters and simulation modes), calculation, and presentation. In the setting module, the user can interactively customize model parameters, compliances, resistance, Emax of the ventricular contractility, total blood volume, and unstressed volume. The hemodynamics are calculated in three phases: filling (late diastole), ejection (systole), and flow (early diastole). In response to the user's settings, the simulator graphically presents the hemodynamics: the pressure-volume relations of the artery, vein, and ventricle, the venous return curves, and the stroke volume curves. The mean filling pressure is calculated at approximately 7 mmHg at the initial setting. The venous return curves, linear and concave, are dependent on the venous compliance. The hemodynamic equilibrium point is marked on the crossing point of venous return curve and the stroke volume curve. Users can interactively do discovery learning, and try and confirm their interests and get their questions answered about hemodynamic concepts by using the simulator.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"21"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterosynaptic plasticity-induced modulation of synapses. 异突触可塑性诱导的突触调节。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-12-06 DOI: 10.1186/s12576-023-00893-1

Masoumeh Kourosh-Arami, Alireza Komaki, Masoumeh Gholami, Seyed Hossein Marashi, Sara Hejazi

{"title":"Heterosynaptic plasticity-induced modulation of synapses.","authors":"Masoumeh Kourosh-Arami, Alireza Komaki, Masoumeh Gholami, Seyed Hossein Marashi, Sara Hejazi","doi":"10.1186/s12576-023-00893-1","DOIUrl":"10.1186/s12576-023-00893-1","url":null,"abstract":"Plasticity is a common feature of synapses that is stated in different ways and occurs through several mechanisms. The regular action of the brain needs to be balanced in several neuronal and synaptic features, one of which is synaptic plasticity. The different homeostatic processes, including the balance between excitation/inhibition or homeostasis of synaptic weights at the single-neuron level, may obtain this. Homosynaptic Hebbian-type plasticity causes associative alterations of synapses. Both homosynaptic and heterosynaptic plasticity characterize the corresponding aspects of adjustable synapses, and both are essential for the regular action of neural systems and their plastic synapses.In this review, we will compare homo- and heterosynaptic plasticity and the main factors affecting the direction of plastic changes. This review paper will also discuss the diverse functions of the different kinds of heterosynaptic plasticity and their properties. We argue that a complementary system of heterosynaptic plasticity demonstrates an essential cellular constituent for homeostatic modulation of synaptic weights and neuronal activity.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"33"},"PeriodicalIF":2.6,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle. 高强度间歇训练可减轻运动诱导的hsp70辅助骨骼肌选择性自噬。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-11-21 DOI: 10.1186/s12576-023-00884-2

Jiao Lu, Liu-Mei Zhang, Jing-Jing Liu, Yu-Ting Liu, Xiao-Ye Lin, Xue-Qi Wang, Yuan Zhang, Qiang Tang, Lin Liu

{"title":"High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle.","authors":"Jiao Lu, Liu-Mei Zhang, Jing-Jing Liu, Yu-Ting Liu, Xiao-Ye Lin, Xue-Qi Wang, Yuan Zhang, Qiang Tang, Lin Liu","doi":"10.1186/s12576-023-00884-2","DOIUrl":"10.1186/s12576-023-00884-2","url":null,"abstract":"This study was designed to probe the effect of chaperone-assisted selective autophagy (CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the alteration of CASA in muscle fibers with pre-high-intensity interval training (HIIT) intervention-induced muscle adaptation in response to exhaustive exercise. Rats were randomly divided into a control group; an exhaustive exercise group; and an HIIT + exhaustive exercise group. Results show myofibril damage and BiP levels were increased after exhaustive exercise, and the levels of the HSP70, BAG3, ubiquitin, autophagy-related proteins, and their interactions were increased. HIIT intervention before exhaustive exercise could decrease myofibril injury and BiP levels, accompanied by down-regulation of HSP70/BAG3 complex and selective autophagy. In conclusion, exhaustive exercise promotes CASA to clear protein aggregation for keeping proteostasis in muscle fibers; pre-HIIT intervention improves myofibril injury and unfold protein response caused by exhaustive exercise, which might contribute to inhibit the augmentation of CASA.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"32"},"PeriodicalIF":2.6,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological roles of chloride ions in bodily and cellular functions. 氯离子在身体和细胞功能中的生理作用。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-11-15 DOI: 10.1186/s12576-023-00889-x

Yoshinori Marunaka

{"title":"Physiological roles of chloride ions in bodily and cellular functions.","authors":"Yoshinori Marunaka","doi":"10.1186/s12576-023-00889-x","DOIUrl":"10.1186/s12576-023-00889-x","url":null,"abstract":"Physiological roles of Cl-, a major anion in the body, are not well known compared with those of cations. This review article introduces: (1) roles of Cl- in bodily and cellular functions; (2) the range of cytosolic Cl- concentration ([Cl-]c); (3) whether [Cl-]c could change with cell volume change under an isosmotic condition; (4) whether [Cl-]c could change under conditions where multiple Cl- transporters and channels contribute to Cl- influx and efflux in an isosmotic state; (5) whether the change in [Cl-]c could be large enough to act as signals; (6) effects of Cl- on cytoskeletal tubulin polymerization through inhibition of GTPase activity and tubulin polymerization-dependent biological activity; (7) roles of cytosolic Cl- in cell proliferation; (8) Cl--regulatory mechanisms of ciliary motility; (9) roles of Cl- in sweet/umami taste receptors; (10) Cl--regulatory mechanisms of with-no-lysine kinase (WNK); (11) roles of Cl- in regulation of epithelial Na+ transport; (12) relationship between roles of Cl- and H+ in body functions.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"31"},"PeriodicalIF":2.6,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134649232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes. 肥胖者和正常体重者不同代谢表型血小板反应蛋白-1/ toll样受体4 (TSP1/TLR4)通路与维生素D水平的关系

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-11-14 DOI: 10.1186/s12576-023-00887-z

Eman Y Khairy, Azza Saad

{"title":"Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes.","authors":"Eman Y Khairy, Azza Saad","doi":"10.1186/s12576-023-00887-z","DOIUrl":"10.1186/s12576-023-00887-z","url":null,"abstract":"Thrombospondin-1 (TSP1) contributes to obesity-associated inflammation via activating Toll-like receptor 4 (TLR4). The regulatory role of vitamin D on this pathway has been suggested. This study aimed to investigate the relationship between TSP1/TLR4 pathway and vitamin D in obese and normal weight subjects with different metabolic phenotypes. Thirty obese and thirty normal weight men were selected. Anthropometric parameters and serum TSP1, TLR4, TNF-α, vitamin D, and metabolic profile were determined. Metabolic phenotypes of obese and normal weight subjects were determined. Findings revealed enhanced TSP1/TLR4/TNF-α levels and reduced 25(OH)D levels in obese compared to normal weight subjects and metabolically unhealthy compared to metabolically healthy subjects. TSP1 correlated positively with parameters of unhealthy metabolic profile. TSP1, TLR4 and TNF-α levels significantly negatively correlated with vitamin D levels. In conclusion, vitamin D might exert a regulatory role on TSP1/TLR4 pathway, providing a potential mechanism that links hypovitaminosis D with risk of metabolic dysfunction.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"29"},"PeriodicalIF":2.6,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical exercise for a healthy pregnancy: the role of placentokines and exerkines. 体育锻炼对健康妊娠的影响:胎盘因子和运动因子的作用。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-11-14 DOI: 10.1186/s12576-023-00885-1

Hamed Alizadeh Pahlavani, Ismail Laher, Katja Weiss, Beat Knechtle, Hassane Zouhal

{"title":"Physical exercise for a healthy pregnancy: the role of placentokines and exerkines.","authors":"Hamed Alizadeh Pahlavani, Ismail Laher, Katja Weiss, Beat Knechtle, Hassane Zouhal","doi":"10.1186/s12576-023-00885-1","DOIUrl":"10.1186/s12576-023-00885-1","url":null,"abstract":"Complications such as diabetes and preeclampsia can occur during pregnancy. Moderate-intensity exercise can prevent such complications by releasing placentokines and exerkines, such as apelin, adiponectin, leptin, irisin, and chemerin. Exercise and apelin increase thermogenesis and glucose uptake in pregnancy by activating AMPK, PI3K, PGC-1α, AKT1, UCP3, and sarcolipin. Exercise increases apelin levels to reduce preeclampsia symptoms by increasing eNOS, NO, placental growth factor (PlGF), and VEGF and decreasing levels of fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng), and oxidative stress. A negative relationship has been reported between plasma leptin and VO2peak/kg and VO2peak in women with gestational diabetes. In active women, decreases in leptin levels reduce the risk of preeclampsia by ~ 40%. Higher adiponectin levels are associated with greater physical activity and lead to increased insulin sensitivity. Increased adiponectin levels in preeclampsia and exercise counteract inflammatory and atherogenic activities while also having vascular protective effects. Exercise increases irisin levels that correlate negatively with fasting glucose, insulin concentration, and glycosylated hemoglobin levels. Irisin augments mRNA expression levels of UCP1 and cell death-inducing DNA fragmentation factor-like effector A (cidea) to cause browning of adipose tissue, increased thermogenesis, and increased energy consumption. Irisin concentrations in mothers with preeclampsia in the third trimester negatively correlate with systolic and diastolic blood pressure. Expression levels of chemerin, IL-6, and TNF-α are increased in gestational diabetes, and the increases in chemerin in late pregnancy positively correlate with the ratio of sFlt-1 to PlGF as a marker of preeclampsia. The effects of physical exercise on placentokines and exerkines in women at various stages of pregnancy remain poorly understood.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"30"},"PeriodicalIF":2.6,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10718036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Febuxostat ameliorates muscle degeneration and movement disorder of the dystrophin mutant model in Caenorhabditis elegans. 非布索坦改善秀丽隐杆线虫肌营养不良蛋白突变模型的肌肉退化和运动障碍。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-11-10 DOI: 10.1186/s12576-023-00888-y

Sawako Yoshina, Luna Izuhara, Rei Mashima, Yuka Maejima, Naoyuki Kamatani, Shohei Mitani

引用次数: 0

Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery-Dreifuss muscular dystrophy caused by an LMNA gene mutation. 在由LMNA基因突变引起的Emery Dreifuss肌营养不良小鼠模型中，Emerin缺乏不会加剧心肌病。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-11-08 DOI: 10.1186/s12576-023-00886-0

Eiji Wada, Kohei Matsumoto, Nao Susumu, Megumi Kato, Yukiko K Hayashi

{"title":"Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery-Dreifuss muscular dystrophy caused by an LMNA gene mutation.","authors":"Eiji Wada, Kohei Matsumoto, Nao Susumu, Megumi Kato, Yukiko K Hayashi","doi":"10.1186/s12576-023-00886-0","DOIUrl":"10.1186/s12576-023-00886-0","url":null,"abstract":"Emery-Dreifuss muscular dystrophy (EDMD), caused by mutations in genes encoding nuclear envelope proteins, is clinically characterized by muscular dystrophy, early joint contracture, and life-threatening cardiac abnormalities. To elucidate the pathophysiological mechanisms underlying striated muscle involvement in EDMD, we previously established a murine model with mutations in Emd and Lmna (Emd-/-/LmnaH222P/H222P; EH), and reported exacerbated skeletal muscle phenotypes and no notable cardiac phenotypes at 12 weeks of age. We predicted that lack of emerin in LmnaH222P/H222P mice causes an earlier onset and more pronounced cardiac dysfunction at later stages. In this study, cardiac abnormalities of EDMD mice were compared at 18 and 30 weeks of age. Contrary to our expectations, physiological and histological analyses indicated that emerin deficiency causes no prominent differences of cardiac involvement in LmnaH222P/H222P mice. These results suggest that emerin does not contribute to cardiomyopathy progression in LmnaH222P/H222P mice.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"27"},"PeriodicalIF":2.6,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71521882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review. 评估热适应表型的分子生物标志物：叙述性范围界定综述。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2023-10-17 DOI: 10.1186/s12576-023-00882-4

J Corbett, J S Young, M J Tipton, J T Costello, T B Williams, E F Walker, B J Lee, C E Stevens

{"title":"Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.","authors":"J Corbett, J S Young, M J Tipton, J T Costello, T B Williams, E F Walker, B J Lee, C E Stevens","doi":"10.1186/s12576-023-00882-4","DOIUrl":"10.1186/s12576-023-00882-4","url":null,"abstract":"Heat acclimation/acclimatisation (HA) mitigates heat-related decrements in physical capacity and heat-illness risk and is a widely advocated countermeasure for individuals operating in hot environments. The efficacy of HA is typically quantified by assessing the thermo-physiological responses to a standard heat acclimation state test (i.e. physiological biomarkers), but this can be logistically challenging, time consuming, and expensive. A valid molecular biomarker of HA would enable evaluation of the heat-adapted state through the sampling and assessment of a biological medium. This narrative review examines candidate molecular biomarkers of HA, highlighting the poor sensitivity and specificity of these candidates and identifying the current lack of a single 'standout' biomarker. It concludes by considering the potential of multivariable approaches that provide information about a range of physiological systems, identifying a number of challenges that must be overcome to develop a valid molecular biomarker of the heat-adapted state, and highlighting future research opportunities.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"73 1","pages":"26"},"PeriodicalIF":2.6,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0