Journal of Physiological Sciences最新文献_第10页

Strength training improves heart function, collagen and strength in rats with heart failure. 力量训练可以改善心力衰竭大鼠的心脏功能、胶原蛋白和力量。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00899-3

Leisiane G Dias, Carlos H O Reis, Leonardo Dos Santos, Walter Krause Neto, Ana Paula Lima-Leopoldo, Julien S Baker, André S Leopoldo, Danilo S Bocalini

{"title":"Strength training improves heart function, collagen and strength in rats with heart failure.","authors":"Leisiane G Dias, Carlos H O Reis, Leonardo Dos Santos, Walter Krause Neto, Ana Paula Lima-Leopoldo, Julien S Baker, André S Leopoldo, Danilo S Bocalini","doi":"10.1186/s12576-024-00899-3","DOIUrl":"https://doi.org/10.1186/s12576-024-00899-3","url":null,"abstract":"Background/objectives: Myocardial infarction (MI) frequently leads to cardiac remodeling and failure with impaired life quality, playing an important role in cardiovascular deaths. Although physical exercise is a well-recognized effective non-pharmacological therapy for cardiovascular diseases, the effects of strength training (ST) on the structural and functional aspects of cardiac remodeling need to be further documented. In this study, we aimed to investigate the role of a linear block ST protocol in the rat model of MI.Methods and results: After 6 weeks of MI induction or sham surgery, male adult rats performed ST for the following 12 weeks. The ladder-based ST program was organized in three mesocycles of 4 weeks, with one load increment for each block according to the maximal carrying load test. After 12 weeks, the infarcted-trained rats exhibited an increase in performance, associated with reduced cardiac hypertrophy and pulmonary congestion compared with the untrained group. Despite not changing MI size, the ST program partially prevented cardiac dilatation and ventricular dysfunction assessed by echocardiography and hemodynamics, and interstitial fibrosis evaluated by histology. In addition, isolated cardiac muscles from infarcted-trained rats had improved contractility parameters in a steady state, and in response to calcium or stimuli pauses.Conclusions: The ST in infarcted rats increased the capacity to carry mass, associated with attenuation of cardiac remodeling and pulmonary congestion with improving cardiac function that could be attributed, at least in part, to the improvement of myocardial contractility.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"10"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis. TGF-β1/ smad3信号通路在酒精性肝纤维化性别差异中的作用机制

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00901-y

Xiaomin Hong, Sanqiang Li, Renli Luo, Mengli Yang, Junfei Wu, Shuning Chen, Siyu Zhu

{"title":"Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis.","authors":"Xiaomin Hong, Sanqiang Li, Renli Luo, Mengli Yang, Junfei Wu, Shuning Chen, Siyu Zhu","doi":"10.1186/s12576-024-00901-y","DOIUrl":"https://doi.org/10.1186/s12576-024-00901-y","url":null,"abstract":"The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups. Liver injury and fibrosis were assessed using histopathology and serology. Western blotting was performed to analyze the expression of relevant factors. HSC-T6 cells were divided into estradiol + saline, estradiol + ethanol, testosterone + saline, and testosterone + ethanol groups, and similar assessments were conducted in vitro. Compared with the female model group, the male model group exhibited significantly increased GPT, GOT, TNF-α, IL-6, and testosterone levels, fibrosis rate, and TGF-β1, Smad3, and PCNA expression, and significantly decreased estradiol levels and Caspase-3 expression. The apoptosis rate was higher in the estradiol + ethanol group than in the testosterone + ethanol group, although the testosterone + ethanol group exhibited significantly increased TNF-α, IL-6, Collagen-I, α-SMA, TGF-β1, Smad3, and PCNA expression, and significantly decreased Caspase-3 expression. Alcoholic liver fibrosis showed significant gender differences associated with the TGF-β1/Smad3-signaling pathway.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"13"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC. Part 1: from its discovery and phenotype characterization to the molecular entity identification. 体积敏感/调节性阴离子通道VSOR/VRAC的生理学研究。第一部分：从其发现、表型表征到分子实体鉴定。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-023-00897-x

Yasunobu Okada

引用次数: 0

Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex. 年龄对大鼠嗅球及新皮层烟碱能血流调节的影响。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00913-8

Sae Uchida, Fusako Kagitani

引用次数: 0

Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC: part 2: its activation mechanisms and essential roles in organic signal release. 体积敏感/调节性阴离子通道VSOR/VRAC的生理学：第2部分：其激活机制及其在有机信号释放中的重要作用。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00926-3

Yasunobu Okada

{"title":"Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC: part 2: its activation mechanisms and essential roles in organic signal release.","authors":"Yasunobu Okada","doi":"10.1186/s12576-024-00926-3","DOIUrl":"https://doi.org/10.1186/s12576-024-00926-3","url":null,"abstract":"The volume-sensitive outwardly rectifying or volume-regulated anion channel, VSOR/VRAC, which was discovered in 1988, is expressed in most vertebrate cell types, and is essentially involved in cell volume regulation after swelling and in the induction of cell death. This series of review articles describes what is already known and what remains to be uncovered about the functional and molecular properties as well as the physiological and pathophysiological roles of VSOR/VRAC. This Part 2 review article describes, from the physiological and pathophysiological standpoints, first the pivotal roles of VSOR/VRAC in the release of autocrine/paracrine organic signal molecules, such as glutamate, ATP, glutathione, cGAMP, and itaconate, as well as second the swelling-independent and -dependent activation mechanisms of VSOR/VRAC. Since the pore size of VSOR/VRAC has now well been evaluated by electrophysiological and 3D-structural methods, the signal-releasing activity of VSOR/VRAC is here discussed by comparing the molecular sizes of these organic signals to the channel pore size. Swelling-independent activation mechanisms include a physicochemical one caused by the reduction of intracellular ionic strength and a biochemical one caused by oxidation due to stimulation by receptor agonists or apoptosis inducers. Because some organic substances released via VSOR/VRAC upon cell swelling can trigger or augment VSOR/VRAC activation in an autocrine fashion, swelling-dependent activation mechanisms are to be divided into two phases: the first phase induced by cell swelling per se and the second phase caused by receptor stimulation by released organic signals.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"34"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interactive effects of different exercises and hawthorn consumption on the pain threshold of TMT-induced Alzheimer male rats. 不同运动和山楂摄取量对tmt诱导的老年痴呆雄性大鼠痛阈的交互作用。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00925-4

Ensiyeh Almasi, Ali Heidarianpour, Maryam Keshvari

{"title":"The interactive effects of different exercises and hawthorn consumption on the pain threshold of TMT-induced Alzheimer male rats.","authors":"Ensiyeh Almasi, Ali Heidarianpour, Maryam Keshvari","doi":"10.1186/s12576-024-00925-4","DOIUrl":"https://doi.org/10.1186/s12576-024-00925-4","url":null,"abstract":"Exercise increases the pain threshold in healthy people. However, the pain threshold modulation effect of exercise and hawthorn is unclear because of its potential benefits in people with persistent pain, including those with Alzheimer's disease. Accordingly, after the induction of Alzheimer's disease by trimethyl chloride, male rats with Alzheimer's disease were subjected to a 12-week training regimen consisting of resistance training, swimming endurance exercises, and combined exercises. In addition, hawthorn extract was orally administered to the rats. Then, their pain threshold was evaluated using three Tail-flick, Hot-plate, and Formalin tests. Our results showed that Alzheimer's decreased the pain threshold in all three behavioral tests. Combined exercise with hawthorn consumption had the most statistically significant effect on Alzheimer's male rats' pain threshold in all three experiments. A combination of swimming endurance and resistance exercises with hawthorn consumption may modulate hyperalgesia in Alzheimer's rats. Future studies need to determine the effects of these factors on the treatment and/or management of painful conditions. GRAPHICAL ABSTRACT.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"36"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglia mediate the increase in slow-wave sleep associated with high ambient temperature. 小胶质细胞介导与高环境温度相关的慢波睡眠的增加。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00929-0

Sena Hatori, Futaba Matsui, Zhiwen Zhou, Hiroaki Norimoto

引用次数: 0

From bench to bedside: US-Japan Collaborative Workshop on the NVU. 从实验台到病床：美日NVU合作研讨会。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-03 DOI: 10.1186/s12576-024-00917-4

{"title":"From bench to bedside: US-Japan Collaborative Workshop on the NVU.","authors":"","doi":"10.1186/s12576-024-00917-4","DOIUrl":"https://doi.org/10.1186/s12576-024-00917-4","url":null,"abstract":"The joint workshop between U.S. and Japanese researchers, supported by The U.S.-Japan Brain Research Cooperative Program, convened in January 2023 at Keio University Mita campus in Tokyo, Japan. The workshop had a threefold objective. Firstly, it aimed to facilitate robust exchanges between U.S. and Japanese researchers engaged in Neurovascular Unit (NVU) research, enhancing the global network of scholars in the field. Secondly, it aimed to encourage the initiation of collaborative research projects, fostering interdisciplinary efforts and synergistic advancements in understanding the brain vascular physiology and central nervous system. Lastly, the workshop emphasized the nurturing of young researchers, recognizing their pivotal role in shaping the future of NVU research. Throughout the workshop, participants discussed fundamental aspects of the NVU, exploring its complex connections and vital functions. By sharing their expertise and insights, the workshop attendees sought to uncover novel approaches to mitigate the burden of neurological diseases for individuals worldwide. This report provides a summary of the presentations and discussions held during the workshop, showcasing the collective efforts and progress made by the participants.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 Suppl 1 ","pages":"31"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat. 神经性疼痛模型大鼠杏仁核中央核对有害和非有害机械刺激的血清素释放反应的改变。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00910-x

Ryota Tokunaga, Hideshi Shibata, Mieko Kurosawa

引用次数: 0

An interactive simulator to deepen the understanding of Guyton's venous return curve. 交互式模拟器加深对盖顿静脉回流曲线的理解。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-01-01 Epub Date: 2025-01-02 DOI: 10.1186/s12576-024-00912-9

Noritaka Mamorita, Akihiro Takeuchi, Hirotoshi Kamata

{"title":"An interactive simulator to deepen the understanding of Guyton's venous return curve.","authors":"Noritaka Mamorita, Akihiro Takeuchi, Hirotoshi Kamata","doi":"10.1186/s12576-024-00912-9","DOIUrl":"https://doi.org/10.1186/s12576-024-00912-9","url":null,"abstract":"Mean circulatory filling pressure, venous return curve, and Guyton's graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or understand them adequately. To deepen students' understanding of the graphical analysis, in place of having to perform live animal experiments, we developed an interactive cardiovascular simulator, as a self-learning tool, as a web application. The minimum closed-loop model consisted of a ventricle, an artery, resistance, and a vein, excluding venous resistance. The simulator consists of three modules: setting (parameters and simulation modes), calculation, and presentation. In the setting module, the user can interactively customize model parameters, compliances, resistance, Emax of the ventricular contractility, total blood volume, and unstressed volume. The hemodynamics are calculated in three phases: filling (late diastole), ejection (systole), and flow (early diastole). In response to the user's settings, the simulator graphically presents the hemodynamics: the pressure-volume relations of the artery, vein, and ventricle, the venous return curves, and the stroke volume curves. The mean filling pressure is calculated at approximately 7 mmHg at the initial setting. The venous return curves, linear and concave, are dependent on the venous compliance. The hemodynamic equilibrium point is marked on the crossing point of venous return curve and the stroke volume curve. Users can interactively do discovery learning, and try and confirm their interests and get their questions answered about hemodynamic concepts by using the simulator.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"21"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0