Journal of Physiological Sciences最新文献_第2页

The difference in arterial baroreflex sensitivity between the supine and standing positions in healthy subjects.

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI: 10.1016/j.jphyss.2025.100006

Teruhiko Sakamoto, Satoshi Mitsuyama, Toru Nagasawa, Kazuomi Kario, Seiji Ozawa

引用次数: 0

Rebastinib inhibits FoxO1 activity and reduces dexamethasone-induced atrophy and its-related gene expression in cultured myotubes.

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI: 10.1016/j.jphyss.2025.100012

Tomoki Sato, Akihito Morita, Yui Watanabe, Yumi Naito, Haruka Kawaji, Takumi Nakagawa, Hiroki Hamaguchi, Yasuko Manabe, Nobuharu L Fujii, Naohisa Ogo, Akira Asai, Yasutomi Kamei, Shinji Miura

{"title":"Rebastinib inhibits FoxO1 activity and reduces dexamethasone-induced atrophy and its-related gene expression in cultured myotubes.","authors":"Tomoki Sato, Akihito Morita, Yui Watanabe, Yumi Naito, Haruka Kawaji, Takumi Nakagawa, Hiroki Hamaguchi, Yasuko Manabe, Nobuharu L Fujii, Naohisa Ogo, Akira Asai, Yasutomi Kamei, Shinji Miura","doi":"10.1016/j.jphyss.2025.100012","DOIUrl":"10.1016/j.jphyss.2025.100012","url":null,"abstract":"FoxO1, a transcription factor, is upregulated in skeletal muscle during atrophy and inactivation of FoxO1 is a potential strategy to prevent muscle loss. This study identified Rebastinib as a potent suppressor of FoxO1 activity among protein kinase inhibitors. To determine whether Rebastinib inhibits atrophy-related ubiquitin ligases gene expression and mitigates atrophy in mouse skeletal muscle-derived cells, we investigated its protective effects of the compound against dexamethasone (DEX)-induced muscle atrophy using C2C12 myotubes. Rebastinib inhibited the DEX-induced upregulation of atrogin-1 and MuRF-1 mRNA, and atrogin-1 protein. Rebastinib also suppressed protein degradation and increased myotube diameter in DEX-treated C2C12 myotubes. Additionally, Rebastinib ameliorated the DEX- and cachexia-induced reduction in contractile force generation. Although the precise mechanisms underlying the action of Rebastinib against muscle atrophy and its efficacy in vivo remains to be elucidated, this compound shows great potential as a therapeutic agent for muscle atrophy.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100012"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-06 DOI: 10.1016/j.jphyss.2025.100014

Kosuke Horii, Katsushige Ono, Tomoko Sumi, Mayo Higashihara, Nobuhiro Zaima, Seiji Masuda, Masaki Morishima

{"title":"Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.","authors":"Kosuke Horii, Katsushige Ono, Tomoko Sumi, Mayo Higashihara, Nobuhiro Zaima, Seiji Masuda, Masaki Morishima","doi":"10.1016/j.jphyss.2025.100014","DOIUrl":"10.1016/j.jphyss.2025.100014","url":null,"abstract":"There is growing evidence that eicosapentaenoic acid (EPA) uptake has beneficial effects on various cardiovascular diseases. However, electrophysiological actions of EPA remain poorly documented. To investigate the potential antiarrhythmic effects of EPA, mice were fed a high-fat diet (HFD) or an HFD supplemented with EPA for eight weeks. Electrocardiogram (ECG) recordings in combined with esophageal electrical stimulation revealed that HFD-fed mice exhibited bradycardia, reduced P-wave amplitude, and prolonged P-wave duration. Atrial fibrillation (AF) was induced in 100 % of HFD mice, which was only in 50 % of EPA-supplemented mice with significantly shorter durations. HFD-fed mice showed decreased expression of Cav1.2-mRNA, increased expression of Kv1.5-mRNA, elevated expression of inflammatory cytokines (IL-1β, TNF-α, and IL-10), and larger fibrotic area in atrial tissue, which were all reversed by EPA supplementation. These findings suggest that long-term dietary intake of EPA may help maintain normal atrial function and structure, thereby reducing the risk of AF.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100014"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermosensitive TRPM2: The regulatory mechanisms of its temperature sensitivity and physiological functions.

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1016/j.jphyss.2025.100008

Makiko Kashio

引用次数: 0

Single acupressure on ST36 does not modulate skin blood flow and sympathetic nerve activity during and after cold stimulation of the hand.

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-08 DOI: 10.1016/j.jphyss.2025.100011

Hironori Watanabe, Mitsuko Hanaoka, Taisuke Sugi, Yuta Masuda, Kei Nagashima

{"title":"Single acupressure on ST36 does not modulate skin blood flow and sympathetic nerve activity during and after cold stimulation of the hand.","authors":"Hironori Watanabe, Mitsuko Hanaoka, Taisuke Sugi, Yuta Masuda, Kei Nagashima","doi":"10.1016/j.jphyss.2025.100011","DOIUrl":"10.1016/j.jphyss.2025.100011","url":null,"abstract":"Acupressure on ST36 (Zusanli), located on the lower leg, commonly used to optimize autonomic nerve activity and systemic blood flow in traditional Chinese medicine. However, its efficacy remains controversial. This study hypothesized that a single acupressure on ST36 attenuates sympathetic nerve activity and mitigate skin vasoconstriction in response to cold stimulation. Twelve participants received either 5-min acupressure or sham pressure in the right ST36; subsequently, their left hand was immersed in cold water (10°C) for 10 min. Heart rate (HR), arterial pressure, skin temperature, and blood flow in both fingers were monitored. Autonomic nerve activity was assessed by HR variability. Water immersion decreased skin temperature and blood flow in both fingers with an increase in arterial pressure. However, there were no differences in these values or HR variability between the acupressure and sham trials. Acupressure on ST36 affected neither sympathetic nerve activity nor skin vasoconstrictive response during cold-water immersion.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100011"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPA1 and thermosensitivity.

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1016/j.jphyss.2025.100010

Makoto Tominaga, Moe Iwata

引用次数: 0

Enhanced cardiac vagal activity and mood after low-dose hypoxic gas inhalation in healthy young adults. 健康年轻人吸入低剂量低氧气体后心脏迷走神经活动和情绪增强。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1016/j.jphyss.2024.100002

Dongmin Lee, Yudai Yamazaki, Ryuta Kuwamizu, Naoki Aoike, Masahiro Okamoto, Morimasa Kato, Hideaki Soya

{"title":"Enhanced cardiac vagal activity and mood after low-dose hypoxic gas inhalation in healthy young adults.","authors":"Dongmin Lee, Yudai Yamazaki, Ryuta Kuwamizu, Naoki Aoike, Masahiro Okamoto, Morimasa Kato, Hideaki Soya","doi":"10.1016/j.jphyss.2024.100002","DOIUrl":"10.1016/j.jphyss.2024.100002","url":null,"abstract":"Developing strategies to enhance cardiac vagal activity (CVA) is essential for improving mood and managing stress. Although hypoxia inhalation may boost CVA, the optimal acute hypoxic conditions remain unclear. Therefore, we aimed to achieve a comprehensive understanding of the hypoxic conditions required to improve CVA and mood following hypoxia. Twenty-one healthy adults participated in both normobaric hypoxic (NH; FIO2: 13.5 %) and normoxic (NN; FIO2: 20.9 %) conditions. We monitored heart rate variability (HRV), percutaneous oxygen saturation (SpO2), and mood across pre-, hypoxia, and post-sessions and assessed psychophysiological stress using the Baevsky Stress Index (SI). Under hypoxia, SpO2 decreased to 88.1 %, accompanied by reductions in vagally-mediated HRV, followed by supercompensation post-hypoxia. Additionally, mood declined during hypoxia but rapidly rebounded, correlating with CVA and SI fluctuations. These results indicate that acute low-dose hypoxic gas inhalation at FIO2: 13.5 % enhances CVA and mood post-hypoxia, offering a practical method for building resilience.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100002"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effects of fenestration in Fontan circulation using a lumped parameter model. 用集总参数模型评价开窗对方潭循环的影响。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-12-21 DOI: 10.1186/s12576-024-00947-y

Naohiro Horio, Shuji Shimizu, Yasuhiro Kotani, Yoshinori Miyahara, Shingo Kasahara

{"title":"Evaluation of the effects of fenestration in Fontan circulation using a lumped parameter model.","authors":"Naohiro Horio, Shuji Shimizu, Yasuhiro Kotani, Yoshinori Miyahara, Shingo Kasahara","doi":"10.1186/s12576-024-00947-y","DOIUrl":"10.1186/s12576-024-00947-y","url":null,"abstract":"Fenestration has been reported to enhance Fontan hemodynamics in several cases of Fontan circulation. However, the indication criteria for fenestration remain under discussion. To assess the effectiveness of fenestration in Fontan circulation, we conducted a theoretical analysis using a computational model of the fenestrated Fontan circulation. The cardiac chambers and vascular systems were modeled using the time-varying elastance model and the modified Windkessel model, respectively. When the pulmonary vascular resistance index was 4.01 Wood units m2, fenestration significantly reduced central venous pressure from 18.0 to 16.1 mmHg and decreased stressed blood volume from 610 to 555 ml. However, in the models with reduced ventricular end-systolic elastance, increased ventricular stiffness constant, or heightened systemic vascular resistance, the advantages of fenestration were diminished. Thus, fenestration may effectively improve the hemodynamics of Fontan circulation in patients with elevated pulmonary vascular resistance.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"58"},"PeriodicalIF":2.6,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential role of exercise in mitigating fertility toxicity associated with immune checkpoint inhibitors (ICIs) in cancer patients. 运动在减轻癌症患者与免疫检查点抑制剂（ICIs）相关的生育毒性中的潜在作用

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-11-30 DOI: 10.1186/s12576-024-00950-3

Parivash Jamrasi, Mia Tazi, Nur Afiqah Zulkifli, Jun Hyun Bae, Wook Song

{"title":"The potential role of exercise in mitigating fertility toxicity associated with immune checkpoint inhibitors (ICIs) in cancer patients.","authors":"Parivash Jamrasi, Mia Tazi, Nur Afiqah Zulkifli, Jun Hyun Bae, Wook Song","doi":"10.1186/s12576-024-00950-3","DOIUrl":"10.1186/s12576-024-00950-3","url":null,"abstract":"Over the last decade, therapeutic advances in cancer immunotherapy have rapidly progressed, leading to an expansion of clinical trials and the development of novel immune checkpoint inhibitors (ICIs) and combination treatments. While ICIs offer substantial clinical benefits, they are also associated with various side effects, notably concerning endocrine function and potential gonadal damage following the initiation of immunotherapy. Exercise has demonstrated promise in enhancing treatment efficacy, including symptom reduction in cancer patients. Research has also established the benefits of exercise in managing fertility and reproductive health. However, there is limited data on the effectiveness of exercise in mitigating fertility-related side effects specifically in patients undergoing ICIs therapy. Given that a significant number of cancer patients are of reproductive age, it is crucial to address potential sexual side effects and offer fertility preservation options. Ensuring that patients are well-informed and supported in their reproductive health decisions is vital. This review reports the prevalence of immune-related adverse effects linked to fertility in cancer patients undergoing ICIs, explores the potential mechanisms by which ICIs may impact reproductive health, and emphasizes the role of exercise in mitigating these adverse effects.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"57"},"PeriodicalIF":2.6,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Age-related alteration of the involvement of CD36 for salivary secretion from the parotid gland in mice. 更正：CD36参与小鼠腮腺唾液分泌与年龄有关。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-11-27 DOI: 10.1186/s12576-024-00945-0

Keitaro Satoh, Yuta Ohno, Haruna Nagase, Masanori Kashimata, Kazunori Adachi

引用次数: 0