Journal of Physiological Sciences最新文献_第3页

Promoting arousal associated with physical activity with the vitamin B₁ derivative TTFD.

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-11-26 DOI: 10.1016/j.jphyss.2024.100001

Toshiaki Hata, François Grenier, Taichi Hiraga, Mariko Soya, Masahiro Okamoto, Hideaki Soya

{"title":"Promoting arousal associated with physical activity with the vitamin B1 derivative TTFD.","authors":"Toshiaki Hata, François Grenier, Taichi Hiraga, Mariko Soya, Masahiro Okamoto, Hideaki Soya","doi":"10.1016/j.jphyss.2024.100001","DOIUrl":"https://doi.org/10.1016/j.jphyss.2024.100001","url":null,"abstract":"Physical inactivity, which is a global issue, reduces physical and mental vitality, particularly impairing prefrontal-cortex-based mental health. This may trigger social withdrawal and depression, hindering the ability to have an active lifestyle. However, we have identified a beneficial agent, a vitamin B1 derivative called thiamine tetrahydrofurfuryl disulfide (TTFD), that enhances physical activity through dopaminergic regulation in the medial prefrontal cortex (mPFC) of rats. Since the brain dopaminergic system also regulates the sleep-wake cycle via the ascending arousal system, we postulated that TTFD may promote arousal. To test this, we performed electroencephalograms and electromyograms in rats, monitoring their physical activity and sleep-wake cycles after TTFD injection. Analysis revealed that TTFD acutely promotes arousal, reduces slow-wave sleep (SWS) and rapid eye movement (REM) sleep, and promotes increased physical activity. TTFD not only promotes physical activity but also increases arousal, thereby potentially contributing to enhanced mental health.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 1","pages":"100001"},"PeriodicalIF":2.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPV4 activation by core body temperature has multimodal functions in the central nervous system. 核心体温激活的 TRPV4 在中枢神经系统中具有多模式功能。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-11-22 DOI: 10.1186/s12576-024-00948-x

Koji Shibasaki

{"title":"TRPV4 activation by core body temperature has multimodal functions in the central nervous system.","authors":"Koji Shibasaki","doi":"10.1186/s12576-024-00948-x","DOIUrl":"10.1186/s12576-024-00948-x","url":null,"abstract":"Brain temperature is strictly regulated by various endogenous mechanisms and significantly contributes to brain function in homeothermic animals, making it an important factor for health. Thermosensitive transient receptor potential (TRP) channels convert temperature information into electrical signals through cation influx. In particular, TRPV4 is involved in the regulation of brain function. TRPV4, constitutively active in neurons through its activation by brain temperature, increases neuronal firing. TRPV4KO mice have electroencephalogram abnormalities, resulting in depression-like and social behavioral abnormalities. This basic function of TRPV4, as a translator of brain temperature information, has been implicated in several diseases, including epilepsy and stress-induced depression. In addition to its neuronal functions, TRPV4 has many key functions in glia and vasculature that depend on brain temperature and contribute to brain activity. In this review, I summarize the importance of TRPV4 activities in relation to brain temperature and focus on how hyperthermia-induced TRPV4 dysfunction exacerbates brain diseases.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"55"},"PeriodicalIF":2.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats. 通过腰骶部排便中枢作用的胃泌素激动剂对大鼠促排便作用的性别双态性。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-11-22 DOI: 10.1186/s12576-024-00949-w

Shumpei Tsukamoto, Tomoya Sawamura, Natsufu Yuki, Kazuhiro Horii, Yuuki Horii, Takeshi Homma, Shouichiro Saito, Takahiko Shiina, Yasutake Shimizu

{"title":"Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats.","authors":"Shumpei Tsukamoto, Tomoya Sawamura, Natsufu Yuki, Kazuhiro Horii, Yuuki Horii, Takeshi Homma, Shouichiro Saito, Takahiko Shiina, Yasutake Shimizu","doi":"10.1186/s12576-024-00949-w","DOIUrl":"10.1186/s12576-024-00949-w","url":null,"abstract":"We investigated the effects of a centrally penetrant ghrelin agonist, RQ-00538053, on colorectal motility in female rats in comparison with that in male rats. Intravenous administration of RQ-00538053 enhanced colorectal motility in female rats. However, approximately tenfold higher doses were required to induce responses in female rats similar to those in male rats. Higher doses were required even when the agonist was intrathecally administered to the lumbosacral spinal cord in female rats. The results of RT-qPCR showed that the level of ghrelin receptor expression in the lumbosacral spinal cord was lower in female rats than in male rats, suggesting that the lower expression level of the receptor may contribute, at least in part, to the sex differences in the action of RQ-00538053. The sexually dimorphic action of a ghrelin agonist will be important for future works aiming to utilize ghrelin agonists as novel drugs to improve constipation.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"54"},"PeriodicalIF":2.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of systemic ventricular assist in failing Fontan patients: a theoretical analysis using a computational model. 全身性心室辅助对 Fontan 衰竭患者的影响：利用计算模型进行的理论分析。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-11-02 DOI: 10.1186/s12576-024-00946-z

Eiri Kisamori, Yasuhiro Kotani, Toshiaki Shishido, Shingo Kasahara, Shuji Shimizu

{"title":"Effects of systemic ventricular assist in failing Fontan patients: a theoretical analysis using a computational model.","authors":"Eiri Kisamori, Yasuhiro Kotani, Toshiaki Shishido, Shingo Kasahara, Shuji Shimizu","doi":"10.1186/s12576-024-00946-z","DOIUrl":"10.1186/s12576-024-00946-z","url":null,"abstract":"Mechanical circulatory support is a potential treatment for failing Fontan patients. In this study, we performed a theoretical analysis using a computational model to clarify the effects of systemic ventricular assist device (VAD) in failing Fontan patients. Cardiac chambers and vascular systems were described using the time-varying elastance model and modified Windkessel model, respectively. A VAD was simulated as a nonlinear function. In systolic and diastolic ventricular dysfunction and atrioventricular valve regurgitation models, systemic VAD increased the cardiac index and decreased the central venous pressure (CVP). However, in the high pulmonary vascular resistance model, CVP became extremely high above 15 mmHg to maintain the cardiac index when the pulmonary vascular resistance index (PVRI) was above 5 Wood units m2. In Fontan patients with ventricular dysfunction or atrioventricular valve regurgitation, systemic VAD efficiently improves the hemodynamics. In Fontan patients with PVRI of > 5 Wood units m2, systemic VAD seems ineffective.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"53"},"PeriodicalIF":2.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADAM8 promotes alcoholic liver fibrosis through the MAPK signaling pathway. ADAM8 通过 MAPK 信号通路促进酒精性肝纤维化。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-10-16 DOI: 10.1186/s12576-024-00943-2

Mengli Yang, Sanqiang Li, Renli Luo, Yadi Zhao, Yue Sun, Haoyuan Li, Qinyi Cui, Junfei Wu, Longfei Mao

{"title":"ADAM8 promotes alcoholic liver fibrosis through the MAPK signaling pathway.","authors":"Mengli Yang, Sanqiang Li, Renli Luo, Yadi Zhao, Yue Sun, Haoyuan Li, Qinyi Cui, Junfei Wu, Longfei Mao","doi":"10.1186/s12576-024-00943-2","DOIUrl":"https://doi.org/10.1186/s12576-024-00943-2","url":null,"abstract":"The effect and molecular regulatory mechanism of A Disintegrin and Metalloproteinase 8 (ADAM8) were explored in alcoholic liver fibrosis (ALF). C57BL/6N male mice were randomly divided into control, alcohol, and ADAM8-sgRNA3 plasmid groups. The control group received control liquid diet, while the alcohol and ADAM8-sgRNA3 plasmid groups were given alcohol liquid feed diet combined with ethanol gavage treatment for 8 weeks to induce ALF modeling. In addition, the ADAM8-sgRNA3 plasmid group was injected with the effective ADAM8-sgRNA3 plasmid, while the alcohol and control group mice were injected with an equivalent amount of physiological saline. LX-2 human hepatic stellate cells were divided into control, alcohol, si-ADAM8-2, and si-ADAM8-NC groups and induced for 48 h for model establishment in vitro. Serological detection, pathological staining, Western blotting, qRT-PCR and CCK8 assay were performed for experiments. Compared with the alcohol group, ADAM8 mRNA, protein and, positive area rate, serological indicators, pathological changes, and the expression of liver fibrosis marker and MAPK signaling pathway-related factors in the ADAM8-sgRNA3 plasmid group significantly decreased in vivo. Compared with the alcohol group, ADAM8 mRNA and protein expression, cell viability, and the expression of liver fibrosis markers and MAPK signaling pathway-related factors (p-ERK1/2, PCNA, Bcl-2, p-c-Jun, TGFβ1, p-p38 MAPK and HSP27) reduced significantly in the si-ADAM8-2 group. Therefore, ADAM8 promotes ALF through the MAPK signaling pathway, a promising target for treating ALF.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"52"},"PeriodicalIF":2.6,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced glycation end products promote ROS production via PKC/p47 phox axis in skeletal muscle cells. 高级糖化终产物通过 PKC/p47 phox 轴促进骨骼肌细胞产生 ROS。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-10-05 DOI: 10.1186/s12576-024-00944-1

Shinichiro Suzuki, Tatsuya Hayashi, Tatsuro Egawa

引用次数: 0

Thermosensing ability of TRPC5: current knowledge and unsettled questions. TRPC5 的热感应能力：现有知识和悬而未决的问题。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-10-03 DOI: 10.1186/s12576-024-00942-3

Alexandra Ptakova, Viktorie Vlachova

引用次数: 0

Acupuncture improves spatial learning and memory impairment caused by herpes simplex virus type-1 in rats through the p38 MAPK/CREB pathway. 针灸可通过 p38 MAPK/CREB 通路改善 1 型单纯疱疹病毒导致的大鼠空间学习和记忆损伤。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-10-03 DOI: 10.1186/s12576-024-00941-4

Hongjiao Jin, Rui Huang, Zhu Li, Mi Liu, Ning Zhao, Haiyan Zhang, Yong Lin

{"title":"Acupuncture improves spatial learning and memory impairment caused by herpes simplex virus type-1 in rats through the p38 MAPK/CREB pathway.","authors":"Hongjiao Jin, Rui Huang, Zhu Li, Mi Liu, Ning Zhao, Haiyan Zhang, Yong Lin","doi":"10.1186/s12576-024-00941-4","DOIUrl":"10.1186/s12576-024-00941-4","url":null,"abstract":"Background: Acupuncture can improve herpes simplex encephalitis (HSE), but the underlying mechanism is not clear. Therefore, we evaluated the cognitive function and apoptosis in hippocampus caused by herpes simplex virus type-1 (HSV-1) in rats after acupuncture and described the molecular mechanism.Methods: Sprague-Dawley rats were induced into HSE models by HSV-1 infection. After 3 days, they received acupuncture at the acupoints of Xuanzhong (GB39), Baihui (GV20), Shenmen (HT7), Shenting (GV24), and Sanyinjiao (SP6), and/or intraperitoneal injection of the p38 MAPK inhibitor SB203580. Morris water maze test was performed on rats. The hippocampus of rats was obtained, and the expression of apoptosis-related genes in the tissues was detected by qRT-PCR. In addition, apoptosis-related proteins and proteins related to the p38 MAPK/CREB pathway in the tissues was detected by western blot.Results: After HSV-1 induction, the rat's escape latency was increased, the time spent on the platform in the target quadrant and the number of platform crossings significantly decreased. In addition, there was an increase in apoptosis in the hippocampus, accompanied by elevated levels of p-p38 and decreased levels of p-CREB. However, these effects could be improved by acupuncture treatment. Interestingly, SB203580 plays a similar role to acupuncture, and acupuncture could further enhance the impacts of SB203580 on cognitive function and apoptosis in hippocampus in HSE rats.Conclusion: Acupuncture improves spatial learning and memory impairment caused by HSV-1 in rats. The functional mechanism of acupuncture may be through the p38 MAPK/CREB pathway.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"49"},"PeriodicalIF":2.6,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11448188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute effects of empagliflozin on open-loop baroreflex function and urine output in streptozotocin-induced type 1 diabetic rats. empagliflozin对链脲佐菌素诱导的1型糖尿病大鼠开环气压反射功能和尿量的急性影响

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-09-28 DOI: 10.1186/s12576-024-00938-z

Toru Kawada, Hiromi Yamamoto, Masafumi Fukumitsu, Takuya Nishikawa, Hiroki Matsushita, Yuki Yoshida, Kei Sato, Hidetaka Morita, Joe Alexander, Keita Saku

{"title":"Acute effects of empagliflozin on open-loop baroreflex function and urine output in streptozotocin-induced type 1 diabetic rats.","authors":"Toru Kawada, Hiromi Yamamoto, Masafumi Fukumitsu, Takuya Nishikawa, Hiroki Matsushita, Yuki Yoshida, Kei Sato, Hidetaka Morita, Joe Alexander, Keita Saku","doi":"10.1186/s12576-024-00938-z","DOIUrl":"https://doi.org/10.1186/s12576-024-00938-z","url":null,"abstract":"Although sympathetic suppression is considered one of the mechanisms for cardioprotection afforded by sodium-glucose cotransporter 2 (SGLT2) inhibitors, whether SGLT2 inhibition acutely modifies sympathetic arterial pressure (AP) regulation remains unclear. We examined the acute effect of an SGLT2 inhibitor, empagliflozin (10 mg/kg), on open-loop baroreflex static characteristics in streptozotocin (STZ)-induced type 1 diabetic and control (CNT) rats (n = 9 each). Empagliflozin significantly increased urine flow [CNT: 25.5 (21.7-31.2) vs. 55.9 (51.0-64.5), STZ: 83.4 (53.7-91.7) vs. 121.2 (57.0-136.0) μL·min-1·kg-1, median (1st-3rd quartiles), P < 0.001 for empagliflozin and STZ]. Empagliflozin decreased the minimum sympathetic nerve activity (SNA) [CNT: 15.7 (6.8-18.4) vs. 10.5 (2.9-19.0), STZ: 36.9 (25.7-54.9) vs. 32.8 (15.1-37.5) %, P = 0.021 for empagliflozin and P = 0.003 for STZ], but did not significantly affect the peripheral arc characteristics assessed by the SNA-AP relationship. Despite the significant increase in urine flow and changes in several baroreflex parameters, empagliflozin preserved the overall sympathetic AP regulation in STZ-induced diabetic rats. The lack of a significant change in the peripheral arc may minimize reflex sympathetic activation, thereby enhancing a cardioprotective benefit of empagliflozin.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"48"},"PeriodicalIF":2.6,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anekomochi glutinous rice provides low postprandial glycemic response by enhanced insulin action via GLP-1 release and vagal afferents activation. Anekomochi 糯米通过释放 GLP-1 和激活迷走神经传入增强胰岛素作用，从而降低餐后血糖反应。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2024-09-27 DOI: 10.1186/s12576-024-00940-5

Kento Ohbayashi, Yudai Sugiyama, Taichi Nohmi, Kazusa Nishimura, Tetsuya Nakazaki, Yo-Ichiro Sato, Takehiro Masumura, Yusaku Iwasaki

{"title":"Anekomochi glutinous rice provides low postprandial glycemic response by enhanced insulin action via GLP-1 release and vagal afferents activation.","authors":"Kento Ohbayashi, Yudai Sugiyama, Taichi Nohmi, Kazusa Nishimura, Tetsuya Nakazaki, Yo-Ichiro Sato, Takehiro Masumura, Yusaku Iwasaki","doi":"10.1186/s12576-024-00940-5","DOIUrl":"https://doi.org/10.1186/s12576-024-00940-5","url":null,"abstract":"Glutinous rice (mochi rice), compared to non-glutinous rice (uruchi rice), exhibits a wide range of glycemic index (GI) values, from low to high. However, the underlying mechanisms behind the variation in GI values remain poorly understood. In this study, we aimed to identify rice cultivars with a low postprandial glycemic response and investigate the mechanisms, focusing on insulin and incretin hormones. We examined seven glutinous rice cultivars and three non-glutinous rice cultivars. We discovered that Anekomochi, a glutinous rice cultivar, has the lowest postprandial glycemic response. Anekomochi significantly enhanced glucagon-like peptide-1 (GLP-1) secretion while suppressing insulin secretion. These effects were completely blunted by inhibiting GLP-1 receptor signaling and denervating the common hepatic branch of vagal afferent nerves that are crucial for sensing intestinal GLP-1. Our findings demonstrate that Anekomochi markedly enhances insulin action via GLP-1 release and vagal afferent neural pathways, thereby leading to a lower postprandial glycemic response.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"74 1","pages":"47"},"PeriodicalIF":2.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0