{"title":"C-fiber-related brain responses evoked by laser heat pulses applied to the back.","authors":"Benjamin Provencher, Mathieu Piché","doi":"10.1016/j.jphyss.2025.100018","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of the present study was to examine C-fiber-related brain responses evoked by laser heat stimuli applied to the lumbar area, and to determine the stimulation protocol that produces the most reliable responses. Thirty healthy volunteers completed the study. Combinations of different stimuli (single pulses or trains of three pulses) with different pulse durations (7 or 14 ms) were used to compare C-fiber-related brain responses between protocols. The four protocols elicited comparable C-fiber-related brain responses to laser heat pulses. However, pulse trains of 7 ms pulses at 0.67 Hz elicited C-LEPs in the greatest proportion of participants (86.7 %). C-LEPs occurred within a 500 ms to 1500 ms post-stimulus time window, consistent with the perception associated with C-fiber activation. These results provide novel data on C-fiber-related brain responses to painful stimuli and a reliable stimulation protocol for future studies on low back pain.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100018"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physiological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jphyss.2025.100018","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of the present study was to examine C-fiber-related brain responses evoked by laser heat stimuli applied to the lumbar area, and to determine the stimulation protocol that produces the most reliable responses. Thirty healthy volunteers completed the study. Combinations of different stimuli (single pulses or trains of three pulses) with different pulse durations (7 or 14 ms) were used to compare C-fiber-related brain responses between protocols. The four protocols elicited comparable C-fiber-related brain responses to laser heat pulses. However, pulse trains of 7 ms pulses at 0.67 Hz elicited C-LEPs in the greatest proportion of participants (86.7 %). C-LEPs occurred within a 500 ms to 1500 ms post-stimulus time window, consistent with the perception associated with C-fiber activation. These results provide novel data on C-fiber-related brain responses to painful stimuli and a reliable stimulation protocol for future studies on low back pain.
期刊介绍：
The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound.
Fields covered:
Adaptation and environment
Autonomic nervous function
Biophysics
Cell sensors and signaling
Central nervous system and brain sciences
Endocrinology and metabolism
Excitable membranes and neural cell physiology
Exercise physiology
Gastrointestinal and kidney physiology
Heart and circulatory physiology
Molecular and cellular physiology
Muscle physiology
Physiome/systems biology
Respiration physiology
Senses.
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