{"title":"延伸波沿肌纤维的传播源于端板区域的早期局部收缩。","authors":"Tomonori Hayashi, Naoya Nakahara, Shigeru Morimoto, Maki Yamaguchi, Kazuhiro Hirano, Shigeru Takemori","doi":"10.1016/j.jphyss.2025.100023","DOIUrl":null,"url":null,"abstract":"<p><p>We investigated the propagation of extending waves along twitching muscle fibers triggered by the internal shortening of early local contraction in the end-plate region. Bullfrog sartorius muscles were minimally stimulated, and the displacement of carbon particles attached to the muscle surface was captured using a high-speed camera. We found an extending wave along the fiber at a velocity of 5.35 ± 0.33 m·s⁻¹, faster than the conduction of action potentials at 3.04 ± 0.31 m·s⁻¹. Local compression of the muscle surface blocked the propagation of the extending wave, indicating its mechanical nature. Muscle stretching increased the extending wave velocity. These findings provide direct evidence that mechanically transmitted extending waves originate from early local contractions in the end-plate region and propagate along muscle fibers ahead of the contraction wave.</p>","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100023"},"PeriodicalIF":2.6000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Extending wave propagation along muscle fibers originates from early local contraction at the end-plate region.\",\"authors\":\"Tomonori Hayashi, Naoya Nakahara, Shigeru Morimoto, Maki Yamaguchi, Kazuhiro Hirano, Shigeru Takemori\",\"doi\":\"10.1016/j.jphyss.2025.100023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We investigated the propagation of extending waves along twitching muscle fibers triggered by the internal shortening of early local contraction in the end-plate region. Bullfrog sartorius muscles were minimally stimulated, and the displacement of carbon particles attached to the muscle surface was captured using a high-speed camera. We found an extending wave along the fiber at a velocity of 5.35 ± 0.33 m·s⁻¹, faster than the conduction of action potentials at 3.04 ± 0.31 m·s⁻¹. Local compression of the muscle surface blocked the propagation of the extending wave, indicating its mechanical nature. Muscle stretching increased the extending wave velocity. These findings provide direct evidence that mechanically transmitted extending waves originate from early local contractions in the end-plate region and propagate along muscle fibers ahead of the contraction wave.</p>\",\"PeriodicalId\":16832,\"journal\":{\"name\":\"Journal of Physiological Sciences\",\"volume\":\"75 2\",\"pages\":\"100023\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-05-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Physiological Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jphyss.2025.100023\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physiological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jphyss.2025.100023","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Extending wave propagation along muscle fibers originates from early local contraction at the end-plate region.
We investigated the propagation of extending waves along twitching muscle fibers triggered by the internal shortening of early local contraction in the end-plate region. Bullfrog sartorius muscles were minimally stimulated, and the displacement of carbon particles attached to the muscle surface was captured using a high-speed camera. We found an extending wave along the fiber at a velocity of 5.35 ± 0.33 m·s⁻¹, faster than the conduction of action potentials at 3.04 ± 0.31 m·s⁻¹. Local compression of the muscle surface blocked the propagation of the extending wave, indicating its mechanical nature. Muscle stretching increased the extending wave velocity. These findings provide direct evidence that mechanically transmitted extending waves originate from early local contractions in the end-plate region and propagate along muscle fibers ahead of the contraction wave.
期刊介绍:
The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound.
Fields covered:
Adaptation and environment
Autonomic nervous function
Biophysics
Cell sensors and signaling
Central nervous system and brain sciences
Endocrinology and metabolism
Excitable membranes and neural cell physiology
Exercise physiology
Gastrointestinal and kidney physiology
Heart and circulatory physiology
Molecular and cellular physiology
Muscle physiology
Physiome/systems biology
Respiration physiology
Senses.