Influence of endurance versus resistance exercise training on central and peripheral chemoreflexes in young healthy individuals.

IF 2.6 4区 医学 Q2 PHYSIOLOGY
Thalia Babbage, Ana L C Sayegh, Jui-Lin Fan, Nicholas Gant, Julian F R Paton, James P Fisher
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引用次数: 0

Abstract

Heightened central and peripheral chemoreflex sensitivity are associated with poor outcomes, but therapeutic approaches to target them are lacking. Endurance and resistance exercise training improve a multitude of physiological outcomes, but their effects on ventilatory chemoreflex sensitivity are unclear. Accordingly, the cardiorespiratory responses to steady-state isocapnic hypoxia (10 % O2, 5-minutes) and hyperoxic hypercapnic rebreathing (5 % CO2-95 % O2) were compared in endurance, resistance, and untrained groups. Central chemoreflex sensitivity was taken as the slope of the relationship between minute ventilation (V̇E) and end-tidal partial pressure of CO2. Peripheral chemoreflex sensitivity was determined from the absolute increase in V̇E from baseline to peak V̇E expressed relative to the fall in oxygen saturation. Neither central (P = 0.093) nor peripheral (P = 0.847) ventilatory chemoreflex sensitivities were different between groups. Future investigations should seek to understand whether exercise training modality influences central and peripheral chemoreflex sensitivity in older and clinical populations.

耐力和阻力运动训练对年轻健康个体中枢和外周化学反射的影响。
中枢和外周化学反射敏感性增高与预后不良有关,但目前缺乏针对它们的治疗方法。耐力和阻力运动训练改善了许多生理结果,但它们对通气化学反射敏感性的影响尚不清楚。因此,比较了耐力组、阻力组和未训练组对稳态等氧低氧(10% O2, 5分钟)和高氧高碳酸再呼吸(5% co2 - 95% O2)的心肺反应。中心化学反射敏感性取分钟通气量(V (E))与末潮分压CO2之间关系的斜率。外周化学反射敏感性是由相对于血氧饱和度下降的V (E)从基线到峰值的绝对增加来确定的。中央(P = 0.093)和外周(P = 0.847)通气化学反射敏感性组间无差异。未来的研究应寻求了解运动训练方式是否影响老年人和临床人群的中枢和外周化学反射敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
4.30%
发文量
27
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.
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