中国南宁地区健康儿童（0~18 岁）血清 25- 羟维生素 D3 的年龄、季节和性别特异性参考区间。

IF 2.6 4区医学 Q2 PHYSIOLOGY

Journal of Physiological Sciences Pub Date : 2024-01-02 DOI:10.1186/s12576-023-00895-z

Dong-Yi Zhou, Shang-Mou Wei, Chun-Ling Zhu, Yu-Hong Wei, Xiao-Mei Wang, Li-Ling Yi, Si-Tao Yang, Qi-Liu Peng

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引用次数: 0

摘要

建立儿童血清 25- 羟基维生素 D3 [25（OH）D]的特定参考区间（RIs）对于提高佝偻病和生长迟缓等疾病诊断和预后监测的准确性至关重要。该研究纳入了 6627 名健康儿童，以确定中国南宁地区儿童 25（OH）D 的特定参考值。结果表明，血清25（OH）D水平在年龄、季节和性别间存在显著统计学差异，血清25（OH）D的年龄特异性参考值为：0～≤1岁为20.3～53.6 ng/mL，2～≤3岁为18.9～49.6 ng/mL。在春夏和秋冬季，4 ~ ≤ 6 岁儿童血清 25(OH)D 的年龄、季节特异性 RI 分别为 15.8 ~ 42.6 纳克/毫升和 15.2 ~ 37.7 纳克/毫升。7~≤18岁男性和女性血清25（OH）D的年龄、性别相关系数分别为12.1~36.1纳克/毫升和10.8~35.3纳克/毫升。该研究成功地建立了血清25（OH）D的RIs，这可能有助于改善中国南宁地区儿童的疾病诊断和监测。

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Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D₃ for healthy children (0 ~ 18 years old) in Nanning area of China.

Establishing specific reference intervals (RIs) of serum 25-hydroxyvitamin D3 [25(OH)D] for children is essential for improving the accuracy of diagnosis and prognosis monitoring of diseases such as rickets and growth retardation. The study including 6,627 healthy children was conducted to establish specific RIs of 25(OH)D for children in Nanning area of China. The results showed that there were statistically significant differences among age, season, and gender of serum 25(OH)D levels, and the age-specific RIs of serum 25(OH)D were 20.3 ~ 53.6 ng/mL for 0 ~ ≤ 1 year and 18.9 ~ 49.6 ng/mL for 2 ~ ≤ 3 years. The age-, season-specific RIs of serum 25(OH)D for 4 ~ ≤ 6 years in spring-summer and autumn-winter were 15.8 ~ 42.6 ng/mL and 15.2 ~ 37.7 ng/mL, respectively. The age-, gender-specific RIs of serum 25(OH)D for 7 ~ ≤ 18 years for males and females were 12.1 ~ 36.1 ng/mL and 10.8 ~ 35.3 ng/mL, respectively. This study successfully established the RIs of serum 25(OH)D, which may help to improve disease diagnosis and monitoring for children in the Nanning area of China.

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来源期刊

Journal of Physiological Sciences 医学-生理学

CiteScore

4.40

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.