Journal of Physiological Sciences最新文献_第7页

Estrogen-dependent effects of vagotomy and endogenous opioids on temporomandibular joint-responsive neurons in trigeminal subnucleus caudalis. 迷走神经切断术和内源性阿片对三叉神经尾侧亚核颞下颌关节反应神经元的雌激素依赖性影响。

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-11-01 Epub Date: 2025-10-17 DOI: 10.1016/j.jphyss.2025.100046

Akimasa Tashiro, David A Bereiter, Yuna Kani, Yuji Morimoto

{"title":"Estrogen-dependent effects of vagotomy and endogenous opioids on temporomandibular joint-responsive neurons in trigeminal subnucleus caudalis.","authors":"Akimasa Tashiro, David A Bereiter, Yuna Kani, Yuji Morimoto","doi":"10.1016/j.jphyss.2025.100046","DOIUrl":"10.1016/j.jphyss.2025.100046","url":null,"abstract":"Temporomandibular joint (TMJ) disorders are common orofacial pain conditions influenced by multiple factors. This study examined how vagotomy and endogenous opioids affect TMJ-responsive neurons in the trigeminal subnucleus caudalis/cervical junction (Vc/C1-2) in female rats under different estrogen levels. Under low estrogen, cervical vagotomy enhanced TMJ unit responses to levels seen in high estrogen conditions but had no additional effect under high estrogen. Vagotomy did not change chemical stimulation (ATP) thresholds or spontaneous activity, suggesting a central neural mechanism. Responses to mechanical stimulation of the skin over the TMJ were unaffected. Naloxone increased ATP-evoked responses under low estrogen but had no added effect after vagotomy or under high estrogen. Naloxone also did not alter spontaneous activity or mechanical responses. These findings indicate that vagal input and endogenous opioids significantly modulate TMJ neuron activity under low estrogen, while high estrogen levels limit further excitation, implying estrogen-dependent regulation of vagus and opioid effects on Vc/C1-2 neurons.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 3","pages":"100046"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12556235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATF4 transcriptionally activates NUPR1 to promote ferroptosis in chondrocytes and osteoarthritis development. ATF4转录激活NUPR1，促进软骨细胞铁下垂和骨关节炎的发展。

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-11-01 Epub Date: 2025-08-05 DOI: 10.1016/j.jphyss.2025.100039

Chen Kuang, Taiyang Liao, Lishi Jie, Yibao Wei, Deren Liu, Enrui Hu, Liang Ding, Peimin Wang

引用次数: 0

METTL14-mediated m6A modification of DUSP6 mRNA participating in postoperative cognitive dysfunction due to sevoflurane anesthesia. mettl14介导的m6A修饰DUSP6 mRNA参与七氟醚麻醉术后认知功能障碍

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-11-01 Epub Date: 2025-10-25 DOI: 10.1016/j.jphyss.2025.100048

Shengfeng Deng, Guo Mu, Jun Li, Xuan Yu, Qiang Li, Bin Lu

{"title":"METTL14-mediated m6A modification of DUSP6 mRNA participating in postoperative cognitive dysfunction due to sevoflurane anesthesia.","authors":"Shengfeng Deng, Guo Mu, Jun Li, Xuan Yu, Qiang Li, Bin Lu","doi":"10.1016/j.jphyss.2025.100048","DOIUrl":"10.1016/j.jphyss.2025.100048","url":null,"abstract":"Background: To investigate the mechanisms underlying sevoflurane-induced POCD, C57BL/6 J mice and SH-SY5Y cells were treated with sevoflurane for model establishment.Methods: After the treatment with sevoflurane, CCK-8, EdU and flow cytometry were employed to detect cell damage. The levels of N6-methyladenosine (m6A), METTL14 and DUSP6 were determined by qPCR and Western blot. The interaction between METTL14 and DUSP6 was analyzed using RIP-qPCR and Me-RIP methodologies. The cognitive function in mice were assessed by water maze test.Results: After sevoflurane treatment, the cell viability, cell proliferation and METTL14 expression were markedly suppressed, while apoptosis was significantly enhanced. METTL14 overexpression elevated the levels of m6A and DUSP6, increased the binding level of METTL14 to DUSP6 mRNA, reducing damage to cells and cognitive dysfunction of mice. Knockdown of DUSP6 negated the beneficial effects observed with METTL14 overexpression.Conclusion: Sevoflurane induced POCD by regulating METTL14/DUSP6 through m6A methylation.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 3","pages":"100048"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage depletion lowers blood pressure and reduces renal fibrosis progression in existing hypertension mice model. 在高血压小鼠模型中，巨噬细胞消耗降低血压并减缓肾纤维化进展。

IF 3.2 4区医学

Journal of Physiological Sciences Pub Date : 2025-11-01 Epub Date: 2025-10-27 DOI: 10.1016/j.jphyss.2025.100049

Joseph Kasyoki Peter, Ryusuke Umene, Chia-Hsien Wu, Yasuna Nakamura, Norito Washimine, Ryoko Yamamoto, Denis Muriuki, Caroline Ngugi, Kavoo Linge, Joseph K Kweri, Tsuyoshi Inoue

{"title":"Macrophage depletion lowers blood pressure and reduces renal fibrosis progression in existing hypertension mice model.","authors":"Joseph Kasyoki Peter, Ryusuke Umene, Chia-Hsien Wu, Yasuna Nakamura, Norito Washimine, Ryoko Yamamoto, Denis Muriuki, Caroline Ngugi, Kavoo Linge, Joseph K Kweri, Tsuyoshi Inoue","doi":"10.1016/j.jphyss.2025.100049","DOIUrl":"10.1016/j.jphyss.2025.100049","url":null,"abstract":"Uncontrolled hypertension is a global health issue with 40 % of hypertensive patients not achieving blood pressure control with current therapies. Previously, we demonstrated renal macrophage infiltration during hypertension development with macrophage depletion leading to reduced blood pressure and renal fibrosis. However, the effect of macrophage depletion in existing hypertension has not been evaluated. We induced hypertension in mice then depleted macrophages and assessed blood pressure and renal fibrosis. Separately induced hypertension and assessed renal macrophage population and fibrosis early in hypertension. Results showed increased renal macrophage, Acta2 early in hypertension development. Macrophage depletion led to reduced blood pressure in the hypertensive mice, decreased kidney Col1a1, Acta2, Col3a1 and Fn1. This study shows that renal macrophage infiltration and fibrosis begin early in hypertension development and depleting macrophages in hypertension reduces blood pressure and suppress renal fibrosis. This shows macrophages are a potential target in treatment of hypertension.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 3","pages":"100049"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12616062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate changes related to risky selections and outcomes in rat gambling tasks. 大鼠赌博任务中与风险选择和结果相关的心率变化。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-10 DOI: 10.1016/j.jphyss.2025.100022

Fumiya Fukushima, Atsushi Tamura, Nahoko Kuga, Takuya Sasaki

引用次数: 0

Editorial: Special issue on thermosensitive TRP channels. 社论：关于热敏TRP通道的特刊。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-03-29 DOI: 10.1016/j.jphyss.2025.100020

Makoto Tominaga

引用次数: 0

Extending wave propagation along muscle fibers originates from early local contraction at the end-plate region. 延伸波沿肌纤维的传播源于端板区域的早期局部收缩。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.1016/j.jphyss.2025.100023

Tomonori Hayashi, Naoya Nakahara, Shigeru Morimoto, Maki Yamaguchi, Kazuhiro Hirano, Shigeru Takemori

引用次数: 0

Influence of endurance versus resistance exercise training on central and peripheral chemoreflexes in young healthy individuals. 耐力和阻力运动训练对年轻健康个体中枢和外周化学反射的影响。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-15 DOI: 10.1016/j.jphyss.2025.100027

Thalia Babbage, Ana L C Sayegh, Jui-Lin Fan, Nicholas Gant, Julian F R Paton, James P Fisher

{"title":"Influence of endurance versus resistance exercise training on central and peripheral chemoreflexes in young healthy individuals.","authors":"Thalia Babbage, Ana L C Sayegh, Jui-Lin Fan, Nicholas Gant, Julian F R Paton, James P Fisher","doi":"10.1016/j.jphyss.2025.100027","DOIUrl":"10.1016/j.jphyss.2025.100027","url":null,"abstract":"Heightened central and peripheral chemoreflex sensitivity are associated with poor outcomes, but therapeutic approaches to target them are lacking. Endurance and resistance exercise training improve a multitude of physiological outcomes, but their effects on ventilatory chemoreflex sensitivity are unclear. Accordingly, the cardiorespiratory responses to steady-state isocapnic hypoxia (10 % O2, 5-minutes) and hyperoxic hypercapnic rebreathing (5 % CO2-95 % O2) were compared in endurance, resistance, and untrained groups. Central chemoreflex sensitivity was taken as the slope of the relationship between minute ventilation (V̇E) and end-tidal partial pressure of CO2. Peripheral chemoreflex sensitivity was determined from the absolute increase in V̇E from baseline to peak V̇E expressed relative to the fall in oxygen saturation. Neither central (P = 0.093) nor peripheral (P = 0.847) ventilatory chemoreflex sensitivities were different between groups. Future investigations should seek to understand whether exercise training modality influences central and peripheral chemoreflex sensitivity in older and clinical populations.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100027"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xanthine oxidase inhibitor allopurinol preserves cardiac function after experimental malocclusion induced by occlusal disharmony in mice. 黄嘌呤氧化酶抑制剂别嘌呤醇对小鼠咬合不协调所致实验性错颌合的心脏功能有保护作用。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-06-29 DOI: 10.1016/j.jphyss.2025.100029

Takao Mitsubayashi, Kenji Suita, Yoshiki Ohnuki, Misao Ishikawa, Aiko Ito, Ichiro Matsuo, Go Miyamoto, Mariko Abe, Akinaka Morii, Yasumasa Mototani, Megumi Nariyama, Ren Matsubara, Yoshio Hayakawa, Satoshi Okumura

{"title":"Xanthine oxidase inhibitor allopurinol preserves cardiac function after experimental malocclusion induced by occlusal disharmony in mice.","authors":"Takao Mitsubayashi, Kenji Suita, Yoshiki Ohnuki, Misao Ishikawa, Aiko Ito, Ichiro Matsuo, Go Miyamoto, Mariko Abe, Akinaka Morii, Yasumasa Mototani, Megumi Nariyama, Ren Matsubara, Yoshio Hayakawa, Satoshi Okumura","doi":"10.1016/j.jphyss.2025.100029","DOIUrl":"10.1016/j.jphyss.2025.100029","url":null,"abstract":"Oxidative stress caused by poor oral condition is associated with systemic diseases, including cardiovascular disease. In this work, therefore, we examined the effect of allopurinol, an inhibitor of the reactive oxygen species (ROS)-producing enzyme xanthine oxidase, on cardiac dysfunction in our bite-opening (BO) mouse model, in which a suitable appliance is cemented onto the mandibular incisior. After two weeks, we confirmed that cardiac function was significantly decreased in the BO group compared to the control, while allopurinol ameliorated the dysfunction. The impairment of cardiac function in BO mice was associated with increased production of ROS by xanthine oxidase, leading to the activation of calmodulin kinase II, and altered phosphorylation of ryanodine receptor 2 and phospholamban. These changes were also suppressed by allopurinol. Our results suggest that oxidative stress might play an important role in the development of cardiac dysfunction, and further indicate that allopurinol is protective against BO-induced cardiac dysfunction.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100029"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective serotonin reuptake inhibitors (SSRIs) suppress Na⁺- dependent Mg²⁺ efflux in rat ventricular myocytes. 选择性血清素再摄取抑制剂（SSRIs）抑制大鼠心室肌细胞Na+依赖性Mg2+外排。

IF 2.6 4区医学

Journal of Physiological Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-12 DOI: 10.1016/j.jphyss.2025.100025

Michiko Tashiro, Masato Konishi, Hana Inoue, Utako Yokoyama

{"title":"Selective serotonin reuptake inhibitors (SSRIs) suppress Na+- dependent Mg2+ efflux in rat ventricular myocytes.","authors":"Michiko Tashiro, Masato Konishi, Hana Inoue, Utako Yokoyama","doi":"10.1016/j.jphyss.2025.100025","DOIUrl":"10.1016/j.jphyss.2025.100025","url":null,"abstract":"Na+/Mg2+ exchange transport, the Na+ gradient-driven Mg2+ extrusion system, plays a key role in cellular Mg2+ homeostasis. To date, the molecular entity and selective inhibitors of Na+/Mg2+ exchanger have not been fully explored. Intracellular free Mg2+ concentration ([Mg2+]i) was measured in ventricular myocytes acutely isolated from rat hearts. After soaking the cells in high-Mg2+ low-Na+ solution to increase [Mg2+]i, the addition of extracellular Na+ caused a decrease in [Mg2+]i. We analyzed the rate of decrease in [Mg2+]i as Na+/Mg2+ exchange transport activity. The suppression of the rate of decrease in [Mg2+]i caused by sertraline, a selective serotonin reuptake inhibitor (SSRI), was concentration dependent (IC50 8.9 μM) and reversible. Other SSRIs, namely paroxetine and fluvoxamine, were less effective than sertraline. In conclusion, sertraline inhibited Na+/Mg2+ exchange transport more effectively than any previously reported inhibitors of Na+/Mg2+ exchanger. Sertraline could be used as a tool to characterize the functions of Na+/Mg2+ exchanger.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"75 2","pages":"100025"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0