Journal of Perinatology最新文献_第6页

Navigating parental hesitancy in public health: the case for RSV immunization in newborns. 引导父母在公共卫生方面的犹豫：新生儿呼吸道合胞病毒免疫的案例。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-11 DOI: 10.1038/s41372-025-02282-5

Michael K Baumgartner, Gregor Hanslik, Mara Schneider, Manuela Franitza, Michael Schneider, Henrike Rieger, Hans-Christoph von Andrian, Melanie L Conrad, Fabian B Fahlbusch

{"title":"Navigating parental hesitancy in public health: the case for RSV immunization in newborns.","authors":"Michael K Baumgartner, Gregor Hanslik, Mara Schneider, Manuela Franitza, Michael Schneider, Henrike Rieger, Hans-Christoph von Andrian, Melanie L Conrad, Fabian B Fahlbusch","doi":"10.1038/s41372-025-02282-5","DOIUrl":"https://doi.org/10.1038/s41372-025-02282-5","url":null,"abstract":"Respiratory syncytial virus (RSV) poses a significant risk to newborns, particularly during the first months of life, and remains a leading cause of pediatric hospitalization in Germany. Despite the approval of innovative immunoprophylaxis methods like nirsevimab, parental hesitancy persists, driven by knowledge gaps and concerns about safety. This study assesses the healthcare burden of RSV during the 2022/2023 and 2023/2024 seasons and explores parental perspectives on immunization just prior to the widespread availability of nirsevimab in late 2024. Data revealed a significant hospital burden, including rising intensive care admissions requiring respiratory support. A survey conducted in two Bavarian maternity wards found that while 78% of parents were aware of RSV, only 53% supported postnatal immunization. These findings highlight the groundbreaking potential of RSV immunization and underscore the urgent need for targeted communication strategies to address parental concerns to ensure successful implementation of these programs.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and outcomes of preterm infants with early pulmonary hypertension. 早产儿早期肺动脉高压的特点和结局。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-11 DOI: 10.1038/s41372-025-02295-0

Rachel Mullaly, Aisling Smith, Claire Murphy, Seán Armstrong, Orla Franklin, Naomi McCallion, Afif El-Khuffash

{"title":"Characteristics and outcomes of preterm infants with early pulmonary hypertension.","authors":"Rachel Mullaly, Aisling Smith, Claire Murphy, Seán Armstrong, Orla Franklin, Naomi McCallion, Afif El-Khuffash","doi":"10.1038/s41372-025-02295-0","DOIUrl":"https://doi.org/10.1038/s41372-025-02295-0","url":null,"abstract":"Objective: This study investigates incidence, outcomes and echocardiographic characteristics of preterm infants with early pulmonary hypertension (PH) compared to those without.Study design: A prospective observational study of infants born <29 weeks gestation between July 2021-March 2024. Echocardiograms were performed at 24-48 h and 36 weeks postmenstrual age (PMA). Early PH was defined as bidirectional or right-to-left shunt across the ductus.Result: Early PH was identified in 20/166 (12%) infants. These infants had higher mortality than controls (55% vs 11%; P < 0.01). Initial echocardiogram revealed differences in twist(°) (5.1 vs 7.9; P = 0.03), torsion(°/mm) (0.29 vs 0.41; P = 0.04), systolic time(ms) (146 vs 162; P < 0.01) and isovolumic relaxation time(ms) (58 vs 46; P < 0.01), with several persistent abnormalities at 36 weeks PMA.Conclusion: Preterm infants with early PH have higher mortality and distinct echocardiographic profiles, with functional alterations persisting to 36 weeks PMA in survivors. Early identification and targeted management may improve outcomes.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations for obstetric management of births 22-25 weeks' gestation. 妊娠22-25周分娩的产科管理注意事项。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-11 DOI: 10.1038/s41372-025-02289-y

Felicia V LeMoine, Ashley N Battarbee, Colm P Travers, Cheryl Battersby, Kelly S Gibson

引用次数: 0

Gastroesophageal reflux during postpyloric versus gastric tube feeding in preterm infants with bronchopulmonary dysplasia. 支气管肺发育不良早产儿幽门后与胃管喂养期间胃食管反流的比较

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-10 DOI: 10.1038/s41372-025-02301-5

Erik A Jensen, Carolyn M Orians, Kathleen Gibbs, Matthew Ryan

{"title":"Gastroesophageal reflux during postpyloric versus gastric tube feeding in preterm infants with bronchopulmonary dysplasia.","authors":"Erik A Jensen, Carolyn M Orians, Kathleen Gibbs, Matthew Ryan","doi":"10.1038/s41372-025-02301-5","DOIUrl":"https://doi.org/10.1038/s41372-025-02301-5","url":null,"abstract":"Background: Whether postpyloric feeding reduces gastroesophageal reflux (GER) in very preterm infants with bronchopulmonary dysplasia (BPD) is uncertain.Methods: Prospective observational study comparing GER profiles measured using 24-h esophageal pH-impedance monitoring in infants with BPD receiving clinically prescribed postpyloric (n = 21) or gastric (n = 24) tube feeding.Results: Participants (median gestational age 25.0 weeks, IQR 24.1-26.9) underwent testing at a median postmenstrual age of 46.6 weeks (IQR 42.7-52.4). The number of GER episodes recorded by impedance varied widely (median 27, range 1-195). Postpyloric versus gastric feeding was associated with fewer GER episodes (median, IQR: 16, 5-41 vs. 40, 19-60; p = 0.07) and less exposure of the proximal esophagus to reflux (median duration, IQR: 0.1 min, 0.005-0.6 vs. 0.77 min, 0.16-1.8; p = 0.045), but a higher proportion of acidic (pH < 4) GER episodes (median, IQR: 91%, 70-100 vs. 31%, 16-54; p < 0.001).Conclusion: Postpyloric feeding may reduce total GER burden but increase the relative proportion of acidic GER in infants with BPD.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective study describing splanchnic NIRS and clinical outcomes in encephalopathic neonates receiving minimal enteral nutrition during therapeutic hypothermia. 一项前瞻性研究描述了在治疗性低温期间接受最低限度肠内营养的脑病新生儿内脏NIRS和临床结果。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-10 DOI: 10.1038/s41372-025-02270-9

Tatiana A Nuzum, Sean M Bailey, Martha Caprio, Elena V Wachtel

{"title":"A prospective study describing splanchnic NIRS and clinical outcomes in encephalopathic neonates receiving minimal enteral nutrition during therapeutic hypothermia.","authors":"Tatiana A Nuzum, Sean M Bailey, Martha Caprio, Elena V Wachtel","doi":"10.1038/s41372-025-02270-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02270-9","url":null,"abstract":"Objective: To compare regional splanchnic oxygenation (SrSO2) levels and clinical outcomes between infants who received minimal enteral nutrition (MEN) during Therapeutic Hypothermia (TH), and those who did not.Study design: A prospective, interventional cohort study with a historic control group at two Regional Perinatal Centers (NCT05471336).Results: Participant demographics and clinical illness severity were similar between MEN (n = 40) and control (n = 40) groups. There were no significant safety events. SrSO2 levels were normal in both groups throughout. Subjects that received MEN experienced fewer central line days (5.8 v 6.9, p = 0.005) and higher rates of human milk feeding (77% v 46%, p = 0.010), and achieved full oral feeds sooner (9.9 v 13.4 days, p = 0.043).Conclusion: Splanchnic tissue oxygenation was normal in both groups, and similar between groups throughout TH. Providing MEN during TH appears safe and effective, resulting in several important clinical benefits.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does early high-volume enteral feeding initiation increase the total days on full feeds in very preterm infants? 早期开始大量肠内喂养是否会增加极早产儿全喂养的总天数？

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-09 DOI: 10.1038/s41372-025-02279-0

Kaitlin Hannan, Brenda Poindexter, Kera McNelis

引用次数: 0

Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial. 根据现行方案（24小时）与根据临床状态（从6小时开始）在脐动脉多普勒中出生的产前舒张末期血流逆转（REDF）的新生儿中开始肠内喂养：一项随机对照试验。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-06 DOI: 10.1038/s41372-025-02288-z

Rishi Kathuria, Kanya Mukhopadhyay

{"title":"Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial.","authors":"Rishi Kathuria, Kanya Mukhopadhyay","doi":"10.1038/s41372-025-02288-z","DOIUrl":"10.1038/s41372-025-02288-z","url":null,"abstract":"Objective: To compare the effects of initiating feeds at 24 h versus at 6 h in neonates with reversed end-diastolic flow (REDF) and determine the incidence of feed intolerance (FI) and necrotizing enterocolitis (NEC).Design: Pilot randomized controlled trial.Methods: Neonates with REDF (n = 52) were randomized to start feeds at 6 h (n = 26) or 24 h (n = 26) to assess FI, NEC, time to full feeds, sepsis, mortality, weight and gestation at discharge, and hospital stay.Results: FI was observed in 14 (54%) neonates in 6 h group and 17 (65%) in 24 h group, with comparable NEC rates. Neonates in the 6 h group achieved full feeds faster (8 vs. 11 days) and had shorter hospital stay (17 vs. 32 days). Death and sepsis rates were similar.Conclusions: Feed initiation at 6 h in REDF neonates did not increase the risk of FI or NEC.Trial registration: Clinical trial registry of India (CTRI/2023/02/050025); 23/02/2023.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of maternal position on cerebral oxygenation in premature infants during Kangaroo care: a randomised controlled trial. 袋鼠式护理期间母亲体位对早产儿脑氧合的影响：一项随机对照试验。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-05 DOI: 10.1038/s41372-025-02287-0

Iyshwarya Stapleton, Sarah Murphy, Susan Vaughan, Brian Henry Walsh, Kannan Natchimuthu, Vicki Livingstone, Eugene Dempsey

{"title":"The effect of maternal position on cerebral oxygenation in premature infants during Kangaroo care: a randomised controlled trial.","authors":"Iyshwarya Stapleton, Sarah Murphy, Susan Vaughan, Brian Henry Walsh, Kannan Natchimuthu, Vicki Livingstone, Eugene Dempsey","doi":"10.1038/s41372-025-02287-0","DOIUrl":"https://doi.org/10.1038/s41372-025-02287-0","url":null,"abstract":"Objective: To assess whether there was an optimal maternal position (30° versus 60° incline) for kangaroo mother care.Design: Single centre cross-over randomised controlled trial. Mothers were randomly assigned to start at either a 30° or 60° angle. Primary outcomes were the mean cerebral near-infrared spectroscopy (NIRS) values. Secondary outcomes included median peripheral saturations and heart rates.Results: Twenty infants were included in the final analysis: median gestational age at birth was 28+1 weeks and median birth weight was 985 g. No significant differences were observed in the primary outcomes or the secondary outcomes at either angle.Conclusions: Maternal positioning at a 30° or 60° incline did not impact on cerebral oxygenation values in very preterm infants. Either position was associated with clinical stability.Trial registration number: ClinicalTrials.gov ID NCT05686252.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the best nutritional strategy for moderate to late preterm infants? 中度至晚期早产儿的最佳营养策略是什么？

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-03 DOI: 10.1038/s41372-025-02283-4

Ambika Bhatnagar, Catherine O Buck

引用次数: 0

Artificial intelligence in pediatric medicine: a call for rigorous reporting standards. 儿科医学中的人工智能：呼吁制定严格的报告标准。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-02 DOI: 10.1038/s41372-025-02284-3

James S Barry, Kristyn Beam, Ryan M McAdams

引用次数: 0