Journal of Perinatology最新文献_第6页

The effect of using dexmedetomidine versus morphine as sedation on long-term neurodevelopmental outcomes of encephalopathic neonates undergoing therapeutic hypothermia.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-20 DOI: 10.1038/s41372-025-02227-y

Tatiana A Nuzum, Sadaf H Kazmi, Elena V Wachtel

{"title":"The effect of using dexmedetomidine versus morphine as sedation on long-term neurodevelopmental outcomes of encephalopathic neonates undergoing therapeutic hypothermia.","authors":"Tatiana A Nuzum, Sadaf H Kazmi, Elena V Wachtel","doi":"10.1038/s41372-025-02227-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02227-y","url":null,"abstract":"Objective: To compare neurodevelopmental outcomes using Bayley Scales of Infant Development (BSID), between encephalopathic neonates undergoing therapeutic hypothermia (TH), sedated with either continuous dexmedetomidine or intermittent morphine.Study design: Retrospective, observational cohort study including encephalopathic neonates born between 2014 - 2022 that underwent TH at two Regional Perinatal Centres, and completed neurodevelopmental follow-up assessments.Results: There were no significant differences in demographics or short-term neurologic outcomes between morphine (n = 30) and dexmedetomidine (n = 32) groups. At 12 months, median motor composite scores (104 vs 98.5, p = 0.02) and median fine motor scaled scores (SS) (11 vs 10, p = 0.01) were significantly higher in the dexmedetomidine group. Median expressive language SS were slightly higher in the morphine group (11 v 10, p = 0.05). BSID scores at 18-24 months were similar.Conclusion: This study supports the use of dexmedetomidine as first-line sedation agent during TH, given comparable 18-24 month neurodevelopmental outcomes.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfluoroalkyl substances and preterm birth.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-18 DOI: 10.1038/s41372-025-02231-2

Anne M Mullin, Abby F Fleisch, Clementina Mesaros, Rachel Ledyard, Michele R Hacker, Heather H Burris

引用次数: 0

Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-17 DOI: 10.1038/s41372-025-02230-3

Kata Kovacs, Regan E Giesinger, Zsuzsanna Varga, Miklos Szabo, Agnes Jermendy, Patrick J McNamara

{"title":"Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability.","authors":"Kata Kovacs, Regan E Giesinger, Zsuzsanna Varga, Miklos Szabo, Agnes Jermendy, Patrick J McNamara","doi":"10.1038/s41372-025-02230-3","DOIUrl":"https://doi.org/10.1038/s41372-025-02230-3","url":null,"abstract":"Objective: To analyze the approach to cardiovascular care and long-term outcomes in infants undergoing hypothermia for neonatal encephalopathy (NE).Study design: This is a retrospective cohort study of 152 infants with NE [SickKids Hospital (Center A, n = 74) or Semmelweis University (Center B, n = 78)], who developed hypotension and underwent neonatal follow-up. Primary outcome was defined as death or neurodevelopmental impairment (<70 on Bayley-II or <85 points on Bayley-III test).Result: The presence of hypoxic injury in the brain MRI increased the odds of adverse outcome by 10.5 fold. In addition, for every 24 h increase in the duration of cardiovascular support the odds of adverse outcome increased by 12%. In a subgroup of patients with detailed echocardiography evaluation lower tricuspid annulus plane systolic excursion was noted in the non-survivors.Conclusion: Hypoxic brain injury and longer cardiovascular therapy are independently associated with the adverse long-term outcome in patients with NE.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying barriers to complying with new restrictive NICU transfusion guidelines.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-16 DOI: 10.1038/s41372-025-02225-0

Sarah M Tweddell, Thomas M Morelli, Timothy M Bahr, Ashley Krueger, Robert D Christensen, Robin K Ohls

引用次数: 0

Early hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-13 DOI: 10.1038/s41372-025-02222-3

Sankalp Dudeja, Shiv Sajan Saini, Venkataseshan Sundaram, Sourabh Dutta, Naresh Sachdeva, Praveen Kumar

{"title":"Early hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial","authors":"Sankalp Dudeja, Shiv Sajan Saini, Venkataseshan Sundaram, Sourabh Dutta, Naresh Sachdeva, Praveen Kumar","doi":"10.1038/s41372-025-02222-3","DOIUrl":"10.1038/s41372-025-02222-3","url":null,"abstract":"To compare early hydrocortisone (initiated along with vasoactive therapy) vs. placebo for all-cause mortality within next 14 days among neonates with fluid-refractory shock. Neonates with fluid-refractory shock were randomly assigned to receive hydrocortisone or saline placebo alongside vasoactive drugs. If they developed catecholamine-resistant shock, the study drug was replaced with open-label hydrocortisone. Eighty-four neonates were randomized (early hydrocortisone=43 and placebo=41). Median gestational age of our cohort (n = 84) was 30.3 weeks [interquartile range (IQR): 27.7, 32.5] and median birth weight was 1148 grams (IQR: 860, 1419). The 14-day all-cause mortality was comparable between early hydrocortisone and placebo groups [OR 0.53 (95% CI 0.19, 1.52)]. Both groups had similar duration of vasoactive drugs and vasoactive-inotrope scores, incidence of adverse effects of hydrocortisone and incidence of medium-term complications. We did not observe a significant reduction in 14-day mortality with early hydrocortisone compared to placebo in fluid-refractory neonatal shock.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 3","pages":"342-349"},"PeriodicalIF":2.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate heart rate changes in late preterm infants receiving resuscitation in the delivery room.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-13 DOI: 10.1038/s41372-025-02220-5

Yafa Davydova, Dina Elachi, Rebecca Miller, Charlene Thomas, Corrina Oxford, Jeffrey Perlman

{"title":"Immediate heart rate changes in late preterm infants receiving resuscitation in the delivery room.","authors":"Yafa Davydova, Dina Elachi, Rebecca Miller, Charlene Thomas, Corrina Oxford, Jeffrey Perlman","doi":"10.1038/s41372-025-02220-5","DOIUrl":"https://doi.org/10.1038/s41372-025-02220-5","url":null,"abstract":"Objectives: Assess heart rate (HR) trends in the minutes following delivery in late preterm infants 34-36 6/7 weeks with spontaneous respirations and compare trends in infants with delayed transition requiring interventions and assess the direct potential impact of these interventions on HR changes.Design: Prospective observational single center study in 20 late preterm infants born via cesarean section utilizing the NeoBeat which uses dry electrode technology to obtain blinded HR measures in infants with spontaneous respirations versus infants requiring interventions i.e.: positive pressure ventilation, continuous positive airway pressure or suctioning.Results: Initial HR in spontaneously breathing infants (n = 8) was higher versus those requiring interventions, differences that persisted through five minutes. Iatrogenic bradycardia ranging from 65 to 90 beats/minute was induced by interventions in five(42%) of 12 infants.Conclusions: Initial HR in spontaneously breathing late preterm infants was significantly higher compared to infants who received interventions. Respiratory interventions induced sudden unanticipated bradycardia in many cases.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duration of continuous positive airway pressure: associations with length of stay and oral feeding patterns in a level IV neonatal intensive care unit.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-11 DOI: 10.1038/s41372-025-02221-4

Caroline Massarelli, Andrea Weintraub, Douglas Bush, Veniamin Ratner, Courtney Juliano

引用次数: 0

Outpatient tapering of buprenorphine in opioid use disorder pregnancies may improve neonatal outcomes.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-10 DOI: 10.1038/s41372-025-02211-6

Darshan Shah, Rakesh Adelli, Alyson Chroust, Nicole Lewis, Martin Olsen

{"title":"Outpatient tapering of buprenorphine in opioid use disorder pregnancies may improve neonatal outcomes.","authors":"Darshan Shah, Rakesh Adelli, Alyson Chroust, Nicole Lewis, Martin Olsen","doi":"10.1038/s41372-025-02211-6","DOIUrl":"10.1038/s41372-025-02211-6","url":null,"abstract":"Objective: The main objective of the study was to compare neonatal outcomes: the incidence of NOWS, length of hospital stay (LOS), admission to neonatal intensive care (NICU), birth weight, treatment with morphine, and head circumference between newborns of mothers who had tapering of buprenorphine (T group) during pregnancy to non-tapering of buprenorphine (NT group).Study design: It was a prospective, pilot, case-control trial of pregnant women done in North-East Tennessee in pregnancy with opioid use disorder (OUD) in the tapered (T) group as a part of clinical care while the NT group did not taper medication.Results: Significant differences were observed among neonatal outcomes; average birth weight and head circumference (p < 0.05) and admission to NICU (p < 0.05) between the two groups by t-test, and in maternal buprenorphine doses, 1.47 versus 7.6 (p < 0.0001).Conclusion: Comprehensive outpatient buprenorphine tapering can be done in OUD pregnancy with improved neonatal outcomes after careful discussion with providers of the risks and benefits.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meeting the emotional and behavioral health needs of bereaved NICU parents.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-10 DOI: 10.1038/s41372-025-02218-z

Olivia Ruth, Sasha Amiri, Amy E Baughcum, Christine A Fortney, Janell Robinson, Sara Munoz-Blanco, Stephanie K Kukora

引用次数: 0

Impact of a patent ductus arteriosus on non-invasive pre- and post-ductal blood pressures in extremely preterm infants during the first two postnatal weeks

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-10 DOI: 10.1038/s41372-025-02223-2

Adrianne R. Bischoff, Amy A. Hobson, Patrick J. McNamara, Danielle R. Rios

引用次数: 0