Journal of PerinatologyPub Date : 2025-06-01Epub Date: 2025-03-17DOI: 10.1038/s41372-025-02260-x
Matthew J Drago, Gabriella Raviv, Andrea Weintraub, Katherine Guttmann
{"title":"Maternal fetal medicine, obstetric, and neonatology perspectives on joint prenatal counseling at periviable gestational ages.","authors":"Matthew J Drago, Gabriella Raviv, Andrea Weintraub, Katherine Guttmann","doi":"10.1038/s41372-025-02260-x","DOIUrl":"10.1038/s41372-025-02260-x","url":null,"abstract":"<p><strong>Objective: </strong>To explore perspectives of maternal fetal medicine specialists (MFMs), obstetricians (OBs), and neonatologists (Neos) about antenatal counseling at periviable gestational ages and examine how those perceptions impact multidisciplinary counseling.</p><p><strong>Study design: </strong>Semi-structured interviews were conducted and thematic analysis performed until thematic saturation.</p><p><strong>Results: </strong>Interviews of 7 Neos and 8 OB/MFMs identified three themes: (1) roles in periviability counseling; (2) training and lifelong learning to develop/enhance communication skills; and (3) managing interdisciplinary dynamics. Participants agreed on consult content and the appropriate subspecialist to discuss specific topics but differed in their approaches. Subspecialty perspectives differed on resuscitation, survival, and developmental outcomes. Formal communication skills training was identified as a means to scaffold conversations into a uniform approach.</p><p><strong>Conclusion: </strong>Despite near universal agreement that joint perviability counseling would be beneficial, logistical barriers and lack of a shared framework may hinder its implementation. Formal communication skills training may support organized joint counseling.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"745-754"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-06-01Epub Date: 2025-05-07DOI: 10.1038/s41372-025-02315-z
Sarah A Swenson, Megan E Paulsen, Kelsey Carrigan, Rachael Stover-Haney, Delaney Wilton, Brittney Skalland, Andrea L Lampland, Ellen Diego, Maria Kroupina, Erin A Osterholm, Ann Downey
{"title":"Implementation of perinatal mental health screening for parents of infants in a level IV neonatal intensive care unit: A quality improvement initiative.","authors":"Sarah A Swenson, Megan E Paulsen, Kelsey Carrigan, Rachael Stover-Haney, Delaney Wilton, Brittney Skalland, Andrea L Lampland, Ellen Diego, Maria Kroupina, Erin A Osterholm, Ann Downey","doi":"10.1038/s41372-025-02315-z","DOIUrl":"10.1038/s41372-025-02315-z","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to establish standardized perinatal mental health (PMH) screening performed by social workers for parents in the neonatal intensive care unit (NICU) at 1, 2, 4, and 6 months, increasing screening rates from 0% to 70% within 6 months.</p><p><strong>Study design: </strong>Baseline data evaluated informal PMH assessments. Primary measure was percent of parents screened and was monitored by statistical process control charts. Process measures were percent of parents with scores above threshold for referral for further evaluation and/or treatment, appropriately referred, and declining screening. Balancing measures were negative perceptions of screening.</p><p><strong>Results: </strong>The centerline for screening rate was 80% for mothers and 72% for partners. Screening increased concerns detected beyond 1 month from 12 to 60. Concerns representing partners increased from 3/52 (6%) to 18/60 (30%).</p><p><strong>Conclusion: </strong>Standardized NICU PMH screening improved identification of PMH concerns beyond the first weeks of admission for both mothers and partners.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"859-866"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does ventilatory assistance before umbilical cord clamping reduce the risk of early death or intraventricular hemorrhage in extremely preterm infants?","authors":"Kaquanta Barlow, Shoshana Newman-Lindsay, Evan Giusto, Anup Katheria, Satyan Lakshminrusimha","doi":"10.1038/s41372-025-02258-5","DOIUrl":"10.1038/s41372-025-02258-5","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"881-884"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outcomes of spontaneous pneumothorax in neonates: treatments vs. expectant management.","authors":"Anat Margaliot, Laurence Mangel, Yarden Waxman, Moria Be'er, Ronella Marom, Jacky Herzlich","doi":"10.1038/s41372-025-02259-4","DOIUrl":"10.1038/s41372-025-02259-4","url":null,"abstract":"<p><strong>Background: </strong>Neonatal pneumothorax is dependent on severity of symptoms and leak size. Treatment of Pneumothorax with Nitrogen washout is controversial.</p><p><strong>Objective: </strong>To compare outcomes of neonates treated for spontaneous pneumothorax (SP) compared with those managed expectantly.</p><p><strong>Methods: </strong>A retrospective review of medical records of neonates (≥34weeks) diagnosed with SP born between 2011 and 2021. Neonatal characteristics and outcomes were compared between neonates treated for SP with either targeted oxygen therapy (to stabilize saturation ≥93%) or nitrogen washout and those under expectant management.</p><p><strong>Results: </strong>Among neonates with respiratory distress and desaturation (n = 64), nitrogen washout reduced median time to resolution compared to targeted oxygen therapy (31 [12-67] vs 81 [31.8-123.5] hours, p = 0.012). Expectantly managed neonates with distress (n = 87) experienced delayed feeding initiation, while time to resolution and hospital stay were similar.</p><p><strong>Conclusion: </strong>Nitrogen washout is superior to targeted oxygen therapy in time to resolution in infants presenting with respiratory distress and desaturation.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"837-842"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark Kaczor, Roland Hentz, Paul E Youssef, Anthony Fine, Jennifer Fang
{"title":"Impact of teleneonatology on time to goal temperature in outborn neonates with hypoxic-ischemic encephalopathy requiring therapeutic hypothermia.","authors":"Mark Kaczor, Roland Hentz, Paul E Youssef, Anthony Fine, Jennifer Fang","doi":"10.1038/s41372-025-02324-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02324-y","url":null,"abstract":"<p><strong>Objective: </strong>We assessed whether teleneonatology reduces time to goal temperature and early neurologic morbidity or mortality in outborn neonates with hypoxic-ischemic encephalopathy (HIE) that required therapeutic hypothermia (TH).</p><p><strong>Study design: </strong>This retrospective observational study included outborn neonates with HIE treated with TH. The exposure was teleneonatology consultation. The primary outcome was time from birth to goal temperature (33-34 °C). The secondary outcome was a composite of early neurologic morbidity and in-hospital mortality.</p><p><strong>Results: </strong>Of the 77 neonates included in the study, 42 (55%) received teleneonatology consultations. Teleneonatology reduced time to goal temperature (mean ratio 0.76 [95% CI, 0.58, 0.99]). This was partially mediated by earlier transport team activation and more frequent initiation of passive cooling prior to transport team arrival. There was no difference in early neurologic morbidity or mortality.</p><p><strong>Conclusions: </strong>Teleneonatology reduced time to goal temperature in outborn neonates with HIE requiring TH by expediting key steps in care processes.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adly Nanda Al Fattah, Muhammad Pradhiki Mahindra, Mirani Ulfa Yusrika, Muhammad Pradhika Mapindra, Felix Firyanto Widjaja, Vania Permata Putri, Shinda Marizni, Sara L Hillman, Raden Aditya Kusuma
{"title":"Comparison of first trimester preeclampsia combined screening performances with various approaches in the Indonesian population.","authors":"Adly Nanda Al Fattah, Muhammad Pradhiki Mahindra, Mirani Ulfa Yusrika, Muhammad Pradhika Mapindra, Felix Firyanto Widjaja, Vania Permata Putri, Shinda Marizni, Sara L Hillman, Raden Aditya Kusuma","doi":"10.1038/s41372-025-02316-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02316-y","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare Fetal Medicine Foundation (FMF), Indonesian Maternal and Children Health Handbook (MCH-HB), and Indonesian Prenatal Institute (IPI) models for predicting PE.</p><p><strong>Materials/subjects and methods: </strong>Maternal risk factors, biophysical, and biochemical markers were recorded from women screened for PE at 11-14 gestational weeks. The receiving operator curve (ROC) analysis was used to compare the detection rate (DR) among prediction models.</p><p><strong>Results: </strong>For all PE at a 10% false-positive rate (FPR), FMF had a DR 62.9%; MCH-HB had a DR 50.0%; IPI had a DR 66.9%. For early-onset PE, at 10% FPR FMF had a DR 80.3%; MCH-HB had a DR 71.4%; IPI had a DR 81.5%. For preterm PE at 10% FPR, FMF had a DR 70.2%; MCH-HB had a DR 38.5%; IPI had a DR 66.9%.</p><p><strong>Discussion: </strong>IPI algorithm is comparable to FMF and outperforms MCH-HB algorithm for all, early-onset, and preterm PE screening.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas D O'Connor, Louis J Martin, Rachel L Tullar, Brandon P Brown, Zeynep N I Salih
{"title":"A survey of parental experiences while viewing MRI images at a fetal care center.","authors":"Nicholas D O'Connor, Louis J Martin, Rachel L Tullar, Brandon P Brown, Zeynep N I Salih","doi":"10.1038/s41372-025-02319-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02319-9","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily Willey, Michelle Mitchell, Carey Ehlert, Jacob Swoveland, Tracy Zembles
{"title":"Time to positive blood cultures in neonatal sepsis evaluations.","authors":"Emily Willey, Michelle Mitchell, Carey Ehlert, Jacob Swoveland, Tracy Zembles","doi":"10.1038/s41372-025-02323-z","DOIUrl":"https://doi.org/10.1038/s41372-025-02323-z","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the time to blood culture positivity among neonates evaluated for sepsis to determine when antibiotics may be safely discontinued.</p><p><strong>Study design: </strong>Retrospective review of clinically relevant blood culture time to positivity from infants in a neonatal intensive care unit. The primary endpoint was overall median time to blood culture positivity. Secondary endpoints compared time to positivity among gram-positive versus gram-negative organisms, early versus late onset sepsis, and a sub-analysis excluding contaminants.</p><p><strong>Result: </strong>Among 151 cultures, the overall median time to positivity was 17 h (IQR 12-23). Most (47/48, 97.9%) gram-negative organisms resulted within 24 h and most (88/94, 93.6%) gram-positive by 36 h. All (13/13, 100%) early onset cultures resulted within 24 h and most (132/138, 95.7%) late onset by 36 h.</p><p><strong>Conclusion: </strong>Antibiotics for neonatal sepsis evaluation may be safely discontinued in well-appearing infants without an identified infection source with negative cultures at 36 h.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koert de Waal, Enrico Petoello, Edward Crendal, Nilkant Phad
{"title":"Reference ranges of left ventricular diastolic multimodal ultrasound parameters in stable preterm infants in the early and late neonatal intensive care admission period.","authors":"Koert de Waal, Enrico Petoello, Edward Crendal, Nilkant Phad","doi":"10.1038/s41372-025-02278-1","DOIUrl":"https://doi.org/10.1038/s41372-025-02278-1","url":null,"abstract":"<p><strong>Background: </strong>Diastolic dysfunction often precedes systolic dysfunction and provides opportunity for management strategies. We aim to present reference ranges for diastolic function parameters in stable preterm infants at 2 timepoints.</p><p><strong>Methods: </strong>Ultrasound scans of clinically stable preterm infants < 30 weeks gestation with no antenatal or postnatal complications were analysed for left heart size, mitral blood flows, myocardial velocities and shortening during the early (3 to 21 days) and late (corrected gestation 34 to 37 weeks) neonatal period.</p><p><strong>Results: </strong>92 early scans and 64 late scans were included. Mitral blood flow and myocardial velocities increased with augmented atrial function leading to higher EA and e'a' ratios and with relatively high Ee' ratio.</p><p><strong>Conclusion: </strong>We present reference values for many left ventricular multimodal diastolic ultrasound parameters in preterm infants with uncomplicated fetal and neonatal development to guide prospective studies that explore diastolic function and diastolic heart failure in preterm infants.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krishna Manohar, Fikir M Mesfin, Jessica Belchos, Brandon P Brown, Cameron Colgate, Lava Timsina, Joshua Brown, Rachel Tullar, Brian W Gray
{"title":"Beyond the womb: prenatal MRI's prognostic abilities for morbidity and mortality in neonates with omphaloceles.","authors":"Krishna Manohar, Fikir M Mesfin, Jessica Belchos, Brandon P Brown, Cameron Colgate, Lava Timsina, Joshua Brown, Rachel Tullar, Brian W Gray","doi":"10.1038/s41372-025-02321-1","DOIUrl":"https://doi.org/10.1038/s41372-025-02321-1","url":null,"abstract":"<p><strong>Background: </strong>Managing omphaloceles poses challenges in prenatal consultation and perinatal care. We hypothesized that specific fetal MRI findings could predict morbidity and mortality in these patients.</p><p><strong>Methods: </strong>We analyzed fetal MRI studies demonstrating omphaloceles from 2006 to 2022 and conducted a retrospective review of medical records. Predictor variables were correlated with outcomes using univariate and multivariate analyses, and Receiver Operating Characteristic (ROC) curves were optimized with Youden's J statistic.</p><p><strong>Results: </strong>Among 46 omphalocele patients, 89% survived to birth, with an overall mortality rate of 37%. Significant predictors of mortality included stomach/spleen herniation, severe anomalies, omphalocele-associated syndromes, membrane rupture, lower observed/expected total fetal lung volume (O/E TFLV), and increased percentage of liver herniation. The need for deferred repair correlated with liver/stomach herniation and \"giant-omphalocele.\" ROC analysis identified mortality cut points at O/E TFLV < 42% and liver herniation >77%, while deferred repair was indicated at liver herniation >51%.</p><p><strong>Conclusion: </strong>This study identified prenatal MRI findings associated with mortality and deferred repair, aiding in risk prediction and family counseling.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}