Journal of Perinatology最新文献_第6页

Changes in lung aeration with high-flow nasal cannula compared to nasal CPAP in preterm infants. 高流量鼻插管与鼻CPAP对早产儿肺通气的影响。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-23 DOI: 10.1038/s41372-025-02267-4

Anup Katheria, Felix Ines, Judith Hough, Wade Rich, Ana Morales, Shashank Sanjay, Debra Poeltler, Neil Finer

{"title":"Changes in lung aeration with high-flow nasal cannula compared to nasal CPAP in preterm infants.","authors":"Anup Katheria, Felix Ines, Judith Hough, Wade Rich, Ana Morales, Shashank Sanjay, Debra Poeltler, Neil Finer","doi":"10.1038/s41372-025-02267-4","DOIUrl":"https://doi.org/10.1038/s41372-025-02267-4","url":null,"abstract":"Objective: To compare the degree of atelectasis in preterm infants on nasal continuous airway pressure (nCPAP) versus high-flow nasal cannula (HFNC) at 8 L/min.Study design: A cross-over study of infants <29 weeks gestational age (GA) receiving nCPAP and underwent 6-hours of HFNC at 8 L/min before returning to nCPAP. Electrical Impedance Tomography was used to measure lung aeration.Results: 78 infants with median GA of 27 weeks [26, 28] were studied. HFNC was non-inferior to CPAP across the 4 periods (overall mean 2.1 ± 2.9, lower bound of confidence interval -0.9). Infants that failed HFNC had higher dependent silent spaces (DSS) measurements (1.6[0.48, 4.7] vs 0.30[0.0, 2.7], P = 0.046).Conclusion: This study of premature infants <29 weeks GA at birth demonstrated that HFNC was non-inferior to nCPAP as measured by DSS. Infants that failed HFNC had a higher percentage of DSS than those who tolerated HFNC for 6 hours suggesting decreased lung aeration.Clinicaltrials: gov ID: NCT03700606.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy. 妊娠期暴露于糖尿病后第一周婴儿脂肪因子浓度的变化。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-22 DOI: 10.1038/s41372-025-02269-2

Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck

{"title":"Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.","authors":"Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck","doi":"10.1038/s41372-025-02269-2","DOIUrl":"10.1038/s41372-025-02269-2","url":null,"abstract":"Objective: Characterize changes in neonatal energy metabolism hormones in first postnatal week.Study design: Concentrations of leptin, adiponectin, insulin, resistin, and ghrelin were measured in cord and infant blood collected in the first postnatal week in a prospective cohort of term and preterm infants. Change over time in each hormone was modeled using linear mixed effects regression.Result: Among 106 infants, 65 (61%) were preterm and 44 (42%) were exposed to diabetes (DM) in pregnancy. DM group had higher leptin [between group difference β 2.5 (95%CI: 1.72-3.70)] and resistin [β 1.5 (95%CI:1.14, 1.92)] and lower ghrelin [β 0.49] [95%CI: (0.32-0.76)] versus non-DM group. Preterm infants had lower adiponectin [β 0.80 (95%CI: 0.67-0.96)] versus term group. Insulin varied by DM and prematurity (interaction-term p value < 0.05).Conclusion: In this cohort, hormone concentrations varied by DM and prematurity. Early alterations in energy metabolism hormones may reflect changes in developmental programming which persist in the early postnatal period.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's next in neonatal acute kidney injury? Discussion from the pediatric academic society neonatal nephrology focus group. 新生儿急性肾损伤的下一步是什么？来自儿科学会新生儿肾病焦点小组的讨论。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-21 DOI: 10.1038/s41372-025-02263-8

Heidi J Steflik, Matthew W Harer, David T Selewski, Michelle C Starr

引用次数: 0

Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates. 日本新生儿未结合胆红素和胆红素-白蛋白结合水平。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-20 DOI: 10.1038/s41372-025-02266-5

Kazuki Nishizawa, Yoshinori Katayama, Yong-Kye Lee

引用次数: 0

Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia: a narrative review. 新生儿先天性膈疝的血流动力学精度指导手术时机：叙述性回顾。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-19 DOI: 10.1038/s41372-025-02265-6

John T Wren, Neil Patel, Matthew T Harting, Patrick J McNamara

引用次数: 0

Maternal fetal medicine, obstetric, and neonatology perspectives on joint prenatal counseling at periviable gestational ages. 母胎医学，产科和新生儿联合产前咨询在围孕龄的观点。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-17 DOI: 10.1038/s41372-025-02260-x

Matthew J Drago, Gabriella Raviv, Andrea Weintraub, Katherine Guttmann

{"title":"Maternal fetal medicine, obstetric, and neonatology perspectives on joint prenatal counseling at periviable gestational ages.","authors":"Matthew J Drago, Gabriella Raviv, Andrea Weintraub, Katherine Guttmann","doi":"10.1038/s41372-025-02260-x","DOIUrl":"https://doi.org/10.1038/s41372-025-02260-x","url":null,"abstract":"Objective: To explore perspectives of maternal fetal medicine specialists (MFMs), obstetricians (OBs), and neonatologists (Neos) about antenatal counseling at periviable gestational ages and examine how those perceptions impact multidisciplinary counseling.Study design: Semi-structured interviews were conducted and thematic analysis performed until thematic saturation.Results: Interviews of 7 Neos and 8 OB/MFMs identified three themes: (1) roles in periviability counseling; (2) training and lifelong learning to develop/enhance communication skills; and (3) managing interdisciplinary dynamics. Participants agreed on consult content and the appropriate subspecialist to discuss specific topics but differed in their approaches. Subspecialty perspectives differed on resuscitation, survival, and developmental outcomes. Formal communication skills training was identified as a means to scaffold conversations into a uniform approach.Conclusion: Despite near universal agreement that joint perviability counseling would be beneficial, logistical barriers and lack of a shared framework may hinder its implementation. Formal communication skills training may support organized joint counseling.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insensible water loss in extremely preterm infants cared for in incubators with 70% and 90% relative humidity. 在相对湿度为70%和90%的恒温箱中护理的极早产儿的不知觉失水。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-16 DOI: 10.1038/s41372-025-02261-w

Narendra Dereddy, Deborah Ruth, Jianbin Zhu, Julie Pepe, William Oh

引用次数: 0

Management of the patent ductus arteriosus among infants born at 23 to 32 weeks' gestation between 2011 to 2022: a report from in the Children's Hospitals Neonatal Consortium. 2011年至2022年妊娠23至32周出生婴儿动脉导管未闭的处理：来自儿童医院新生儿联合会的报告

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-15 DOI: 10.1038/s41372-025-02257-6

Mark F Weems, Molly K Ball, Isabella Zaniletti, Sharifa Habib, Shannon Hamrick, Theresa R Grover, Sarah Keene, Karna Murthy, Michael Padula, Ranjit Philip, Rakesh Rao, Shawn Sen, Philip T Levy, Sharada H Gowda

{"title":"Management of the patent ductus arteriosus among infants born at 23 to 32 weeks' gestation between 2011 to 2022: a report from in the Children's Hospitals Neonatal Consortium.","authors":"Mark F Weems, Molly K Ball, Isabella Zaniletti, Sharifa Habib, Shannon Hamrick, Theresa R Grover, Sarah Keene, Karna Murthy, Michael Padula, Ranjit Philip, Rakesh Rao, Shawn Sen, Philip T Levy, Sharada H Gowda","doi":"10.1038/s41372-025-02257-6","DOIUrl":"https://doi.org/10.1038/s41372-025-02257-6","url":null,"abstract":"Objective: This study reports on patent ductus arteriosus (PDA) therapy trends across the Children's Hospital Neonatal Consortium.Study design: We performed a 12-year (2011-2022) retrospective study of premature infants (< 33 weeks) with a PDA. We utilized descriptive statistics to compare demographic, inpatient, and discharge characteristics in 3-year epochs.Result: From 54,813 infants, 19,843 (36%) had a diagnosis of PDA. Use of pharmacotherapy increased 44% (relative) over time, mostly with increased acetaminophen use. There was a 12.7-fold increase in exposure to multiple PDA medications over the study period. While the rate of definitive closure did not change, use of transcatheter PDA closure increased from 0 to 20.3% and surgical ligation decreased from 25.1% to 3.6%.Conclusion: There has been an increase in the use of multiple pharmacotherapies for PDA, especially among infants born <27 weeks' gestation. Transcatheter PDA closure has overtaken surgical ligation as the primary method of definitive PDA closure.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac biomarkers predict low right ventricle performance in neonatal encephalopathy. 心脏生物标志物预测新生儿脑病的低右心室表现。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-15 DOI: 10.1038/s41372-025-02262-9

Shiran Sara Moore, Anie Lapointe, Emmanouil Rampakakis, Jessica Simoneau, Pierre Elias, Alishia Poccia, Asim Al Balushi, Adel Schwertani, Pia Wintermark, Gabriel Altit

{"title":"Cardiac biomarkers predict low right ventricle performance in neonatal encephalopathy.","authors":"Shiran Sara Moore, Anie Lapointe, Emmanouil Rampakakis, Jessica Simoneau, Pierre Elias, Alishia Poccia, Asim Al Balushi, Adel Schwertani, Pia Wintermark, Gabriel Altit","doi":"10.1038/s41372-025-02262-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02262-9","url":null,"abstract":"Objective: Study the association between cardiac biomarkers and echocardiography parameters of ventricular performance in neonates with neonatal encephalopathy (NE).Methods: Prospective observational study (2016-2021) of neonates undergoing therapeutic hypothermia (TH). Neonates with brain injury had repeated echocardiography and biomarkers measurements on day of life (DOL) 2, 3, 4, and 10. Pearson correlation and generalized linear mixed effect models were used to account for repeated measurements. Receiver operating characteristic curves were constructed to assess sensitivity/specificity.Results: 56 neonates had 128 measurements. Creatine Kinase (CK) and cardiac troponin-I (CTn-I) were associated with right ventricular (RV) function. A CK of 1961 U/L and a CTn-I of 91 ng/L identified low Tricuspid Annular Plane Systolic Excursion (<7 mm) with sensitivities of 93% and 79%, and specificities of 55% and 74%, respectively.Conclusions: Elevated CK and CTn-I were associated with decreased RV performance. Trending these markers can be used to suspect altered RV function and may flag optimal timing for evaluation(s) by echocardiography during TH.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential direct bilirubin values in preterm infants. 顺序直接胆红素值在早产儿。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-15 DOI: 10.1038/s41372-025-02264-7

Abigail McCay, Odinaka Onuigbo, MaCee Boyle, Sahla Esam, Shreya Gaddipati, Charles B Chen, Sanu Yadav, Akshaya Vachharajani

引用次数: 0