Journal of Perinatology最新文献_第6页

Racial disparities and outcomes in neonatal hypoxic-ischemic encephalopathy. 新生儿缺氧缺血性脑病的种族差异和结局。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 Epub Date: 2025-06-21 DOI: 10.1038/s41372-025-02335-9

Marwa M Elgendy, Ceyda Acun, Josef Cortez, Hany Aly, Mohamed A Mohamed

{"title":"Racial disparities and outcomes in neonatal hypoxic-ischemic encephalopathy.","authors":"Marwa M Elgendy, Ceyda Acun, Josef Cortez, Hany Aly, Mohamed A Mohamed","doi":"10.1038/s41372-025-02335-9","DOIUrl":"10.1038/s41372-025-02335-9","url":null,"abstract":"Objectives: To investigate racial disparities in the prevalence, severity, intervention, and outcomes of hypoxic-ischemic encephalopathy (HIE) among neonates in the United States.Study design: We analyzed data from the National Inpatient Sample (NIS) dataset, including full-term infants diagnosed with HIE from 2010 to 2018. Regression analysis was performed to control for clinical and demographic variables.Results: Out of 31,249,100 infants, 23,475 (0.09%) were diagnosed with HIE. African American neonates had a 60% higher likelihood of developing HIE compared to Caucasians, adjusted odds ratio (aOR) 1.60 (1.52-1.69, p < 0.001), and were twice as likely to experience severe HIE, aOR 2.06 (1.77-2.39, p < 0.001). Overall mortality was significantly higher among African American infants, aOR 2.14, (2.02-2.26, p < 0.001). Mortality within HIE infants did not differ between African American and Caucasian infants aOR 0.88 (0.78-1.0), p < 0.61. Native American infants had a significantly lower chance of receiving hypothermia therapy compared to Caucasian infants, aOR 0.48 (0.29-0.77), p = 0.002.Conclusion: Racial disparity exists in the prevalence, severity, and management of HIE. African Americans experience a higher prevalence and severity of HIE. Native Americans are less likely to receive hypothermia therapy for HIE.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"1047-1050"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation in NICU utilization: a narrative review and path forward. 新生儿重症监护室利用率的变化：回顾与展望。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 Epub Date: 2024-10-01 DOI: 10.1038/s41372-024-02129-5

David A Paul, Stephen A Pearlman

引用次数: 0

Towards a new taxonomy of preterm birth. 建立早产儿新分类法。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 Epub Date: 2024-11-20 DOI: 10.1038/s41372-024-02183-z

David K Stevenson, Alan L Chang, Ronald J Wong, Jonathan D Reiss, Brice Gaudillière, Karl G Sylvester, Xuefeng B Ling, Martin S Angst, Gary M Shaw, Michael Katz, Nima Aghaeepour, Ivana Marić

{"title":"Towards a new taxonomy of preterm birth.","authors":"David K Stevenson, Alan L Chang, Ronald J Wong, Jonathan D Reiss, Brice Gaudillière, Karl G Sylvester, Xuefeng B Ling, Martin S Angst, Gary M Shaw, Michael Katz, Nima Aghaeepour, Ivana Marić","doi":"10.1038/s41372-024-02183-z","DOIUrl":"10.1038/s41372-024-02183-z","url":null,"abstract":"Disease categories traditionally reflect a historical clustering of clinical phenotypes based on biologic and nonbiologic features. Multiomics approaches have striven to identify signatures to develop individualized categorizations through tests and/or therapies for 'personalized' medicine. Precision health classifies clinical syndromes into endotype clusters based on novel technological advancements, which can reveal insights into the etiologies of phenotypical syndromes. A new taxonomy of preterm birth should be considered in this context, as not all preterm infants of similar gestational ages are the same because most have different biologic vulnerabilities and hence different health trajectories. Even the choice of interventions may affect observed clinical conditions. Thus, a new taxonomy of prematurity would help to advance the field of neonatology, but also obstetrics and perinatology by adopting anticipatory and more targeted approaches to the care of preterm infants with the intent of preventing and treating some of the most common newborn pathologic conditions.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"1158-1162"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants. 极早产儿5分钟血氧饱和度与新生儿死亡和脑室内出血之间的关系

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 Epub Date: 2024-12-11 DOI: 10.1038/s41372-024-02194-w

Siyuan Jiang, Xin Cui, Anup Katheria, Neil N Finer, Mihoko V Bennett, Jochen Profit, Henry C Lee

{"title":"Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants.","authors":"Siyuan Jiang, Xin Cui, Anup Katheria, Neil N Finer, Mihoko V Bennett, Jochen Profit, Henry C Lee","doi":"10.1038/s41372-024-02194-w","DOIUrl":"10.1038/s41372-024-02194-w","url":null,"abstract":"Objective: To assess the relationship between 5-min oxygen saturation (SpO2) and outcomes in extremely preterm infants.Study design: This cohort study included infants ≤28 weeks' gestation across nine hospitals from 2020 to 2022. Death and / or severe intraventricular hemorrhage (IVH) were compared between infants with 5-min SpO2 < 80% and 80-100% using Poisson regression models. Receiver Operating Characteristic (ROC) curve and optimal breakpoint analysis were used to estimate the optimal breakpoint of 5-min SpO2 in relation to outcomes.Result: Of 390 infants, 184 (47.2%) had 5-min SpO2 < 80%. A 5-min SpO2 < 80% was independently associated with increased risks of death and / or severe IVH, early death, and severe IVH. ROC analysis of 5-min SpO2 identified optimal breakpoint at 81-85%, above which no additional benefit in outcomes was observed.Conclusion: Our findings support the current recommendation of 5-min SpO2 target of ≥80% for extremely preterm infants.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"1145-1151"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal point-of-care ultrasound-steps for program development. 新生儿护理点超声步骤程序开发。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 DOI: 10.1038/s41372-025-02359-1

Shazia Bhombal, Yogen Singh, Stephanie Marshall, Shanmukha Mukthapuram, María V Fraga

引用次数: 0

An Advanced Neonatal Resuscitation Educational Program in a Surgical Neonatal Intensive Care Unit: Development, Implementation and Audit from 2014 to 2023. 外科新生儿重症监护病房的高级新生儿复苏教育计划：2014年至2023年的发展、实施和审核。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 Epub Date: 2024-12-10 DOI: 10.1038/s41372-024-02192-y

Nicole M Anderson, Andrea Kitchen, Amy McKenzie, Chloe Joynt

{"title":"An Advanced Neonatal Resuscitation Educational Program in a Surgical Neonatal Intensive Care Unit: Development, Implementation and Audit from 2014 to 2023.","authors":"Nicole M Anderson, Andrea Kitchen, Amy McKenzie, Chloe Joynt","doi":"10.1038/s41372-024-02192-y","DOIUrl":"10.1038/s41372-024-02192-y","url":null,"abstract":"Objective: The design, implementation and audit of a multidisciplinary advanced neonatal resuscitation education initiative for \"in unit\" events in a quaternary NICU over a 9-year period, divided into 3-year epochs of \"pre\", \"implementation\" and \"maintenance\" is described.Study design: A didactic and simulation quality improvement initiative focused on teaching and reinforcing specific algorithms endorsed by the American Heart Association (AHA) to target resuscitation needs of older neonates including surgical and cardiac conditions. Qualitative and quantitative data pre and post implementation was audited.Results: Post education implementation, team members performed quicker hemodynamic assessments and applied CPR and/or bolus epinephrine correctly in higher proportions during acute events. During supraventricular tachycardia, vagal maneuver use and medication administration time improved.Conclusion: Advanced neonatal resuscitation education and reinforcement targeted for event etiology, allow for AHA algorithms to be successfully taught and performed within a quaternary NICU with improvement in hemodynamic assessments and AHA algorithm implementation.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"1129-1136"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the treatment and outcomes of different severities of neonatal hypoxic ischemic encephalopathy in California: a retrospective cohort study. 加利福尼亚不同程度新生儿缺氧缺血性脑病的治疗和预后的变化：一项回顾性队列研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 Epub Date: 2025-01-26 DOI: 10.1038/s41372-025-02212-5

Carolyn Fall, Rebecca J Baer, Henry C Lee, Gretchen Bandoli, Christina D Chambers

{"title":"Changes in the treatment and outcomes of different severities of neonatal hypoxic ischemic encephalopathy in California: a retrospective cohort study.","authors":"Carolyn Fall, Rebecca J Baer, Henry C Lee, Gretchen Bandoli, Christina D Chambers","doi":"10.1038/s41372-025-02212-5","DOIUrl":"10.1038/s41372-025-02212-5","url":null,"abstract":"Objective: Evaluate the changes in management and outcomes of Californian infants with hypoxic ischemic encephalopathy (HIE).Study design: Infants with HIE were identified from a California administrative birth cohort using ICD codes and divided into two epochs, Epoch 1 (2010-2015) and Epoch 2 (2016-2019). Risk ratios (RR) for induced hypothermia (IH) in each epoch and their outcomes were calculated using log-linear regression.Results: In this cohort, 4779 infants with HIE were identified. Incidence of HIE in California increased yearly from 0.5/1000 California births to a peak of 1.5/1000 births in 2018. The use of IH in infants with mild HIE increased in Epoch 2 compared to Epoch 1. There was no significant difference in outcomes between epochs for infants with mild HIE that received IH including no difference in neonatal seizures.Conclusion: Significantly more infants with mild HIE received IH since 2015 in California, but no significant difference in outcomes.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"1064-1072"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

General movement assessments in neonates born with congenital gastrointestinal anomalies: a single site, retrospective study. 先天性胃肠异常新生儿的一般运动评估：单部位回顾性研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-08-01 Epub Date: 2025-02-21 DOI: 10.1038/s41372-024-02207-8

Lisa Soumekh, Samantha Bell, Sandra L Espinosa, Tristan Grogan, Kalpashri Kesavan, Kara L Calkins

{"title":"General movement assessments in neonates born with congenital gastrointestinal anomalies: a single site, retrospective study.","authors":"Lisa Soumekh, Samantha Bell, Sandra L Espinosa, Tristan Grogan, Kalpashri Kesavan, Kara L Calkins","doi":"10.1038/s41372-024-02207-8","DOIUrl":"10.1038/s41372-024-02207-8","url":null,"abstract":"Objective: We aimed to characterize general movements in neonates with congenital gastrointestinal anomalies and to compare them to general movements in extremely low birth weight (ELBW) infants.Study design: This was a retrospective, single-site study. Subjects were divided into two groups: those with gastrointestinal (GI) anomalies and ELBW infants (birth weight <1 kg). The primary outcome was general movement assessments.Result: Ninety-six infants were included (n = 51, GI group and n = 45, ELBW group). The rates of abnormal general movements between the groups were comparable (writhing movements: 61% vs. 59%, p = 0.89; fidgety movements: 20% vs. 36%, p = 0.13). Writhing movements were different (100% poor repertoire, 0% cramped synchronous in the GI group vs. 50% poor repertoire and 50% cramped synchronous in the ELBW group, p < 0.001).Conclusion: Infants with gastrointestinal anomalies are at risk for abnormal general movements. Abnormal fidgety general movements may be an early biomarker for future motor deficits.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"1099-1104"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental perception of pain in premature babies in neonatal intensive care unit: a qualitative study. 新生儿重症监护病房早产儿父母疼痛感知：一项定性研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-07-28 DOI: 10.1038/s41372-025-02341-x

Su Ren Wong, Ingrid M Wilson, Lester E Jones, Eunice Jun Lu Teo, Sing Ting Joy Chong, Jasmine Ling Xuan Chia, Gregory Sin, Zubair Amin

{"title":"Parental perception of pain in premature babies in neonatal intensive care unit: a qualitative study.","authors":"Su Ren Wong, Ingrid M Wilson, Lester E Jones, Eunice Jun Lu Teo, Sing Ting Joy Chong, Jasmine Ling Xuan Chia, Gregory Sin, Zubair Amin","doi":"10.1038/s41372-025-02341-x","DOIUrl":"10.1038/s41372-025-02341-x","url":null,"abstract":"Objective: To examine parents' awareness and perceptions of their premature baby's experience of pain, due to invasive procedures performed during admission to the Neonatal Intensive Care Unit (NICU).Study design: Parents of premature babies, who had been admitted to NICU, were recruited from a tertiary hospital in Singapore. Fifteen semi-structured interviews, with individual parents, were conducted. Data were analyzed using a Constructivist Grounded Theory approach including constant comparison and iterative coding. and theoretical sampling.Results: Eleven mothers and four fathers were interviewed. A central theme of 'Adjustment' was identified with four key aspects: (1) Acknowledging the pain, (2) Seeking assurance, (3) Parental presence, and (4) Learning entrustment.Conclusion: Attention to parent's needs associated with their perception of neonatal pain, will facilitate the transition to parenthood and support development of parental identity and competence in those with premature infants in NICU.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal acute kidney injury and neurodevelopmental impairment: investigating associations in very low birthweight infants. 新生儿急性肾损伤和神经发育障碍：调查极低出生体重婴儿的关联。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-07-25 DOI: 10.1038/s41372-025-02370-6

Jeffrey E King, Jill C Newman, Olivia Kinsinger, Molly Mead, Megan D Rodgers, Amy L Ruddy-Humphries, Cassandra Coleman, David T Selewski, Heidi J Steflik

{"title":"Neonatal acute kidney injury and neurodevelopmental impairment: investigating associations in very low birthweight infants.","authors":"Jeffrey E King, Jill C Newman, Olivia Kinsinger, Molly Mead, Megan D Rodgers, Amy L Ruddy-Humphries, Cassandra Coleman, David T Selewski, Heidi J Steflik","doi":"10.1038/s41372-025-02370-6","DOIUrl":"https://doi.org/10.1038/s41372-025-02370-6","url":null,"abstract":"Objective: Associations between neonatal acute kidney injury (AKI) and neurodevelopmental impairment (NDI) remains understudied. We hypothesized AKI is associated with NDI in very low birthweight (VLBW) infants.Study design: A single-center, retrospective cohort study of VLBW infants with and without AKI during hospitalization evaluated in developmental clinic at 18 to 35 months of age. Associations between AKI and NDI were examined using bivariate and multivariable generalized linear mixed modeling.Result: Of 203 infants included, 64 (32%) experienced neonatal AKI and 76 (37%) developed NDI. The relative risk of NDI was significantly higher in those with AKI (RR 1.67, 95% CI 1.18-2.36; p < 0.01). In multivariable analysis, AKI was not an independent predictor of NDI (aRR 1.07, 95% CI 0.68-1.68; p = 0.77).Conclusion: In bivariate analyses, AKI was a significant predictor of NDI. In a multivariable model, AKI was no longer an independent predictor of NDI. Further investigation is warranted.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0