一个临床医生对氧气的思考：太少或太多，生命的平衡。

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-08-20 DOI:10.1038/s41372-025-02398-8

David K Stevenson, Ronald J Wong, Jonathan D Reiss, Ivana Marić, Anca M Paşca, Terence L Ahern

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引用次数: 0

摘要

氧（O2）是地球上最丰富的元素，对所有复杂的真核生物都是必不可少的。因为缺氧或过度暴露于氧气都是有害的，达到理想的平衡对人类的生存至关重要。从这个角度来看，我们讨论血红蛋白在氧气运输和组织氧合中的基本作用。我们还讨论了O2的作用。可以在氧化应激中发挥作用，有时在脆弱的个体中启动炎症级联反应，例如那些缺乏抗氧化防御或免疫失调的个体。早产新生儿可能特别容易发生这种氧化损伤。

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A clinician's musings on oxygen: Too little or too much with life in the balance.

The most abundant element on Earth, oxygen (O₂) is essential for all complex, eukaryotic life. Because under- (hypoxia) or overexposure (hyperoxia) to O₂ can be detrimental, achieving the ideal balance is crucial for human survival. In this perspective, we discuss the fundamental role of hemoglobin in O₂ transport and tissue oxygenation. We also discuss the role that O_2. can play in oxidative stress, sometimes initiating inflammatory cascades in vulnerable individuals, such as those with deficiencies in antioxidant defenses or with immune dysregulation. Preterm newborns may be especially prone to such oxidative injury.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.