Journal of Perinatology最新文献

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Short-term and long-term effects of vitamin D supplementation for preterm infants: a systematic review and meta-analysis. 补充维生素D对早产儿的短期和长期影响:系统回顾和荟萃分析。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-10-07 DOI: 10.1038/s41372-025-02440-9
Seung Hyun Shin, Hyun Jung Kim, Ju Sun Heo
{"title":"Short-term and long-term effects of vitamin D supplementation for preterm infants: a systematic review and meta-analysis.","authors":"Seung Hyun Shin, Hyun Jung Kim, Ju Sun Heo","doi":"10.1038/s41372-025-02440-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02440-9","url":null,"abstract":"<p><p>Meta-analysis conducted to evaluate the effectiveness of high-dose (≥800 IU/day) and low-dose (<800 IU/day) vitamin D supplementation on preterm infants. Study quality was evaluated using the Revised Cochrane risk-of-bias tool 2 for randomized trials. 21 studies included 1130 infants. Regarding short-term (before 40 weeks' postmenstrual age [PMA] or at discharge) outcomes, high-dose vitamin D supplementation was associated with increased serum 25-hydroxyvitamin D (25[OH]D) levels (mean difference 15.62 [13.35-17.88]) and growth velocities, as well as decreased vitamin D deficiency (VDD), skeletal hypomineralization, and mortality. In the subgroup analysis of high-dose supplementation stratified by dosage, 800 IU/day significantly increased serum 25(OH)D levels (mean difference 13.99 [9.03-18.95]) and reduced the risk of VDD (risk difference -0.21 [-0.32 to -0.10]) compared to 400 IU/day, without increasing the risk of vitamin D excess. The long-term outcomes assessed after 40 weeks' PMA or at follow-up visits showed no significant differences in vitamin D status or neurodevelopmental outcomes between the high-dose and low-dose groups. The certainty of the evidence ranges from moderate to very low. High-dose vitamin D supplementation improved short-term outcomes by increasing serum 25(OH)D levels, promoting growth, and reducing mortality. Among the high-dose regimens, 800 IU/day appeared to be the most appropriate dose.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experiences of NICU healthcare workers serving a high-risk population in a border community in Hidalgo County, Texas. 德克萨斯州伊达尔戈县边境社区新生儿重症监护病房医护人员为高危人群服务的经验
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-10-07 DOI: 10.1038/s41372-025-02441-8
Emily Gurwitz, Dynio Honrubia, Henry C Lee
{"title":"Experiences of NICU healthcare workers serving a high-risk population in a border community in Hidalgo County, Texas.","authors":"Emily Gurwitz, Dynio Honrubia, Henry C Lee","doi":"10.1038/s41372-025-02441-8","DOIUrl":"https://doi.org/10.1038/s41372-025-02441-8","url":null,"abstract":"<p><strong>Objective: </strong>Hidalgo County, Texas, located on the U.S.-Mexico border, is home to over 850 000 residents. Approximately 90% are Hispanic and 25% are foreign-born. Located here is the 65-bed level III neonatal intensive care unit at Doctor's Hospital at Renaissance. This study aims to describe aspects of this unit that are unique and may have contributed to its success in serving a high-risk population.</p><p><strong>Study design: </strong>Semi-structured interviews were conducted with a variety of providers. The interviews were transcribed and qualitatively coded, and emergent themes were analyzed.</p><p><strong>Results: </strong>Thirty-four providers consisting of twenty nurses, three physicians, and eleven others participated. Emergent themes included the perceived importance of language and cultural concordance between patient families and providers and staff consistency.</p><p><strong>Conclusion: </strong>The non-clinical features of this unit reported on by its providers are deserving of additional research that clarifies their clinical effects and replicability at other institutions serving similar populations.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multisensory stimulation by mothers: impact on neonatal pain and maternal anxiety during heel blood collection: a randomized controlled trial. 母亲的多感官刺激:对新生儿疼痛的影响和母亲在足跟采血期间的焦虑:一项随机对照试验。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-10-06 DOI: 10.1038/s41372-025-02436-5
Ayşenur Akkaya-Gül, Nurcan Özyazıcıoğlu, Ezgi Çelikboya-Kabadayı
{"title":"Multisensory stimulation by mothers: impact on neonatal pain and maternal anxiety during heel blood collection: a randomized controlled trial.","authors":"Ayşenur Akkaya-Gül, Nurcan Özyazıcıoğlu, Ezgi Çelikboya-Kabadayı","doi":"10.1038/s41372-025-02436-5","DOIUrl":"https://doi.org/10.1038/s41372-025-02436-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects of maternal multisensory stimulation on neonatal pain and maternal state anxiety during heel blood collection in neonates.</p><p><strong>Study design: </strong>A randomized controlled trial was conducted from July 2019 to January 2020 in neonatal units, with 80 newborns in intervention(n = 40) and control (n = 40) groups. In the intervention group, mothers provided multisensory stimulation (speech, touch, skin odor, breastfeeding, eye contact), while the control group received routine care. Neonatal Infant Pain Scale (NIPS) and maternal state anxiety inventory were evaluated.</p><p><strong>Results: </strong>NIPS scores and maternal anxiety were significantly lower in the intervention group (p < 0.001). A positive correlation was found between NIPS and maternal anxiety in the intervention group (r = 0.372, p = 0.018).</p><p><strong>Conclusions: </strong>Maternal multisensory stimulation reduces neonatal pain and maternal anxiety. These findings emphasize the importance of pediatric nurses considering neonatal comfort and maternal emotional well-being during medical procedures.</p><p><strong>Clinical trial registration: </strong>The protocol for this randomized controlled experimental trial is registered on ClinicalTrials.gov. The clinical trial registration number is https://clinicaltrials.gov ; NCT05606458.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying optimal positive end-expiratory pressure with electrical impedance tomography guidance in severe bronchopulmonary dysplasia. 用电阻抗断层扫描识别严重支气管肺发育不良患者的最佳呼气末正压。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-09-30 DOI: 10.1038/s41372-025-02433-8
Jessica E Shui, Carolyn J LaVita, Glasiele C Alcala, John H Nichols, Romal K Jassar, Rodica M Turcu, Paul H Lerou, Maurizio F Cereda, Ryan W Carroll, Roberta Ribeiro De Santis Santiago, Lorenzo Berra
{"title":"Identifying optimal positive end-expiratory pressure with electrical impedance tomography guidance in severe bronchopulmonary dysplasia.","authors":"Jessica E Shui, Carolyn J LaVita, Glasiele C Alcala, John H Nichols, Romal K Jassar, Rodica M Turcu, Paul H Lerou, Maurizio F Cereda, Ryan W Carroll, Roberta Ribeiro De Santis Santiago, Lorenzo Berra","doi":"10.1038/s41372-025-02433-8","DOIUrl":"https://doi.org/10.1038/s41372-025-02433-8","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility of electrical impedance tomography (EIT) guided positive end-expiratory pressure (PEEP) titration to identify optimal PEEP in infants with severe bronchopulmonary dysplasia (BPD).</p><p><strong>Study design: </strong>Case series of five EIT guided PEEP titrations in infants with severe BPD compared to a case series of five infants, without lung disease, requiring intubation. Optimal PEEP was identified as minimal percentage of lung overdistension and collapse. Lung function, bedside ventilatory and clinical data were tracked post EIT guided optimal PEEP titration.</p><p><strong>Result: </strong>Four out of the five EIT assessments in infants with BPD identified an optimal PEEP that was sustained for at least three weeks. Three of the four successful assessments led to a decrease in PEEP, compared to baseline, and one confirmed the baseline PEEP was optimal.</p><p><strong>Conclusion: </strong>EIT assessments can be a novel tool to aide identification of optimal PEEP in infants with heterogeneous lung disease.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of maternal primary language with neurodevelopmental outcomes in high-risk infants. 高危婴儿母语与神经发育结局的关系。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-09-29 DOI: 10.1038/s41372-025-02438-3
Nicole Nghiem, Maria Martes Gomez, My H Vu, Alexis Deavenport-Saman, Douglas Vanderbilt, Ashwini Lakshmanan, Sarah Wang, Ani Boodaghian, Christine B Mirzaian
{"title":"Association of maternal primary language with neurodevelopmental outcomes in high-risk infants.","authors":"Nicole Nghiem, Maria Martes Gomez, My H Vu, Alexis Deavenport-Saman, Douglas Vanderbilt, Ashwini Lakshmanan, Sarah Wang, Ani Boodaghian, Christine B Mirzaian","doi":"10.1038/s41372-025-02438-3","DOIUrl":"https://doi.org/10.1038/s41372-025-02438-3","url":null,"abstract":"<p><strong>Objective: </strong>Examine whether maternal primary language (English or a minoritized language) is associated with differences in infant developmental outcomes.</p><p><strong>Study design: </strong>This retrospective cohort study included 253 infants from a high-risk infant follow-up clinic at a quaternary care center in the U.S. who underwent developmental evaluation at 6, 12, and 24 months corrected age. The Bayley Scales, 3rd and 4th editions, were used to assess development.</p><p><strong>Result: </strong>At 6- and 12-month visits, the minoritized-language group had significantly lower scores than the English-language group in cognitive, language, and motor domains. By the 24-month visit, the minoritized-language group appeared to catch up in cognitive and motor domains but a significant difference in language skills persisted.</p><p><strong>Conclusion: </strong>Our findings indicate disparities in developmental outcomes, particularly in language skills at 24 months corrected age, based on maternal primary language, underscoring the need for further research to inform targeted interventions to address these disparities.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parents' perspectives on the use of statistics to convey uncertainty in the NICU: a qualitative analysis. 在新生儿重症监护室中,父母对使用统计数据传达不确定性的看法:一项定性分析。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-09-29 DOI: 10.1038/s41372-025-02439-2
Jeanne A Krick, Caitlin E Toffler, Nina Y Zhou, Marin Arnolds
{"title":"Parents' perspectives on the use of statistics to convey uncertainty in the NICU: a qualitative analysis.","authors":"Jeanne A Krick, Caitlin E Toffler, Nina Y Zhou, Marin Arnolds","doi":"10.1038/s41372-025-02439-2","DOIUrl":"https://doi.org/10.1038/s41372-025-02439-2","url":null,"abstract":"<p><strong>Objective: </strong>Explore NICU parents' perspectives on how statistics are used to communicate prognostic uncertainty.</p><p><strong>Study design: </strong>A secondary qualitative grounded theory analysis of semi-structured interviews with parents of current and past NICU patients focusing on their experience with prognostic uncertainty.</p><p><strong>Results: </strong>Parents had varying opinions on the use of statistics. These views depended on many factors, including the motives for sharing statistics, their child's clinical status, their own emotional state, and their relationship with the provider communicating the uncertainty. Depending upon how statistics were utilized, parents felt they could be helpful and desired at times, but also harmful and counterproductive at others. Parents also shared recommendations on how statistics should be utilized in communicating uncertainty.</p><p><strong>Conclusion: </strong>This study reveals an important parental perspective on communication for anyone caring for critically ill neonates. In sharing recommendations for communicating uncertainty with statistics, this study can help providers enhance relationships with parents.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in delivery hospital risk-adjusted outcomes for very low birthweight infants: the role of NICU volume and level of care. 极低出生体重儿的分娩医院风险调整结果差异:新生儿重症监护室容量和护理水平的作用
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-09-27 DOI: 10.1038/s41372-025-02434-7
Gia Yannekis, Sarah N Kunz, Molly Passarella, Brielle Formanowski, Scott A Lorch
{"title":"Disparities in delivery hospital risk-adjusted outcomes for very low birthweight infants: the role of NICU volume and level of care.","authors":"Gia Yannekis, Sarah N Kunz, Molly Passarella, Brielle Formanowski, Scott A Lorch","doi":"10.1038/s41372-025-02434-7","DOIUrl":"10.1038/s41372-025-02434-7","url":null,"abstract":"<p><strong>Objective: </strong>Describe racial and ethnic differences in delivery hospital NICU risk-adjusted mortality and morbidity rates (RAMMR), stratified by volume and level of care.</p><p><strong>Study design: </strong>Cross-sectional analysis of all very low birthweight (<1500 g; VLBW) infants born in Michigan, Oregon, and South Carolina between 2010 and 2020 and Pennsylvania between 2010 and 2018 (n = 37,784). Lorenz concentration curves and indices were used to describe differences in NICU RAMMR by race and ethnicity. Analysis was performed for overall cohort; high-level, high-volume NICUs; and low-level and/or low-volume NICUs.</p><p><strong>Result: </strong>Despite being most frequently born at high-level, high-volume centers, Non-Hispanic Black (NHB) neonates were overrepresented at hospitals with high RAMMR and all other groups were overrepresented at hospitals with lower RAMMR. Differences were most pronounced in the low-level and/or low-volume cohort.</p><p><strong>Conclusion: </strong>NHB VLBW infants born at hospitals with low-level and/or low-volume NICUs are disproportionately exposed to adverse outcomes and must be the focus of future policy interventions.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation and reliability of a scale for prolonged pain assessment in Brazilian neonates. 巴西新生儿长期疼痛评估量表的有效性和可靠性。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-09-24 DOI: 10.1038/s41372-025-02430-x
Amanda Dos Santos Erhardt, Mariana Bueno, Taís Beppler Martins, Natália Alves Menegol, André Luís Ferreira Meireles, Dayane Montemezzo, Monique van Dijk, Luciana Sayuri Sanada
{"title":"Validation and reliability of a scale for prolonged pain assessment in Brazilian neonates.","authors":"Amanda Dos Santos Erhardt, Mariana Bueno, Taís Beppler Martins, Natália Alves Menegol, André Luís Ferreira Meireles, Dayane Montemezzo, Monique van Dijk, Luciana Sayuri Sanada","doi":"10.1038/s41372-025-02430-x","DOIUrl":"https://doi.org/10.1038/s41372-025-02430-x","url":null,"abstract":"<p><p>To evaluate the convergent construct validity, intra- and inter-rater reliability, and internal consistency of the COMFORTneo-Brazil scale.</p><p><strong>Study design: </strong>The study included neonates between 24 and 42 weeks of gestational age. Convergent construct validity was analyzed by comparing COMFORTneo-Brazil scores with those from the Échelle Douleur Inconfort Nouveau-Né (EDIN) scale. Two trained raters performed bedside evaluations and video assessments, separated by 10-14 days, to assess intra- and inter-rater reliability. Spearman's correlation, linear weighted kappa, intraclass correlation coefficient (ICC), Bland-Altman plots, and Cronbach's alpha were used in the analysis.</p><p><strong>Results: </strong>One hundred and thirty-three evaluations were conducted. There was excellent convergent validity between COMFORTneo-Brazil and EDIN scores (rho = 0.929; p < 0.001). The COMFORTneo-Brazil demonstrated excellent intra- and inter-rater reliability (ICC > 0.9). Internal consistency was also high (Cronbach's alpha = 0.858).</p><p><strong>Conclusions: </strong>The COMFORTneo-Brazil is a valid and reliable tool for prolonged pain assessment in neonates.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Maternity care practices supportive of breastfeeding in U.S. advanced neonatal care units, United States, 2022. 更正:美国高级新生儿护理单位支持母乳喂养的产妇护理实践,美国,2022年。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-09-24 DOI: 10.1038/s41372-025-02404-z
E Anstey, A Noiman, E Boundy, J Nelson
{"title":"Correction: Maternity care practices supportive of breastfeeding in U.S. advanced neonatal care units, United States, 2022.","authors":"E Anstey, A Noiman, E Boundy, J Nelson","doi":"10.1038/s41372-025-02404-z","DOIUrl":"https://doi.org/10.1038/s41372-025-02404-z","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation. 经导管关闭动脉导管未闭与手术结扎对极早产儿神经发育的影响。
IF 2.4 3区 医学
Journal of Perinatology Pub Date : 2025-09-23 DOI: 10.1038/s41372-025-02417-8
D C Kaluarachchi, V Y Chock, B T Do, M A Rysavy, M N Sankar, M M Laughon, C H Backes, T T Colaizy, E F Bell, P J McNamara, S R Hintz, G Natarajan
{"title":"Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation.","authors":"D C Kaluarachchi, V Y Chock, B T Do, M A Rysavy, M N Sankar, M M Laughon, C H Backes, T T Colaizy, E F Bell, P J McNamara, S R Hintz, G Natarajan","doi":"10.1038/s41372-025-02417-8","DOIUrl":"https://doi.org/10.1038/s41372-025-02417-8","url":null,"abstract":"<p><strong>Background: </strong>There is a paucity of data on neurodevelopmental outcomes in preterm infants who undergo transcatheter patent ductus arteriosus (PDA) closure (TCPC).</p><p><strong>Objective: </strong>To evaluate neurodevelopmental impairment (NDI) or death at 2 years among preterm infants treated with TCPC compared to surgical ligation.</p><p><strong>Methods: </strong>Retrospective cohort study of infants born at <27 weeks' gestation at NICHD NRN sites. Comparisons were made between infants who underwent TCPC and PDA ligation.</p><p><strong>Results: </strong>TCPC and surgical ligation were performed on 99 and 279 infants, respectively. Death or severe NDI occurred in 49% of infants with TCPC and 40% with surgical ligation. There was no difference in odds of death or severe NDI between the two groups [aOR 1.12 95% CI: 0.55-2.26)].</p><p><strong>Conclusion: </strong>TCPC had similar odds of death or severe NDI compared to surgical ligation. These findings need to be evaluated in large prospective studies as the management practice around the TCPC evolves.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov ID: Generic Database: NCT00063063.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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