Journal of Perinatology最新文献

Response of the ductus arteriosus to acetaminophen or indomethacin in extremely low birth weight infants.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-18 DOI: 10.1038/s41372-024-02199-5

Courtney C Sutton, James C Slaughter, Mhd Wael Alrifai, Jennifer Hale, Jeff Reese

{"title":"Response of the ductus arteriosus to acetaminophen or indomethacin in extremely low birth weight infants.","authors":"Courtney C Sutton, James C Slaughter, Mhd Wael Alrifai, Jennifer Hale, Jeff Reese","doi":"10.1038/s41372-024-02199-5","DOIUrl":"https://doi.org/10.1038/s41372-024-02199-5","url":null,"abstract":"Objective: Acetaminophen and indomethacin are used for medical management of a patent ductus arteriosus. This study compared the efficacy of these agents in ELBW infants.Study design: This was a retrospective study of all courses of indomethacin and acetaminophen. Baseline characteristics, details of pharmacologic therapy, toxicity, and acetaminophen serum concentrations were collected. The primary analysis compared rates of ductus closure with indomethacin versus acetaminophen using Pearson's Chi-squared test.Results: Ductus closure after a single course of therapy was similar between acetaminophen and indomethacin 16% vs. 18%, (p = 0.79). No differences were found in gestational age, birth weight, patient acuity, toxicity, or acetaminophen concentrations between those courses that resulted in closure compared to those that did not. When comparing single-agent exposure, indomethacin was initiated earlier (9.0 vs. 13.5 days, p = 0.022) but PDA closure rates were similar between groups.Conclusion: Acetaminophen and indomethacin produced similar rates of ductus closure in this population.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nebulized salbutamol for the treatment of transient tachypnea of the newborn: a randomized controlled trial.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-17 DOI: 10.1038/s41372-024-02201-0

Aditi Dhaka, Sonu Kumar, Poonam Singh, Mayank Priyadarshi, Suman Chaurasia, Nowneet Kumar Bhat, Sriparna Basu

{"title":"Nebulized salbutamol for the treatment of transient tachypnea of the newborn: a randomized controlled trial.","authors":"Aditi Dhaka, Sonu Kumar, Poonam Singh, Mayank Priyadarshi, Suman Chaurasia, Nowneet Kumar Bhat, Sriparna Basu","doi":"10.1038/s41372-024-02201-0","DOIUrl":"https://doi.org/10.1038/s41372-024-02201-0","url":null,"abstract":"Objective: To compare the efficacy of nebulized salbutamol in reducing respiratory distress in late preterm and term neonates with transient tachypnea of newborn (TTN).Study design: Double-blind, placebo-controlled randomized trial.Methods: Neonates with TTN (n = 134) were allocated to nebulized salbutamol (n = 67) versus placebo (normal saline) (n = 67). The primary outcome was the duration of tachypnea (respiratory rate >60/min). Secondary outcomes were maximum Downes score and fraction of inspired oxygen (FiO2) after nebulization, duration of respiratory support, and adverse effects of salbutamol nebulization.Results: Median duration of tachypnea was 12.5 (10-16) vs. 12 (10.4-14) hours in salbutamol and placebo groups, respectively; p = 0.489. Almost all neonates received positive-pressure respiratory support at delivery room and subsequently. Maximum Downe's score, FiO2 requirement, and duration of respiratory support were similar. No adverse effect of salbutamol was documented.Conclusion: There was no difference in the duration of tachypnea with nebulized salbutamol compared to placebo in late preterm and term neonates with TTN.Clinical trial registration: Clinical trial registry of India, Registration no: CTRI/2023/05/052441, Registered prospectively on 10/05/2023, https://ctri.icmr.org.in/.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bemiparin in neonatal thrombosis: therapeutic dosing and safety.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-16 DOI: 10.1038/s41372-024-02200-1

Maria Sanchez-Holgado, Mercedes Sampedro, Carlos Zozaya, Celia Permuy Romero, Patricia Alvarez-Garcia, Leticia La Banda-Montalvo, Clara Nieto, Adelina Pellicer

{"title":"Bemiparin in neonatal thrombosis: therapeutic dosing and safety.","authors":"Maria Sanchez-Holgado, Mercedes Sampedro, Carlos Zozaya, Celia Permuy Romero, Patricia Alvarez-Garcia, Leticia La Banda-Montalvo, Clara Nieto, Adelina Pellicer","doi":"10.1038/s41372-024-02200-1","DOIUrl":"https://doi.org/10.1038/s41372-024-02200-1","url":null,"abstract":"Objective: To evaluate the therapeutic dose and safety of bemiparin in neonatal thrombosis treatment.Study design: A retrospective review was conducted on infants treated with bemiparin between 2018 and 2023 at a tertiary hospital.Results: 72 neonates with a mean gestational age of 37 weeks were included. Twenty were preterm, with a median gestational age of 33.5 weeks and a median birth weight of 1847.5 grams. The mean (SD) initial and therapeutic bemiparin doses were 170.5 (31) and 200 (37.2) IU/kg/day, respectively. Only 32% of patients reached the therapeutic target range (TTR) with the initial dose. Preterm infants required higher doses to reach TTR (215 vs 194.7 IU/kg/day, p = 0.05). Adverse events were minimal (1.4%) and unrelated to the starting dose or prematurity.Conclusion: Bemiparin appears to be a potential therapeutic option for anticoagulation in neonates; however, targeted anti-Xa levels were rarely achieved with the initial dose and most patients required uptitration.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transitioning medically complex infants home: lessons learned from quality improvement efforts.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-14 DOI: 10.1038/s41372-024-02189-7

Dan Benscoter, Kristin Voos, Christine L Schuler, Andrea J Hoberman, Heather C Kaplan, Pierce Kuhnell, Carole M Lannon

{"title":"Transitioning medically complex infants home: lessons learned from quality improvement efforts.","authors":"Dan Benscoter, Kristin Voos, Christine L Schuler, Andrea J Hoberman, Heather C Kaplan, Pierce Kuhnell, Carole M Lannon","doi":"10.1038/s41372-024-02189-7","DOIUrl":"https://doi.org/10.1038/s41372-024-02189-7","url":null,"abstract":"Objective: Decrease: 1) time from tracheostomy or gastrostomy tube placement to discharge home, and 2) avoidable readmissions within 7 days post-discharge, for medically complex infants.Study design: Five neonatology units and representatives from Medicaid and Managed Care Organizations participated. Measures included length of stay (LOS) from surgery to discharge, readmissions, and time from surgery to identifying home nursing. We used statistical process control (SPC) methods and bivariate tests for post-hoc before-after comparisons.Result: Among 421 infants, no avoidable readmissions occurred in the final 25 months. LOS and all-cause readmissions were unchanged (SPC). LOS changes were variable, ranging from -39.5 days (tracheostomy and ventilator) to +30.8 days (tracheostomy without ventilator) and not significant. Median time to identify home nursing was 70.1 days (range 2-428).Conclusion: Although lack of skilled home nursing precluded improving transitions from NICU to home in medically complex infants, all avoidable readmissions were eliminated for 25 months.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The feasibility of virtual home visits to address unmet needs after NICU discharge.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-14 DOI: 10.1038/s41372-024-02180-2

Jonathan S Litt, Julie Belmont, Paige T Church, Julianna Howland, Jane E Stewart

引用次数: 0

Early medical risks to language development in extremely preterm infants. 极早产儿语言发育的早期医疗风险。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-13 DOI: 10.1038/s41372-024-02191-z

Paige M Nelson, Francesca Scheiber, Ö Ece Demir-Lira, Heidi M Harmon

{"title":"Early medical risks to language development in extremely preterm infants.","authors":"Paige M Nelson, Francesca Scheiber, Ö Ece Demir-Lira, Heidi M Harmon","doi":"10.1038/s41372-024-02191-z","DOIUrl":"https://doi.org/10.1038/s41372-024-02191-z","url":null,"abstract":"Objective: To study the mechanistic role of neonatal morbidities on language performance in extremely preterm (EP) infants.Study design: We conducted secondary analyses on EP infants born at a single tertiary care center, investigating whether neonatal morbidities mediated associations between gestational age and language performance at 18-26 months corrected age.Results: Infants born at 25-26 weeks (n = 298) outperformed those born at 22-24 weeks (n = 177) in expressive communication, receptive communication, composite language, and cognition. Retinopathy of prematurity (ROP), grade 2/3 bronchopulmonary dysplasia (BPD), and cognition partially explained gestational age effects on expressive and receptive communication. In the final sequential path models, infants born 22-24 weeks gestation were more likely to be diagnosed with grade 2/3 BPD, which was linked to diminished cognitive skills, and reduced language skills.Conclusion: Families of EP infants born under 25 weeks or with ROP and/or grade 2/3 BPD should be counseled about higher language impairment risk and receive proactive intervention.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inter-center variations in inpatient outcomes for infants with gastroschisis from the Children's Hospitals Neonatal Consortium.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-11 DOI: 10.1038/s41372-024-02160-6

Con Yee Ling, Isabella Zaniletti, Stefanie Riddle, Jacobson Elizabeth, Stephanie G Korff, Angela L Chandler, L Corbin Downey, Michael A Padula, Jacquelyn R Evans, Theresa R Grover, Karna Murthy

{"title":"Inter-center variations in inpatient outcomes for infants with gastroschisis from the Children's Hospitals Neonatal Consortium.","authors":"Con Yee Ling, Isabella Zaniletti, Stefanie Riddle, Jacobson Elizabeth, Stephanie G Korff, Angela L Chandler, L Corbin Downey, Michael A Padula, Jacquelyn R Evans, Theresa R Grover, Karna Murthy","doi":"10.1038/s41372-024-02160-6","DOIUrl":"https://doi.org/10.1038/s41372-024-02160-6","url":null,"abstract":"Objective: To estimate inter-center variation (ICV) in hospital length of stay (LOS) and oral feeding at discharge among infants with gastroschisis.Study design: The Children's Hospitals Neonatal Consortium's (CHNC) database was used to identify hospitalized survivors with gastroschisis. Two outcomes were evaluated: LOS and discharge without tube feedings. Hospital outcomes were evaluated in unadjusted and adjusted analyses. Generalized linear models with log link for gamma distribution were used to model LOS and logistic regression for discharge without tube feeds.Results: For 3987 surviving infants with gastroschisis, LOS and discharge within 70 days with exclusively oral feeding both exhibited significant ICV. Differences persisted in multivariable analyses. Risk-adjusted LOS (68% difference) and oral feeding at discharge (6.4-fold difference) varied significantly between centers.Conclusion: Hospital of care was independently associated with LOS and exclusive oral feeding at discharge rates for infants with gastroschisis. Management differences, potentially influenced by parental preferences, contributed to variation.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kidney injury in neonates after implementation of a standardized neonatal nephrology consult program: a single center experience.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-11 DOI: 10.1038/s41372-024-02197-7

Mayra Kotlik, Benjamin Holland, Kathryn Lowe, Samantha Wallace, Anna Latimer, Jennifer L Chmielewski, Paulomi Chaudhry, Danielle E Soranno, Cara L Slagle, Michelle C Starr

引用次数: 0

Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-11 DOI: 10.1038/s41372-024-02194-w

Siyuan Jiang, Xin Cui, Anup Katheria, Neil N Finer, Mihoko V Bennett, Jochen Profit, Henry C Lee

{"title":"Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants.","authors":"Siyuan Jiang, Xin Cui, Anup Katheria, Neil N Finer, Mihoko V Bennett, Jochen Profit, Henry C Lee","doi":"10.1038/s41372-024-02194-w","DOIUrl":"https://doi.org/10.1038/s41372-024-02194-w","url":null,"abstract":"Objective: To assess the relationship between 5-min oxygen saturation (SpO2) and outcomes in extremely preterm infants.Study design: This cohort study included infants ≤28 weeks' gestation across nine hospitals from 2020 to 2022. Death and / or severe intraventricular hemorrhage (IVH) were compared between infants with 5-min SpO2 < 80% and 80-100% using Poisson regression models. Receiver Operating Characteristic (ROC) curve and optimal breakpoint analysis were used to estimate the optimal breakpoint of 5-min SpO2 in relation to outcomes.Result: Of 390 infants, 184 (47.2%) had 5-min SpO2 < 80%. A 5-min SpO2 < 80% was independently associated with increased risks of death and / or severe IVH, early death, and severe IVH. ROC analysis of 5-min SpO2 identified optimal breakpoint at 81-85%, above which no additional benefit in outcomes was observed.Conclusion: Our findings support the current recommendation of 5-min SpO2 target of ≥80% for extremely preterm infants.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structured pre-delivery huddles enhance confidence in managing newborns with critical congenital heart disease in the delivery room.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-10 DOI: 10.1038/s41372-024-02196-8

Alyssa R Thomas, Caitlin Bowen, Elisa Abdulhayoglu, Elizabeth Brennick, Kendra Woo, Margaret F Everett, Eleonore Valencia, Kristen T Leeman, Simon M Manning, Elisabeth Kaza

{"title":"Structured pre-delivery huddles enhance confidence in managing newborns with critical congenital heart disease in the delivery room.","authors":"Alyssa R Thomas, Caitlin Bowen, Elisa Abdulhayoglu, Elizabeth Brennick, Kendra Woo, Margaret F Everett, Eleonore Valencia, Kristen T Leeman, Simon M Manning, Elisabeth Kaza","doi":"10.1038/s41372-024-02196-8","DOIUrl":"https://doi.org/10.1038/s41372-024-02196-8","url":null,"abstract":"Background: Newborns with critical congenital heart disease (CCHD) require specialized delivery room management, but varying experience and knowledge can reduce confidence and impact care.Methods: A pre-delivery, structured huddle checklist was introduced, addressing team roles, expected physiology, and management plans. PDSA cycles incorporated guidelines and simulation-based education to improve confidence in specialized resuscitation strategies. Surveys were conducted at baseline and 6 months.Results: Baseline, all-respondent confidence in managing \"all types of CCHD\" was somewhat confident (median 3/5; IQR 2-4) increasing to moderately confident (4/5; IQR 2-4) at 6 months (p = 0.59). Respondents with 0-3 years' experience showed increased confidence over 6 months in identifying unstable infants (from baseline 24% to 67% moderately/very confident, p = 0.005), prostaglandin E1 needs (from 24% to 62%, p = 0.013) and sedation requirements (from 5% to 33%, p = 0.045).Conclusion: Structured huddles improved confidence among less experienced team members, emphasizing the importance of shared mental models before CCHD deliveries.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0