Journal of Perinatology最新文献

Applications of lung ultrasound in preterm infants: implications for respiratory distress syndrome and bronchopulmonary dysplasia. 肺超声在早产儿中的应用：对呼吸窘迫综合征和支气管肺发育不良的影响。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-19 DOI: 10.1038/s41372-026-02849-w

Nicole Stephenson, Cara Beth Carr, Daniel Park, Matthew Laughon

{"title":"Applications of lung ultrasound in preterm infants: implications for respiratory distress syndrome and bronchopulmonary dysplasia.","authors":"Nicole Stephenson, Cara Beth Carr, Daniel Park, Matthew Laughon","doi":"10.1038/s41372-026-02849-w","DOIUrl":"https://doi.org/10.1038/s41372-026-02849-w","url":null,"abstract":"Lung ultrasound (LUS) has emerged as a promising bedside imaging modality in neonatal intensive care units, offering real-time assessment of lung aeration without exposure to ionizing radiation. These advantages are particularly relevant for preterm infants, who are vulnerable to cumulative radiation exposure and evolving pulmonary disease. In this narrative review, we synthesize current evidence on the functional clinical applications of lung ultrasound in preterm infants. We focus on how LUS has been studied to guide early respiratory management, predict the need for surfactant and escalation of respiratory support, assess extubation readiness, identify infants at increased risk for bronchopulmonary dysplasia, and monitor disease trajectory and response to therapy throughout the NICU course, including emerging data on longer-term respiratory outcomes. While available studies demonstrate promising diagnostic and prognostic value, interpretation is limited by heterogeneity in acquisition protocols, scoring systems, timing of assessment, and operator dependence. Further multicenter studies with standardized protocols are needed to define the role of LUS in routine neonatal respiratory care.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting tracheostomy using ventilator support at 36 and 44 weeks in infants with grade 2 or 3 bronchopulmonary dysplasia. 预测2级或3级支气管肺发育不良婴儿在36周和44周时使用呼吸机支持的气管切开术。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-19 DOI: 10.1038/s41372-026-02926-0

Jonathan C Levin, Joshua Ray Tanzer, Christopher H Schmid, Robin L McKinney

引用次数: 0

Early enteral nutrition with mothers' own milk, donor human milk, or a combination of both on neonatal feeding milestones: a cross-sectional study. 早期肠内营养与母亲自己的母乳，供体母乳，或两者结合在新生儿喂养里程碑：一项横断面研究。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-19 DOI: 10.1038/s41372-026-02928-y

Lyssa Lamport, Hamed Samavat, Allison Gomes, Melanie Newkirk, Laura Byham-Gray, Jane Ziegler

{"title":"Early enteral nutrition with mothers' own milk, donor human milk, or a combination of both on neonatal feeding milestones: a cross-sectional study.","authors":"Lyssa Lamport, Hamed Samavat, Allison Gomes, Melanie Newkirk, Laura Byham-Gray, Jane Ziegler","doi":"10.1038/s41372-026-02928-y","DOIUrl":"https://doi.org/10.1038/s41372-026-02928-y","url":null,"abstract":"Objective: To evaluate the association between early enteral nutrition (EN) with mothers' own milk (MOM), donor human milk (DHM), or a combination on time to human milk (HM) fortification, time to full EN, and parenteral nutrition (PN) duration.Study design: Cross-sectional retrospective chart review of 359 preterm infants grouped by HM type. A generalized linear model was used to analyze the impact of HM type on days to HM fortification, full EN, and PN duration.Results: Median gestational age was 28.9 (27.1-30.4) weeks; mean birth weight was 1060.5 ± 248.9 g. HM fortification occurred at 5.0 (4.0-7.0) days, full EN at 9.0 (7.0-11.0) days, and PN duration was 10.0 (9.0-13.0) days. No significant differences were found across HM groups for HM fortification (P = 0.787), full EN (P = 0.724), or PN days (P = 0.71).Conclusion: Early feeding with MOM, DHM, or both does not delay achievement of neonatal feeding milestones in preterm infants.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of extremely low gestational age newborns receiving milrinone and possible risk factors associated with the development of systemic hypotension. 极低胎龄新生儿接受米力酮治疗的特点及发生全身性低血压的可能危险因素。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-16 DOI: 10.1038/s41372-026-02773-z

Trassanee Chatmethakul, Adrianne R Bischoff, Danielle R Rios, Patrick J McNamara

引用次数: 0

Distinct birth size and postnatal growth patterns in preterm twins and singletons: an etiology-based analysis from the INTERPRACTICE-21^st study. 早产双胞胎和单胎的不同出生尺寸和产后生长模式：来自interpractice -21研究的病因学分析。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-14 DOI: 10.1038/s41372-026-02912-6

Paola Roggero, Francesca Giuliani, Robert B Gunier, Adele Winsey, Stephen A Rauch, Montserrat Izquierdo Renau, Irma Alejandra Coronado Zarco, Shabina Ariff, Maria Albertina S Rego, Constanza Soto Conti, Roseline Ochieng, Funda Tuzun, Jacqueline Asibey, Chandrakala Bada Shekharappa, Alexandre Lapillonne, Gabriela Tavcioska, Leila Cheikh Ismail, Camilla Menis, Marina Markelova, Ricardo Nieto, Josephine N A Agyeman-Duah, Sonia Deantoni, Brenda Frias Madrid, Fabio Mosca, Irina Ryumina, Monica Fumagalli, Brenda Eskenazi, Zulfiqar Bhutta, Aris Papageorghiou, Stephen Kennedy, Jose Villar

{"title":"Distinct birth size and postnatal growth patterns in preterm twins and singletons: an etiology-based analysis from the INTERPRACTICE-21st study.","authors":"Paola Roggero, Francesca Giuliani, Robert B Gunier, Adele Winsey, Stephen A Rauch, Montserrat Izquierdo Renau, Irma Alejandra Coronado Zarco, Shabina Ariff, Maria Albertina S Rego, Constanza Soto Conti, Roseline Ochieng, Funda Tuzun, Jacqueline Asibey, Chandrakala Bada Shekharappa, Alexandre Lapillonne, Gabriela Tavcioska, Leila Cheikh Ismail, Camilla Menis, Marina Markelova, Ricardo Nieto, Josephine N A Agyeman-Duah, Sonia Deantoni, Brenda Frias Madrid, Fabio Mosca, Irina Ryumina, Monica Fumagalli, Brenda Eskenazi, Zulfiqar Bhutta, Aris Papageorghiou, Stephen Kennedy, Jose Villar","doi":"10.1038/s41372-026-02912-6","DOIUrl":"https://doi.org/10.1038/s41372-026-02912-6","url":null,"abstract":"Objective: Compare birth size and postnatal growth between preterm twins and singletons across gestational age categories and etiologic subgroups.Study design: Preterm twins and singletons (n = 3245) were classified into nine subgroups based on predefined preterm birth etiologies. Postnatal growth (weight, length and head circumference) trajectories were evaluated using multilevel linear regression models accounting for repeated measurements, expressed as z-score changes from birth to hospital discharge based on INTERGROWTH-21st Standards.Results: Twins were significantly smaller at birth than singletons, particularly in late preterm category, but not in the very preterm category. Twin postnatal growth was slower (unadjusted models); most differences attenuated or reversed after adjusting for birth size and key covariates. Twins in the 'pre-eclampsia' subgroup showed greater adjusted postnatal weight, whereas weight gain was persistently lower in the 'perinatal sepsis' subgroup.Conclusion: Preterm twins and singletons have distinct intrauterine and postnatal growth patterns, varying by preterm birth etiology and gestational age categories.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Perinatal prediction of mortality for neonates born at 22-25 weeks gestation. 更正：妊娠22-25周出生的新生儿围产期死亡率预测。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-14 DOI: 10.1038/s41372-026-02920-6

Xuxin Chen, Tianyao Lu, Davide De Francisco, Jeffrey B Gould, Susan R Hintz, Deirdre J Lyell, Xiao Xu, Lillian Sie, Matthew A Rysavy, Nima Aghaeepour, Henry C Lee

引用次数: 0

Long-term outcomes of preterm infants admitted to single-family rooms versus an open-bay neonatal intensive care unit: A randomized controlled trial. 早产儿入住单户病房与开放式新生儿重症监护病房的长期预后：一项随机对照试验。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-12 DOI: 10.1038/s41372-026-02927-z

Michael J Vincer, Christy G Woolcott, Darlene J Inglis, Tanya M Myles, Susan M MacDonald, Jehier Afifi, C David Simpson, Satvinder Ghotra, Walid El-Naggar, Balpreet Singh, Danielle Styranko, Sharon Unger, Souvik Mitra, Douglas D McMillan, Jon S Dorling

{"title":"Long-term outcomes of preterm infants admitted to single-family rooms versus an open-bay neonatal intensive care unit: A randomized controlled trial.","authors":"Michael J Vincer, Christy G Woolcott, Darlene J Inglis, Tanya M Myles, Susan M MacDonald, Jehier Afifi, C David Simpson, Satvinder Ghotra, Walid El-Naggar, Balpreet Singh, Danielle Styranko, Sharon Unger, Souvik Mitra, Douglas D McMillan, Jon S Dorling","doi":"10.1038/s41372-026-02927-z","DOIUrl":"https://doi.org/10.1038/s41372-026-02927-z","url":null,"abstract":"Objective: To compare long-term outcomes of preterm infants in single-family room (SFR) vs. open-bay (OB) neonatal intensive care unit (NICU).Study design: This randomized controlled trial took place in a tertiary NICU from April 2018 to June 2019. Infants <31 weeks gestation or ≤1500 grams birthweight were randomly assigned upon admission to SFR or OB. The primary outcome was death or neurodevelopmental impairment (NDI; cerebral palsy, language delay, cognitive delay, blindness, or deafness) at 36 months corrected age. Secondary outcomes were mortality, NDI components, and safety measures.Results: Of 85 infants (43 SFR, 42 OB), there was no difference in primary outcome (40.5% SFR vs. 47.4% OB, p = 0.644). Secondary outcomes did not differ except mortality, which was lower in SFR (1/41, 2.4%) than OB (8/42, 19.0%), p = 0.029.Conclusions: Composite outcome of death/NDI at 36 months corrected age was similar; however, reduction in mortality was noted in SFR. This trial was registered 6 Mar 2019 with ClinicalTrials.gov, NCT03867669 ( https://clinicaltrials.gov/search?cond=NCT03867669 ).","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sixty golden minutes: a quality improvement bundle reduces morbidities in at-risk preterm infants. 60黄金分钟：质量改善一揽子计划可降低高危早产儿的发病率。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-12 DOI: 10.1038/s41372-026-02925-1

Justin Kotliar, Priyanka Tiwari, Yafa Davydova, Brienne Lubor, Christine Karotseris, Jane Taikina, Cailinn Connolly, Elizabeth Farra, Laura Milless, Vivien Yap, Lauren Blatt

{"title":"Sixty golden minutes: a quality improvement bundle reduces morbidities in at-risk preterm infants.","authors":"Justin Kotliar, Priyanka Tiwari, Yafa Davydova, Brienne Lubor, Christine Karotseris, Jane Taikina, Cailinn Connolly, Elizabeth Farra, Laura Milless, Vivien Yap, Lauren Blatt","doi":"10.1038/s41372-026-02925-1","DOIUrl":"https://doi.org/10.1038/s41372-026-02925-1","url":null,"abstract":"Objective: Timely interventions during the \"Golden Hour\" (GH) reduce neonatal morbidity and mortality. We aimed to decrease hypothermia, time to antibiotics and intravenous fluids (IVF) initiation and invasive ventilation by 25%, bronchopulmonary dysplasia (BPD) by 10% and achieve 50% adherence to a GH bundle in our NICU.Study design: We conducted a quality improvement initiative using seven Plan-Do-Study-Act cycles (December 2021-October 2023) for infants <32 weeks gestation and/or ≤ 1500 grams. Outcomes were analyzed using statistical process control charts.Results: Over the study period, moderate-severe hypothermia decreased from 25% to 0%, the mean time to antibiotics improved from 132 to 77 min and IVF initiation within GH increased from 30% to 86%. Grade 2/3 BPD decreased from 37% to 19%. GH bundle adherence reached 88%.Conclusion: Implementation of a structured golden hour bundle, incorporating standardized admission workflows, improved thermoregulation practices, and optimized early respiratory management, resulted in improved outcomes in at-risk preterm infants.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of growth and morbidity outcomes in preterm infants using two different intravenous lipid emulsions. 两种不同静脉注射脂质乳剂对早产儿生长和发病率的影响。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-08 DOI: 10.1038/s41372-026-02865-w

Alexyss Guy, Austin Han, Diana Kwiatkowski, Anna C Felmer, Christina Gerber, Rachel H Lee, Amrita Nayak, Rebecca Goodman, Dave Gothard, Rita M Ryan, Jaime Marasch, Zeyar T Htun

{"title":"Comparison of growth and morbidity outcomes in preterm infants using two different intravenous lipid emulsions.","authors":"Alexyss Guy, Austin Han, Diana Kwiatkowski, Anna C Felmer, Christina Gerber, Rachel H Lee, Amrita Nayak, Rebecca Goodman, Dave Gothard, Rita M Ryan, Jaime Marasch, Zeyar T Htun","doi":"10.1038/s41372-026-02865-w","DOIUrl":"https://doi.org/10.1038/s41372-026-02865-w","url":null,"abstract":"Objectives: To compare growth z-scores and prematurity-related comorbidities for preterm infants receiving Soybean Oil-Intravenous Lipid Emulsion (SO-ILE) versus Soybean + Medium-chain triglycerides + Olive + Fish oil ILE (SMOF-ILE).Study design: A multicenter, retrospective cohort study of 347 preterm infants <32 weeks' gestational age with birth weight ≤1500 grams who received SO-ILE or SMOF-ILE for at least seven consecutive days.Results: SO-ILE group (n = 179) demonstrated significantly improved growth for length (p ≤ 0.001) and head circumference z-scores (p = 0.015) at 36 weeks' postmenstrual age and significantly worse growth for weight z-scores at 1 month (p = 0.017) compared to the SMOF-ILE group (n = 168). SO-ILE group had significantly lower rates of bronchopulmonary dysplasia (BPD) (p < 0.001) and urinary tract infections (UTI) (p = 0.045).Conclusion: In this population, SO-ILE had better outcomes for growth, BPD, and UTI compared to SMOF-ILE. Therefore, SO-ILE remains a reasonable lipid emulsion for preterm infants until more evidence is available.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Trial design, conflict of interest, and evidence independence in the JASMINE trial and its economic evaluations". 对“JASMINE试验及其经济评估中的试验设计、利益冲突和证据独立性”的回应。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-10-07 DOI: 10.1038/s41372-026-02929-x

Katsumi Mizuno

引用次数: 0