Journal of Perinatology最新文献

Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-06 DOI: 10.1038/s41372-025-02288-z

Rishi Kathuria, Kanya Mukhopadhyay

{"title":"Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial.","authors":"Rishi Kathuria, Kanya Mukhopadhyay","doi":"10.1038/s41372-025-02288-z","DOIUrl":"10.1038/s41372-025-02288-z","url":null,"abstract":"Objective: To compare the effects of initiating feeds at 24 h versus at 6 h in neonates with reversed end-diastolic flow (REDF) and determine the incidence of feed intolerance (FI) and necrotizing enterocolitis (NEC).Design: Pilot randomized controlled trial.Methods: Neonates with REDF (n = 52) were randomized to start feeds at 6 h (n = 26) or 24 h (n = 26) to assess FI, NEC, time to full feeds, sepsis, mortality, weight and gestation at discharge, and hospital stay.Results: FI was observed in 14 (54%) neonates in 6 h group and 17 (65%) in 24 h group, with comparable NEC rates. Neonates in the 6 h group achieved full feeds faster (8 vs. 11 days) and had shorter hospital stay (17 vs. 32 days). Death and sepsis rates were similar.Conclusions: Feed initiation at 6 h in REDF neonates did not increase the risk of FI or NEC.Trial registration: Clinical trial registry of India (CTRI/2023/02/050025); 23/02/2023.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of maternal position on cerebral oxygenation in premature infants during Kangaroo care: a randomised controlled trial.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-05 DOI: 10.1038/s41372-025-02287-0

Iyshwarya Stapleton, Sarah Murphy, Susan Vaughan, Brian Henry Walsh, Kannan Natchimuthu, Vicki Livingstone, Eugene Dempsey

{"title":"The effect of maternal position on cerebral oxygenation in premature infants during Kangaroo care: a randomised controlled trial.","authors":"Iyshwarya Stapleton, Sarah Murphy, Susan Vaughan, Brian Henry Walsh, Kannan Natchimuthu, Vicki Livingstone, Eugene Dempsey","doi":"10.1038/s41372-025-02287-0","DOIUrl":"https://doi.org/10.1038/s41372-025-02287-0","url":null,"abstract":"Objective: To assess whether there was an optimal maternal position (30° versus 60° incline) for kangaroo mother care.Design: Single centre cross-over randomised controlled trial. Mothers were randomly assigned to start at either a 30° or 60° angle. Primary outcomes were the mean cerebral near-infrared spectroscopy (NIRS) values. Secondary outcomes included median peripheral saturations and heart rates.Results: Twenty infants were included in the final analysis: median gestational age at birth was 28+1 weeks and median birth weight was 985 g. No significant differences were observed in the primary outcomes or the secondary outcomes at either angle.Conclusions: Maternal positioning at a 30° or 60° incline did not impact on cerebral oxygenation values in very preterm infants. Either position was associated with clinical stability.Trial registration number: ClinicalTrials.gov ID NCT05686252.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the best nutritional strategy for moderate to late preterm infants?

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-03 DOI: 10.1038/s41372-025-02283-4

Ambika Bhatnagar, Catherine O Buck

引用次数: 0

Artificial intelligence in pediatric medicine: a call for rigorous reporting standards.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-02 DOI: 10.1038/s41372-025-02284-3

James S Barry, Kristyn Beam, Ryan M McAdams

引用次数: 0

Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-02 DOI: 10.1038/s41372-025-02285-2

Chiara Autilio, Lhousseine Touqui, Silvia Foligno, Raquel Arroyo, Paul S Kingma, Alejandro A Alonso, Jesus Perez-Gil, Daniele De Luca

{"title":"Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators.","authors":"Chiara Autilio, Lhousseine Touqui, Silvia Foligno, Raquel Arroyo, Paul S Kingma, Alejandro A Alonso, Jesus Perez-Gil, Daniele De Luca","doi":"10.1038/s41372-025-02285-2","DOIUrl":"https://doi.org/10.1038/s41372-025-02285-2","url":null,"abstract":"Objectives: To study the effect of hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators DESIGN: Prospective, pragmatic study enrolling asphyxiated neonates without lung injury. Surfactant proteins (SP), Club cell secretory protein (CC-10), tumor growth factor-β1 (TGF-β1), human fibroblast growth factor-2 (hFGF) and anti-inflammatory interleukins (IL) were measured in broncho-alveolar lavage fluids obtained before, during and after hypothermia.Results: Twelve neonates were studied. SP-A, -B, -C, -D and CC-10 levels were similar before, during and after hypothermia. IL-10, IL-13, IL-14 were inconsistently detected only in five out of twelve patients and not in all timepoints; TGF-β1 was always undetectable. hFGF decreased during hypothermia (pre = 92 [52-193.6], during = 19.4 [0-42.6], post = 31.8 [0-83] ng/mL, p = 0.026) with levels before hypothermia being significantly higher than those obtained during and after the treatment (post hoc p = 0.025).Conclusions: In cooled neonates without any lung disorder, hypothermia is associated with lower hFGF but not with any changes in surfactant proteins or anti-inflammatory molecules.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of congenital heart disease and prematurity on brain injury from a national registry.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-02 DOI: 10.1038/s41372-025-02281-6

Giulia P Lima, Sarah U Morton, Isabella Zaniletti, Philip Levy, Nathaly Sweeney, Leeann Pavlek, Shannon E G Hamrick, Sharada H Gowda, Rakesh Rao, Molly K Ball, Paulomi M Chaudhry

引用次数: 0

Tiny baby math: supralinear implications for management of infants born at less than 24 weeks gestation.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-31 DOI: 10.1038/s41372-025-02273-6

Johan Ågren, Nima Naseh, Edward F Bell, Matthew A Rysavy

引用次数: 0

Dynamic association between plasma interleukin-1 family concentrations and bronchopulmonary dysplasia in extremely premature infants.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-30 DOI: 10.1038/s41372-025-02275-4

Qingling Li, Cuihui Li, Yunbei Rao, Dongshan Han, Xuan Wang, Lingling Yang, Yiran Chen, Chuanzhong Yang, Xueyu Chen

{"title":"Dynamic association between plasma interleukin-1 family concentrations and bronchopulmonary dysplasia in extremely premature infants.","authors":"Qingling Li, Cuihui Li, Yunbei Rao, Dongshan Han, Xuan Wang, Lingling Yang, Yiran Chen, Chuanzhong Yang, Xueyu Chen","doi":"10.1038/s41372-025-02275-4","DOIUrl":"10.1038/s41372-025-02275-4","url":null,"abstract":"Objective: To evaluate the longitudinal changes of IL-1α, IL-1β, and IL-1Ra in extremely preterm infants and investigate the dynamic association with bronchopulmonary dysplasia (BPD).Methods: Plasma samples were collected from extremely preterm infants at postnatal day (PD) 7,28 and PMA 36 weeks. IL-1 cytokines concentrations were measured by Bio-Plex Pro (human cytokine panel). Univariate and multivariate logistic regression analysis were conducted to explore the association between the cytokines and BPD.Results: BPD infants exhibited significantly higher concentrations of IL-1α (10.75 vs. 8.18 pg/ml, p = 0.026), IL-1β (2.00 vs. 1.50 pg/ml, p = 0.046), and IL-1Ra (878.50 vs. 262.40 pg/ml, p = 0.011) compared to non-BPD infants at PD 28. Higher IL-1α concentration (≥8.09 pg/ml) at PD 28 was independently associated with BPD development (OR: 8.272, 95% CI: 1.127-60.705, p = 0.038).Conclusions: Increased IL-1α concentrations at PD 28 were independently associated with an increased risk of BPD.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of inferior vena cava measurements into routine functional echocardiography in preterm neonates. Are We There Yet?

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-28 DOI: 10.1038/s41372-025-02271-8

Irem Unal, Ebru Yalin Imamoglu, Sibel Hatice Ozumut, Fahri Ovali

{"title":"Integration of inferior vena cava measurements into routine functional echocardiography in preterm neonates. Are We There Yet?","authors":"Irem Unal, Ebru Yalin Imamoglu, Sibel Hatice Ozumut, Fahri Ovali","doi":"10.1038/s41372-025-02271-8","DOIUrl":"https://doi.org/10.1038/s41372-025-02271-8","url":null,"abstract":"Objective: To evaluate baseline inferior vena cava measurements and investigate the clinical factors that may affect inferior vena cava diameters and hemodynamic changes during the first week of life in preterm neonates.Study design: This prospective observational study included a consecutive cohort of 30 preterm neonates born at < 34 weeks gestation. Echocardiographic parameters and inferior vena cava diameters were measured on postnatal 1st, 3rd, and 7th days, and inferior vena cava indices were calculated.Results: Significant changes in inferior vena cava parameters were observed during the first postnatal week. The median inferior vena cava maximum diameter increased from 2.77 [2.36-3.33] mm on the 1st day to 3.09 [2.59-3.47] mm on the 3rd day, then decreased to 2.63 [2.32-3.27] mm on the 7th day (p: 0.048). The median inferior vena cava indices, including collapsibility, distensibility, and respiratory variation indices, were 22.24%, 28.61%, and 25.02% on the 1st day, respectively. These indices peaked on day 3 (26.20%, 35.51%, and 30.15%, respectively) before decreasing by day 7 (21.45%, 27.33%, and 24.03%, respectively) (p: 0.034 for all indices).Conclusion: This study reported baseline inferior vena cava parameters in preterm neonates during the first week of life. These inferior vena cava parameters might be integrated into routine hemodynamic assessment to determine preload and intravascular volume status. Further studies with larger samples are needed to assess inferior vena cava parameters in preterm neonates more accurately and reliably.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality improvement initiative to decrease severe intraventricular hemorrhage rates in preterm infants by implementation of a care bundle.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-27 DOI: 10.1038/s41372-025-02274-5

Samantha D Peltola, Uduak S Akpan, Dmitry Tumin, Penni Huffman

引用次数: 0