Journal of Perinatology最新文献

Does ventilatory assistance before umbilical cord clamping reduce the risk of early death or intraventricular hemorrhage in extremely preterm infants?

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-08 DOI: 10.1038/s41372-025-02258-5

Kaquanta Barlow, Shoshana Newman-Lindsay, Evan Giusto, Anup Katheria, Satyan Lakshminrusimha

引用次数: 0

Electrical impedance tomography imaging of ventilation and perfusion in bronchopulmonary dysplasia.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-07 DOI: 10.1038/s41372-025-02236-x

Katelyn G Enzer, Nilton Barbosa da Rosa, Christopher Rocheleau, Gary Saulnier, Jennifer L Mueller, Christopher D Baker

引用次数: 0

Diagnostic evaluation to identify infection-attributable stillbirth. 诊断评估以确定感染导致的死胎。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-06 DOI: 10.1038/s41372-025-02253-w

Sarah A Coggins, Jourdan E Triebwasser, Karen M Puopolo

{"title":"Diagnostic evaluation to identify infection-attributable stillbirth.","authors":"Sarah A Coggins, Jourdan E Triebwasser, Karen M Puopolo","doi":"10.1038/s41372-025-02253-w","DOIUrl":"https://doi.org/10.1038/s41372-025-02253-w","url":null,"abstract":"Objective: To characterize stillbirth evaluations, including the frequency and yield of investigations for infections causing stillbirth.Study design: Retrospective cohort of stillbirths at three university-affiliated perinatal centers from 2017 to 2022. The primary outcome was adherence to American College of Obstetrics and Gynecology core stillbirth evaluation recommendations (placental pathology, fetal autopsy, and fetal genetic testing). We further characterized the prevalence and yield of specific testing to evaluate for infection-attributable stillbirth etiologies.Results: The cohort included 399 stillbirths. Placental pathology was performed in 387 cases (97.0%), fetal genetic testing in 163 (40.9%), and fetal autopsy in 126 (31.6%). Fetal bacterial cultures were obtained in 73 (18.2%) cases; potential pathogens were isolated in 21/73 (28.8%). Viral testing was sent infrequently, with variable yield. Six stillbirths had infections identified as probable etiologies.Conclusions: Adherence to core stillbirth evaluation recommendations was poor, and infection testing was infrequent. Infection-attributable stillbirth prevalence may be underestimated.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective randomized pilot trial comparing weekly vs. biweekly Darbepoetin administration to preterm infants. 一项前瞻性随机试验，比较了早产儿每周服用达贝泊汀与每两周服用达贝泊汀的情况。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-06 DOI: 10.1038/s41372-025-02247-8

Timothy M Bahr, Robert D Christensen, Kimberlee A Weaver-Lewis, Danielle M Scott, Erick Gerday, Jared J Tuttle, Robin K Ohls

{"title":"A prospective randomized pilot trial comparing weekly vs. biweekly Darbepoetin administration to preterm infants.","authors":"Timothy M Bahr, Robert D Christensen, Kimberlee A Weaver-Lewis, Danielle M Scott, Erick Gerday, Jared J Tuttle, Robin K Ohls","doi":"10.1038/s41372-025-02247-8","DOIUrl":"https://doi.org/10.1038/s41372-025-02247-8","url":null,"abstract":"Background: Administering darbepoetin (Darbe) to preterm infants stimulates erythropoiesis, increases red blood cell (RBC) mass, and reduces RBC transfusions. We typically administer 10 µg/kg weekly until 34 weeks corrected gestation; however, we are uncertain whether this dose could be given every other week (biweekly) with equal efficacy.Methods: Infants ≤32 weeks were randomized to receive Darbe 10 µg/kg/dose weekly or biweekly for six weeks, tracking complete blood counts, absolute reticulocyte counts (ARC), iron status (RET-He), and RBC transfusions.Results: We enrolled 71 infants (1027 ± 369 grams, 27.3 ± 2.8 weeks). During the study period, the weekly-dosed group had a higher adjusted mean ARC (48,000/μL higher, 95% C.I. 9700-87,000/μL; p = 0.019). However, RET-He, Hgb, and transfusion-free survival were not different between groups (p = 0.071, p = 0.244, and p = 0.762).Conclusions: Weekly Darbe results in a higher six-week ARC than biweekly dosing. However, given similar clinical outcomes, perhaps biweekly dosing may be a cost-effective alternative.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpersonal relationships after prenatal diagnosis of congenital heart disease: Social stressors and supports.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-06 DOI: 10.1038/s41372-025-02250-z

Emily Marshall, Colette Gramszlo, Alejandra Perez Ramirez, Anne E Kazak, Amanda J Shillingford, Cynthia M Ortinau, Sarah L Kelly, Nadine Kasparian, Lindsay A Edwards, Allison A Divanovic, Jo Ann Davis, Samantha C Butler, Katherine Braley, Erin Riegel, Erica Sood

{"title":"Interpersonal relationships after prenatal diagnosis of congenital heart disease: Social stressors and supports.","authors":"Emily Marshall, Colette Gramszlo, Alejandra Perez Ramirez, Anne E Kazak, Amanda J Shillingford, Cynthia M Ortinau, Sarah L Kelly, Nadine Kasparian, Lindsay A Edwards, Allison A Divanovic, Jo Ann Davis, Samantha C Butler, Katherine Braley, Erin Riegel, Erica Sood","doi":"10.1038/s41372-025-02250-z","DOIUrl":"https://doi.org/10.1038/s41372-025-02250-z","url":null,"abstract":"Objective: To identify social stressors and supports for expectant parents after prenatal diagnosis of congenital heart disease (CHD) and inform interventions to reduce distress.Method: Parents of children diagnosed prenatally with CHD (N = 37) were purposively sampled across eight health systems. Qualitative data were collected using crowdsourcing methods and coded/analyzed using thematic analysis.Results: Social stressors increasing distress after prenatal diagnosis were widely endorsed: (1) feelings of loneliness (most common: 68%), (2) well-meaning yet unhelpful comments, (3) loss of celebration of pregnancy, (4) information overload, and (5) untimely/insensitive discussions surrounding pregnancy termination. Social supports included: (1) emotional support and small acts of kindness, (2) hope/connection through the experiences of others, (3) informational support, (4) nurturing normalcy and the joy of pregnancy, and (5) connection through religion/spirituality.Conclusion: Interpersonal relationships are vital for coping with prenatal diagnosis. Interventions to reduce distress after prenatal diagnosis should attend to common social stressors.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voices of parents of children with major congenital anomalies admitted to the NICU: initial diagnosis, hospitalization, and discharge home.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-05 DOI: 10.1038/s41372-025-02255-8

Jessica Lyon, Natalie McAndrew, Alexis Geich, Tala AbuZahra, Steven R Leuthner, Joanne Lagatta, Krishna Acharya

{"title":"Voices of parents of children with major congenital anomalies admitted to the NICU: initial diagnosis, hospitalization, and discharge home.","authors":"Jessica Lyon, Natalie McAndrew, Alexis Geich, Tala AbuZahra, Steven R Leuthner, Joanne Lagatta, Krishna Acharya","doi":"10.1038/s41372-025-02255-8","DOIUrl":"10.1038/s41372-025-02255-8","url":null,"abstract":"Objective: To identify challenges vs. supports in the NICU and after NICU discharge for parents of an infant with a major congenital anomaly.Study design: Qualitative study.Results: We interviewed 18 parents (13 mothers, 5 fathers) whose children were admitted to our our NICU with a major congenital anomaly. In the NICU, challenges were navigating parenthood with significant impact on parent mental health, adjusting to changing healthcare providers, and need for better interdisciplinary communication. After discharge home, challenges were an initial adjustment to life without NICU monitoring, loss of NICU medical resources, burden of caregiving, continued healthcare utilization, and financial impact.Conclusion: Key supports that were helpful to families were empathetic and consistent healthcare teams throughout their care journey, especially nurses; healthcare team members who went beyond medical care, consistent communication, parent engagement in NICU care, ongoing parent mental health support, and peer resources after discharge home.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extended-spectrum β-lactamase-producing Enterobacterales infections among infants following vertical colonization in a neonatal intensive care unit.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-05 DOI: 10.1038/s41372-025-02256-7

Mimori Abe, Yuto Otsubo, Tomoyuki Tame, Kaoru Okazaki, Yuho Horikoshi

{"title":"Extended-spectrum β-lactamase-producing Enterobacterales infections among infants following vertical colonization in a neonatal intensive care unit.","authors":"Mimori Abe, Yuto Otsubo, Tomoyuki Tame, Kaoru Okazaki, Yuho Horikoshi","doi":"10.1038/s41372-025-02256-7","DOIUrl":"10.1038/s41372-025-02256-7","url":null,"abstract":"Objective: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) has become prevalent among neonates. The present study aimed to describe the incidence of ESBL-E colonization among neonates admitted to a NICU and the incidence of subsequent ESBL-E infection among those with ESBL-E colonization.Study design: Patients admitted to the NICU at Tokyo Metropolitan Children's Medical Center between April 2011 and March 2023 were enrolled. On admission, the subjects were routinely screened for ESBL-E using pharyngeal and rectal swabs, and those colonized with ESBL-E were assessed for the development of an invasive ESBL-E infection during their NICU stay.Results: ESBL-E was isolated in 105 of the 8247 neonates (1.3%) admitted to the NICU. Among these patients, 12 (11.4%) experienced the development of an invasive ESBL-E infection.Conclusion: Although ESBL-E colonization occurred in only 1.3% of the neonates admitted to the NICU, 11.4% of them experienced the development of an ESBL-E infection.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy and short-term implications of prenatally diagnosed vascular rings: a single center study.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-04 DOI: 10.1038/s41372-025-02244-x

Nicolle M Ceneri, Michelle L Udine, Manan H Desai, Steven J Staffa, Wendy Ho, Leanne Buckels, Stephanie R Lacey, Mary T Donofrio

{"title":"Diagnostic accuracy and short-term implications of prenatally diagnosed vascular rings: a single center study.","authors":"Nicolle M Ceneri, Michelle L Udine, Manan H Desai, Steven J Staffa, Wendy Ho, Leanne Buckels, Stephanie R Lacey, Mary T Donofrio","doi":"10.1038/s41372-025-02244-x","DOIUrl":"https://doi.org/10.1038/s41372-025-02244-x","url":null,"abstract":"Objective: To assess the diagnostic accuracy and postnatal outcomes of fetuses with a suspected vascular ring (VR).Study design: Single-center retrospective study of patients with suspected VR by fetal echocardiography. Postnatal evaluation included echocardiography +/- cross-sectional imaging. Outcomes, including symptomatology and surgery, were recorded and compared between VR types.Results: Of 68 suspected fetal VRs, 81% were confirmed postnatally. Concordance between fetal and postnatal anatomy was 76%. Five neonates required resuscitation unrelated to VR. Symptoms presented in 13 patients (median 45 days), independent of VR type. Surgical intervention was performed in 15 patients (median 99 days); 80% were symptomatic. At a median follow-up of 6 months, 4 patients were symptomatic including 3 postoperative.Conclusions: Fetal echocardiography accurately identifies and characterizes VR anatomy in most instances. Specialized delivery planning in uncomplicated cases is unnecessary given absence of symptoms at birth. Fetal diagnosis may not indicate surgical disease, as symptoms do not occur in all and early surgery does not guarantee symptom resolution.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piloting the better research interactions for every family (BRIEF) researcher intervention to support recruitment for a neonatal clinical trial: parent experience and infant enrollment.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-04 DOI: 10.1038/s41372-025-02245-w

Elliott Mark Weiss, Devan M Duenas, Andrea Kelsh, Megan M Gray, Ellie Oslin, Devinae Mcneil, Sandra E Juul, Stephanie A Kraft

{"title":"Piloting the better research interactions for every family (BRIEF) researcher intervention to support recruitment for a neonatal clinical trial: parent experience and infant enrollment.","authors":"Elliott Mark Weiss, Devan M Duenas, Andrea Kelsh, Megan M Gray, Ellie Oslin, Devinae Mcneil, Sandra E Juul, Stephanie A Kraft","doi":"10.1038/s41372-025-02245-w","DOIUrl":"https://doi.org/10.1038/s41372-025-02245-w","url":null,"abstract":"Objective: Recruiting for neonatal clinical trials is difficult for families and participation rates are low. We partnered with the DIVI (Darbepoetin plus slow-release IntraVenous Iron) trial for pilot feasibility evaluation of the BRIEF (Better Research Interactions for Every Family) intervention.Study design: Pre/post design to compare infant data and parent surveys and interviews before and after the BRIEF intervention as well as comparing DIVI enrolled and DIVI not enrolled.Results: Enrollment rates and parental experiences were similar in pre- and post-BRIEF eras. Most respondents reported positive interactions with researchers. Parents who declined DIVI reported somewhat worse experiences compared to those who enrolled. Interview respondents reported widely variable experiences. The narrow enrollment window emerged as particularly important to parents' recruitment experience.Conclusions: The BRIEF intervention was well received and is ready for larger scale testing to assess its impact on parental experience and enrollment rates. Future work should address short enrollment windows common in neonatal clinical trials.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary function tests in the neonatal intensive care unit and beyond: a clinical review.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-28 DOI: 10.1038/s41372-025-02243-y

Mitzi A Go, Kelvin D MacDonald, Manuel Durand, Cindy T McEvoy

引用次数: 0