Journal of Perinatology最新文献

The role of genetic testing in small for gestational age infants. 基因检测在小胎龄婴儿中的作用。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-26 DOI: 10.1038/s41372-025-02343-9

Eric Kalimi, Emily Zhao, Brittany Wise-Oringer, Ronald J Wapner, Lorraine Dugoff, Caitlin Baptiste, Alex Lyford, Thomas Hays

{"title":"The role of genetic testing in small for gestational age infants.","authors":"Eric Kalimi, Emily Zhao, Brittany Wise-Oringer, Ronald J Wapner, Lorraine Dugoff, Caitlin Baptiste, Alex Lyford, Thomas Hays","doi":"10.1038/s41372-025-02343-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02343-9","url":null,"abstract":"Small for gestational age (SGA) infants face increased morbidity, mortality, and long-term health risks, yet causes of SGA remain unclear. While placental insufficiency and environmental factors contribute, genetic disorders play a significant role. Syndromes like Silver-Russell and Noonan are linked to SGA, but the overall genetic contribution remains uncertain. We reviewed literature on genomic sequencing in SGA and fetal growth restriction (which often precedes SGA) and identified 161 single-gene disorders. The top ten genes explained one-third of cases, but half were attributable to unique genes. Genetic disorders were frequently accompanied by congenital anomalies (often skeletal dysplasia) and developmental delays. Current guidelines for genetic evaluation of SGA are limited. Our findings support consideration of exome or genome sequencing, particularly in the setting of congenital anomalies or developmental delays. Early identification of genetic disorders can enable tailored therapy. Given the complexity of the SGA genetic landscape, prospective genomic studies are urgently needed.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants. 早期肠外脂质摄入支持早产儿足月期小脑神经代谢。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-23 DOI: 10.1038/s41372-025-02336-8

Sudeepta K Basu, Katherine M Ottolini, Kushal J Kapse, Julius Ngwa, Steve C N Hui, Nickie Andescavage, Jonathan Murnick, Adre J du Plessis, Catherine Limperopoulos

{"title":"Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.","authors":"Sudeepta K Basu, Katherine M Ottolini, Kushal J Kapse, Julius Ngwa, Steve C N Hui, Nickie Andescavage, Jonathan Murnick, Adre J du Plessis, Catherine Limperopoulos","doi":"10.1038/s41372-025-02336-8","DOIUrl":"https://doi.org/10.1038/s41372-025-02336-8","url":null,"abstract":"Objectives: The impact of crucial early parenteral nutrition on neurometabolism of the preterm brain remains unclear. This study characterizes the relationship of parenteral lipid and caloric intake with cerebellar neurometabolites.Methods: Very premature infants [born ≤32-week gestational age (GA)] in a prospective observational cohort study underwent a proton magnetic resonance spectroscopy (1H-MRS) acquisition from a cerebellar voxel at term-age. Parenteral lipid and caloric intake (g/kg/d or kcal/kg/d) in the first 4 weeks of life were calculated by chart review.Results: 48 preterm infants born at 28.3 ± 2.4 weeks GA underwent 1H-MRS at 38.9 ± 1.9 weeks postmenstrual age. Cerebellar N-acetylaspartate [NAA] positively correlated with 4-week parenteral lipid (Rho = 0.4, p = 0.005) and caloric (Rho = 0.3, p = 0.047) intake. Glutamate [Glx] demonstrated a positive trend. Adjusted for covariates, 4-week parenteral lipid intake was associated with higher NAA (B coefficient = 0.89, p = 0.003) and Glx (B = 1.72, p = 0.045).Conclusions: Parenteral lipid intake is associated with higher cerebellar NAA and Glx concentrations, supporting brain development in preterm infants.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial disparities and outcomes in neonatal hypoxic-ischemic encephalopathy. 新生儿缺氧缺血性脑病的种族差异和结局。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-21 DOI: 10.1038/s41372-025-02335-9

Marwa M Elgendy, Ceyda Acun, Josef Cortez, Hany Aly, Mohamed A Mohamed

{"title":"Racial disparities and outcomes in neonatal hypoxic-ischemic encephalopathy.","authors":"Marwa M Elgendy, Ceyda Acun, Josef Cortez, Hany Aly, Mohamed A Mohamed","doi":"10.1038/s41372-025-02335-9","DOIUrl":"10.1038/s41372-025-02335-9","url":null,"abstract":"Objectives: To investigate racial disparities in the prevalence, severity, intervention, and outcomes of hypoxic-ischemic encephalopathy (HIE) among neonates in the United States.Study design: We analyzed data from the National Inpatient Sample (NIS) dataset, including full-term infants diagnosed with HIE from 2010 to 2018. Regression analysis was performed to control for clinical and demographic variables.Results: Out of 31,249,100 infants, 23,475 (0.09%) were diagnosed with HIE. African American neonates had a 60% higher likelihood of developing HIE compared to Caucasians, adjusted odds ratio (aOR) 1.60 (1.52-1.69, p < 0.001), and were twice as likely to experience severe HIE, aOR 2.06 (1.77-2.39, p < 0.001). Overall mortality was significantly higher among African American infants, aOR 2.14, (2.02-2.26, p < 0.001). Mortality within HIE infants did not differ between African American and Caucasian infants aOR 0.88 (0.78-1.0), p < 0.61. Native American infants had a significantly lower chance of receiving hypothermia therapy compared to Caucasian infants, aOR 0.48 (0.29-0.77), p = 0.002.Conclusion: Racial disparity exists in the prevalence, severity, and management of HIE. African Americans experience a higher prevalence and severity of HIE. Native Americans are less likely to receive hypothermia therapy for HIE.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of bacterial and fungal infections among level IV neonatal units in North America. 北美四级新生儿单位中细菌和真菌感染的流行病学。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-20 DOI: 10.1038/s41372-025-02337-7

Yo Nishihara, Isabella Zaniletti, Jeanne Zenge, Blair Weikel, Sarah Parker, Karna Murthy, Michael A Padula, Theresa Grover

{"title":"Epidemiology of bacterial and fungal infections among level IV neonatal units in North America.","authors":"Yo Nishihara, Isabella Zaniletti, Jeanne Zenge, Blair Weikel, Sarah Parker, Karna Murthy, Michael A Padula, Theresa Grover","doi":"10.1038/s41372-025-02337-7","DOIUrl":"10.1038/s41372-025-02337-7","url":null,"abstract":"Background: Neonatal infections cause significant morbidity and mortality. A comprehensive analysis of bloodstream infections (BSI), urinary tract infections (UTI) and meningitis across level IV neonatal intensive care units (NICUs) is lacking.Methods: This retrospective cohort study utilized data from the Children's Hospitals Neonatal Database (CHND) between January 2011 to December 2022. Patients with positive blood, urine, and cerebrospinal fluid (CSF) cultures were assessed. BSI trends across five geographic zones and a 10-year trend were studied.Results: Of 172,921 patients, 15,541 (9.0%) had a culture-positive BSI, UTI, and/or meningitis. Within the 18,281 positive cultures (9794 BSI, 7097 UTI and 1390 CSF), 21,919 pathogens were identified. Infection rates were inversely related to gestational age. Pathogen distribution varied across regions, and over 10 years, Coagulase negative Staphylococcus declined, while E. coli and S. aureus proportions increased.Conclusion: Understanding infection trends in level IV NICUs can inform targeted preventive strategies and quality improvement initiatives.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hours based scheduling in neonatology: a practical approach. 新生儿学时制调度：一种实用的方法。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-19 DOI: 10.1038/s41372-025-02332-y

Annemarie Stroustrup, Patrick J McNamara, Trent E Tipple, Satyan Lakshminrusimha

引用次数: 0

Changes in cardiorespiratory status after transcatheter patent ductus arteriosus closure. 经导管动脉导管未闭关闭后心肺状态的变化。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-16 DOI: 10.1038/s41372-025-02329-7

Camryn Coley, Rishika Sakaria, Ranjit Philip, Shyam Sathanandam, Mark F Weems

{"title":"Changes in cardiorespiratory status after transcatheter patent ductus arteriosus closure.","authors":"Camryn Coley, Rishika Sakaria, Ranjit Philip, Shyam Sathanandam, Mark F Weems","doi":"10.1038/s41372-025-02329-7","DOIUrl":"https://doi.org/10.1038/s41372-025-02329-7","url":null,"abstract":"Objective: We aim to assess short-term cardiorespiratory outcomes of neonates after transcatheter patent ductus arteriosus (PDA) closure. We hypothesize pre-procedure respiratory severity score (RSS) ≥ 4 is associated with increased risk of post-transcatheter cardiorespiratory syndrome (PTCS).Study design: This was a retrospective study of infants who underwent transcatheter PDA closure from January 2022 to December 2022. Patients were divided by pre-procedure RSS and analyzed for the development of PTCS or hypertensive cardiorespiratory failure.Result: The study included 46 patients with a mean birthweight of 699 g and procedure weight of 1098 g. PTCS was identified in 5 (11%) patients with no differences based on pre-procedure RSS (8 vs 14%, p = 0.66). Post-procedure hypertension was found in 28 (61%) patients (58 vs 64%, p = 0.77), and occurred with respiratory failure in 12 (26%) patients (33 vs 18%, p = 0.32).Conclusion: Pre-procedure RSS was not associated with post-procedure outcomes. While PTCS occurred infrequently, post-procedure hypertension was common.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a remote patient monitoring program on cost of care for neonates with inadequate oral feeding. 远程患者监测项目对口服喂养不足新生儿护理成本的影响。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-12 DOI: 10.1038/s41372-025-02334-w

Christina R Fisher, Dmitry Dukhovny, Jamie B Warren

{"title":"Effects of a remote patient monitoring program on cost of care for neonates with inadequate oral feeding.","authors":"Christina R Fisher, Dmitry Dukhovny, Jamie B Warren","doi":"10.1038/s41372-025-02334-w","DOIUrl":"https://doi.org/10.1038/s41372-025-02334-w","url":null,"abstract":"Objective: Remote patient monitoring (RPM) facilitates early discharge of infants with inadequate oral feeding. We aim to determine the financial impact of discharge with RPM compared to continued hospitalization.Study design: Patients discharged on RPM between May 2019 and June 2024 were eligible. Days of home nasogastric tube feeds and total physician time per episode were recorded. Direct cost estimates for each aspect of RPM and continued hospitalization were used to calculate cost savings of RPM use from a health care system perspective. One- and two-way sensitivity analyses were performed.Results: One hundred eighty infants were included. RPM decreased the hospital stay by 9.2 days/patient (mean). An RPM episode cost $1,768.24 (mean), while hypothetical continued hospitalization cost $13,978.32 (mean); a difference of $12,210.08. Sensitivity analyses showed that inpatient hospital cost variations were the primary driver of savings.Conclusion: RPM programs for neonates with inadequate oral feeding can reduce direct medical costs.Clinical trial resgistration: None.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing the risk of sudden unexpected infant death: the caffeine hypothesis. 降低婴儿意外猝死的风险：咖啡因假说。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-10 DOI: 10.1038/s41372-025-02333-x

Thomas Hegyi, Barbara M Ostfeld

引用次数: 0

Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia. 抗生素暴露强度、肠道微生物群紊乱和早产新生儿菌血症结局之间的关系。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-09 DOI: 10.1038/s41372-025-02330-0

Hope Hendricks, Shani Israel, Jörn-Hendrik Weitkamp, Suman Pakala, Seesandra Rajagopala, Ritu Banerjee

{"title":"Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia.","authors":"Hope Hendricks, Shani Israel, Jörn-Hendrik Weitkamp, Suman Pakala, Seesandra Rajagopala, Ritu Banerjee","doi":"10.1038/s41372-025-02330-0","DOIUrl":"https://doi.org/10.1038/s41372-025-02330-0","url":null,"abstract":"Background: Neonatal microbiome dysbiosis is associated with infectious complications.Methods: Prospective weekly stools were collected over 1 year from hospitalized preterm infants with birthweight ≤2000 g and postnatal age (PNA) ≤2 months. Neonates with bacteremia (cases) were matched to uninfected controls. Stools were analyzed using whole metagenome sequencing. Intensity of antibiotic exposure was compared using an Antibiotic Spectrum Index (ASI).Results: We analyzed 398 stools from 40 cases and 39 controls. Cases had lower α diversity beyond 4 weeks PNA. Cases with subsequent infections after index bacteremia had persistently lower α diversity, while cases without subsequent infections demonstrated recovery of microbiome diversity. Compared to controls, cases had greater ASI at multiple timepoints, higher Enterococcus spp. and lower anaerobe abundance.Conclusions: Compared to controls, premature neonates with bacteremia had intestinal microbiomes with lower α diversity, higher Enterococcus spp. and lower anaerobe abundance. These changes were associated with recurrent infectious complications.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction of human milk fortifier and the development of neonatal acute kidney injury. 母乳强化剂的引入与新生儿急性肾损伤的发展。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-06-07 DOI: 10.1038/s41372-025-02326-w

Chelsea Young, Veronika Shabanova, Jason Greenberg, Steven Peterec, Sarah N Taylor

引用次数: 0