Jessica E Shui, Carolyn J LaVita, Glasiele C Alcala, John H Nichols, Romal K Jassar, Rodica M Turcu, Paul H Lerou, Maurizio F Cereda, Ryan W Carroll, Roberta Ribeiro De Santis Santiago, Lorenzo Berra
{"title":"用电阻抗断层扫描识别严重支气管肺发育不良患者的最佳呼气末正压。","authors":"Jessica E Shui, Carolyn J LaVita, Glasiele C Alcala, John H Nichols, Romal K Jassar, Rodica M Turcu, Paul H Lerou, Maurizio F Cereda, Ryan W Carroll, Roberta Ribeiro De Santis Santiago, Lorenzo Berra","doi":"10.1038/s41372-025-02433-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility of electrical impedance tomography (EIT) guided positive end-expiratory pressure (PEEP) titration to identify optimal PEEP in infants with severe bronchopulmonary dysplasia (BPD).</p><p><strong>Study design: </strong>Case series of five EIT guided PEEP titrations in infants with severe BPD compared to a case series of five infants, without lung disease, requiring intubation. Optimal PEEP was identified as minimal percentage of lung overdistension and collapse. Lung function, bedside ventilatory and clinical data were tracked post EIT guided optimal PEEP titration.</p><p><strong>Result: </strong>Four out of the five EIT assessments in infants with BPD identified an optimal PEEP that was sustained for at least three weeks. Three of the four successful assessments led to a decrease in PEEP, compared to baseline, and one confirmed the baseline PEEP was optimal.</p><p><strong>Conclusion: </strong>EIT assessments can be a novel tool to aide identification of optimal PEEP in infants with heterogeneous lung disease.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Identifying optimal positive end-expiratory pressure with electrical impedance tomography guidance in severe bronchopulmonary dysplasia.\",\"authors\":\"Jessica E Shui, Carolyn J LaVita, Glasiele C Alcala, John H Nichols, Romal K Jassar, Rodica M Turcu, Paul H Lerou, Maurizio F Cereda, Ryan W Carroll, Roberta Ribeiro De Santis Santiago, Lorenzo Berra\",\"doi\":\"10.1038/s41372-025-02433-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To assess the feasibility of electrical impedance tomography (EIT) guided positive end-expiratory pressure (PEEP) titration to identify optimal PEEP in infants with severe bronchopulmonary dysplasia (BPD).</p><p><strong>Study design: </strong>Case series of five EIT guided PEEP titrations in infants with severe BPD compared to a case series of five infants, without lung disease, requiring intubation. Optimal PEEP was identified as minimal percentage of lung overdistension and collapse. Lung function, bedside ventilatory and clinical data were tracked post EIT guided optimal PEEP titration.</p><p><strong>Result: </strong>Four out of the five EIT assessments in infants with BPD identified an optimal PEEP that was sustained for at least three weeks. Three of the four successful assessments led to a decrease in PEEP, compared to baseline, and one confirmed the baseline PEEP was optimal.</p><p><strong>Conclusion: </strong>EIT assessments can be a novel tool to aide identification of optimal PEEP in infants with heterogeneous lung disease.</p>\",\"PeriodicalId\":16690,\"journal\":{\"name\":\"Journal of Perinatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Perinatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41372-025-02433-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41372-025-02433-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Identifying optimal positive end-expiratory pressure with electrical impedance tomography guidance in severe bronchopulmonary dysplasia.
Objective: To assess the feasibility of electrical impedance tomography (EIT) guided positive end-expiratory pressure (PEEP) titration to identify optimal PEEP in infants with severe bronchopulmonary dysplasia (BPD).
Study design: Case series of five EIT guided PEEP titrations in infants with severe BPD compared to a case series of five infants, without lung disease, requiring intubation. Optimal PEEP was identified as minimal percentage of lung overdistension and collapse. Lung function, bedside ventilatory and clinical data were tracked post EIT guided optimal PEEP titration.
Result: Four out of the five EIT assessments in infants with BPD identified an optimal PEEP that was sustained for at least three weeks. Three of the four successful assessments led to a decrease in PEEP, compared to baseline, and one confirmed the baseline PEEP was optimal.
Conclusion: EIT assessments can be a novel tool to aide identification of optimal PEEP in infants with heterogeneous lung disease.
期刊介绍：
The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development.
The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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