Journal of Perinatology最新文献_第2页

An Advanced Neonatal Resuscitation Educational Program in a Surgical Neonatal Intensive Care Unit: Development, Implementation and Audit from 2014 to 2023.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-10 DOI: 10.1038/s41372-024-02192-y

Nicole M Anderson, Andrea Kitchen, Amy McKenzie, Chloe Joynt

{"title":"An Advanced Neonatal Resuscitation Educational Program in a Surgical Neonatal Intensive Care Unit: Development, Implementation and Audit from 2014 to 2023.","authors":"Nicole M Anderson, Andrea Kitchen, Amy McKenzie, Chloe Joynt","doi":"10.1038/s41372-024-02192-y","DOIUrl":"https://doi.org/10.1038/s41372-024-02192-y","url":null,"abstract":"Objective: The design, implementation and audit of a multidisciplinary advanced neonatal resuscitation education initiative for \"in unit\" events in a quaternary NICU over a 9-year period, divided into 3-year epochs of \"pre\", \"implementation\" and \"maintenance\" is described.Study design: A didactic and simulation quality improvement initiative focused on teaching and reinforcing specific algorithms endorsed by the American Heart Association (AHA) to target resuscitation needs of older neonates including surgical and cardiac conditions. Qualitative and quantitative data pre and post implementation was audited.Results: Post education implementation, team members performed quicker hemodynamic assessments and applied CPR and/or bolus epinephrine correctly in higher proportions during acute events. During supraventricular tachycardia, vagal maneuver use and medication administration time improved.Conclusion: Advanced neonatal resuscitation education and reinforcement targeted for event etiology, allow for AHA algorithms to be successfully taught and performed within a quaternary NICU with improvement in hemodynamic assessments and AHA algorithm implementation.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteral nutritional practices in extremely preterm infants: a survey of U.S. NICUs.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-09 DOI: 10.1038/s41372-024-02198-6

Mar Romero-Lopez, Mamta Naik, Lindsay F Holzapfel, Jon E Tyson, Claudia Pedroza, Kaashif A Ahmad, Matthew A Rysavy, Waldemar A Carlo, Yuxin Zhang, Covi Tibe, Ariel A Salas

引用次数: 0

Understanding and addressing mental health challenges of families admitted to the neonatal intensive care unit.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-07 DOI: 10.1038/s41372-024-02187-9

Ashley D Osborne, Daphna Yasova Barbeau, Tiffany Gladdis, Kara Hansen, Tonia Branche, Emily R Miller, Christine C Pazandak, Margaret K Hoge, Michelle Spencer, Diana Montoya-Williams, Ryan Barbeau, Heather Padratzik, Stephen Lassen

引用次数: 0

Alloimmunization to low and high prevalence blood group antigens: rare causes of hemolytic disease of the fetus and newborn.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-07 DOI: 10.1038/s41372-024-02186-w

Douglas P Blackall, Mark W Tomlinson

引用次数: 0

Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-06 DOI: 10.1038/s41372-024-02188-8

Kristin Sohn, Victoria Palacios, Reese Clark

{"title":"Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies.","authors":"Kristin Sohn, Victoria Palacios, Reese Clark","doi":"10.1038/s41372-024-02188-8","DOIUrl":"https://doi.org/10.1038/s41372-024-02188-8","url":null,"abstract":"Objective: To utilize an evidence-based probiotic protocol to achieve a 50% reduction in necrotizing enterocolitis (NEC) ≥ stage 2 and bloody stools.Study design: From January 2022 through September 2023, daily enteral Bifidobacterium longum ssp. infantis EVC001 (B. infantis EVC001) was administered to babies ≤ 33 6/7 weeks gestation until 36 weeks post menstrual age. Feeding tolerance and complications were compared to babies admitted during the prior two-year period. Fisher's Exact test was used to analyze proportional data and t test was used for continuous variables.Results: A total of 265 babies received EVC001, and a total of 277 babies formed the pre-probiotic cohort. Probiotic use was associated with decreased NEC ≥ stage 2 (p = 0.0058), reduced bloody stools (p < 0.0001), decreased time to full enteral feeds (p < 0.0001), and decreased total parenteral nutrition (TPN) days (p < 0.0001).Conclusion: Administration of B. infantis EVC001 was associated with a decrease in NEC, a decrease in bloody stools, and improvement in feeding tolerance in premature babies.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kidney injury associated with increased costs in the neonatal intensive care unit: analysis of Pediatric Health Information System database.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-05 DOI: 10.1038/s41372-024-02193-x

Heidi J Steflik, David T Selewski, Corinne Corrigan, Daniel L Brinton

{"title":"Acute kidney injury associated with increased costs in the neonatal intensive care unit: analysis of Pediatric Health Information System database.","authors":"Heidi J Steflik, David T Selewski, Corinne Corrigan, Daniel L Brinton","doi":"10.1038/s41372-024-02193-x","DOIUrl":"https://doi.org/10.1038/s41372-024-02193-x","url":null,"abstract":"Objective: Compare neonatal intensive care unit hospitalization costs between neonates with and without AKI; identify predictors of AKI-associated costs. We hypothesized neonates with AKI would amass more costs than those without AKI.Study design: Retrospective, multicenter cohort study of surviving neonates cared for 2015-2021 in Pediatric Health Information System database. The primary outcome was estimated hospitalization costs.Results: Data from 304,725 neonates were evaluated, 8774 (3%) with AKI and 295,951 (97%) without AKI. Neonates with AKI had $58,807 greater adjusted costs than those without AKI. AKI-associated costs were most strongly driven by Feudtner Pediatric Complex Chronic Conditions Classifications (cardiovascaular, congenital/genetic, gastrointestinal, medical technology) and gestational age. Adjusted costs decreased with increasing gestational age, regardless of AKI status.Conclusions: AKI is independently associated with increased hospital costs. Knowledge of these drivers can help in identifying high-value practices for cost mitigation strategies.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical and sociodemographic characteristics related to feeding therapy referral and service provision for preterm infants in the neonatal intensive care unit.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-04 DOI: 10.1038/s41372-024-02184-y

Tiana T Nguyen, Roberta Pineda, Stacey Reynolds, Elizabeth E Rogers, Audrey E Kane

{"title":"Medical and sociodemographic characteristics related to feeding therapy referral and service provision for preterm infants in the neonatal intensive care unit.","authors":"Tiana T Nguyen, Roberta Pineda, Stacey Reynolds, Elizabeth E Rogers, Audrey E Kane","doi":"10.1038/s41372-024-02184-y","DOIUrl":"https://doi.org/10.1038/s41372-024-02184-y","url":null,"abstract":"Objective: To determine the scope of feeding therapy for preterm infants in the NICU and medical and sociodemographic factors related to feeding therapy referral and service provision.Study design: Retrospective study of infants born <37 weeks gestation in a level IV NICU between January 2017 and December 2019.Result: Among 547 infants, 27% of infants received a feeding therapy referral, and 74% of those referrals were problem-based referrals. Feeding therapy referrals were more likely among infants with lower gestational ages and birthweights (both p < 0.001). In addition, infants with greater medical complexity, who required oxygen at 36 weeks, who had a history of mechanical ventilation, and who had a higher postmenstrual age at discharge were more likely to be referred to feeding therapy (all p < 0.001).Conclusion: While medical factors relate to feeding therapy referrals, there are other complex person and system factors that determine feeding therapy referral and service provision.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elective high frequency oscillatory ventilation versus conventional mechanical ventilation on the chronic lung disease or death in preterm infants administered surfactant: a systematic review and meta-analysis.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-12-02 DOI: 10.1038/s41372-024-02185-x

Xiaoqin Yu, Qin Tan, Jie Li, Yuan Shi, Long Chen

{"title":"Elective high frequency oscillatory ventilation versus conventional mechanical ventilation on the chronic lung disease or death in preterm infants administered surfactant: a systematic review and meta-analysis.","authors":"Xiaoqin Yu, Qin Tan, Jie Li, Yuan Shi, Long Chen","doi":"10.1038/s41372-024-02185-x","DOIUrl":"https://doi.org/10.1038/s41372-024-02185-x","url":null,"abstract":"Background: Use of elective high frequency oscillatory ventilation (HFOV) compared with conventional mechanical ventilation (CMV) results in a small reduction in the risk of chronic lung disease (CLD) or death, but the evidence is weak. Our objective was to explore whether elective HFOV was associated with less CLD or death as compared with CMV in preterm infants administered surfactant.Methods: We conducted a systematic review and meta-analysis, including 1835 ventilated participants from 11 randomized controlled trials comparing elective HFOV with CMV between February 1993 and February 2014. The primary outcome was the incidence of CLD or death.Results: Compared with CMV, elective HFOV was associated with less CLD or death (relative risk (RR) 0.76, 95% confidence interval (CI) 0.61-0.94, p = 0.01) (p = 0.01, I2 = 55%), CLD (RR 0.71, 95%CI 0.53-0.93, p = 0.01) (p = 0.03, I2 = 50%), and ≥2nd stages of retinopathy of prematurity (RR 0.77, 95%CI 0.62-0.94, p = 0.01) (p = 0.42, I2 = 0%). In the subgroup of > 1 dose of surfactant, compared with CMV, elective HFOV was also related to less CLD or death (RR 0.87, 95%CI 0.77-0.98, p = 0.02) (p = 0.10, I2 = 42%). No differences were found in the incidences of death, grade 3 or 4 of intraventricular hemorrhage, periventricular leukomalacia, airleak and necrotizing enterocolitis between the two groups.Conclusion: Elective HFOV is superior to CMV in reducing the incidence of CLD or death in ventilated preterm infants administered surfactant, especially in the subgroup of >1 dose of surfactant.Trial registry: International Prospective Register of Systematic Reviews: No.: CRD42022301033; URL: https://www.crd.york.ac.uk/PROSPERO/ .","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral magnetic resonance spectroscopy - insights into preterm brain injury.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-28 DOI: 10.1038/s41372-024-02172-2

Magdalena Zasada, Paulina Karcz, Marta Olszewska, Aleksandra Kowalik, Wojciech Zasada, Izabela Herman-Sucharska, Przemko Kwinta

{"title":"Cerebral magnetic resonance spectroscopy - insights into preterm brain injury.","authors":"Magdalena Zasada, Paulina Karcz, Marta Olszewska, Aleksandra Kowalik, Wojciech Zasada, Izabela Herman-Sucharska, Przemko Kwinta","doi":"10.1038/s41372-024-02172-2","DOIUrl":"https://doi.org/10.1038/s41372-024-02172-2","url":null,"abstract":"Objective: Magnetic resonance spectroscopy (1H-MRS) may provide clinically relevant data regarding metabolic processes that govern the course of preterm brain injury.Study design: 46 very preterm infants (VP) were evaluated by magnetic resonance imaging and 1H-MRS at term-equivalent age. Brain injury was assessed according to the Kidokoro scale. Moreover, 17 term-born infants with hypoxic-ischemic encephalopathy (HIE) were scanned. The metabolic profile of the central nervous system was obtained from the bilateral thalamus.Result: The Lipids/Creatine, Choline/Creatine, N-acetyl aspartate/Choline, Lactate/N-acetyl aspartate, and Lactate/Creatine ratios differed between VP infants with moderate+severe brain damage and those without brain injury. Moreover, VP infants with moderate+severe brain damage had higher Lactate/ N-acetyl aspartate and Lactate/Creatine ratios than HIE group.Conclusion: There were significant differences in the cerebral metabolite profile at TEA between VP infants with and without brain injury. The 1H-MRS profile of VP infants with moderate+severe brain damage may reflect profound chronic metabolic alterations.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical utility of rapid whole genome sequencing in neonatal patients receiving extracorporeal membrane oxygenation (ECMO). 对接受体外膜氧合（ECMO）的新生儿患者进行快速全基因组测序的临床实用性。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-27 DOI: 10.1038/s41372-024-02181-1

Milan D Amin, Kristen Wigby, Denise Suttner, Anna-Kaisa Niemi, Lucia Guidugli, Jeanne Carroll

{"title":"Clinical utility of rapid whole genome sequencing in neonatal patients receiving extracorporeal membrane oxygenation (ECMO).","authors":"Milan D Amin, Kristen Wigby, Denise Suttner, Anna-Kaisa Niemi, Lucia Guidugli, Jeanne Carroll","doi":"10.1038/s41372-024-02181-1","DOIUrl":"https://doi.org/10.1038/s41372-024-02181-1","url":null,"abstract":"Objective: The objective of this study is to describe the impact of rapid and ultra-rapid whole genome sequencing (rWGS/urWGS) on the care of neonatal intensive care (NICU) patients who require extracorporeal membrane oxygenation (ECMO).Study design: This is a retrospective cohort study at a single-center NICU in a tertiary children's hospital. The study population includes NICU patients treated with ECMO from May 2017 to September 2023. Patients were evaluated for whether whole genome was completed, speed of testing (rapid vs. ultra-rapid), diagnostic rate, and clinical utility.Result: Twenty-six (72%) patients had rWGS/urWGS. A diagnosis associated with the patient's phenotype was made in 12 patients (46%). A change in clinical management was made due to rWGS/urWGS in 10 patients (38%) including avoidance of imaging studies, decisions regarding goals of care, and screening studies.Conclusion: This study demonstrates a high diagnostic rate and clinical utility of rWGS/urWGS for NICU patients requiring ECMO.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0