Journal of Perinatology最新文献

{"title":"Clinical characteristics and treatment analysis of neonatal testicular torsion.","authors":"Chengpin Tao, Yongsheng Cao, Zhikang Yu","doi":"10.1038/s41372-025-02249-6","DOIUrl":"https://doi.org/10.1038/s41372-025-02249-6","url":null,"abstract":"<p><strong>Background: </strong>Neonatal testicular torsion is a rare but critical condition that requires prompt diagnosis and treatment. While early surgical intervention may offer some benefit, in many prenatal cases, preventing testicular loss remains challenging, even with timely intervention. Early recognition remains challenging due to subtle clinical presentations in newborns.</p><p><strong>Objective: </strong>This study aims to analyze the clinical characteristics, diagnostic methods, and treatment outcomes of neonatal testicular torsion, providing a reference for early diagnosis and intervention of the disease.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on cases of neonatal testicular torsion admitted to Anhui Provincial Children's Hospital from August 2014 to June 2024. Information collected included the infants' age, at diagnosis onset time, clinical manifestations, diagnostic methods, surgical treatment, and postoperative follow-up results.</p><p><strong>Results: </strong>This study included 21 cases of neonatal testicular torsion. Among them, 1 case involved bilateral testicular torsion, and the remaining 20 cases involved unilateral torsion, with 11 cases on the right side and 9 on the left. The median age at diagnosis of the patients was 1 day (IQR: 1-3), and the median onset time was 24 h (IQR: 10-60). All patients underwent surgical exploration, revealing a median torsion angle of 720 degrees (IQR: 360-720). The average surgery duration was 57.9 min (SD: 25.9). In the case of bilateral testicular torsion, the blood supply was restored after detorsion, and the testicles were preserved. However, in the 20 cases of unilateral torsion, necrotic testicles were removed. Postoperative follow-up over an average period of 31.3 months (SD: 11.5) showed no atrophy in the preserved testicles, with good development of the contralateral testicles and no recurrence of torsion.</p><p><strong>Conclusion: </strong>Neonatal testicular torsion is rare and urgent, often prenatally occurring with high testicular necrosis risk. Ultrasound is crucial for diagnosing cryptorchid testicular torsion. Clinical uncertainty requires prompt surgical exploration to save the testicle.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the refineR algorithm to generate indirect reference intervals for newborn infants for the parameters \"Micro-R\" and \"HYPO-He\".","authors":"Timothy M Bahr, Kelly Doyle, Robin K Ohls, Robert D Christensen","doi":"10.1038/s41372-025-02251-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02251-y","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quality improvement project improving post-operative transitions of care in a level IV NICU.","authors":"Hannah Fischer, Diane Buckley, Jessica Ford, John Juneau, Daniel Kahn, Carrie Moore, Julia Springate Spalding, Tamina Singh","doi":"10.1038/s41372-025-02228-x","DOIUrl":"https://doi.org/10.1038/s41372-025-02228-x","url":null,"abstract":"<p><strong>Objective: </strong>Transitions of care are critical periods when NICU patients are at risk for miscommunication leading to patient harm. This quality improvement project aimed to decrease post-operative hand-off-related failures and improve communication in a level IV NICU.</p><p><strong>Project design: </strong>The Vermont Oxford Network transitions of care framework was used to develop a safe surgical hand-off definition; (1) all team members present, (2) a structured hand-off format utilized, and (3) an environment conducive for hand-off. Interventions included using standardization for process improvement, scripting ideal communication, and simulation to establish behavioral norms of effective communication.</p><p><strong>Results: </strong>Post-surgical hand-off-related care failures decreased from 75% pre-implementation to 6% post-implementation (p < 0.00001) by increasing the percentage of hand-offs meeting pre-defined criteria.</p><p><strong>Conclusion: </strong>Using quality improvement methods to implement process and behavioral changes to improve communication, our team reached our goal of decreasing post-operative hand-off-related care failures.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-tidal carbon monoxide for routine monitoring of significant hemolysis in the management of newborn hyperbilirubinemia.","authors":"Shanice Wells, Ramya Balasubramanian, Khang Nguyen, David L Schutzman","doi":"10.1038/s41372-025-02242-z","DOIUrl":"https://doi.org/10.1038/s41372-025-02242-z","url":null,"abstract":"<p><strong>Objective: </strong>Assess the efficacy of routine ETCOc for all newborns in managing neonatal hyperbilirubinemia.</p><p><strong>Study design: </strong>Retrospective chart review of 1029 consecutive well-baby nursery admissions following the 2022 AAP hyperbilirubinemia guidelines. Only ETCOc, not type, Rh, and DAT, was used to determine if significant hemolysis was present in sufficient degree to affect bilirubin management. A cost-benefit analysis comparing the two methods was conducted.</p><p><strong>Result: </strong>2.8% of infants required phototherapy, and 1.1% were readmitted for hyperbilirubinemia. The closer an infant's bilirubin level was to the phototherapy threshold, the higher the ETCOc. 12 of 29 DAT negative infants with ETCOc ≥ 2.5 PPM who received phototherapy would have gone home with significant hemolysis at risk for readmission or kernicterus if not for the use of ETCOc.</p><p><strong>Conclusion: </strong>ETCOc is preferable for assessing significant hemolysis in the newborn, can be used to safely manage newborn hyperbilirubinemia, and results in cost savings.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caveats when interpreting meta-analyses of randomized controlled trials for patent ductus arteriosus in preterm infants.","authors":"Takashi Shima","doi":"10.1038/s41372-025-02248-7","DOIUrl":"https://doi.org/10.1038/s41372-025-02248-7","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of video review to enhance recognition of intubation attempt duration and success in fetal care center delivery room resuscitations.","authors":"Morgan E Hill, Jae H Kim, Stefanie Riddle","doi":"10.1038/s41372-025-02240-1","DOIUrl":"https://doi.org/10.1038/s41372-025-02240-1","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfer validity testing of a virtual reality simulation for umbilical venous catheter placement.","authors":"Harris Nisar, Nicole M Rau, Taylor Gohman, M Jawad Javed, Avinash Gupta","doi":"10.1038/s41372-025-02246-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02246-9","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late onset hearing loss in very low birth weight infants.","authors":"Chloe A Liu, Lynn M Iwamoto","doi":"10.1038/s41372-025-02233-0","DOIUrl":"10.1038/s41372-025-02233-0","url":null,"abstract":"<p><strong>Objective: </strong>To determine the impact of a referral protocol for very low birth weight (VLBW) infants and document the incidence rate of late onset hearing loss.</p><p><strong>Study design: </strong>Retrospective study (2003-2015) of post-discharge hearing outcomes and risk factors in the VLBW infant population, before and after the institution of a standardized follow-up program. Risk factors were compared between cases and matched controls.</p><p><strong>Results: </strong>Late onset hearing loss detection increased from 2.2 per 100 VLBW infants to 6.9 per 100 post standardization. The follow-up compliance rate nearly doubled. The age at diagnosis decreased from 31 to 12 months postnatal age. The detection of conductive loss increased four-fold, while sensorineural hearing loss remained unchanged.</p><p><strong>Conclusion: </strong>A significant proportion late onset hearing loss in VLBW infants is conductive, which can negatively impact speech and language development. A standardized process is essential for early detection and optimal outcomes.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics associated with death or tracheostomy in infants with bronchopulmonary dysplasia following predominant non-invasive respiratory support.","authors":"Heidi Morris, Megan Reilly, Huayan Zhang, Xiaoyue Dong, Kathleen Gibbs, Catherine M Avitabile, Sara B DeMauro, Nicolas A Bamat","doi":"10.1038/s41372-025-02234-z","DOIUrl":"https://doi.org/10.1038/s41372-025-02234-z","url":null,"abstract":"<p><strong>Objective: </strong>Identify characteristics associated with death or tracheostomy (D/T) in preterm infants with bronchopulmonary dysplasia (BPD) predominantly managed with non-invasive respiratory support prior to 36 weeks postmenstrual age (PMA).</p><p><strong>Study design: </strong>Retrospective cohort study at Children's Hospital of Philadelphia of 134 infants meeting inclusion criteria between 2010 and 2017. Various clinical characteristics were considered as predictor variables of the primary outcome, D/T; those associated at p < 0.10 in bivariable logistic regression were evaluated in multivariable models.</p><p><strong>Results: </strong>Twenty-one (16%) infants had D/T. Treatment with pulmonary vasodilators and the presence of pulmonary hypertension (PH) on echocardiogram at 36 weeks PMA were associated with D/T in bivariable analyses. Pulmonary vasodilator use remained statistically significant in adjusted multivariable models.</p><p><strong>Conclusions: </strong>We identified a strong association between PH and D/T in this cohort. Our findings emphasize the importance of specialized BPD management that includes early identification of PH in this high-risk population.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice.","authors":"Chelsea Lockyear, Ashley Stark, Henry P Foote, Anthony Agyeman, Manar Bouleqcha, Noam Cohen, Clare Matusevich, Ansley Pantsari, Shuyan Wang, Sharla Rent, William Malcolm, Veeral N Tolia, Rachel G Greenberg, Samia Aleem","doi":"10.1038/s41372-025-02238-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02238-9","url":null,"abstract":"<p><strong>Objective: </strong>To determine current prescribing practice of acid-suppressive therapy in preterm infants admitted to the neonatal intensive care unit (NICU).</p><p><strong>Study design: </strong>Cohort study of infants 22 to 27 weeks gestation discharged from Pediatrix Medical Group NICUs between 2015 and 2020.</p><p><strong>Results: </strong>Of 13,735 infants meeting inclusion criteria, 11% were exposed to acid-suppressive therapy during hospitalization, with 3% of those treated on the day of discharge. Exposed infants had lower birthweights (BW) (p < 0.001). 42% of infants exposed to acid-suppressive therapy received a gastroesophageal reflux disease (GERD) diagnosis (p < 0.001). Median (25th-75th percentile) duration of use was 7 (4-14) days. Use decreased overall during the 5-year period (p < 0.001).</p><p><strong>Conclusion: </strong>Acid-suppressive therapies are used commonly in preterm infants and receipt is higher in infants with lower BWs. Use has significantly decreased over time and appears to be targeted, with many infants treated for one-week courses and without a diagnosis of GERD.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}