Journal of Perinatology最新文献_第2页

Feasibility of volume targeted- positive pressure ventilation for preterm infants requiring invasive ventilation in the delivery room. 为需要在产房进行有创通气的早产儿实施容量目标正压通气的可行性。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-27 DOI: 10.1038/s41372-025-02280-7

Ruben Vaidya, Paul Visintainer, Rachana Singh

{"title":"Feasibility of volume targeted- positive pressure ventilation for preterm infants requiring invasive ventilation in the delivery room.","authors":"Ruben Vaidya, Paul Visintainer, Rachana Singh","doi":"10.1038/s41372-025-02280-7","DOIUrl":"https://doi.org/10.1038/s41372-025-02280-7","url":null,"abstract":"Background: Positive pressure ventilation (PPV) with high variability in delivered tidal volume (TV) may cause volutrauma. We aimed to assess feasibility of providing Volume Targeted-Positive Pressure Ventilation (VT-PPV) to preterm infants receiving invasive mechanical ventilation via endotracheal tube in the delivery room (DR).Design/methods: TV measurements were available from a respiratory function monitor (RFM) to adjust peak inspiratory pressures to target TV of 4-6 ml/kg for participants in the intervention cohort (VT-PPV). This data was compared with a historic cohort (HC), where providers were blinded from RFM measurements.Results: With VT-PPV, goal TV (4-6 ml/kg) was provided 40.1% of times (vs. HC:23.6%, p = 0.002); low TV (<4 ml/kg) was provided 8.6% of times (vs. HC:28.1%, p ≤ 0.001). There was no difference in higher TV provided in the two cohorts.Conclusion: Providing VT-PPV in intubated preterm infants may be feasible in DR and may result in increased number of breaths in target range.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies to reduce CMV infectivity in breastmilk to preterm babies - impact on transmission, nutrients, and bioactivity: a systematic review and meta-analysis. 降低母乳对早产儿巨细胞病毒感染的策略——对传播、营养和生物活性的影响：一项系统综述和荟萃分析

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-27 DOI: 10.1038/s41372-025-02254-9

Akshita Singh, Adam Bartlett, Vanessa Clifford, Brendan McMullan, Pamela Palasanthiran

{"title":"Strategies to reduce CMV infectivity in breastmilk to preterm babies - impact on transmission, nutrients, and bioactivity: a systematic review and meta-analysis.","authors":"Akshita Singh, Adam Bartlett, Vanessa Clifford, Brendan McMullan, Pamela Palasanthiran","doi":"10.1038/s41372-025-02254-9","DOIUrl":"10.1038/s41372-025-02254-9","url":null,"abstract":"Introduction: Postnatal CMV infection (pCMV) acquired via breastmilk is associated with morbidity and mortality in vulnerable infants (<32 weeks or <1500 g). 'Treatment' of breast milk reduces CMV infectivity but quantitative impact on transmission, viral loads, bioactive and nutritional elements is unknown. We conducted a systematic review and meta-analysis to assess how each method impacts CMV transmission rates and viral loads and provide a narrative review of their impact on nutritional and bioactive elements.Methods: Three search strategies for MEDLINE and EMBASE were used to identify articles studying the impact of treatment methods on CMV transmission (Arm A), nutritional elements (Arm B) and bioactive elements (Arm C). Two authors independently screened articles against inclusion and exclusion criteria. Included articles underwent quality assessment using the ROBINS-I tool. Quantitative analysis of data extracted from arm A is presented, alongside narrative reviews of arms B and C.Results: Twenty-six studies (n = 3024 infants) were included for arm A. Heat treatment methods and freeze thawing resulted in 82% and 53% reduction CMV transmission respectively, compared to untreated milk. Correlation between viral load magnitude and transmission risk was not significant. Macronutrients remained largely stable after treatment, but bioactive elements were significantly degraded by heat treatment methods. High Pressure Processing was significantly better at preserving bioactive elements compared to heat treatment.Conclusion: Heat treatment is most effective in reducing CMV infectivity in breastmilk but is associated with higher degradation of bioactive elements, whilst microwave irradiation and HPP eliminate CMV in breastmilk and preserve its immunological integrity.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurodevelopmental outcomes at age 3 years of preterm infants born at 22-31 weeks' gestation. 妊娠22-31周出生的3岁早产儿的神经发育结局。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-26 DOI: 10.1038/s41372-025-02268-3

Yumi Kono, Satoshi Kusuda, Toshihiko Nishida, Rintaro Mori, Katsuaki Toyoshima, Hatoko Sasaki, Naohiro Yonemoto, Atsushi Uchiyama, Masanori Fujimura

{"title":"Neurodevelopmental outcomes at age 3 years of preterm infants born at 22-31 weeks' gestation.","authors":"Yumi Kono, Satoshi Kusuda, Toshihiko Nishida, Rintaro Mori, Katsuaki Toyoshima, Hatoko Sasaki, Naohiro Yonemoto, Atsushi Uchiyama, Masanori Fujimura","doi":"10.1038/s41372-025-02268-3","DOIUrl":"https://doi.org/10.1038/s41372-025-02268-3","url":null,"abstract":"Objective: To evaluate neurodevelopmental outcomes of very preterm infants by gestational age (GA) using high follow-up rate data.Study design: This secondary analysis included infants born before 32 weeks' gestation in 2012-2014 from the Improvement of NICU practices and Team Approach Cluster randomized controlled Trial (INTACT). The primary outcome was survival without moderate or severe neurodevelopmental impairment (NDI).Results: Among 2722 infants, NICU survival rate was 96.5%, ranging 72.1-99.6% at 22-31 weeks. At age three years, 2336 (89.5% of 2610 survivors) were completely assessed; 303 had moderate NDI and 183 had severe NDI. Of these, the proportions of infants surviving without NDI increased with GA; 45.2% at 22 weeks, 57.5% at 23 weeks, 88.1% at 31 weeks.Conclusion: Although survival without NDI varied by GA, more than half (55.0%, 83/151) of infants born at 22-23 weeks who survived to age three years were without neurodevelopmental sequelae.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fifty billion dollar question: does formula cause necrotizing enterocolitis? 价值500亿美元的问题：配方奶粉会导致坏死性小肠结肠炎吗？

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-26 DOI: 10.1038/s41372-025-02277-2

Mark A Underwood

引用次数: 0

Response to the letter. 对信的回应。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-24 DOI: 10.1038/s41372-025-02272-7

Gabriel Erzinger, Mateus de Miranda Gauza, Silvia M Cardoso

引用次数: 0

Molecular evidence of the sex-specific effects of prenatal opioid exposure. 产前阿片类药物暴露的性别特异性效应的分子证据。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-24 DOI: 10.1038/s41372-025-02276-3

Francesca Carasi-Schwartz, Kiran Singh, Tomoko Kaneko-Tarui, Meghan I Short, Mario Cordova, Elizabeth Yen

引用次数: 0

Changes in lung aeration with high-flow nasal cannula compared to nasal CPAP in preterm infants. 高流量鼻插管与鼻CPAP对早产儿肺通气的影响。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-23 DOI: 10.1038/s41372-025-02267-4

Anup Katheria, Felix Ines, Judith Hough, Wade Rich, Ana Morales, Shashank Sanjay, Debra Poeltler, Neil Finer

{"title":"Changes in lung aeration with high-flow nasal cannula compared to nasal CPAP in preterm infants.","authors":"Anup Katheria, Felix Ines, Judith Hough, Wade Rich, Ana Morales, Shashank Sanjay, Debra Poeltler, Neil Finer","doi":"10.1038/s41372-025-02267-4","DOIUrl":"https://doi.org/10.1038/s41372-025-02267-4","url":null,"abstract":"Objective: To compare the degree of atelectasis in preterm infants on nasal continuous airway pressure (nCPAP) versus high-flow nasal cannula (HFNC) at 8 L/min.Study design: A cross-over study of infants <29 weeks gestational age (GA) receiving nCPAP and underwent 6-hours of HFNC at 8 L/min before returning to nCPAP. Electrical Impedance Tomography was used to measure lung aeration.Results: 78 infants with median GA of 27 weeks [26, 28] were studied. HFNC was non-inferior to CPAP across the 4 periods (overall mean 2.1 ± 2.9, lower bound of confidence interval -0.9). Infants that failed HFNC had higher dependent silent spaces (DSS) measurements (1.6[0.48, 4.7] vs 0.30[0.0, 2.7], P = 0.046).Conclusion: This study of premature infants <29 weeks GA at birth demonstrated that HFNC was non-inferior to nCPAP as measured by DSS. Infants that failed HFNC had a higher percentage of DSS than those who tolerated HFNC for 6 hours suggesting decreased lung aeration.Clinicaltrials: gov ID: NCT03700606.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy. 妊娠期暴露于糖尿病后第一周婴儿脂肪因子浓度的变化。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-22 DOI: 10.1038/s41372-025-02269-2

Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck

{"title":"Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.","authors":"Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck","doi":"10.1038/s41372-025-02269-2","DOIUrl":"10.1038/s41372-025-02269-2","url":null,"abstract":"Objective: Characterize changes in neonatal energy metabolism hormones in first postnatal week.Study design: Concentrations of leptin, adiponectin, insulin, resistin, and ghrelin were measured in cord and infant blood collected in the first postnatal week in a prospective cohort of term and preterm infants. Change over time in each hormone was modeled using linear mixed effects regression.Result: Among 106 infants, 65 (61%) were preterm and 44 (42%) were exposed to diabetes (DM) in pregnancy. DM group had higher leptin [between group difference β 2.5 (95%CI: 1.72-3.70)] and resistin [β 1.5 (95%CI:1.14, 1.92)] and lower ghrelin [β 0.49] [95%CI: (0.32-0.76)] versus non-DM group. Preterm infants had lower adiponectin [β 0.80 (95%CI: 0.67-0.96)] versus term group. Insulin varied by DM and prematurity (interaction-term p value < 0.05).Conclusion: In this cohort, hormone concentrations varied by DM and prematurity. Early alterations in energy metabolism hormones may reflect changes in developmental programming which persist in the early postnatal period.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's next in neonatal acute kidney injury? Discussion from the pediatric academic society neonatal nephrology focus group. 新生儿急性肾损伤的下一步是什么？来自儿科学会新生儿肾病焦点小组的讨论。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-21 DOI: 10.1038/s41372-025-02263-8

Heidi J Steflik, Matthew W Harer, David T Selewski, Michelle C Starr

引用次数: 0

Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates. 日本新生儿未结合胆红素和胆红素-白蛋白结合水平。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-03-20 DOI: 10.1038/s41372-025-02266-5

Kazuki Nishizawa, Yoshinori Katayama, Yong-Kye Lee

引用次数: 0