Journal of Perinatology最新文献_第3页

Day-2 echocardiography and cardiovascular biomarkers measurements in neonates with hypoxic-ischemic encephalopathy with or without brain injury. 新生儿缺氧缺血性脑病伴或不伴脑损伤的第2天超声心动图和心血管生物标志物测量

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-19 DOI: 10.1038/s41372-025-02419-6

Anie Lapointe, Pia Wintermark, Emmanouil Rampakakis, Punnannee Wutthigate, Shiran Sara Moore, Jessica Simoneau, Gabriel Altit

{"title":"Day-2 echocardiography and cardiovascular biomarkers measurements in neonates with hypoxic-ischemic encephalopathy with or without brain injury.","authors":"Anie Lapointe, Pia Wintermark, Emmanouil Rampakakis, Punnannee Wutthigate, Shiran Sara Moore, Jessica Simoneau, Gabriel Altit","doi":"10.1038/s41372-025-02419-6","DOIUrl":"https://doi.org/10.1038/s41372-025-02419-6","url":null,"abstract":"Objective: To assess the association between day-2 cardiac function and brain injury in neonates with HIE undergoing therapeutic hypothermia.Study design: A prospective single-center study (2016-2021) including neonates ≥36 weeks gestation with moderate to severe HIE treated with TH. Brain injuries were evaluated using MRI and a validated scoring system, and logistic regression identified cardiovascular predictors.Results: Among 55 neonates, 33 (60%) had brain injuries. Day-2 ventricular dysfunction was found in 16 (29%). Neonates with brain injuries had higher gestational age, more severe aEEG patterns, and higher Sarnat scores. Significant predictors of brain injury included higher gestational age, severe initial aEEG patterns, and increased left ventricular strain. No significant differences were observed in standard echocardiography measurements.Conclusion: Severe initial aEEG patterns and increased left ventricular strain, rather than day-2 cardiac dysfunction, were more predictive of brain injury in HIE neonates. Early assessments may further clarify the role of hemodynamics.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current prenatal counseling of congenital heart disease in trisomy 18, pediatric cardiologists' perspective: a Fetal Heart Society Research Collaborative Study. 目前18三体先天性心脏病的产前咨询，儿科心脏病专家的观点：胎儿心脏学会研究合作研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-18 DOI: 10.1038/s41372-025-02392-0

Katherine A Kosiv, Bob G Wong, Rebecca A Anderson, John C Carey

{"title":"Current prenatal counseling of congenital heart disease in trisomy 18, pediatric cardiologists' perspective: a Fetal Heart Society Research Collaborative Study.","authors":"Katherine A Kosiv, Bob G Wong, Rebecca A Anderson, John C Carey","doi":"10.1038/s41372-025-02392-0","DOIUrl":"https://doi.org/10.1038/s41372-025-02392-0","url":null,"abstract":"Objective: Survival outcomes are shifting in trisomy 18 as cardiac disease is being repaired in infancy reminiscent of trisomy 21. The landscape of prenatal counseling related to cardiac disease and trisomy 18 is unknown.Study design: A survey was distributed to pediatric cardiologists presenting two scenarios of cardiac disease varying by genetic diagnosis: trisomy 18 vs 21. Respondents were asked if cardiac surgery would be offered and ranked the importance of various factors in decision-making.Result: Sixty three percent described surgery as an option in trisomy 18 compared to 97% in trisomy 21. Genetic diagnosis was most important in trisomy 18 compared to neonatal survival in trisomy 21. Quality of life and survival to discharge were least important in trisomy 18 compared to genetic diagnosis in trisomy 21.Conclusion: Significant variability in prenatal counseling exists for trisomy 18. Indecision may be influenced by the genetic diagnosis, survival, and quality of life.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feeding outcomes of preterm infants discharged with feeding tubes. 使用喂食管出院早产儿的喂养效果。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-18 DOI: 10.1038/s41372-025-02422-x

Anisa Lakhani, Barbara McElhanon, Zhulin He, Nikhila Raol, William G Sharp, Heidi Karpen

{"title":"Feeding outcomes of preterm infants discharged with feeding tubes.","authors":"Anisa Lakhani, Barbara McElhanon, Zhulin He, Nikhila Raol, William G Sharp, Heidi Karpen","doi":"10.1038/s41372-025-02422-x","DOIUrl":"https://doi.org/10.1038/s41372-025-02422-x","url":null,"abstract":"Objective: To evaluate feeding outcomes in preterm infants discharged with feeding tubes (FT).Study design: Retrospective study comparing infants ≤30 weeks gestational age discharged with a nasogastric tube (NGT) or surgically placed feeding tube (spFT) from 2012-2020. The primary outcome was feeding status at 12 months corrected age, defined as full oral feeds (FOF) or feeding tube dependence (FTD) if ongoing FT use.Results: 217 infants were included: 130 discharged with an NGT (60%), 87 with spFT (40%). More NGT infants achieved FOF (NGT = 76%, spFT=24%, p < 0.001). FTD was associated with small for gestational age (aOR= 2.75, p = 0.034), severe bronchopulmonary dysplasia (aOR= 2.36, p = 0.029), and continuous feeds (aOR= 4.06, p < 0.001). Increased oral intake at discharge decreased FTD odds (aOR=0.74, p = 0.010). Infants with spFT had higher healthcare utilization for FT complications (spFT=60%, NGT = 19%, p < 0.001).Conclusions: These findings can guide FT selection and optimize follow-up for infants at risk of FTD.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends of care patterns and outcomes of very low birth weight infants (≤1500 g) born after 27 weeks of gestation in South Wales, UK. 英国南威尔士27周后出生的极低出生体重儿（≤1500克）的护理模式和结局趋势

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-18 DOI: 10.1038/s41372-025-02431-w

Lieve Boel, Mirain Davies, Nitin Goel, Ian Paul Morris, Sujoy Banerjee, Vasiliki Makri, Chuen Poon, Anitha James, Mallinath Chakraborty

{"title":"Trends of care patterns and outcomes of very low birth weight infants (≤1500 g) born after 27 weeks of gestation in South Wales, UK.","authors":"Lieve Boel, Mirain Davies, Nitin Goel, Ian Paul Morris, Sujoy Banerjee, Vasiliki Makri, Chuen Poon, Anitha James, Mallinath Chakraborty","doi":"10.1038/s41372-025-02431-w","DOIUrl":"https://doi.org/10.1038/s41372-025-02431-w","url":null,"abstract":"Objective: To analyse trends of outcomes of very low birth weight (VLBW) infants born after 27 weeks of gestation over 15 years in South Wales, UK.Study design: Trends of clinical outcomes were analysed by deriving multivariable logistic regression models and presented as odds ratios (aOR) with 95% confidence intervals (95% CI). A p-value of <0.05 was considered to be statistically significant.Results: Between 2007 and 2021, 2321 infants were included in the cohort. There was a decline in the incidence of mortality (aOR 0.941; 95% CI 0.895, 0.988), severe brain injury (0.937; 0.893, 0.982), necrotising enterocolitis (0.911; 0.862, 0.964) and sepsis (0.949; 0.920, 0.978). At birth, odds of mechanical ventilation (0.909; 0.888, 0.930) & receipt of surfactant (0.920; 0.899, 0.942), and mechanical ventilation after admission (0.940; 0.919, 0.961) were significantly reduced. Analysis of a subgroup of 1797 preterm infants born before 32 weeks suggested significant improvement in all major outcomes studied.Discussion: Trends of care patterns and outcomes improved over time in this cohort of VLBW infants in South Wales, especially preterm infants below 32 weeks of gestation.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective observational study quantifying maternal-fetal fentanyl transmission in epidural analgesia infusion using umbilical cord blood and neonatal meconium. 使用脐带血和新生儿胎粪进行硬膜外镇痛输注时芬太尼母婴传播的前瞻性观察研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-18 DOI: 10.1038/s41372-025-02416-9

Nanyaly M Santiago-Aponte, Dongxiao Sun, Tonya S King, Tammy E Corr

{"title":"Prospective observational study quantifying maternal-fetal fentanyl transmission in epidural analgesia infusion using umbilical cord blood and neonatal meconium.","authors":"Nanyaly M Santiago-Aponte, Dongxiao Sun, Tonya S King, Tammy E Corr","doi":"10.1038/s41372-025-02416-9","DOIUrl":"https://doi.org/10.1038/s41372-025-02416-9","url":null,"abstract":"Objective: To determine whether fetal exposure to maternal epidural fentanyl can result in a positive meconium drug test.Study design: Quantitative evaluation of fentanyl levels in cord blood and meconium of infants ≥37 weeks whose mothers received epidural analgesia was performed using High Performance Liquid Chromatography-tandem Mass Spectrometry. The association between dose and duration of maternal epidural and fentanyl levels in cord blood and meconium was evaluated.Results: In 298 mother-infant dyads, median duration of fentanyl epidural was 6.8 hours. There was a strong positive correlation between epidural duration and fentanyl levels in meconium (Spearman rho = 0.70, 95%CI [0.64-0.76]), p < 0.001). Positive predictive value for fentanyl detection in meconium >0.05 ng/g for epidural exposure of >4 hours was 93.9%.Conclusion: There is a strong positive correlation between maternal epidural duration and fentanyl in meconium. Providers can anticipate a positive meconium drug screen for fentanyl in the setting of a maternal epidural.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Identifying performance differences between two pulse oximetry systems in simulated critical neonatal conditions. 修正：确定两种脉搏血氧仪系统在模拟新生儿危急情况下的性能差异。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-18 DOI: 10.1038/s41372-025-02405-y

Brian King, Jake Dove, Scott J McGonigle, Warwick A Ames, Zachary A Vesoulis

引用次数: 0

Ketogenic diet in neonates: effects, pitfalls, and a paradigm from a preterm newborn affected by pyruvate dehydrogenase deficiency. 生酮饮食对新生儿的影响：丙酮酸脱氢酶缺乏症对早产新生儿的影响、缺陷和范例。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-17 DOI: 10.1038/s41372-025-02427-6

Sokratis Katsoudas, Luis A Umana, Rebekah Clarke, Jennifer Thomas, Michelle Machie, Dimitrios Angelis

引用次数: 0

Prevalence, predictors, and patterns of residential mobility by the parents of preterm infants. 早产儿父母居住流动的患病率、预测因素和模式。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-17 DOI: 10.1038/s41372-025-02414-x

Daria Murosko, Timothy Nelin, Priya Sharma, Vicky Tam, Elynna Volkova, Kristan Scott, Emily F Gregory, Scott Lorch

{"title":"Prevalence, predictors, and patterns of residential mobility by the parents of preterm infants.","authors":"Daria Murosko, Timothy Nelin, Priya Sharma, Vicky Tam, Elynna Volkova, Kristan Scott, Emily F Gregory, Scott Lorch","doi":"10.1038/s41372-025-02414-x","DOIUrl":"10.1038/s41372-025-02414-x","url":null,"abstract":"Objective: Describe how preterm infants experience residential mobility, or moving, before age 2 years.Study design: This retrospective cohort study included 9267 preterm infants followed in a mid-Atlantic urban and suburban primary care network. Multivariable regression modeling identified patient and community factors associated with residential mobility, defined by a change in Census Block Group.Results: 2494 infants (27%) moved before age 2 years; 559 (6%) moved more than once. Extreme prematurity, compared to late prematurity, was associated with increased odds of mobility (aOR 1.26, 95% CI 1.03-1.54). Governmental insurance, male sex, a positive or missing post-partum depression screen, and neighborhood deprivation were also positively associated with mobility. Among movers, 741 (30%) first relocated before 6 months of age, and mobility rates decreased with increasing chronologic age.Conclusion: Early-life residential mobility is common among preterm infants, particularly extremely preterm infants. These findings have implications for discharge preparation among this vulnerable group.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung ultrasound score and left ventricular eccentricity index in preterm infants with respiratory failure - a pilot study. 呼吸衰竭早产儿肺超声评分和左心室偏心率指数的初步研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-17 DOI: 10.1038/s41372-025-02429-4

Jacob Kelner, Naveed Hussain, Henry Chicaiza, Shalin Parekh

{"title":"Lung ultrasound score and left ventricular eccentricity index in preterm infants with respiratory failure - a pilot study.","authors":"Jacob Kelner, Naveed Hussain, Henry Chicaiza, Shalin Parekh","doi":"10.1038/s41372-025-02429-4","DOIUrl":"https://doi.org/10.1038/s41372-025-02429-4","url":null,"abstract":"Objective: To investigate the association between lung ultrasound score (LUS) and left ventricular eccentricity index at end-systole (LVEI-s) and end-diastole (LVEI-d) in preterm infants with respiratory failure.Study design: This prospective pilot study included 38 ultrasounds on 20 premature infants with Transient Tachypnea of the Newborn (TTN) and Respiratory Distress Syndrome (RDS) requiring non-invasive ventilation at birth. LUS, LVEI-s, and LVEI-d were obtained daily for 72 h. Linear regression analysis was performed to determine correlation.Results: LUS positively correlated with LVEI-s (r = 0.47, p = <0.01) and LVEI-d (r = 0.63, p = <0.01) during the 72-hour study period in the RDS group, but not the TTN group. Correlation increased over the first 24 h (LVEI-s: r = 0.69, p = <0.01; LVEI-d: r = 0.68, p = <0.01) in the RDS group.Conclusion: As LUS increases, both LVEI-s and LVEI-d demonstrate measurable changes in infants with RDS. This association may enhance precision in diagnostic stratification and optimizing fluid management in neonatal lung disease.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct gastroesophageal reflux characteristics in preterm-born infants fed human milk versus formula: insights for clinical practice on outcomes. 不同的胃食管反流特征的早产儿喂养母乳与配方奶粉：洞察临床实践的结果。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-09-17 DOI: 10.1038/s41372-025-02421-y

Erika K Osborn, Zakia Sultana, Faith Bala, Enas Alshaikh, Sudarshan R Jadcherla

{"title":"Distinct gastroesophageal reflux characteristics in preterm-born infants fed human milk versus formula: insights for clinical practice on outcomes.","authors":"Erika K Osborn, Zakia Sultana, Faith Bala, Enas Alshaikh, Sudarshan R Jadcherla","doi":"10.1038/s41372-025-02421-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02421-y","url":null,"abstract":"Objective: To compare the characteristics of gastroesophageal reflux (GER) and clinical outcomes among human milk-fed vs. formula-fed infants evaluated for GER disease (GERD).Methods: Preterm-born infants (N = 316, 30.1 ± 3.4 weeks gestation) referred for 24-h pH-impedance testing at 39.8 ± 1.4 weeks postmenstrual age. GER characteristics, short- and long-term outcomes were compared between the human milk- vs. formula-fed infants.Results: Human milk-fed infants (vs. formula-fed) had a greater acid reflux index (ARI), and an increased number of acid reflux events, prolonged acid events, and greater proximal acid exposure (P < 0.05). There were no differences (P > 0.05) in symptoms, acid clearance, bolus clearance, distal baseline impedance, and discharge outcomes. Bayley composite scores at 2 years were distinct (P < 0.05) for the distribution (%) of receptive and fine motor skills, favoring human milk-fed infants.Conclusions: Despite the pathophysiology caused by acid-GER events, human milk properties may provide better adaptation and modulation of neurosensory and neuromotor responses upon esophageal provocation.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0