Journal of Perinatology最新文献_第3页

Clinical utility of rapid whole genome sequencing in neonatal patients receiving extracorporeal membrane oxygenation (ECMO). 对接受体外膜氧合（ECMO）的新生儿患者进行快速全基因组测序的临床实用性。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-27 DOI: 10.1038/s41372-024-02181-1

Milan D Amin, Kristen Wigby, Denise Suttner, Anna-Kaisa Niemi, Lucia Guidugli, Jeanne Carroll

{"title":"Clinical utility of rapid whole genome sequencing in neonatal patients receiving extracorporeal membrane oxygenation (ECMO).","authors":"Milan D Amin, Kristen Wigby, Denise Suttner, Anna-Kaisa Niemi, Lucia Guidugli, Jeanne Carroll","doi":"10.1038/s41372-024-02181-1","DOIUrl":"https://doi.org/10.1038/s41372-024-02181-1","url":null,"abstract":"Objective: The objective of this study is to describe the impact of rapid and ultra-rapid whole genome sequencing (rWGS/urWGS) on the care of neonatal intensive care (NICU) patients who require extracorporeal membrane oxygenation (ECMO).Study design: This is a retrospective cohort study at a single-center NICU in a tertiary children's hospital. The study population includes NICU patients treated with ECMO from May 2017 to September 2023. Patients were evaluated for whether whole genome was completed, speed of testing (rapid vs. ultra-rapid), diagnostic rate, and clinical utility.Result: Twenty-six (72%) patients had rWGS/urWGS. A diagnosis associated with the patient's phenotype was made in 12 patients (46%). A change in clinical management was made due to rWGS/urWGS in 10 patients (38%) including avoidance of imaging studies, decisions regarding goals of care, and screening studies.Conclusion: This study demonstrates a high diagnostic rate and clinical utility of rWGS/urWGS for NICU patients requiring ECMO.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finding treasure in the journey: a single center quality improvement bundle to reduce bronchopulmonary dysplasia. 在旅途中寻找宝藏：减少支气管肺发育不良的单中心质量改进捆绑计划。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-26 DOI: 10.1038/s41372-024-02190-0

Nichole Adiletta, Anne Denslow, Renee Martinez, Beverly Walti, Pernilla Fridolfsson, Julie Rockey, David Tirol, Kim Kierulff, Kushal Y Bhakta, Michel Mikhael

{"title":"Finding treasure in the journey: a single center quality improvement bundle to reduce bronchopulmonary dysplasia.","authors":"Nichole Adiletta, Anne Denslow, Renee Martinez, Beverly Walti, Pernilla Fridolfsson, Julie Rockey, David Tirol, Kim Kierulff, Kushal Y Bhakta, Michel Mikhael","doi":"10.1038/s41372-024-02190-0","DOIUrl":"https://doi.org/10.1038/s41372-024-02190-0","url":null,"abstract":"Background: Reducing bronchopulmonary dysplasia (BPD) utilizing a single intervention has been challenging. The quality improvement (QI) bundle approach may better address BPD multifactorial risk factors.Methods: A single-center interdisciplinary quality improvement (QI) initiative to enhance respiratory care for preterm infants born less than 30 weeks gestation.Global aim: To reduce BPD in preterm infants.Smart aim: Introduce and implement a comprehensive, evidence-based respiratory care bundle within 12 months, targeting areas needing improvement in our practices.Results: Our preplanned improvement targets were achieved for all process measures. Overall BPD incidence did not change (45% vs. 44.3%). After the QI intervention, inborn infants had a lower BPD rate, though not statistically significant (38.7% vs. 30.3%, p = 0.22), with a significant reduction in grade 1 BPD (24.5% vs. 12.4%, p = 0.032).Conclusion: Structured interdisciplinary QI work tailored to local settings can improve respiratory care and possibly amend the outcomes of infants at risk for BPD.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes, safety and health economics of introduction of video laryngoscopy-assisted less invasive surfactant administration. 引入视频喉镜辅助微创表面活性给药的结果、安全性和卫生经济学。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-22 DOI: 10.1038/s41372-024-02162-4

Venkata Gupta, Barry Weinberger, Stephanie G Galanti, Jimikumar Patel, Gangajal Kasniya, Dalibor Kurepa

{"title":"Outcomes, safety and health economics of introduction of video laryngoscopy-assisted less invasive surfactant administration.","authors":"Venkata Gupta, Barry Weinberger, Stephanie G Galanti, Jimikumar Patel, Gangajal Kasniya, Dalibor Kurepa","doi":"10.1038/s41372-024-02162-4","DOIUrl":"https://doi.org/10.1038/s41372-024-02162-4","url":null,"abstract":"Background: Less invasive surfactant administration (LISA) is associated with better outcomes than InSurE (Intubation-Surfactant administration-Extubation). Video-laryngoscopy (VL) facilitates intubation in neonates, however safety and cost-effectiveness of VL-assisted LISA have not been evaluated.Methods: We compared the outcomes of infants receiving VL-assisted LISA (n = 67) with a historical cohort of infants who received InSurE (n = 52). Secondary aims were to evaluate safety and cost-effectiveness.Results: VL-assisted LISA was associated with reduced duration of non-invasive ventilation (NIV), reduced duration of oxygen therapy, reduced composite days on NIV and mechanical ventilation (MV), and shorter NICU stay with lower hospital costs for infants ≥29 weeks GA, compared to InSurE. In the VL-assisted LISA group, 66% of the tracheal catheters were placed on the first attempt and 16% of infants displayed desaturation during placement.Conclusion: In infants ≥29 weeks GA, VL-assisted LISA reduced exposure to NIV, oxygen, NIV and MV combined, length of stay, and cost of care compared to InSurE.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practice variation in therapeutic hypothermia for hypoxic ischemic encephalopathy among neonates with congenital heart disease in the United States. 美国先天性心脏病新生儿缺氧缺血性脑病治疗性低温疗法的实践差异。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-22 DOI: 10.1038/s41372-024-02173-1

Vonita Chawla, Allison M Peluso, Molly K Ball, Sarah Tabbutt, David K Bailly, Dana Mueller, Rakesh Rao, Philip T Levy

引用次数: 0

Salivary cortisol is not associated with dexamethasone response in preterm infants with evolving bronchopulmonary dysplasia. 唾液皮质醇与支气管肺发育不良早产儿的地塞米松反应无关。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-21 DOI: 10.1038/s41372-024-02177-x

Tamorah Lewis, Erik A Jensen, Sherry Courtney, Jonathan Slaughter, Matthew J Kielt, Narayan Prahbu Iyer, Cheri Gauldin, Christopher Nitkin, Hung-Wen Yeh, William Truog

{"title":"Salivary cortisol is not associated with dexamethasone response in preterm infants with evolving bronchopulmonary dysplasia.","authors":"Tamorah Lewis, Erik A Jensen, Sherry Courtney, Jonathan Slaughter, Matthew J Kielt, Narayan Prahbu Iyer, Cheri Gauldin, Christopher Nitkin, Hung-Wen Yeh, William Truog","doi":"10.1038/s41372-024-02177-x","DOIUrl":"https://doi.org/10.1038/s41372-024-02177-x","url":null,"abstract":"Objective: Short-term treatment efficacy of systemic dexamethasone (DEX) in preterm infants with bronchopulmonary dysplasia (BPD) is highly variable. Our objective was to assess if salivary cortisol may serve as a reliable biomarker of steroid response.Study design: Multi-site prospective observational cohort study. Salivary cortisol was measured before and after DEX treatment. Respiratory Severity Score (RSS) quantified clinical response.Results: Fifty-four infants with median (inter-quartile range) gestational age of 25.1 (24.1,26.5) weeks initiated DEX at 30 (23,48) days' postnatal age. Median baseline and post-treatment cortisol levels were 0.3 (0.2,0.6) μg/dl; 8.3 (5.5,16.5) nmol/L and 0.2 (0.1,0.3) μg/dl; 5.5 (2.8,8.3) nmol/L, respectively. RSS values decreased by a median of 3.1(1.6,5.0) Change in RSS did not correlate with baseline cortisol or change in cortisol levels.Conclusion: In this first study to assess salivary cortisol as a biomarker for DEX response in BPD, salivary cortisol did not predict dexamethasone response.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-procedure pain in preterm neonates undergoing retinopathy of prematurity (ROP) screening: a prospective cohort study. 接受早产儿视网膜病变（ROP）筛查的早产儿术后疼痛：一项前瞻性队列研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-21 DOI: 10.1038/s41372-024-02107-x

Raman Singla, Ankit Verma, Vivek Kumar, Purna Chandra, Parijat Chandra, Anu Thukral, M Jeeva Sankar, Ramesh Agarwal, Ashok Kumar Deorari

{"title":"Post-procedure pain in preterm neonates undergoing retinopathy of prematurity (ROP) screening: a prospective cohort study.","authors":"Raman Singla, Ankit Verma, Vivek Kumar, Purna Chandra, Parijat Chandra, Anu Thukral, M Jeeva Sankar, Ramesh Agarwal, Ashok Kumar Deorari","doi":"10.1038/s41372-024-02107-x","DOIUrl":"https://doi.org/10.1038/s41372-024-02107-x","url":null,"abstract":"Objective: To evaluate the pain intensity in preterm infants during 48 h post retinopathy of prematurity (ROP) screening by binocular fundoscopy.Design: Prospective cohort study.Settings: Level-III-NICU in India.Participants: 83 Neonates undergoing first ROP screening.Main outcome measures: Pain assessment using the premature infant pain profile-revised (PIPP-R) score at baseline and 5 min, 30 min, 6 h, 24 h, and 48 h post-procedure.Results: The mean gestation and birth weight was 29.8 (2.3) weeks and 1256 (344)g respectively. The median (IQR) PIPP-R score at baseline was 0 which significantly increased to 10.5 (8,12.5) 5 min (immediately) after the procedure. At 30 min and 6 h, scores were 7 (5,8) and 4.5 (3,5.5) respectively. After 24 h and 48 h, it decreased to 3 (0,5) and 0 (0,4.5) respectively. Nearly 59% (95%CI:40%-83%) of neonates had severe pain (PIPP-R score > 12) immediately after procedure.Conclusion: A majority of neonates experience severe pain immediately after ROP screening, and mild-moderate pain continues for 6 h. Hence, an additional pharmacological agent should be considered for reducing neonatal pain.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do timing and severity of gestational COVID-19 impact perinatal and neonatal outcomes? 妊娠期 COVID-19 的发生时间和严重程度会影响围产期和新生儿预后吗？

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-21 DOI: 10.1038/s41372-024-02179-9

Júlia Candel-Pau, Daniel Suqué-Tusell, Sílvia Maya-Enero, Carlos Ramon-Iglesias, Beatriz Valle-Del-Barrio, Maria Ángeles López-Vílchez

{"title":"Do timing and severity of gestational COVID-19 impact perinatal and neonatal outcomes?","authors":"Júlia Candel-Pau, Daniel Suqué-Tusell, Sílvia Maya-Enero, Carlos Ramon-Iglesias, Beatriz Valle-Del-Barrio, Maria Ángeles López-Vílchez","doi":"10.1038/s41372-024-02179-9","DOIUrl":"10.1038/s41372-024-02179-9","url":null,"abstract":"Objective: To examine the relationship between gestational COVID-19 and perinatal-neonatal outcomes.Study design: Prospective cohort study. Neonates born at Hospital del Mar (Barcelona) between 2020 and 2022 were classified into two cohorts according to their mother's COVID-19 status during pregnancy. Prenatal and postnatal variables were compared between the COVID-19 and the control cohort, and depending on timing and severity of maternal infection.Results: We included 2701 neonates and observed higher rates of respiratory distress (5.7% vs 3.3%, p = 0.044) and pathological jaundice (7.7% vs 4.1%, p = 0.007) in the COVID-19 cohort, without differences between trimesters. We did not find statistically significant differences in other perinatal outcomes. The logistic regression analyses showed that maternal COVID-19 was not a risk factor for prematurity (OR:1.23;CI:0.75-2.03; p = 0.407).Conclusions: Infants born to mothers with COVID-19 during pregnancy in our hospital showed higher rates of respiratory distress and pathological jaundice, without increased rates of prematurity or other morbidities.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sociodemographic characteristics of maternal presence in neonatal intensive care: an intersectional analysis. 新生儿重症监护中产妇的社会人口特征：交叉分析。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-21 DOI: 10.1038/s41372-024-02175-z

Dana B McCarty, Shelley D Golden, Renée M Ferrari, Bharathi J Zvara, Wylin D Wilson, Meghan E Shanahan

{"title":"Sociodemographic characteristics of maternal presence in neonatal intensive care: an intersectional analysis.","authors":"Dana B McCarty, Shelley D Golden, Renée M Ferrari, Bharathi J Zvara, Wylin D Wilson, Meghan E Shanahan","doi":"10.1038/s41372-024-02175-z","DOIUrl":"https://doi.org/10.1038/s41372-024-02175-z","url":null,"abstract":"Objective: Maternal presence in the Neonatal Intensive Care (NICU) supports infant and maternal health, yet mothers face visitation challenges. Based on intersectionality theory, we hypothesized that mothers of Black infants with lower socioeconomic status (SES) living further from the hospital would demonstrate the lowest rates of maternal presence.Study design: We extracted infant race, Medicaid status, and maternal home address from 238 infant medical charts. The primary outcome was rate of maternal presence. Generalized linear modeling and binomial regression were employed for analysis.Results: Medicaid status was the strongest single predictor of lower rates of maternal presence. Having lower SES was associated with lower rates of maternal presence in mothers of white infants, and living at a distance from the hospital was associated with lower maternal presence in mothers of higher SES.Conclusions: Interventions to support maternal presence in the NICU should address resource-related challenges experienced by mothers of lower SES.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pinch of salt to enhance preemie growth? 放一小撮盐能促进早产儿生长？

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-20 DOI: 10.1038/s41372-024-02174-0

Heidi J Steflik, Stephen A Pearlman, Patrick G Gallagher, Satyan Lakshminrusimha

引用次数: 0

Towards a new taxonomy of preterm birth. 建立早产儿新分类法。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2024-11-20 DOI: 10.1038/s41372-024-02183-z

David K Stevenson, Alan L Chang, Ronald J Wong, Jonathan D Reiss, Brice Gaudillière, Karl G Sylvester, Xuefeng B Ling, Martin S Angst, Gary M Shaw, Michael Katz, Nima Aghaeepour, Ivana Marić

{"title":"Towards a new taxonomy of preterm birth.","authors":"David K Stevenson, Alan L Chang, Ronald J Wong, Jonathan D Reiss, Brice Gaudillière, Karl G Sylvester, Xuefeng B Ling, Martin S Angst, Gary M Shaw, Michael Katz, Nima Aghaeepour, Ivana Marić","doi":"10.1038/s41372-024-02183-z","DOIUrl":"https://doi.org/10.1038/s41372-024-02183-z","url":null,"abstract":"Disease categories traditionally reflect a historical clustering of clinical phenotypes based on biologic and nonbiologic features. Multiomics approaches have striven to identify signatures to develop individualized categorizations through tests and/or therapies for 'personalized' medicine. Precision health classifies clinical syndromes into endotype clusters based on novel technological advancements, which can reveal insights into the etiologies of phenotypical syndromes. A new taxonomy of preterm birth should be considered in this context, as not all preterm infants of similar gestational ages are the same because most have different biologic vulnerabilities and hence different health trajectories. Even the choice of interventions may affect observed clinical conditions. Thus, a new taxonomy of prematurity would help to advance the field of neonatology, but also obstetrics and perinatology by adopting anticipatory and more targeted approaches to the care of preterm infants with the intent of preventing and treating some of the most common newborn pathologic conditions.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0