Journal of Perinatology最新文献_第3页

Neonatal transport for convalescing infants. 康复婴儿的新生儿运输。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-28 DOI: 10.1038/s41372-026-02909-1

Carlo Bellini, Maurizio Gente, Francesca Catani, Maria Del Carmen Rodriguez Perez

引用次数: 0

Current practices in the management of hemodynamically significant patent ductus arteriosus. 血流动力学意义显著的动脉导管未闭的治疗现状。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-28 DOI: 10.1038/s41372-026-02914-4

Paige E Condit, Alexandra A Erdmann, Xiao Zhang, Estelle Ndukwe, Joseph Fernandez, John S Hokanson

{"title":"Current practices in the management of hemodynamically significant patent ductus arteriosus.","authors":"Paige E Condit, Alexandra A Erdmann, Xiao Zhang, Estelle Ndukwe, Joseph Fernandez, John S Hokanson","doi":"10.1038/s41372-026-02914-4","DOIUrl":"https://doi.org/10.1038/s41372-026-02914-4","url":null,"abstract":"Objective: To describe current practices among neonatologists and cardiologists regarding the diagnosis and management of hemodynamically significant patent ductus arteriosus (hsPDA) in premature infants, with particular focus on the valuation of echocardiographic parameters, use of scoring systems, and availability of treatment modalities.Study design: Cross-sectional survey of members of the American Academy of Pediatrics Sections on Neonatal-Perinatal Medicine and Cardiology and Cardiac Surgery, and the Pediheart.net community, regarding approaches to diagnosing and treating hsPDA.Result: 422 providers participated. Only 13.5% recommended routine screening echocardiography. Formal scoring systems were rarely used. Agreement on echocardiographic parameter importance was seen in only two of the nine parameters. Reported treatment availability included medical therapy (99%), surgical ligation (74%), and catheter closure (66%). Catheter closure was more frequently preferred than surgical ligation. Of respondents, 315 were neonatologists (estimated response rate 7% of SONPM), and 107 were cardiologists (estimated response rate 5.4% of SOCCS/Pediheart, noting significant membership overlap between these groups).Conclusion: Substantial differences exist between neonatologists and cardiologists in the perceived value of echocardiographic markers for hsPDA. Formal scoring systems are infrequently used with wide variation in adoption, and catheter-based occlusion has been rapidly adopted. Greater consensus in PDA assessment and management is needed.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome. 比较标准喂养与高热量喂养在新生儿阿片类戒断综合征婴儿中的随机试验研究。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-28 DOI: 10.1038/s41372-026-02913-5

Frances Y Cheng, McKenzie Tuttle, Elyssa Dionne, Veronika Shabanova, Sarah McCollum, Alyssa Morrison, Chandler J McMillan, Sandra N Anyoha, Lynda S Swerling, Amy Petrucelli, Lauren K Lary, Kristen Fulton, Dhatri Abeyaratne, Grace Wang, Christine Hodelin, Lina A Elmansy, Kailey Carlson, Eugene D Shapiro, Matthew R Grossman

{"title":"Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome.","authors":"Frances Y Cheng, McKenzie Tuttle, Elyssa Dionne, Veronika Shabanova, Sarah McCollum, Alyssa Morrison, Chandler J McMillan, Sandra N Anyoha, Lynda S Swerling, Amy Petrucelli, Lauren K Lary, Kristen Fulton, Dhatri Abeyaratne, Grace Wang, Christine Hodelin, Lina A Elmansy, Kailey Carlson, Eugene D Shapiro, Matthew R Grossman","doi":"10.1038/s41372-026-02913-5","DOIUrl":"https://doi.org/10.1038/s41372-026-02913-5","url":null,"abstract":"Objective: We assessed feasibility of high-calorie feeds in infants with NOWS at risk for excessive weight loss managed using Eat, Sleep, Console.Study design: In this double-blind pilot study (NCT04419857, Connecticut, USA), we randomized methadone- or buprenorphine-prenatally-exposed infants <48 h old to standard- or high-calorie feeds. Primary outcomes were enrollment, adherence, and retention; exploratory outcomes included breastfeeding and stooling frequency.Results: From December 2020 to August 2023, 35/65 infants (53.8%) were randomized. During hospitalization, 84% of feeds adhered to the randomized feeding approach. In-hospital retention was 71.4%; 14-day post-discharge retention was 28.6%. Groups did not differ significantly in demographic characteristics, maximum percent weight loss (p = 0.12), length of stay (p = 0.88), or stool frequency (p = 0.59). High-calorie-fed infants more frequently received breastmilk at discharge (p = 0.04).Conclusion: Enrollment, adherence, and in-hospital retention were comparable to other feasibility trials; post-discharge follow-up was poor. Early high-calorie feeding did not appear to be negatively associated with breastfeeding or stooling.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are premature infants with severe bronchopulmonary dysplasia at increased risk for atypical craniosynostosis? 患有严重支气管肺发育不良的早产儿发生不典型颅缝闭闭的风险增加吗？

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-26 DOI: 10.1038/s41372-026-02907-3

Suzanne Greenleaf Martin, Christa Matrone, Mark Stephens, Thais Queliz Pena, Mary Schreck, Richard A Guerrero, Angela Zimmerman, Samer K Elbabaa, Ryan Jafrani, Brent Golden

{"title":"Are premature infants with severe bronchopulmonary dysplasia at increased risk for atypical craniosynostosis?","authors":"Suzanne Greenleaf Martin, Christa Matrone, Mark Stephens, Thais Queliz Pena, Mary Schreck, Richard A Guerrero, Angela Zimmerman, Samer K Elbabaa, Ryan Jafrani, Brent Golden","doi":"10.1038/s41372-026-02907-3","DOIUrl":"https://doi.org/10.1038/s41372-026-02907-3","url":null,"abstract":"Objective: To describe an atypical pattern of secondary craniosynostosis observed in premature infants with severe bronchopulmonary dysplasia (BPD) who required prolonged high-pressure ventilation and tracheostomy.Study design: A single-center retrospective chart review of infants born between January 2020 and May 2025. Inclusion criteria were gestational age 22-28 weeks, severe BPD, tracheostomy placement, and radiologic variables from the medical record.Result: Ten patients met inclusion criteria. The greatest 4-week rise in head circumference percentile was 43 ± 14 percentile points, exceeding concurrent changes in weight and length (P = 0.0023). The weighted mean sustained positive end-expiratory pressure was 10.6 cm H₂O.Conclusion: Extremely premature infants with severe BPD requiring prolonged high-pressure mechanical ventilation may be vulnerable to a novel phenotype of atypical craniosynostosis marked by accelerated head circumference growth, craniosynostosis, and calvarial thickening. Prospective studies are needed to define ventilatory exposure thresholds, clarify mechanisms, and determine neurologic and surgical implications.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of SGA, AGA, and LGA birthweight subclassification on NICU mortality risk identification: a cohort study. SGA、AGA和LGA出生体重亚分类对新生儿重症监护病房死亡风险识别的影响：一项队列研究

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-26 DOI: 10.1038/s41372-026-02903-7

A Nicole Ferguson, Joseph R Stanton, Brandi D Jones, Irene E Olsen, Reese H Clark, Joe Bible, Matthew Reith, Jessica G Woo

{"title":"Impact of SGA, AGA, and LGA birthweight subclassification on NICU mortality risk identification: a cohort study.","authors":"A Nicole Ferguson, Joseph R Stanton, Brandi D Jones, Irene E Olsen, Reese H Clark, Joe Bible, Matthew Reith, Jessica G Woo","doi":"10.1038/s41372-026-02903-7","DOIUrl":"https://doi.org/10.1038/s41372-026-02903-7","url":null,"abstract":"Objective: To assess whether subdividing small (SGA, <10th), appropriate (AGA, 10th-90th), and large (LGA, >90th percentile) for gestational age (GA) birthweight classifications improves mortality risk estimation among preterm infants in neonatal intensive care units (NICUs).Study design: Data from 25,779 singleton inborn NICU infants (24-30 weeks GA) from the Pediatrix Clinical Data Warehouse (2013-2018) were analyzed. Infant birthweights were subclassified into 12 subgroups (extremely SGA [eSGA], <3rd; moderately SGA [mSGA], 3rd-<10th, 8 AGA categories [3-AGA to 9-AGA]; mLGA, >90th-97th; eLGA, >97th percentile). Mortality probability by birthweight category was modeled using logistic regression.Result: Mortality probability was higher for infants classified as eSGA (28.9%, 95% CI [26.4-31.4%]) than mSGA (9.9% [8.7-11.3%]). Smaller AGA infants had higher mortality than larger AGA infants (e.g., 3-AGA: 8.5% [7.5-9.7%] vs. 9-AGA: 5.0% [4.2-5.9%]). Subdividing LGA provided no additional information.Conclusion: Subdivision of SGA and AGA birthweight categories may improve mortality risk prediction among premature infants.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpreting the JASMINE trial in the context of Japanese neonatal care. 在日本新生儿护理的背景下解读JASMINE试验。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-25 DOI: 10.1038/s41372-026-02906-4

Katsumi Mizuno

引用次数: 0

Variations in diagnosis and management of hemodynamically significant patent ductus arteriosus across neonatal intensive care units in the Children's Hospitals Neonatal Consortium. 在儿童医院新生儿联盟的新生儿重症监护病房中，血流动力学意义显著的动脉导管未闭的诊断和管理的差异。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-24 DOI: 10.1038/s41372-026-02910-8

Sharada H Gowda, Philip T Levy, Shannon Hamrick, Sarah Keene, Shawn Sen, Ayan Rajgarhia, Rakesh Rao, Molly K Ball, Mark F Weems

{"title":"Variations in diagnosis and management of hemodynamically significant patent ductus arteriosus across neonatal intensive care units in the Children's Hospitals Neonatal Consortium.","authors":"Sharada H Gowda, Philip T Levy, Shannon Hamrick, Sarah Keene, Shawn Sen, Ayan Rajgarhia, Rakesh Rao, Molly K Ball, Mark F Weems","doi":"10.1038/s41372-026-02910-8","DOIUrl":"https://doi.org/10.1038/s41372-026-02910-8","url":null,"abstract":"Objective: Collate patent ductus arteriosus (PDA) guidelines among Children's Hospitals Neonatal Consortium (CHNC) centers and identify variations in the diagnosis and management of hemodynamically significant PDA (hsPDA).Study design: A descriptive survey requesting written PDA guidelines was sent to CHNC representatives from November 2023 to February 2024. Our study methods were performed in accordance with the survey guidelines and regulations of the CHNC. No PHI identifiers or institutional data were utilized for performing this study.Results: Of 44 centers, 38 (86%) responded; 25 (67%) provided written guidelines. Clinical signs of PDA were included in 18 (72%) guidelines, and 21 (84%) specified echocardiographic criteria for hsPDA. Ibuprofen was the most common first-line therapy, followed by acetaminophen and indomethacin. Most centers outlined a stepwise management approach including fluid restriction, diuretics, pharmacotherapy, and transcatheter closure. Surgical ligation was less frequently recommended.Conclusions: A majority of CHNC centers maintain written hsPDA guidelines incorporating clinical and echocardiographic criteria. Management emphasizes a stepwise approach from expectant to active management with pharmacotherapy and increasing adoption of transcatheter closure, highlighting evolving practice patterns in neonatal PDA care.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing rates of neonatal hypothermia at birth in Tanzania: a quality improvement initiative. 降低坦桑尼亚新生儿出生时体温过低的发生率：一项质量改进倡议。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-24 DOI: 10.1038/s41372-026-02904-6

Chelsea Hartman, Ester Ngowi, Emily Ahn, Aisa Shayo, Nyemo Peter, Jackline Cypriane, Pendo Mlay, Priyanka Tiwari, Jeffrey Perlman

{"title":"Reducing rates of neonatal hypothermia at birth in Tanzania: a quality improvement initiative.","authors":"Chelsea Hartman, Ester Ngowi, Emily Ahn, Aisa Shayo, Nyemo Peter, Jackline Cypriane, Pendo Mlay, Priyanka Tiwari, Jeffrey Perlman","doi":"10.1038/s41372-026-02904-6","DOIUrl":"https://doi.org/10.1038/s41372-026-02904-6","url":null,"abstract":"Objective: The SMART aim was to reduce the rate of neonatal hypothermia by 50% and increase neonatal delivery room (DR) temperature by 0.6 °C. To explore the relationship between hypothermia reduction and early neonatal mortality <7 days.Study design: Prospective QI study using the Model for Improvement through three Plan-Do-Study-Act cycles (PDSA) in neonates <2000g.Interventions: 1. Hypothermia Prevention Care Bundle, 2. In-Person In-Service Training and 3. Audit Implementation.Results: At baseline, mean DR neonatal temperature of 35.9 ± 0.24 °C and rates of overall hypothermia of 99% [66% mild (36-36.4 °C), 33% moderate (32-35.9 °C)] were noted. From the first PDSA cycle, there were centerline (CL) shifts in mean temperature to 36.8 °C and incidence of hypothermia to 5.7% (5.7% mild, 0% moderate). Early mortality rates remained unchanged (CL 12.3%).Conclusion: Hypothermia was almost eliminated in the DR. Because the overall neonatal mortality was unchanged there is insufficient evidence to support a causal relationship between hypothermia and early mortality.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Universal newborn screening for G6PD deficiency and severe hyperbilirubinemia at a tertiary center in Jerusalem. 在耶路撒冷的三级中心进行G6PD缺乏症和严重高胆红素血症的新生儿普遍筛查。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-23 DOI: 10.1038/s41372-026-02901-9

Aviad Schnapp, Ohad Neufeld, Sinan Abu-Leil, Rawan Abu Omar, Haneen Azzam, Noa Ofek Shlomai, Smadar Eventov Friedman

{"title":"Universal newborn screening for G6PD deficiency and severe hyperbilirubinemia at a tertiary center in Jerusalem.","authors":"Aviad Schnapp, Ohad Neufeld, Sinan Abu-Leil, Rawan Abu Omar, Haneen Azzam, Noa Ofek Shlomai, Smadar Eventov Friedman","doi":"10.1038/s41372-026-02901-9","DOIUrl":"https://doi.org/10.1038/s41372-026-02901-9","url":null,"abstract":"Objective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a major risk factor for neonatal hyperbilirubinemia, yet screening protocols are limited to at-risk populations and may miss affected infants.Study design: We reviewed 5413 neonates born at a tertiary center in Jerusalem. Of 4867 with valid results, 81 (1.66%, 2.9% of males) had severe (<2 IU/g Hb) and 108 (2.2%, 4.4% of females) had intermediate enzyme activity (2-10 IU/g Hb). A nested case-control analysis compared newborns with diminished G6PD activity with randomly selected controls.Result: Severe deficiency increased phototherapy risk (OR 4.78; 95% CI 2.60-8.78; p < 0.001). 43.2% of deficient newborns would not have been tested by targeted screening based on family history or ethnicity. Universal screening identified 6.4% of phototherapy-treated neonates who would not have been flagged for treatment under targeted screening.Conclusion: Universal G6PD screening objectively identifies newborns at increased risk for hyperbilirubinemia requiring phototherapy and may support earlier risk-adapted management.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental experiences of discharge preparation and preparedness after infants' hospitalization for surgically correctable congenital anomalies. 婴儿手术矫正先天性畸形住院后的出院准备和准备的父母经验。

IF 2.3 3区医学

Journal of Perinatology Pub Date : 2026-09-22 DOI: 10.1038/s41372-026-02908-2

Adesola C Akinkuotu, Joy E Obayemi, Madelyn Johnson, Jordan Sharpe, Patricia Knoepp, Michael R Phillips, Scott Elton, William Goodnight, Sean E McLean, Darren A DeWalt

{"title":"Parental experiences of discharge preparation and preparedness after infants' hospitalization for surgically correctable congenital anomalies.","authors":"Adesola C Akinkuotu, Joy E Obayemi, Madelyn Johnson, Jordan Sharpe, Patricia Knoepp, Michael R Phillips, Scott Elton, William Goodnight, Sean E McLean, Darren A DeWalt","doi":"10.1038/s41372-026-02908-2","DOIUrl":"https://doi.org/10.1038/s41372-026-02908-2","url":null,"abstract":"Objective: To explore parental experiences of pre-discharge education, discharge preparedness, and post-discharge support after infants' hospitalization for surgically correctable congenital anomalies (SCCAs).Study design: Qualitative study using semi-structured interviews with English-speaking women whose pregnancies were associated with SCCAs from 2018-2023 and resulted in live birth and survival to discharge from a tertiary care children's hospital. Interviews were analyzed thematically.Results: Twenty-two interviews were conducted. SCCAs included congenital diaphragmatic hernia (n = 8), congenital pulmonary airway malformations (n = 4), myelomeningocele (n = 5), gastroschisis (n = 4), or omphalocele (n = 1). Emergent themes were: (1) lack of consistency in pre-discharge education and preparation, (2) balancing anxiety and confidence, (3) parental need for multi-layered post-discharge support, and (4) parent-identified opportunities to strengthen discharge preparation and post-discharge support.Conclusion: Parents of infants with SCCAs receive variable pre-discharge education that may limit self-efficacy and heighten anxiety during the transition home. Interventions including standardized, structured discharge education and post-discharge support may improve parental preparedness and post-discharge confidence.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0