Mayra Kotlik, Benjamin Holland, Kathryn Lowe, Samantha Wallace, Anna Latimer, Jennifer L. Chmielewski, Paulomi Chaudhry, Danielle E. Soranno, Cara L. Slagle, Michelle C. Starr
{"title":"Acute kidney injury in neonates after implementation of a standardized neonatal nephrology consult program: a single center experience","authors":"Mayra Kotlik, Benjamin Holland, Kathryn Lowe, Samantha Wallace, Anna Latimer, Jennifer L. Chmielewski, Paulomi Chaudhry, Danielle E. Soranno, Cara L. Slagle, Michelle C. Starr","doi":"10.1038/s41372-024-02197-7","DOIUrl":"10.1038/s41372-024-02197-7","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 1","pages":"101-103"},"PeriodicalIF":2.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siyuan Jiang, Xin Cui, Anup Katheria, Neil N Finer, Mihoko V Bennett, Jochen Profit, Henry C Lee
{"title":"Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants.","authors":"Siyuan Jiang, Xin Cui, Anup Katheria, Neil N Finer, Mihoko V Bennett, Jochen Profit, Henry C Lee","doi":"10.1038/s41372-024-02194-w","DOIUrl":"https://doi.org/10.1038/s41372-024-02194-w","url":null,"abstract":"<p><strong>Objective: </strong>To assess the relationship between 5-min oxygen saturation (SpO2) and outcomes in extremely preterm infants.</p><p><strong>Study design: </strong>This cohort study included infants ≤28 weeks' gestation across nine hospitals from 2020 to 2022. Death and / or severe intraventricular hemorrhage (IVH) were compared between infants with 5-min SpO2 < 80% and 80-100% using Poisson regression models. Receiver Operating Characteristic (ROC) curve and optimal breakpoint analysis were used to estimate the optimal breakpoint of 5-min SpO2 in relation to outcomes.</p><p><strong>Result: </strong>Of 390 infants, 184 (47.2%) had 5-min SpO2 < 80%. A 5-min SpO2 < 80% was independently associated with increased risks of death and / or severe IVH, early death, and severe IVH. ROC analysis of 5-min SpO2 identified optimal breakpoint at 81-85%, above which no additional benefit in outcomes was observed.</p><p><strong>Conclusion: </strong>Our findings support the current recommendation of 5-min SpO2 target of ≥80% for extremely preterm infants.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alyssa R Thomas, Caitlin Bowen, Elisa Abdulhayoglu, Elizabeth Brennick, Kendra Woo, Margaret F Everett, Eleonore Valencia, Kristen T Leeman, Simon M Manning, Elisabeth Kaza
{"title":"Structured pre-delivery huddles enhance confidence in managing newborns with critical congenital heart disease in the delivery room.","authors":"Alyssa R Thomas, Caitlin Bowen, Elisa Abdulhayoglu, Elizabeth Brennick, Kendra Woo, Margaret F Everett, Eleonore Valencia, Kristen T Leeman, Simon M Manning, Elisabeth Kaza","doi":"10.1038/s41372-024-02196-8","DOIUrl":"10.1038/s41372-024-02196-8","url":null,"abstract":"<p><strong>Background: </strong>Newborns with critical congenital heart disease (CCHD) require specialized delivery room management, but varying experience and knowledge can reduce confidence and impact care.</p><p><strong>Methods: </strong>A pre-delivery, structured huddle checklist was introduced, addressing team roles, expected physiology, and management plans. PDSA cycles incorporated guidelines and simulation-based education to improve confidence in specialized resuscitation strategies. Surveys were conducted at baseline and 6 months.</p><p><strong>Results: </strong>Baseline, all-respondent confidence in managing \"all types of CCHD\" was somewhat confident (median 3/5; IQR 2-4) increasing to moderately confident (4/5; IQR 2-4) at 6 months (p = 0.59). Respondents with 0-3 years' experience showed increased confidence over 6 months in identifying unstable infants (from baseline 24% to 67% moderately/very confident, p = 0.005), prostaglandin E1 needs (from 24% to 62%, p = 0.013) and sedation requirements (from 5% to 33%, p = 0.045).</p><p><strong>Conclusion: </strong>Structured huddles improved confidence among less experienced team members, emphasizing the importance of shared mental models before CCHD deliveries.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole M Anderson, Andrea Kitchen, Amy McKenzie, Chloe Joynt
{"title":"An Advanced Neonatal Resuscitation Educational Program in a Surgical Neonatal Intensive Care Unit: Development, Implementation and Audit from 2014 to 2023.","authors":"Nicole M Anderson, Andrea Kitchen, Amy McKenzie, Chloe Joynt","doi":"10.1038/s41372-024-02192-y","DOIUrl":"https://doi.org/10.1038/s41372-024-02192-y","url":null,"abstract":"<p><strong>Objective: </strong>The design, implementation and audit of a multidisciplinary advanced neonatal resuscitation education initiative for \"in unit\" events in a quaternary NICU over a 9-year period, divided into 3-year epochs of \"pre\", \"implementation\" and \"maintenance\" is described.</p><p><strong>Study design: </strong>A didactic and simulation quality improvement initiative focused on teaching and reinforcing specific algorithms endorsed by the American Heart Association (AHA) to target resuscitation needs of older neonates including surgical and cardiac conditions. Qualitative and quantitative data pre and post implementation was audited.</p><p><strong>Results: </strong>Post education implementation, team members performed quicker hemodynamic assessments and applied CPR and/or bolus epinephrine correctly in higher proportions during acute events. During supraventricular tachycardia, vagal maneuver use and medication administration time improved.</p><p><strong>Conclusion: </strong>Advanced neonatal resuscitation education and reinforcement targeted for event etiology, allow for AHA algorithms to be successfully taught and performed within a quaternary NICU with improvement in hemodynamic assessments and AHA algorithm implementation.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mar Romero-Lopez, Mamta Naik, Lindsay F Holzapfel, Jon E Tyson, Claudia Pedroza, Kaashif A Ahmad, Matthew A Rysavy, Waldemar A Carlo, Yuxin Zhang, Covi Tibe, Ariel A Salas
{"title":"Enteral nutritional practices in extremely preterm infants: a survey of U.S. NICUs.","authors":"Mar Romero-Lopez, Mamta Naik, Lindsay F Holzapfel, Jon E Tyson, Claudia Pedroza, Kaashif A Ahmad, Matthew A Rysavy, Waldemar A Carlo, Yuxin Zhang, Covi Tibe, Ariel A Salas","doi":"10.1038/s41372-024-02198-6","DOIUrl":"https://doi.org/10.1038/s41372-024-02198-6","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley D Osborne, Daphna Yasova Barbeau, Tiffany Gladdis, Kara Hansen, Tonia Branche, Emily R Miller, Christine C Pazandak, Margaret K Hoge, Michelle Spencer, Diana Montoya-Williams, Ryan Barbeau, Heather Padratzik, Stephen Lassen
{"title":"Understanding and addressing mental health challenges of families admitted to the neonatal intensive care unit.","authors":"Ashley D Osborne, Daphna Yasova Barbeau, Tiffany Gladdis, Kara Hansen, Tonia Branche, Emily R Miller, Christine C Pazandak, Margaret K Hoge, Michelle Spencer, Diana Montoya-Williams, Ryan Barbeau, Heather Padratzik, Stephen Lassen","doi":"10.1038/s41372-024-02187-9","DOIUrl":"https://doi.org/10.1038/s41372-024-02187-9","url":null,"abstract":"<p><p>This article reviews the psychological distress experienced by NICU families, including anxiety, postpartum depression (PPD), and post-traumatic stress disorder (PTSD), in addition to providing recommendations for clinicians at the individual, institutional, and national level. Currently, mental health screenings, specialized evaluations, and treatment options are not routinely offered to NICU families and are frequently under-utilized when offered. Here we provide expert opinion recommendations to address challenges in supporting universal screening, offering bedside interventions, including trained mental health professionals in care plans, updating neonatology training competencies, and advocating for policies that support the mental health of NICU families. We advocate that mental health of NICU families be incorporated into the standard of care.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alloimmunization to low and high prevalence blood group antigens: rare causes of hemolytic disease of the fetus and newborn.","authors":"Douglas P Blackall, Mark W Tomlinson","doi":"10.1038/s41372-024-02186-w","DOIUrl":"https://doi.org/10.1038/s41372-024-02186-w","url":null,"abstract":"<p><p>Maternal alloimmunization to paternal blood group antigens is the underlying cause of hemolytic disease of the fetus and newborn. Alloantibodies to the major, clinically significant blood group antigens are readily identified by the blood bank which, in turn, allows for appropriate monitoring of the maternal-fetal unit. However, uncommon blood group antibodies, particularly those directed against low and high prevalence antigens, present a more formidable challenge for obstetricians, neonatologists, and transfusion medicine specialists. This article focuses on these unusual blood group antibodies beginning with a classic case presentation. The identification of these antibodies by the blood bank, their monitoring during pregnancy, and the associated implications for transfusion are then discussed. In these cases, a close collaborative partnership is required to ensure an optimal outcome for mothers and their neonates.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies.","authors":"Kristin Sohn, Victoria Palacios, Reese Clark","doi":"10.1038/s41372-024-02188-8","DOIUrl":"https://doi.org/10.1038/s41372-024-02188-8","url":null,"abstract":"<p><strong>Objective: </strong>To utilize an evidence-based probiotic protocol to achieve a 50% reduction in necrotizing enterocolitis (NEC) ≥ stage 2 and bloody stools.</p><p><strong>Study design: </strong>From January 2022 through September 2023, daily enteral Bifidobacterium longum ssp. infantis EVC001 (B. infantis EVC001) was administered to babies ≤ 33 6/7 weeks gestation until 36 weeks post menstrual age. Feeding tolerance and complications were compared to babies admitted during the prior two-year period. Fisher's Exact test was used to analyze proportional data and t test was used for continuous variables.</p><p><strong>Results: </strong>A total of 265 babies received EVC001, and a total of 277 babies formed the pre-probiotic cohort. Probiotic use was associated with decreased NEC ≥ stage 2 (p = 0.0058), reduced bloody stools (p < 0.0001), decreased time to full enteral feeds (p < 0.0001), and decreased total parenteral nutrition (TPN) days (p < 0.0001).</p><p><strong>Conclusion: </strong>Administration of B. infantis EVC001 was associated with a decrease in NEC, a decrease in bloody stools, and improvement in feeding tolerance in premature babies.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heidi J. Steflik, David T. Selewski, Corinne Corrigan, Daniel L. Brinton
{"title":"Acute kidney injury associated with increased costs in the neonatal intensive care unit: analysis of Pediatric Health Information System database","authors":"Heidi J. Steflik, David T. Selewski, Corinne Corrigan, Daniel L. Brinton","doi":"10.1038/s41372-024-02193-x","DOIUrl":"10.1038/s41372-024-02193-x","url":null,"abstract":"Compare neonatal intensive care unit hospitalization costs between neonates with and without AKI; identify predictors of AKI-associated costs. We hypothesized neonates with AKI would amass more costs than those without AKI. Retrospective, multicenter cohort study of surviving neonates cared for 2015–2021 in Pediatric Health Information System database. The primary outcome was estimated hospitalization costs. Data from 304,725 neonates were evaluated, 8774 (3%) with AKI and 295,951 (97%) without AKI. Neonates with AKI had $58,807 greater adjusted costs than those without AKI. AKI-associated costs were most strongly driven by Feudtner Pediatric Complex Chronic Conditions Classifications (cardiovascaular, congenital/genetic, gastrointestinal, medical technology) and gestational age. Adjusted costs decreased with increasing gestational age, regardless of AKI status. AKI is independently associated with increased hospital costs. Knowledge of these drivers can help in identifying high-value practices for cost mitigation strategies.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 1","pages":"94-100"},"PeriodicalIF":2.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41372-024-02193-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tiana T Nguyen, Roberta Pineda, Stacey Reynolds, Elizabeth E Rogers, Audrey E Kane
{"title":"Medical and sociodemographic characteristics related to feeding therapy referral and service provision for preterm infants in the neonatal intensive care unit.","authors":"Tiana T Nguyen, Roberta Pineda, Stacey Reynolds, Elizabeth E Rogers, Audrey E Kane","doi":"10.1038/s41372-024-02184-y","DOIUrl":"https://doi.org/10.1038/s41372-024-02184-y","url":null,"abstract":"<p><strong>Objective: </strong>To determine the scope of feeding therapy for preterm infants in the NICU and medical and sociodemographic factors related to feeding therapy referral and service provision.</p><p><strong>Study design: </strong>Retrospective study of infants born <37 weeks gestation in a level IV NICU between January 2017 and December 2019.</p><p><strong>Result: </strong>Among 547 infants, 27% of infants received a feeding therapy referral, and 74% of those referrals were problem-based referrals. Feeding therapy referrals were more likely among infants with lower gestational ages and birthweights (both p < 0.001). In addition, infants with greater medical complexity, who required oxygen at 36 weeks, who had a history of mechanical ventilation, and who had a higher postmenstrual age at discharge were more likely to be referred to feeding therapy (all p < 0.001).</p><p><strong>Conclusion: </strong>While medical factors relate to feeding therapy referrals, there are other complex person and system factors that determine feeding therapy referral and service provision.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}