Racial disparities and outcomes in neonatal hypoxic-ischemic encephalopathy.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-06-21 DOI:10.1038/s41372-025-02335-9

Marwa M Elgendy, Ceyda Acun, Josef Cortez, Hany Aly, Mohamed A Mohamed

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引用次数: 0

Abstract

Objectives: To investigate racial disparities in the prevalence, severity, intervention, and outcomes of hypoxic-ischemic encephalopathy (HIE) among neonates in the United States.

Study design: We analyzed data from the National Inpatient Sample (NIS) dataset, including full-term infants diagnosed with HIE from 2010 to 2018. Regression analysis was performed to control for clinical and demographic variables.

Results: Out of 31,249,100 infants, 23,475 (0.09%) were diagnosed with HIE. African American neonates had a 60% higher likelihood of developing HIE compared to Caucasians, adjusted odds ratio (aOR) 1.60 (1.52-1.69, p < 0.001), and were twice as likely to experience severe HIE, aOR 2.06 (1.77-2.39, p < 0.001). Overall mortality was significantly higher among African American infants, aOR 2.14, (2.02-2.26, p < 0.001). Mortality within HIE infants did not differ between African American and Caucasian infants aOR 0.88 (0.78-1.0), p < 0.61. Native American infants had a significantly lower chance of receiving hypothermia therapy compared to Caucasian infants, aOR 0.48 (0.29-0.77), p = 0.002.

Conclusion: Racial disparity exists in the prevalence, severity, and management of HIE. African Americans experience a higher prevalence and severity of HIE. Native Americans are less likely to receive hypothermia therapy for HIE.

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新生儿缺氧缺血性脑病的种族差异和结局。

目的：调查美国新生儿缺氧缺血性脑病（HIE）患病率、严重程度、干预措施和结局的种族差异。研究设计：我们分析了来自国家住院患者样本（NIS）数据集的数据，包括2010年至2018年诊断为HIE的足月婴儿。进行回归分析以控制临床和人口统计学变量。结果：在31,249,100名婴儿中，23,475名（0.09%）被诊断为HIE。非裔美国新生儿发生HIE的可能性比白种人高60%，调整优势比（aOR） 1.60 （1.52-1.69, p）结论：HIE的患病率、严重程度和管理存在种族差异。非裔美国人的HIE患病率和严重程度更高。印第安人接受低温治疗HIE的可能性较小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.